myelin basic protein

Summary

Gene Symbol: myelin basic protein
Description: myelin basic protein
Alias: Mbps, myelin basic protein, Golli-Mbp, MBP S, myelin basic protein Golli-mbp, myelin basic protein S
Species: rat
Products:     myelin basic protein

Top Publications

  1. Gregersen R, Christensen T, Lehrmann E, Diemer N, Finsen B. Focal cerebral ischemia induces increased myelin basic protein and growth-associated protein-43 gene transcription in peri-infarct areas in the rat brain. Exp Brain Res. 2001;138:384-92 pubmed
    ..We studied the expression of myelin basic protein (MBP), a major component of central nervous system myelin, in peri-infarct areas in adult rat brain after ..
  2. Weil M, Mobius W, Winkler A, Ruhwedel T, Wrzos C, Romanelli E, et al. Loss of Myelin Basic Protein Function Triggers Myelin Breakdown in Models of Demyelinating Diseases. Cell Rep. 2016;16:314-322 pubmed publisher
    ..We propose that the aberrant phase transition of MBP molecules from their cohesive to soluble and non-adhesive state is a mechanism triggering myelin breakdown in NMO and possibly in other demyelinating diseases. ..
  3. Ozgen H, Kahya N, de Jonge J, Smith G, Harauz G, Hoekstra D, et al. Regulation of cell proliferation by nucleocytoplasmic dynamics of postnatal and embryonic exon-II-containing MBP isoforms. Biochim Biophys Acta. 2014;1843:517-30 pubmed
    ..protein required for formation of myelin, produced by oligodendrocytes in the central nervous system, is myelin basic protein (MBP)...
  4. Lin S, Huang Y, Zhang L, Heng M, Ptacek L, Fu Y. MicroRNA-23a promotes myelination in the central nervous system. Proc Natl Acad Sci U S A. 2013;110:17468-73 pubmed publisher
    ..The data presented here imply a unique role for miR-23a in the coordination of proteins and noncoding RNAs in generating and maintaining healthy myelin. ..
  5. Bain J, Lester S, Henry W, Pongetti J, Blackman M, Johnson R. Association between maternal periapical lesions and brain inflammation in rat pups. Arch Oral Biol. 2013;58:266-71 pubmed publisher
    ..were solubilized in PBS containing a protease inhibitor, and norepinephrine (NE), IL-6, IL-1-?, TNF-?, and myelin basic protein (MBP) were determined by ELISA...
  6. Wang W, Li Y, Ren J, Xia F, Li J, Zhang Z. Hydrogen rich saline reduces immune-mediated brain injury in rats with acute carbon monoxide poisoning. Neurol Res. 2012;34:1007-15 pubmed publisher
    ..of macrophages, expression of immune-associated cytokines (MIP-1-alpha and ICAM-1), and changes in myelin basic protein (MBP) were monitored by immunohistochemical staining and western blotting...
  7. Griffiths I, Scott I, McCulloch M, Barrie J, McPhilemy K, Cattanach B. Rumpshaker mouse: a new X-linked mutation affecting myelination: evidence for a defect in PLP expression. J Neurocytol. 1990;19:273-83 pubmed
    ..The rsh mutation, however, differs from jp in that affected mice have normal longevity, can breed, produce substantially more myelin and have increased numbers of oligodendrocytes. ..
  8. Kim H, Jo S, Song H, Park Z, Park C. Myelin basic protein as a binding partner and calmodulin adaptor for the BKCa channel. Proteomics. 2007;7:2591-602 pubmed
    ..These included the myelin basic protein (MBP), upon which we performed subsequent biochemical and electrophysiological studies...
  9. Matheus L, Blair G. Identification and characterisation of a cDNA encoding a 17-kDa isoform of rat myelin basic protein. Biochim Biophys Acta. 2003;1630:47-53 pubmed
    The myelin basic proteins (MBPs) are the major proteins of the myelin membrane. Multiple MBP mRNAs and protein isoforms are generated by alternative RNA splicing...

More Information

Publications62

  1. Phokeo V, Kwiecien J, Ball A. Characterization of the optic nerve and retinal ganglion cell layer in the dysmyelinated adult Long Evans Shaker rat: evidence for axonal sprouting. J Comp Neurol. 2002;451:213-24 pubmed
    ..Long Evans Shaker (LES) rat with prolonged dysmyelination of adult axons to determine whether the lack of myelin basic protein (MBP) in adult LES rats could manifest as increases in the population of CNS axons...
