Gene Symbol: Myo1e
Description: myosin IE
Alias: MYR5, Myr3, unconventional myosin-Ie, Unconventional myosin from rat 5, myosin heavy chain myr 3, myosin-Ie, unconventional myosin 1E
Huber L, Fialka I, Paiha K, Hunziker W, Sacks D, Bahler M, et al
. Both calmodulin and the unconventional myosin Myr4 regulate membrane trafficking along the recycling pathway of MDCK cells. Traffic. 2000;1:494-503 pubmed
..Altogether, our data indicate that trafficking at early steps of the endocytic pathway in Madin-Darby Canine Kidney cells depends on the actin-based mechanoenzyme myr4, its light chain CaM, and polymerized actin. ..
Benesh A, Nambiar R, McConnell R, Mao S, Tabb D, Tyska M. Differential localization and dynamics of class I myosins in the enterocyte microvillus. Mol Biol Cell. 2010;21:970-8 pubmed publisher
Stoffler H, Ruppert C, Reinhard J, Bahler M. A novel mammalian myosin I from rat with an SH3 domain localizes to Con A-inducible, F-actin-rich structures at cell-cell contacts. J Cell Biol. 1995;129:819-30 pubmed
..Incubation of NRK cells with Con A stimulated the formation of myr 3-containing structures along cell-cell contacts. These results suggest for myr 3 a function mediated by cell-cell contact. ..
El Mezgueldi M, Tang N, Rosenfeld S, Ostap E. The kinetic mechanism of Myo1e (human myosin-IC). J Biol Chem. 2002;277:21514-21 pubmed
b>Myo1e is the widely expressed subclass-1 member of the myosin-I family. We performed a kinetic analysis of a truncated myo1e that consists of the motor and the single IQ motif with a bound calmodulin...
Dumont R, Zhao Y, Holt J, Bähler M, Gillespie P. Myosin-I isozymes in neonatal rodent auditory and vestibular epithelia. J Assoc Res Otolaryngol. 2002;3:375-89 pubmed
..Myo1c (myosin-Ib or myr 2). and Myo1e (myr 3). By contrast, Myo1a (brush-border myosin-I), Myo1d (myosin lg or myr 4)...
Krendel M, Osterweil E, Mooseker M. Myosin 1E interacts with synaptojanin-1 and dynamin and is involved in endocytosis. FEBS Lett. 2007;581:644-50 pubmed
..two proteins with prominent functions in endocytosis, synaptojanin-1 and dynamin, bind to the SH3 domain of human Myo1E. Myosin 1E co-localizes with clathrin- and dynamin-containing puncta at the plasma membrane and this co-..
Krendel M, Kim S, Willinger T, Wang T, Kashgarian M, Flavell R, et al
. Disruption of Myosin 1e promotes podocyte injury. J Am Soc Nephrol. 2009;20:86-94 pubmed publisher
Myosin 1e (Myo1e) is one of two Src homology 3 domain-containing "long-tailed" type I myosins in vertebrates, whose functions in health and disease are incompletely understood...
Feeser E, Ignacio C, Krendel M, Ostap E. Myo1e binds anionic phospholipids with high affinity. Biochemistry. 2010;49:9353-60 pubmed publisher
b>Myo1e is a single-headed motor protein that has been shown to play roles in clathrin-mediated endocytosis in HeLa cells and podocyte function in the kidney...