Myd88

Summary

Gene Symbol: Myd88
Description: myeloid differentiation primary response 88
Alias: myeloid differentiation primary response protein MyD88, myeloid differentiation primary response gene 88
Species: rat
Products:     Myd88

Top Publications

  1. Honda K, Yanai H, Negishi H, Asagiri M, Sato M, Mizutani T, et al. IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature. 2005;434:772-7 pubmed
    ..plasmacytoid dendritic cells by the Toll-like receptor 9 (TLR9) subfamily, which generates signals via the adaptor MyD88 to elicit robust IFN induction...
  2. Zhou R, Zhang R, Sun Y, Platt S, Szczotka Flynn L, Pearlman E. Innate immune regulation of Serratia marcescens-induced corneal inflammation and infection. Invest Ophthalmol Vis Sci. 2012;53:7382-8 pubmed publisher
    ..Conversely, CFU was significantly lower by 48 hours post infection. In contrast, MyD88(-/-), IL-1R(-/-), TLR4(-/-), and TLR4/5(-/-) corneas infected with S...
  3. Takeuchi O, Hoshino K, Akira S. Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection. J Immunol. 2000;165:5392-6 pubmed
    ..b>MyD88 is shown to be an adaptor molecule essential for TLR family signaling...
  4. Takeuchi O, Takeda K, Hoshino K, Adachi O, Ogawa T, Akira S. Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades. Int Immunol. 2000;12:113-7 pubmed
    b>MyD88 is an adaptor molecule essential for signaling via the Toll-like receptor (TLR)/IL-1 receptor family...
  5. Yu X, Xiao C, Dai H, Wang W, Meng J, Zhang X, et al. [Effect of intrauterine lipopolysaccharide infusion on Toll-like receptor 4 signaling transduction pathway in lungs of perinatal rats]. Zhonghua Er Ke Za Zhi. 2009;47:667-71 pubmed
    ..chain reaction (RT-PCR) analysis was performed to test mRNA expression for TLR4, myeloid differentiation 88 (MyD88) and IL-1beta, while immunohistochemistry was used to evaluate TLR4 and MyD88 expression in lung tissues...
  6. Takano A, Munhoz C, Moriscot A, Gupta S, Barreto Chaves M. S100A8/MYD88/NF-Ò›B: a novel pathway involved in cardiomyocyte hypertrophy driven by thyroid hormone. J Mol Med (Berl). 2017;95:671-682 pubmed publisher
    ..Thus, we aimed to test whether S100A8 and related signaling molecules, myeloid differentiation factor-88 (MyD88) and nuclear factor kappa B (NF-Ò›B), could be associated with the cardiomyocyte hypertrophy induced by TH...
  7. Xu X, Zhang L, Liu Z, Pan Y, Chen D, Yang Z, et al. Therapeutic Efficacy of the Traditional Chinese Medicine Baishaoqiwu on TNBS-induced Colitis is Associated with Down-regulation of the TLR4/MyD88/NF-?B Signaling Pathway. In Vivo. 2016;30:181-6 pubmed
    ..The aim of this study was to examine the efficacy of BSQW on ulcerative colitis (UC) and the TLR4/MyD88/NF-?B signaling pathway in a rat model of colitis...
  8. Brandl K, Plitas G, Schnabl B, Dematteo R, Pamer E. MyD88-mediated signals induce the bactericidal lectin RegIII gamma and protect mice against intestinal Listeria monocytogenes infection. J Exp Med. 2007;204:1891-900 pubmed
    ..Although MyD88-mediated signals are essential for defense against systemic L...
  9. Vijayan V, Khandelwal M, Manglani K, Gupta S, Surolia A. Methionine down-regulates TLR4/MyD88/NF-?B signalling in osteoclast precursors to reduce bone loss during osteoporosis. Br J Pharmacol. 2014;171:107-21 pubmed publisher
    ..siRNA-mediated knockdown of myeloid differentiation primary response 88 [MyD88], a signalling molecule in the toll-like receptor (TLR) signalling cascade, abolished the synthesis of both TRAP5b ..

