Gene Symbol: Myo5b
Description: myosin Vb
Alias: Myr6, unconventional myosin-Vb, Myosin of the dilute-myosin-V family, myosin 5B, myosin heavy chain myr 6
Species: rat
Products:     Myo5b

Top Publications

  1. Nedvetsky P, Stefan E, Frische S, Santamaria K, Wiesner B, Valenti G, et al. A Role of myosin Vb and Rab11-FIP2 in the aquaporin-2 shuttle. Traffic. 2007;8:110-23 pubmed
    ..In summary, we identified myosin Vb as a motor protein involved in AQP2 recycling and show that myosin Vb- and Rab11-FIP2-dependent recycling of AQP2 is an integral part of the AQP2 shuttle. ..
  2. Swiatecka Urban A, Talebian L, Kanno E, Moreau Marquis S, Coutermarsh B, Hansen K, et al. Myosin Vb is required for trafficking of the cystic fibrosis transmembrane conductance regulator in Rab11a-specific apical recycling endosomes in polarized human airway epithelial cells. J Biol Chem. 2007;282:23725-36 pubmed
    ..Taken together, these data indicate that myosin Vb is required for CFTR recycling in Rab11a-specific apical recycling endosomes in polarized human airway epithelial cells. ..
  3. Roland J, Kenworthy A, Peranen J, Caplan S, Goldenring J. Myosin Vb interacts with Rab8a on a tubular network containing EHD1 and EHD3. Mol Biol Cell. 2007;18:2828-37 pubmed
    ..Additionally, dynamic live cell imaging demonstrates distinct pathways for Rab11a and Rab8a vesicle trafficking. These findings indicate that Rab8a and Rab11a define different recycling pathways that both use Myosin Vb. ..
  4. Ishikura S, Klip A. Muscle cells engage Rab8A and myosin Vb in insulin-dependent GLUT4 translocation. Am J Physiol Cell Physiol. 2008;295:C1016-25 pubmed publisher
    ..These results support a model whereby AS160, Rab8A, and myosin Vb are required for insulin-induced GLUT4 translocation in muscle cells, potentially as part of a linear signaling cascade. ..
  5. Chu B, Ge L, Xie C, Zhao Y, Miao H, Wang J, et al. Requirement of myosin Vb.Rab11a.Rab11-FIP2 complex in cholesterol-regulated translocation of NPC1L1 to the cell surface. J Biol Chem. 2009;284:22481-90 pubmed publisher
    ..These results suggest that the efficient transport of NPC1L1 to the PM is dependent on the microfilament-associated myosin Vb.Rab11a.Rab11-FIP2 triple complex. ..
  6. Khandelwal P, Prakasam H, Clayton D, Ruiz W, Gallo L, van Roekel D, et al. A Rab11a-Rab8a-Myo5B network promotes stretch-regulated exocytosis in bladder umbrella cells. Mol Biol Cell. 2013;24:1007-19 pubmed publisher
    ..Additional studies demonstrate that the unconventional motor protein myosin5B motor (Myo5B) works in association with the Rab8a-Rab11a module to promote exocytosis, possibly by ensuring transit of DFVs ..
  7. Provance D, Gourley C, Silan C, Cameron L, Shokat K, Goldenring J, et al. Chemical-genetic inhibition of a sensitized mutant myosin Vb demonstrates a role in peripheral-pericentriolar membrane traffic. Proc Natl Acad Sci U S A. 2004;101:1868-73 pubmed
  8. Ultanir S, Yadav S, Hertz N, Oses Prieto J, Claxton S, Burlingame A, et al. MST3 kinase phosphorylates TAO1/2 to enable Myosin Va function in promoting spine synapse development. Neuron. 2014;84:968-82 pubmed publisher
  9. Liu Y, Xu X, Chen Q, Wang T, Deng C, Song B, et al. Myosin Vb controls biogenesis of post-Golgi Rab10 carriers during axon development. Nat Commun. 2013;4:2005 pubmed publisher
    ..Here, we report that Rab10 interaction with myosin Vb (MYO5B) determines the formation of Rab10 carriers and is important for axon development...

More Information


  1. Lazo O, Gonzalez A, Ascano M, Kuruvilla R, Couve A, Bronfman F. BDNF regulates Rab11-mediated recycling endosome dynamics to induce dendritic branching. J Neurosci. 2013;33:6112-22 pubmed publisher
    ..We propose that Rab11-dependent dendritic recycling provides a mechanism to retain TrkB in dendrites and to increase local signaling to regulate arborization. ..
  2. Szperl A, Golachowska M, Bruinenberg M, Prekeris R, Thunnissen A, Karrenbeld A, et al. Functional characterization of mutations in the myosin Vb gene associated with microvillus inclusion disease. J Pediatr Gastroenterol Nutr. 2011;52:307-13 pubmed publisher
    ..Recently, various MYO5B gene mutations have been identified in patients with MVID...
  3. Lise M, Wong T, Trinh A, Hines R, Liu L, Kang R, et al. Involvement of myosin Vb in glutamate receptor trafficking. J Biol Chem. 2006;281:3669-78 pubmed
    ..These results reveal a novel mechanism for the transport of a specific glutamate receptor subunit in neurons mediated by a member of the myosin V family. ..
  4. Zhao L, Koslovsky J, Reinhard J, Bahler M, Witt A, Provance D, et al. Cloning and characterization of myr 6, an unconventional myosin of the dilute/myosin-V family. Proc Natl Acad Sci U S A. 1996;93:10826-31 pubmed
    ..M., Reed-Fourquet, L., Wu, E. & Wu, J.Y. (1990) Proc. Natl. Acad. Sci. USA 87, 8491-8495]. ..
  5. Boone M, Deen P. Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption. Pflugers Arch. 2008;456:1005-24 pubmed publisher
    ..This review focuses on our recent increase in understanding of the molecular mechanisms underlying AVP-regulated renal water transport in both health and disease. ..
  6. Schumacher Bass S, Vesely E, Zhang L, Ryland K, McEwen D, Chan P, et al. Role for myosin-V motor proteins in the selective delivery of Kv channel isoforms to the membrane surface of cardiac myocytes. Circ Res. 2014;114:982-92 pubmed publisher
    ..5 surface density, of which little is yet known. To investigate the role of the unconventional myosin-V (MYO5A and MYO5B) motors in determining the cell surface density of Kv1.5. ..
  7. Satoh T. Rho GTPases in insulin-stimulated glucose uptake. Small Gtpases. 2014;5:e28102 pubmed publisher
    ..In addition, the role for another Rho family member TC10 and its regulatory mechanism in adipocyte insulin signaling are described. ..
  8. Wang Z, Edwards J, Riley N, Provance D, Karcher R, Li X, et al. Myosin Vb mobilizes recycling endosomes and AMPA receptors for postsynaptic plasticity. Cell. 2008;135:535-48 pubmed publisher
    ..Thus, Ca2+-activated MyoVb captures and mobilizes REs for AMPA receptor insertion and spine growth, providing a mechanistic link between the induction and expression of postsynaptic plasticity. ..