  2. Schlomann U, Wildeboer D, Webster A, Antropova O, Zeuschner D, Knight C, et al. The metalloprotease disintegrin ADAM8. Processing by autocatalysis is required for proteolytic activity and cell adhesion. J Biol Chem. 2002;277:48210-9 pubmed
    ..Soluble ADAM8 protease, consisting of either the metalloprotease domain or the complete ectodomain, cleaved myelin basic protein and a fluorogenic peptide substrate, and was inhibited by batimastat (BB-94, IC(50) approximately 50 nm) ..
  3. Clark R, Miskimins W, Miskimins R. Phosphatidylinositol-3 kinase p85 enhances expression from the myelin basic protein promoter in oligodendrocytes. J Neurochem. 2002;83:565-73 pubmed
    ..We show that overexpression of the p85 subunit enhances expression of myelin basic protein (MBP) upon differentiation of CG4 cells and primary oligodendrocytes...
  4. Zhang R, He J, Zhu S, Zhang H, Wang H, Adilijiang A, et al. Myelination deficit in a phencyclidine-induced neurodevelopmental model of schizophrenia. Brain Res. 2012;1469:136-43 pubmed publisher
    ..Cerebral myelination was measured by the expression of myelin basic protein (MBP), and cerebral mature oligodendrocytes were measured by the expression of glutathione S-transferase (..
  5. Seiberlich V, Bauer N, Schwarz L, Ffrench Constant C, Goldbaum O, Richter Landsberg C. Downregulation of the microtubule associated protein tau impairs process outgrowth and myelin basic protein mRNA transport in oligodendrocytes. Glia. 2015;63:1621-35 pubmed publisher
    ..The disturbance of the balance of tau leads to abnormalities in oligodendrocyte differentiation, neuron-glia contact formation and the early myelination process. ..
  6. Shi X, Chen Y, Nadeem L, Xu G. Beneficial effect of TNF-? inhibition on diabetic peripheral neuropathy. J Neuroinflammation. 2013;10:69 pubmed publisher
    ..We focused on the pathophysiology of the sciatic nerve and examined the expression of myelin basic protein (MBP) under DPN status with or without TNF-? inhibition...
  7. Eftekharpour E, Karimi Abdolrezaee S, Sinha K, Velumian A, Kwiecien J, Fehlings M. Structural and functional alterations of spinal cord axons in adult Long Evans Shaker (LES) dysmyelinated rats. Exp Neurol. 2005;193:334-49 pubmed
    ..These rats have a spontaneous mutation of the gene encoding myelin basic protein which results in severe dysmyelination of the central nervous system (CNS), providing a unique model for ..
  8. Blockx I, De Groof G, Verhoye M, Van Audekerke J, Raber K, Poot D, et al. Microstructural changes observed with DKI in a transgenic Huntington rat model: evidence for abnormal neurodevelopment. Neuroimage. 2012;59:957-67 pubmed publisher
    ..The observed DKI results have been confirmed by myelin basic protein immunohistochemistry, which revealed a reduced fiber staining as well as less ordered fibers in transgenic ..
  9. Tuzun F, Kumral A, Dilek M, Ozbal S, Ergur B, Yesilirmak D, et al. Maternal omega-3 fatty acid supplementation protects against lipopolysaccharide-induced white matter injury in the neonatal rat brain. J Matern Fetal Neonatal Med. 2012;25:849-54 pubmed publisher
    ..FA treatment given either in low or high doses greatly decreased caspase-3 immunoreactivity and increased myelin basic protein immunoreactivity, indicating a decrease in apoptosis and hypomyelination...
  10. Parenti R, Cicirata F, Zappala A, Catania A, La Delia F, Cicirata V, et al. Dynamic expression of Cx47 in mouse brain development and in the cuprizone model of myelin plasticity. Glia. 2010;58:1594-609 pubmed publisher
    ..Taken as a whole the evidence suggests that Cx47 play a key role in myelination. ..
  11. Ghoumari A, Ibanez C, el Etr M, Leclerc P, Eychenne B, O Malley B, et al. Progesterone and its metabolites increase myelin basic protein expression in organotypic slice cultures of rat cerebellum. J Neurochem. 2003;86:848-59 pubmed
    ..Myelination was evaluated by immunofluorescence analysis of the myelin basic protein (MBP)...
