Gene Symbol: Myom2
Description: myomesin 2
Vinkemeier U, Obermann W, Weber K, Fürst D. The globular head domain of titin extends into the center of the sarcomeric M band. cDNA cloning, epitope mapping and immunoelectron microscopy of two titin-associated proteins. J Cell Sci. 1993;106 ( Pt 1):319-30 pubmed
Hornemann T, Kempa S, Himmel M, Hayess K, Furst D, Wallimann T. Muscle-type creatine kinase interacts with central domains of the M-band proteins myomesin and M-protein. J Mol Biol. 2003;332:877-87 pubmed
..Our data propose a simple model for the regulation of this dynamic interaction. ..
Schiaffino S, Reggiani C. Molecular diversity of myofibrillar proteins: gene regulation and functional significance. Physiol Rev. 1996;76:371-423 pubmed
..Both myosin and troponin isoforms contribute to the differences in the resistance to fatigue of muscle fibers...
Porter J, Merriam A, Gong B, Kasturi S, Zhou X, Hauser K, et al
. Postnatal suppression of myomesin, muscle creatine kinase and the M-line in rat extraocular muscle. J Exp Biol. 2003;206:3101-12 pubmed
..Transcripts of the major M-line structural proteins, myomesin 1 and myomesin 2, follow the same pattern of postnatal downregulation, while the embryonic heart-specific EH-myomesin 1 ..
Beqqali A, Monshouwer Kloots J, Monteiro R, Welling M, Bakkers J, Ehler E, et al
. CHAP is a newly identified Z-disc protein essential for heart and skeletal muscle function. J Cell Sci. 2010;123:1141-50 pubmed publisher
..These findings suggest that CHAP is a critical component of the sarcomere with an important role in muscle development. ..
Gokhin D, Lewis R, McKeown C, Nowak R, Kim N, Littlefield R, et al
. Tropomodulin isoforms regulate thin filament pointed-end capping and skeletal muscle physiology. J Cell Biol. 2010;189:95-109 pubmed publisher
..Thus, Tmod3 and -4 compensate for the absence of Tmod1 structurally but not functionally. We conclude that Tmod1 is a novel regulator of skeletal muscle physiology. ..
Rozanski A, Takano A, Kato P, Soares A, Lellis Santos C, Campos J, et al
. M-protein is down-regulated in cardiac hypertrophy driven by thyroid hormone in rats. Mol Endocrinol. 2013;27:2055-65 pubmed publisher
..We concluded that the M-protein expression is strongly and rapidly repressed by T3 in cardiomyocytes, which represents an important aspect for the basis of T3-dependent sarcomeric deleterious effects in the heart. ..