More Information

Publications69

  1. Marta M, Andersson A, Isaksson M, Kämpe O, Lobell A. Unexpected regulatory roles of TLR4 and TLR9 in experimental autoimmune encephalomyelitis. Eur J Immunol. 2008;38:565-75 pubmed publisher
    ..how upstream TLR signals influence autoimmune T cell responses, we studied the role of individual TLR and MyD88, the common TLR adaptor molecule, in the initiation of innate and adaptive immune responses in EAE...
  2. Famakin B, Mou Y, Ruetzler C, Bembry J, Maric D, Hallenbeck J. Disruption of downstream MyD88 or TRIF Toll-like receptor signaling does not protect against cerebral ischemia. Brain Res. 2011;1388:148-56 pubmed publisher
    ..We thereby investigated involvement of the MyD88-dependent (MyD88) and MyD88-independent (TRIF) TLR signaling pathways in 2 in vitro and 2 in vivo models of ..
  3. Yamamoto M, Sato S, Hemmi H, Hoshino K, Kaisho T, Sanjo H, et al. Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science. 2003;301:640-3 pubmed
    Stimulation of Toll-like receptors (TLRs) triggers activation of a common MyD88-dependent signaling pathway as well as a MyD88-independent pathway that is unique to TLR3 and TLR4 signaling pathways leading to interferon (IFN)-beta ..
  4. Chaudhary A, Ganguly K, Cabantous S, Waldo G, Micheva Viteva S, Nag K, et al. The Brucella TIR-like protein TcpB interacts with the death domain of MyD88. Biochem Biophys Res Commun. 2012;417:299-304 pubmed publisher
    ..assays based on Gaussia luciferase and green fluorescent protein, we find that TcpB interacts directly with MyD88 and that this interaction is significantly stronger than the interaction of TcpB with TIRAP, the only other ..
  5. Li T, Wang Y, Liu C, Hu Y, Wu M, Li J, et al. MyD88-dependent nuclear factor-kappaB activation is involved in fibrinogen-induced hypertrophic response of cardiomyocytes. J Hypertens. 2009;27:1084-93 pubmed publisher
    ..demonstrated that the Toll-like receptor 4 (TLR4)-mediated myeloid differentiation primary response protein 88 (MyD88)-dependent nuclear factor-kappaB (NF-kappaB) pathway is involved in cardiac hypertrophy...
  6. Mamidipudi V, Li X, Wooten M. Identification of interleukin 1 receptor-associated kinase as a conserved component in the p75-neurotrophin receptor activation of nuclear factor-kappa B. J Biol Chem. 2002;277:28010-8 pubmed
    ..Altogether, our data provide novel information regarding the proximal components involved in p75 receptor signaling and underscore the importance of the atypical PKC interacting protein p62 in this process. ..
  7. Han L, Li C, Sun B, Xie Y, Guan Y, Ma Z, et al. Protective Effects of Celastrol on Diabetic Liver Injury via TLR4/MyD88/NF-?B Signaling Pathway in Type 2 Diabetic Rats. J Diabetes Res. 2016;2016:2641248 pubmed publisher
    ..The expressions of TLR4, MyD88, NF-?B, and downstream inflammatory factors IL-1? and TNF? in the hepatic tissue of treated rats were ..
  8. Yao H, Chi X, Jin Y, Wang Y, Huang P, Wu S, et al. Dexmedetomidine Inhibits TLR4/NF-κB Activation and Reduces Acute Kidney Injury after Orthotopic Autologous Liver Transplantation in Rats. Sci Rep. 2015;5:16849 pubmed publisher
    ..Dexmedetomidine-pretreatment attenuates OALT-induced AKI in rats which may be contributable to its inhibition of TLR4/MyD88/NF-κB pathway activation. The renoprotective effects are related to α2A-adrenergic receptor subtypes.
  9. Ramirez Ortiz Z, Prasad A, Griffith J, Pendergraft W, Cowley G, Root D, et al. The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity. Nat Immunol. 2015;16:495-504 pubmed publisher
    ..transcription factor STAT1 by the mitogen-activated protein kinase p38 and decreased recruitment of the adaptor MyD88 to TLR7...
  10. Hamerman J, Ogasawara K, Lanier L. Cutting edge: Toll-like receptor signaling in macrophages induces ligands for the NKG2D receptor. J Immunol. 2004;172:2001-5 pubmed
    ..TLR signaling, through the MyD88 adaptor, up-regulates transcription of the retinoic acid early inducible-1 (RAE-1) family of NKG2D ligands, but ..
  11. Rameshrad M, Maleki Dizaji N, Vaez H, Soraya H, Nakhlband A, Garjani A. Lipopolysaccharide Induced Activation of Toll Like Receptor 4 in Isolated Rat Heart Suggests a Local Immune Response in Myocardium. Iran J Immunol. 2015;12:104-16 pubmed publisher