  12. Musse A, Gao W, Rangaraj G, Boggs J, Harauz G. Myelin basic protein co-distributes with other PI(4,5)P2-sequestering proteins in Triton X-100 detergent-resistant membrane microdomains. Neurosci Lett. 2009;450:32-6 pubmed publisher
    The 18.5kDa isoform of myelin basic protein (MBP) has recently been shown to sequester phosphatidylinositol-(4,5)-bis-phosphate (PI(4,5)P(2)) in vesicular membranes in vitro, as do domains of other membrane- and cytoskeleton-associated ..
  13. Zhao L, Guo Y, Ji X, Zhang M. The neuroprotective effect of picroside II via regulating the expression of myelin basic protein after cerebral ischemia injury in rats. BMC Neurosci. 2014;15:25 pubmed publisher
    ..and optimize the therapeutic dose and time window of picroside II by orthogonal test and the expression of myelin basic protein (MBP) in cerebral ischemic injury in rats...
  14. Schmitz Peiffer C, Browne C, Biden T. Characterization of two forms of protein kinase C alpha, with different substrate specificities, from skeletal muscle. Biochem J. 1996;320 ( Pt 1):207-14 pubmed
    ..The results suggest that a modification of PKC alpha in situ limits its substrate specificity, and indicate an additional level of control of the kinase that may be a site for modulation of PKC-mediated signal transduction. ..
  15. Xie F, Zhang J, Fu H, Chen J. Age-related decline of myelin proteins is highly correlated with activation of astrocytes and microglia in the rat CNS. Int J Mol Med. 2013;32:1021-8 pubmed publisher
    ..In the present study, immunohistochemical mapping was used to investigate the overall expression of myelin basic protein (Mbp) and myelin oligodendrocyte glycoprotein (Mog) in the central nervous system (CNS) of rats in ..
  16. Swanborg R. Experimental autoimmune encephalomyelitis in rodents as a model for human demyelinating disease. Clin Immunol Immunopathol. 1995;77:4-13 pubmed
    ..It is clear that important lessons can be learned from the detailed investigation of animal models that may be applicable to human immunological disorders. ..
  17. O Connor L, Goetz B, Kwiecien J, Delaney K, Fletch A, Duncan I. Insertion of a retrotransposon in Mbp disrupts mRNA splicing and myelination in a new mutant rat. J Neurosci. 1999;19:3404-13 pubmed
    ..Myelin deficits result from disruption of the myelin basic protein (Mbp) gene caused by the insertion of an endogenous retrotransposon [early transposons (ETn) element] into ..
  18. Teo M, Manser E, Lim L. Identification and molecular cloning of a p21cdc42/rac1-activated serine/threonine kinase that is rapidly activated by thrombin in platelets. J Biol Chem. 1995;270:26690-7 pubmed
    ..This thrombin-activated protein kinase appears to coprecipitate with another kinase of M(r) 86,000, suggesting that PAK may be part of a thrombin-responsive signaling complex. ..
  19. Dilek M, Kumral A, Okyay E, Ozbal S, Tugyan K, Tuzun F, et al. Protective effects of pentoxifylline on lipopolysaccharide-induced white matter injury in a rat model of periventricular leukomalasia. J Matern Fetal Neonatal Med. 2013;26:1865-71 pubmed publisher
    ..To assess hypomyelination, myelin basic protein (MBP) staining, as a marker of myelination, was evaluated...
  20. Dunkley P, Carnegie P. Amino acid sequence of the smaller basic protein from rat brain myelin. Biochem J. 1974;141:243-55 pubmed
    ..LS23 7BQ, U.K., from whom copies may be obtained on the terms given in Biochem. J. (1973) 131, 5. ..
  21. Zhang H, Ren N, Zhou F, Li J, Lei W, Liu N, et al. Effects of Hindlimb Unweighting on MBP and GDNF Expression and Morphology in Rat Dorsal Root Ganglia Neurons. Neurochem Res. 2016;41:2433-42 pubmed publisher
    ..At the end of HU treatment for 4 weeks, morphological changes were detected. Myelin basic protein (MBP) and degenerated myelin basic protein (dgen-MBP) expressions were analyzed by immunofluorescence and ..
