Myo3a

Summary

Gene Symbol: Myo3a
Description: myosin IIIA
Alias: RGD1560083, myosin-IIIa
Species: rat

Top Publications

  1. Walsh T, Walsh V, Vreugde S, Hertzano R, Shahin H, Haika S, et al. From flies' eyes to our ears: mutations in a human class III myosin cause progressive nonsyndromic hearing loss DFNB30. Proc Natl Acad Sci U S A. 2002;99:7518-23 pubmed
    ..Here, we show that normal hearing in humans requires myosin IIIA, the human homolog of NINAC...
  2. Komaba S, Inoue A, Maruta S, Hosoya H, Ikebe M. Determination of human myosin III as a motor protein having a protein kinase activity. J Biol Chem. 2003;278:21352-60 pubmed
    ..The present study is the first report that clearly demonstrates that the class III myosin is an actin-based motor protein having a protein kinase activity. ..
  3. Schneider M, Dose A, Salles F, Chang W, Erickson F, Burnside B, et al. A new compartment at stereocilia tips defined by spatial and temporal patterns of myosin IIIa expression. J Neurosci. 2006;26:10243-52 pubmed
    ..We show that myosin IIIa, which has been implicated in nonsyndromic progressive hearing loss, is localized at stereocilia tips...
  4. Wallace H, Maden M. Irradiation inhibits the regeneration of aneurogenic limbs. J Exp Zool. 1976;195:353-8 pubmed
  5. Katti C, Dalal J, Dose A, Burnside B, Battelle B. Cloning and distribution of myosin 3B in the mouse retina: differential distribution in cone outer segments. Exp Eye Res. 2009;89:224-37 pubmed publisher
    ..Although vertebrates possess two class III myosin genes, myo3A and myo3B, recent studies have focused on Myo3A because mutations in the human gene are implicated in progressive ..
  6. Dalal J, Stevens S, Alvarez S, Munoz N, Kempler K, Dose A, et al. Mouse class III myosins: kinase activity and phosphorylation sites. J Neurochem. 2011;119:772-84 pubmed publisher
    ..Our findings are a major step toward understanding how the functions of class III myosins are regulated by phosphorylation. ..
  7. Mecklenburg K, Freed S, Raval M, Quintero O, Yengo C, O Tousa J. Invertebrate and vertebrate class III myosins interact with MORN repeat-containing adaptor proteins. PLoS ONE. 2015;10:e0122502 pubmed publisher
    ..Co-precipitation experiments demonstrated that human MORN4 binds to human myosin IIIA (MYO3A)...
  8. Lelli A, Michel V, Boutet de Monvel J, Cortese M, Bosch Grau M, Aghaie A, et al. Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth. J Cell Biol. 2016;212:231-44 pubmed publisher
    ..b>Myosin IIIa, defective in the late-onset deafness form DFNB30, has been proposed to transport espin-1 to the tips of ..
  9. Salles F, Merritt R, Manor U, Dougherty G, Sousa A, Moore J, et al. Myosin IIIa boosts elongation of stereocilia by transporting espin 1 to the plus ends of actin filaments. Nat Cell Biol. 2009;11:443-50 pubmed publisher
    Two proteins implicated in inherited deafness, myosin IIIa, a plus-end-directed motor, and espin, an actin-bundling protein containing the actin-monomer-binding motif WH2, have been shown to influence the length of mechanosensory ..

More Information

Publications12

  1. Gillespie P, Muller U. Mechanotransduction by hair cells: models, molecules, and mechanisms. Cell. 2009;139:33-44 pubmed publisher
  2. Walsh V, Raviv D, Dror A, Shahin H, Walsh T, Kanaan M, et al. A mouse model for human hearing loss DFNB30 due to loss of function of myosin IIIA. Mamm Genome. 2011;22:170-7 pubmed publisher
    The motor protein myosin IIIA is critical for maintenance of normal hearing...
  3. Merritt R, Manor U, Salles F, Grati M, Dose A, Unrath W, et al. Myosin IIIB uses an actin-binding motif in its espin-1 cargo to reach the tips of actin protrusions. Curr Biol. 2012;22:320-5 pubmed publisher
    b>Myosin IIIA (MYO3A) targets actin protrusion tips using a motility mechanism dependent on both motor and tail actin-binding activity [1]...