Gene Symbol: Myo1c
Description: myosin 1C
Alias: Myr2, unconventional myosin-Ic, MMI-beta, MMIb, myosin I beta, myosin IC, myosin IC-like, myosin heavy chain myr 2, myosin-Ic, unconventional myosin Myr2 I heavy chain
Species: rat
Products:     Myo1c

Top Publications

  1. Huber L, Fialka I, Paiha K, Hunziker W, Sacks D, Bahler M, et al. Both calmodulin and the unconventional myosin Myr4 regulate membrane trafficking along the recycling pathway of MDCK cells. Traffic. 2000;1:494-503 pubmed
    ..Altogether, our data indicate that trafficking at early steps of the endocytic pathway in Madin-Darby Canine Kidney cells depends on the actin-based mechanoenzyme myr4, its light chain CaM, and polymerized actin. ..
  2. Bose A, Guilherme A, Robida S, Nicoloro S, Zhou Q, Jiang Z, et al. Glucose transporter recycling in response to insulin is facilitated by myosin Myo1c. Nature. 2002;420:821-4 pubmed
    ..Here we report that the unconventional myosin Myo1c is present in GLUT4-containing vesicles purified from 3T3-L1 adipocytes...
  3. Yip M, Ramm G, Larance M, Hoehn K, Wagner M, Guilhaus M, et al. CaMKII-mediated phosphorylation of the myosin motor Myo1c is required for insulin-stimulated GLUT4 translocation in adipocytes. Cell Metab. 2008;8:384-98 pubmed publisher
    The unconventional myosin Myo1c has been implicated in insulin-regulated GLUT4 translocation to the plasma membrane in adipocytes. We show that Myo1c undergoes insulin-dependent phosphorylation at S701...
  4. Tyska M, Mackey A, Huang J, Copeland N, Jenkins N, Mooseker M. Myosin-1a is critical for normal brush border structure and composition. Mol Biol Cell. 2005;16:2443-57 pubmed
    ..Nevertheless, these results indicate that myosin-1a is a critical multifunctional component of the enterocyte, required for maintaining the normal composition and highly ordered structure of the brush border. ..
  5. Phillips K, Tong S, Goodyear R, Richardson G, Cyr J. Stereociliary myosin-1c receptors are sensitive to calcium chelation and absent from cadherin 23 mutant mice. J Neurosci. 2006;26:10777-88 pubmed
    ..The molecular motor myosin-1c (Myo1c) functions in adaptation of the hair-cell response to sustained mechanical stimuli and is therefore an integral ..
  6. Chinthalapudi K, Taft M, Martin R, Heissler S, Preller M, Hartmann F, et al. Mechanism and specificity of pentachloropseudilin-mediated inhibition of myosin motor activity. J Biol Chem. 2011;286:29700-8 pubmed publisher
  7. Arif E, Wagner M, Johnstone D, Wong H, George B, Pruthi P, et al. Motor protein Myo1c is a podocyte protein that facilitates the transport of slit diaphragm protein Neph1 to the podocyte membrane. Mol Cell Biol. 2011;31:2134-50 pubmed publisher
    ..This study identifies a novel interaction between Neph1 and the motor protein Myo1c, where Myo1c plays an active role in targeting Neph1 to the podocyte cell membrane...
  8. Tiwari A, Jung J, Inamdar S, Nihalani D, Choudhury A. The myosin motor Myo1c is required for VEGFR2 delivery to the cell surface and for angiogenic signaling. Am J Physiol Heart Circ Physiol. 2013;304:H687-96 pubmed publisher
    ..In the current study, performed in primary human endothelial cells, we demonstrate that unconventional myosin 1c (Myo1c; class I family member) regulates the localization of VEGFR2 at the PM...
  9. Satoh T. Rho GTPases in insulin-stimulated glucose uptake. Small Gtpases. 2014;5:e28102 pubmed publisher
    ..In addition, the role for another Rho family member TC10 and its regulatory mechanism in adipocyte insulin signaling are described. ..