  22. Mozafari S, Sherafat M, Javan M, Mirnajafi Zadeh J, Tiraihi T. Visual evoked potentials and MBP gene expression imply endogenous myelin repair in adult rat optic nerve and chiasm following local lysolecithin induced demyelination. Brain Res. 2010;1351:50-6 pubmed publisher
    ..and chiasm by recording the visual evoked potentials (VEPs) from the visual cortex and its correlation with myelin basic protein (MBP) expression in lesion site. Records of VEP were obtained at 2, 7, 14 and 28 days post-injection...
  23. Ye Y, Xiong J, Hu J, Kong M, Cheng L, Chen H, et al. Altered hippocampal myelinated fiber integrity in a lithium-pilocarpine model of temporal lobe epilepsy: a histopathological and stereological investigation. Brain Res. 2013;1522:76-87 pubmed publisher
    ..showed that hippocampal myelinated fibers of the epilepsy group were degenerated with significantly less myelin basic protein (MBP) expression relative to those of control group rats...
  24. Choi B, Kim D, Back D, Kang C, Moon W, Han J, et al. Characterization of White Matter Injury in a Rat Model of Chronic Cerebral Hypoperfusion. Stroke. 2016;47:542-7 pubmed publisher
    ..task, and novel object test; histological investigation of neuroinflammation, oligodendrocytes, myelin basic protein, and nodal or paranodal proteins at the nodes of Ranvier; and serial diffusion tensor imaging...
  25. Schwander M, Sczaniecka A, Grillet N, Bailey J, Avenarius M, Najmabadi H, et al. A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function. J Neurosci. 2007;27:2163-75 pubmed
  26. Homchaudhuri L, Polverini E, Gao W, Harauz G, Boggs J. Influence of membrane surface charge and post-translational modifications to myelin basic protein on its ability to tether the Fyn-SH3 domain to a membrane in vitro. Biochemistry. 2009;48:2385-93 pubmed publisher
    b>Myelin basic protein (MBP) is a highly post-translationally modified, multifunctional structural component of central nervous system myelin, adhering to phospholipid membranes and assembling cytoskeletal proteins, and has previously been ..
  27. Brockschnieder D, Sabanay H, Riethmacher D, Peles E. Ermin, a myelinating oligodendrocyte-specific protein that regulates cell morphology. J Neurosci. 2006;26:757-62 pubmed
    ..Our results demonstrate that Ermin is a novel marker of myelinating oligodendroglia and suggest that it plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis. ..
  28. Sakakibara R, Yamanishi T, Uchiyama T, Hattori T. Acute urinary retention due to benign inflammatory nervous diseases. J Neurol. 2006;253:1103-10 pubmed
    ..Laboratory abnormalities include increased herpes virus titers in sacral herpes, and increased myelin basic protein in the cerebrospinal fluid (CSF) in some cases with MRS...
  29. Lotosh N, Savel eva E, Selishcheva A, Savel ev S. Autoantibodies to neuron-specific proteins S100, GFAP, MBP and NGF in the serum of rats with streptozotocin-induced diabetes. Bull Exp Biol Med. 2013;155:48-51 pubmed
    ..The levels of antibodies to specific neuronal proteins (S100, GFAP, MBP, and NGF) also increased at this term. It is concluded that diabetes with streptozotocin is associated with damage to the blood-brain barrier. ..
  30. Samuels I, Seibenhener M, Neidigh K, Wooten M. Nerve growth factor stimulates the interaction of ZIP/p62 with atypical protein kinase C and targets endosomal localization: evidence for regulation of nerve growth factor-induced differentiation. J Cell Biochem. 2001;82:452-66 pubmed
    ..Collectively, these findings demonstrate that ZIP/p62 acts as a shuttling protein involved in routing activated aPKC to an endosomal compartment and is required for mediating NGF's biological properties. ..
  31. Zhang Y, Zhang W, Lin C, Ding Y, Huang S, Wu J, et al. Neurotrophin-3 gene modified mesenchymal stem cells promote remyelination and functional recovery in the demyelinated spinal cord of rats. J Neurol Sci. 2012;313:64-74 pubmed publisher
    ..The morphological basis of this recovery was evidenced by robust myelin basic protein (MBP) expression and the extensive remyelination...
  32. Suresh S, Wang C, Nanekar R, Kursula P, Edwardson J. Myelin basic protein and myelin protein 2 act synergistically to cause stacking of lipid bilayers. Biochemistry. 2010;49:3456-63 pubmed publisher
    ..b>Myelin basic protein (MBP) and myelin protein 2 (P2) are intimately involved in the generation of the myelin sheath...
