Gene Symbol: Myom1
Description: myomesin 1
Alias: myomesin-1, myomesin 1 (skelemin) 185kDa
Species: rat
Products:     Myom1

Top Publications

  1. Hornemann T, Kempa S, Himmel M, Hayess K, Furst D, Wallimann T. Muscle-type creatine kinase interacts with central domains of the M-band proteins myomesin and M-protein. J Mol Biol. 2003;332:877-87 pubmed
    ..Our data propose a simple model for the regulation of this dynamic interaction. ..
  2. Pinotsis N, Lange S, Perriard J, Svergun D, Wilmanns M. Molecular basis of the C-terminal tail-to-tail assembly of the sarcomeric filament protein myomesin. EMBO J. 2008;27:253-64 pubmed
    ..We predict that the found My12-helix-My13 domain topology may provide a structural template for the filament architecture of the entire C-terminal Ig domain array My9-My13 of myomesin. ..
  3. Schoenauer R, Lange S, Hirschy A, Ehler E, Perriard J, Agarkova I. Myomesin 3, a novel structural component of the M-band in striated muscle. J Mol Biol. 2008;376:338-51 pubmed publisher
    ..We propose that each member of the myomesin family is a component of one of the distinct ultrastructures, the M-lines, which modulate the mechanical properties of the M-bands in different muscle types. ..
  4. Vinkemeier U, Obermann W, Weber K, F├╝rst D. The globular head domain of titin extends into the center of the sarcomeric M band. cDNA cloning, epitope mapping and immunoelectron microscopy of two titin-associated proteins. J Cell Sci. 1993;106 ( Pt 1):319-30 pubmed
  5. Braun A, Bordoy R, Stanchi F, Moser M, Kostka G G, Ehler E, et al. PINCH2 is a new five LIM domain protein, homologous to PINCHand localized to focal adhesions. Exp Cell Res. 2003;284:239-50 pubmed
    ..Finally, we demonstrate that PINCH2 localizes to focal adhesions in NIH 3T3 cells and to Z-disks in primary rat cardiomyocytes. ..
  6. Porter J, Merriam A, Gong B, Kasturi S, Zhou X, Hauser K, et al. Postnatal suppression of myomesin, muscle creatine kinase and the M-line in rat extraocular muscle. J Exp Biol. 2003;206:3101-12 pubmed
    ..Transcripts of the major M-line structural proteins, myomesin 1 and myomesin 2, follow the same pattern of postnatal downregulation, while the embryonic heart-specific EH-..
  7. Weinert S, Bergmann N, Luo X, Erdmann B, Gotthardt M. M line-deficient titin causes cardiac lethality through impaired maturation of the sarcomere. J Cell Biol. 2006;173:559-70 pubmed
  8. Reddy K, Fox J, Price M, Kulkarni S, Gupta S, Das B, et al. Nuclear localization of Myomesin-1: possible functions. J Muscle Res Cell Motil. 2008;29:1-8 pubmed publisher
    ..Gene array analysis showed that the presence of Myomesin-I in the nucleus led to the differential expression of more than 42 genes. These studies show a novel and previously unknown localization and function for Myomesin-I. ..
  9. Beqqali A, Monshouwer Kloots J, Monteiro R, Welling M, Bakkers J, Ehler E, et al. CHAP is a newly identified Z-disc protein essential for heart and skeletal muscle function. J Cell Sci. 2010;123:1141-50 pubmed publisher
    ..These findings suggest that CHAP is a critical component of the sarcomere with an important role in muscle development. ..

More Information


  1. Gokhin D, Lewis R, McKeown C, Nowak R, Kim N, Littlefield R, et al. Tropomodulin isoforms regulate thin filament pointed-end capping and skeletal muscle physiology. J Cell Biol. 2010;189:95-109 pubmed publisher
    ..Thus, Tmod3 and -4 compensate for the absence of Tmod1 structurally but not functionally. We conclude that Tmod1 is a novel regulator of skeletal muscle physiology. ..
  2. Pinotsis N, Chatziefthimiou S, Berkemeier F, Beuron F, Mavridis I, Konarev P, et al. Superhelical architecture of the myosin filament-linking protein myomesin with unusual elastic properties. PLoS Biol. 2012;10:e1001261 pubmed publisher
    ..In general terms, our data demonstrate how repetitive domain modules such as those found in myomesin could generate highly elastic protein structures in highly organized cell systems such as muscle sarcomeres. ..
  3. Kravchenko I, Furalyov V, Chatziefthimiou S, Wilmanns M, Popov V. Induction of insulin-like growth factor 1 splice forms by subfragments of myofibrillar proteins. Mol Cell Endocrinol. 2015;399:69-77 pubmed publisher
  4. Schiaffino S, Reggiani C. Molecular diversity of myofibrillar proteins: gene regulation and functional significance. Physiol Rev. 1996;76:371-423 pubmed
    ..Both myosin and troponin isoforms contribute to the differences in the resistance to fatigue of muscle fibers...
  5. Wooldridge A, Fortner C, Lontay B, Akimoto T, Neppl R, Facemire C, et al. Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle. J Biol Chem. 2008;283:11850-9 pubmed publisher
    ..Our findings suggest roles for SMTNL1 in cGMP/cAMP-mediated adaptations to exercise through mechanisms involving direct modulation of contractile activity. ..
  6. du Puy L, Beqqali A, van Tol H, Monshouwer Kloots J, Passier R, Haagsman H, et al. Sarcosin (Krp1) in skeletal muscle differentiation: gene expression profiling and knockdown experiments. Int J Dev Biol. 2012;56:301-9 pubmed publisher
    ..RNA interference mediated knock-down of SARCOSIN in the C2C12 myoblast cell line appeared to be stimulatory in the early phase of differentiation, but inhibitory at a later phase of differentiation. ..