    ..This myocardial depression was associated with a significant increase in TLR4 expression (p<0.01), MyD88 activity (p<0.01) and TNF-α (p<0.05) concentration in the heart tissue...
  12. Chen Z, Zhang X, Yu L, Hua R, Zhao X, Qin X, et al. Spinal toll-like receptor 4-mediated signalling pathway contributes to visceral hypersensitivity induced by neonatal colonic irritation in rats. Eur J Pain. 2015;19:176-86 pubmed publisher
    ..In this study, we investigated whether the TLR4/myeloid differentiation factor 88 (MyD88)/nuclear factor-kappa B (NF-?B) signalling pathway in the spinal cord contributed to the visceral hypersensitivity ..
  13. Shang T, Ran F, Qiao Q, Liu Z, Liu C. Tanshinone IIA attenuates elastase-induced AAA in rats via inhibition of MyD88-dependent TLR-4 signaling. Vasa. 2014;43:39-46 pubmed publisher
    ..The over-expression of Toll-Like Receptor-4 (TLR-4), Myeloid Differentiation factor 88 (MyD88), Phosphorylated Nuclear Factor ?B (pNF-?B) and Phosphorylated I?B? (pI?B?) induced by elastase perfusion were ..
  14. Hua F, Ha T, Ma J, Gao X, Kelley J, Williams D, et al. Blocking the MyD88-dependent pathway protects the myocardium from ischemia/reperfusion injury in rat hearts. Biochem Biophys Res Commun. 2005;338:1118-25 pubmed
    We examined whether blocking the MyD88 mediated pathway could protect myocardium from ischemia/reperfusion (I/R) injury by transfecting Ad5-dnMyD88 into the myocardium of rats (n=8) 3 days before the hearts were subjected to ischemia (..
  15. Yuan X, Deng Y, Guo X, Shang J, Zhu D, Liu H. Atorvastatin attenuates myocardial remodeling induced by chronic intermittent hypoxia in rats: partly involvement of TLR-4/MYD88 pathway. Biochem Biophys Res Commun. 2014;446:292-7 pubmed publisher
    ..Ventricular remodeling, toll-like receptor 4 (TLR-4), myeloid differentiation primary response protein 88 (MYD88), inflammatory agents and radical oxygen species were determined...
  16. Hazeki K, Masuda N, Funami K, Sukenobu N, Matsumoto M, Akira S, et al. Toll-like receptor-mediated tyrosine phosphorylation of paxillin via MyD88-dependent and -independent pathways. Eur J Immunol. 2003;33:740-7 pubmed
    ..A proximal signaling event of TLR is the direct binding of an adaptor protein MyD88 to TLR and recruitment of the IL-1R-associated kinase (IRAK)...
  17. Bagchi A, Sharma A, Dhingra S, Lehenbauer Ludke A, Al Shudiefat A, Singal P. Interleukin-10 activates Toll-like receptor 4 and requires MyD88 for cardiomyocyte survival. Cytokine. 2013;61:304-14 pubmed publisher
    ..IL-10 caused a significant increase in the expression of CD14, MyD88 and TLR4. TLR4 activation led to the translocation of the interferon regulatory factor 3 (IRF3) into the nucleus...
  18. Zhou C, Zhu Y, Zhao P, Xu C, Zhang M, Huang H, et al. Propofol Inhibits Lipopolysaccharide-Induced Inflammatory Responses in Spinal Astrocytes via the Toll-Like Receptor 4/MyD88-Dependent Nuclear Factor-κB, Extracellular Signal-Regulated Protein Kinases1/2, and p38 Mitogen-Activated Protein Kinase Pathw. Anesth Analg. 2015;120:1361-8 pubmed publisher
    ..The protein expressions of TLR4, myeloid differentiation factor 88 (MyD88), p- extracellular signal-regulated protein kinases (ERK)1/2, p-c-Jun N-terminal kinase, p-p38 mitogen-activated ..
  19. Ulrichts P, Peelman F, Beyaert R, Tavernier J. MAPPIT analysis of TLR adaptor complexes. FEBS Lett. 2007;581:629-36 pubmed
    ..We show that the TLR adaptor Mal is critical for linking Myeloid Differentiation primary response protein 88 (MyD88) to TLR2 and TLR4...
  20. Zhuang Z, Xie J, Wei J, Tang D, Yang L. The effect of n-3/n-6 polyunsaturated fatty acids on acute reflux esophagitis in rats. Lipids Health Dis. 2016;15:172 pubmed
    ..The expressions of interleukin (IL)-1?, IL-8, IL-6 and myeloid differentiation primary response gene 88 (MyD88) in esophageal tissues were evaluated by Western blot and immunohistochemistry after ..
  21. Stewart C, Stuart L, Wilkinson K, van Gils J, Deng J, Halle A, et al. CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer. Nat Immunol. 2010;11:155-61 pubmed publisher
  22. Mackern Oberti J, Maccioni M, Cuffini C, Gatti G, Rivero V. Susceptibility of prostate epithelial cells to Chlamydia muridarum infection and their role in innate immunity by recruitment of intracellular Toll-like receptors 4 and 2 and MyD88 to the inclusion. Infect Immun. 2006;74:6973-81 pubmed