  33. Wei Q, Miskimins W, Miskimins R. Stage-specific expression of myelin basic protein in oligodendrocytes involves Nkx2.2-mediated repression that is relieved by the Sp1 transcription factor. J Biol Chem. 2005;280:16284-94 pubmed
    ..2 regulation have not been identified. In the present study, we found that the myelin basic protein gene is one of the genes that is regulated by Nkx2.2. Expression of Nkx2...
  34. Sakuma H, Park I, Kohyama K, Feng D, Matsumoto Y. Quantitation of myelin oligodendrocyte glycoprotein and myelin basic protein in the thymus and central nervous system and its relationship to the clinicopathologic features of autoimmune encephalomyelitis. J Neurosci Res. 2006;84:606-13 pubmed
    ..was no significant difference in the amount and distribution of myelin oligodendrocyte glycoprotein and myelin basic protein in the thymus and CNS among the three strains and that both acute and chronic EAE lesions in the CNS were ..
  35. Ozgen H, Schrimpf W, Hendrix J, de Jonge J, Lamb D, Hoekstra D, et al. The lateral membrane organization and dynamics of myelin proteins PLP and MBP are dictated by distinct galactolipids and the extracellular matrix. PLoS ONE. 2014;9:e101834 pubmed publisher
    ..5-kDa myelin basic protein (MBP) and transmembrane protein proteolipid protein (PLP) as a function of the typical myelin lipids ..
  36. Boylan K, Takahashi N, Paty D, Sadovnick A, Diamond M, Hood L, et al. DNA length polymorphism 5' to the myelin basic protein gene is associated with multiple sclerosis. Ann Neurol. 1990;27:291-7 pubmed
    A site of DNA polymorphism linked to the myelin basic protein gene, identified as restriction fragment length polymorphism, was analyzed in a population-based study comparing patients with clinically definite multiple sclerosis (MS) and ..
  37. Li W, Chen S, Wang Z, Song X, Wang Y, Zhang M. [Relationship between anti-myelin basic protein antibody and myelinoclasis in rat brain stem after brain trauma]. Nan Fang Yi Ke Da Xue Xue Bao. 2008;28:1028-30 pubmed
    To investigate the relations between anti-myelin basic protein antibody (anti-MBP) variation and myelinoclasis in the brain stem following brain trauma...
  38. Soltoff S. Related adhesion focal tyrosine kinase and the epidermal growth factor receptor mediate the stimulation of mitogen-activated protein kinase by the G-protein-coupled P2Y2 receptor. Phorbol ester or [Ca2+]i elevation can substitute for receptor activat. J Biol Chem. 1998;273:23110-7 pubmed
    ..Although P2Y2 and EGF receptors may both activate a similar multiprotein signaling cascade immediately upstream of MAP kinase, the P2Y2 receptor appears to uniquely utilize [Ca2+]i, PKC, and, subsequently, RAFTK. ..
  39. Kim H, DiBernardo A, Sloane J, Rasband M, Solomon D, Kosaras B, et al. WAVE1 is required for oligodendrocyte morphogenesis and normal CNS myelination. J Neurosci. 2006;26:5849-59 pubmed
    ..Together, these data demonstrate a role for WAVE1 in oligodendrocyte morphogenesis and myelination. ..
  40. Yamaguchi Y, Miyagi Y, Baba H. Two-dimensional electrophoresis with cationic detergents: a powerful tool for the proteomic analysis of myelin proteins. Part 2: analytical aspects. J Neurosci Res. 2008;86:766-75 pubmed
  41. Malotka J, Dornmair K. Alternative splicing and cDNA sequence of myelin basic protein gene of the Lewis rat. Autoimmunity. 1995;20:67-8 pubmed
  42. Guo L, Eviatar Ribak T, Miskimins R. Sp1 phosphorylation is involved in myelin basic protein gene transcription. J Neurosci Res. 2010;88:3233-42 pubmed publisher
    b>Myelin basic protein (MBP), which helps form compact myelin sheets, is a major protein expressed during oligodendrocyte (OL) differentiation. Myelin basic protein expression is regulated mainly at the transcriptional level...
  43. Liu H, Shiryaev S, Chernov A, Kim Y, Shubayev I, Remacle A, et al. Immunodominant fragments of myelin basic protein initiate T cell-dependent pain. J Neuroinflammation. 2012;9:119 pubmed publisher
    ..MMP-9 proteolysis of myelin basic protein (MBP) generated the MBP84-104 and MBP68-86 digest peptides, which are prominent immunogenic epitopes...