More Information


  1. Etournay R, El Amraoui A, Bahloul A, Blanchard S, Roux I, Pezeron G, et al. PHR1, an integral membrane protein of the inner ear sensory cells, directly interacts with myosin 1c and myosin VIIa. J Cell Sci. 2005;118:2891-9 pubmed
    ..Moreover, as both myosins have been implicated in the mechanotransduction slow adaptation process that takes place in the hair bundles, we propose that PHR1 is also involved in this process. ..
  2. Ruppert C, Godel J, Muller R, Kroschewski R, Reinhard J, Bahler M. Localization of the rat myosin I molecules myr 1 and myr 2 and in vivo targeting of their tail domains. J Cell Sci. 1995;108 ( Pt 12):3775-86 pubmed
    ..These results suggest that the tail domains of myr 1 and myr 2 are sufficient for subcellular targeting but that their head domains also contribute significantly to maintaining a proper subcellular localization. ..
  3. Tang N, Lin T, Yang J, Foskett J, Ostap E. CIB1 and CaBP1 bind to the myo1c regulatory domain. J Muscle Res Cell Motil. 2007;28:285-91 pubmed
    b>Myo1c is a member of the myosin-I family that binds phosphoinositides and links the actin cytoskeleton to cellular membranes...
  4. Batters C, Wallace M, Coluccio L, Molloy J. A model of stereocilia adaptation based on single molecule mechanical studies of myosin I. Philos Trans R Soc Lond B Biol Sci. 2004;359:1895-905 pubmed
    ..apparatus to perform single molecule mechanical experiments using the unconventional myosins, Myo1b and Myo1c. The single-headed nature and slow ATPase kinetics of these myosins make them ideal for detailed studies of the ..
  5. Dumont R, Zhao Y, Holt J, Bähler M, Gillespie P. Myosin-I isozymes in neonatal rodent auditory and vestibular epithelia. J Assoc Res Otolaryngol. 2002;3:375-89 pubmed
    ..Using RT-PCR, we found prominent expression of three isozymes, Myo1b (also known as myosin-Ia or myr 1). Myo1c (myosin-Ib or myr 2). and Myo1e (myr 3). By contrast, Myo1a (brush-border myosin-I), Myo1d (myosin lg or myr 4)...
  6. Adamek N, Lieto Trivedi A, Geeves M, Coluccio L. Modification of loop 1 affects the nucleotide binding properties of Myo1c, the adaptation motor in the inner ear. Biochemistry. 2010;49:958-71 pubmed publisher
    b>Myo1c is one of eight members of the mammalian myosin I family of actin-associated molecular motors...
  7. Benesh A, Nambiar R, McConnell R, Mao S, Tabb D, Tyska M. Differential localization and dynamics of class I myosins in the enterocyte microvillus. Mol Biol Cell. 2010;21:970-8 pubmed publisher
  8. Skowron J, Bement W, Mooseker M. Human brush border myosin-I and myosin-Ic expression in human intestine and Caco-2BBe cells. Cell Motil Cytoskeleton. 1998;41:308-24 pubmed
    ..The expression of both myosins-I was also examined during cell-contact induced differentiation of Caco-2BBe cells where expression and changes in localization closely resemble those that accompany differentiation of enterocyte in vivo. ..
  9. Kittelberger N, Breunig M, Martin R, Knölker H, Miklavc P. The role of myosin 1c and myosin 1b in surfactant exocytosis. J Cell Sci. 2016;129:1685-96 pubmed publisher
    ..These findings suggest that class 1 myosins participate in several stages of ATII cell exocytosis and link actin coats to the secretory vesicle membrane to influence vesicle compression. ..
  10. Gillespie P, Muller U. Mechanotransduction by hair cells: models, molecules, and mechanisms. Cell. 2009;139:33-44 pubmed publisher
  11. Kahle M, Pridalová J, Spacek M, Dzijak R, Hozak P. Nuclear myosin is ubiquitously expressed and evolutionary conserved in vertebrates. Histochem Cell Biol. 2007;127:139-48 pubmed
    ..The analysis of genomic sequences indicates that almost identical homologous NMI genes are expressed in mammals, and similar NMI genes in vertebrates. ..
  12. Boguslavsky S, Chiu T, Foley K, Osorio Fuentealba C, Antonescu C, Bayer K, et al. Myo1c binding to submembrane actin mediates insulin-induced tethering of GLUT4 vesicles. Mol Biol Cell. 2012;23:4065-78 pubmed publisher
    ..The molecular machinery involved in GLUT4 vesicle tethering is unknown. We show here that Myo1c, an actin-based motor protein that associates with membranes and actin filaments, is required for insulin-induced ..
  13. Lieto Trivedi A, Coluccio L. Calcium, nucleotide, and actin affect the interaction of mammalian Myo1c with its light chain calmodulin. Biochemistry. 2008;47:10218-26 pubmed publisher
    To investigate the interaction of mammalian class I myosin, Myo1c, with its light chain calmodulin, we expressed (with calmodulin) truncation mutants consisting of the Myo1c motor domain followed by 0-4 presumed calmodulin-binding (IQ) ..