  44. Bijlard M, Klunder B, de Jonge J, Nomden A, Tyagi S, de Vries H, et al. Transcriptional expression of myelin basic protein in oligodendrocytes depends on functional syntaxin 4: a potential correlation with autocrine signaling. Mol Cell Biol. 2015;35:675-87 pubmed publisher
    ..Our data further reveal that the expression of myelin basic protein (MBP), a myelin-specific protein that is synthesized "on site" after transport of its mRNA, depends on the ..
  45. Bayless D, Daniel J. Sex differences in myelin-associated protein levels within and density of projections between the orbital frontal cortex and dorsal striatum of adult rats: implications for inhibitory control. Neuroscience. 2015;300:286-96 pubmed publisher
    ..In Experiment 1, we measured levels of two myelin-associated proteins, myelin basic protein (MBP) and myelin proteolipid protein (PLP), in the OFC and dSTR...
  46. Delaney K, Kwiecien J, Wegiel J, Wisniewski H, Percy D, Fletch A. Familial dysmyelination in a Long Evans rat mutant. Lab Anim Sci. 1995;45:547-53 pubmed
    ..The Long Evans shaker rat represents a novel myelin mutant with a remarkable survival period and appears to have an autosomal recessive mode of inheritance. ..
  47. Roach A, Boylan K, Horvath S, Prusiner S, Hood L. Characterization of cloned cDNA representing rat myelin basic protein: absence of expression in brain of shiverer mutant mice. Cell. 1983;34:799-806 pubmed
    ..A synthetic DNA probe synthesized based on reverse translation of the amino acid sequence of rat myelin basic protein (MBP) was used to select two cDNA clones encoding MBP. A 1...
  48. Hung P, Huang C, Huang H, Tu D, Chang Y. Thyroxin treatment protects against white matter injury in the immature brain via brain-derived neurotrophic factor. Stroke. 2013;44:2275-83 pubmed publisher
    ..The HI group showed ventriculomegaly and marked reduction of myelin basic protein immunoreactivities in the WM...
  49. Laursen L, Chan C, Ffrench Constant C. Translation of myelin basic protein mRNA in oligodendrocytes is regulated by integrin activation and hnRNP-K. J Cell Biol. 2011;192:797-811 pubmed publisher
    ..Here, we show that integrin activation regulates translation of a key sheath protein, myelin basic protein (MBP), by reversing the inhibitory effect of the mRNA 3'UTR...
  50. Farhadi H, Lepage P, Forghani R, Friedman H, Orfali W, Jasmin L, et al. A combinatorial network of evolutionarily conserved myelin basic protein regulatory sequences confers distinct glial-specific phenotypes. J Neurosci. 2003;23:10214-23 pubmed
    b>Myelin basic protein (MBP) is required for normal myelin compaction and is implicated in both experimental and human demyelinating diseases...
  51. Simonen M, Pedersen V, Weinmann O, Schnell L, Buss A, Ledermann B, et al. Systemic deletion of the myelin-associated outgrowth inhibitor Nogo-A improves regenerative and plastic responses after spinal cord injury. Neuron. 2003;38:201-11 pubmed
    ..CST fibers caudal to the lesion-regenerating and/or sprouting from spared intact fibers-were also found to be more frequent in Nogo-A-deficient animals. ..
  52. Majava V, Wang C, Myllykoski M, Kangas S, Kang S, Hayashi N, et al. Structural analysis of the complex between calmodulin and full-length myelin basic protein, an intrinsically disordered molecule. Amino Acids. 2010;39:59-71 pubmed publisher
    b>Myelin basic protein (MBP) is present between the cytoplasmic leaflets of the compact myelin membrane in both the peripheral and central nervous systems, and characterized to be intrinsically disordered in solution...
  53. Kheradmand T, Wolf N, Swanborg R. Myelin basic protein-reactive T cells persist in an inactive state in the bone marrow of Lewis rats that have recovered from autoimmune encephalomyelitis. J Neuroimmunol. 2009;209:26-32 pubmed publisher
    Lewis rats immunized with guinea pig myelin basic protein residues 68-86 develop acute experimental autoimmune encephalomyelitis and recover. The predominant T cell receptor expressed by the encephalitogenic T cells is TCRBV8S2...