    ..Our results demonstrate that PEC express significant levels of TLR4, CD14, TLR2, and the adaptor molecule MyD88 and up-regulate these proteins in response to C. muridarum infection...
  23. Luo S, Chang C, Lee I, Lee C, Lin W, Lin C, et al. Activation of ROS/NF-kappaB and Ca2+/CaM kinase II are necessary for VCAM-1 induction in IL-1beta-treated human tracheal smooth muscle cells. Toxicol Appl Pharmacol. 2009;237:8-21 pubmed publisher
    ..Bay11-7082), HDAC (trichostatin A), and ROS scavenger [N-acetyl-L-cysteine (NAC)] or transfection with siRNAs of MyD88, PKCalpha, Src, p47(phox), p300, and HDAC4...
  24. Lin X, Kong J, Wu Q, Yang Y, Ji P. Effect of TLR4/MyD88 signaling pathway on expression of IL-1β and TNF-α in synovial fibroblasts from temporomandibular joint exposed to lipopolysaccharide. Mediators Inflamm. 2015;2015:329405 pubmed publisher
    ..study, we investigated the roles of Toll-like receptor 4 (TLR4) and its adaptor myeloid differentiation factor 88 (MyD88) in the expression of IL-1β and TNF-α in synovial fibroblasts (SFs) separated from rat temporomandibular ..
  25. Datta S, Novotny M, Li X, Tebo J, Hamilton T. Toll IL-1 receptors differ in their ability to promote the stabilization of adenosine and uridine-rich elements containing mRNA. J Immunol. 2004;173:2755-61 pubmed
    ..of TIR family members to stabilize ARE-containing mRNAs results from their differential use of signaling adaptors MyD88, MyD88 adaptor-like protein, Toll receptor IFN-inducing factor (Trif), and Trif-related adaptor molecule...
  26. Kagan J, Medzhitov R. Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Cell. 2006;125:943-55 pubmed
    ..Signaling downstream from TLRs is initiated by the recruitment of adaptor proteins, including MyD88 and TIRAP...
  27. Rakoff Nahoum S, Medzhitov R. Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Science. 2007;317:124-7 pubmed
    ..We show that the signaling through the adaptor protein MyD88 has a critical role in spontaneous tumor development in mice with heterozygous mutation in the adenomatous ..
  28. Hoebe K, Du X, Georgel P, Janssen E, Tabeta K, Kim S, et al. Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature. 2003;424:743-8 pubmed
    ..Compound homozygosity for mutations at Trif and MyD88 (a cytoplasmic TIR-domain-containing adaptor protein) loci ablates all responses to LPS, indicating that only two ..
  29. Hu Q, Mao D. Histone deacetylase inhibitor SAHA attenuates post-seizure hippocampal microglia TLR4/MYD88 signaling and inhibits TLR4 gene expression via histone acetylation. BMC Neurosci. 2016;17:22 pubmed publisher
    Epilepsy is a common neurological disorder characterized by recurrent unprovoked seizures. Seizure-induced TLR4/MYD88 signaling plays a critical role in activating microglia and triggering neuron apoptosis...
  30. Pimentel G, Lira F, Rosa J, Oliveira J, Losinskas Hachul A, Souza G, et al. Intake of trans fatty acids during gestation and lactation leads to hypothalamic inflammation via TLR4/NF?Bp65 signaling in adult offspring. J Nutr Biochem. 2012;23:265-71 pubmed publisher
    ..05). TLR4, NF?Bp65 and MyD88 were higher (P<.05) in the TC rats than in the CC rats. AdipoR1 was lower in the TC rats than in the CC rats...
  31. Sun J, Li D, Dong Y, Zhu C, Liu J, Li J, et al. Baicalin inhibits toll-like receptor 2/4 expression and downstream signaling in rat experimental periodontitis. Int Immunopharmacol. 2016;36:86-93 pubmed publisher
    ..Compared with the sham group, the levels of TLR2, TLR4 and MyD88 expression and the p38 MAPK and NF-?B activation were up-regulated in the experimental periodontitis group (EPG), ..
  32. Tabeta K, Georgel P, Janssen E, Du X, Hoebe K, Crozat K, et al. Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proc Natl Acad Sci U S A. 2004;101:3516-21 pubmed
    ..We also demonstrate that both the Toll-like receptor (TLR) 9 --> MyD88 and TLR3 --> Trif signaling pathways are activated in vivo on viral inoculation, and that each pathway ..
  33. Sukhotnik I, Haj B, Pollak Y, Dorfman T, Bejar J, Matter I. Effect of bowel resection on TLR signaling during intestinal adaptation in a rat model. Surg Endosc. 2016;30:4416-24 pubmed publisher
    ..The expression of TLR4, MyD88 and TRAF6 in the intestinal mucosa was determined using real-time PCR, Western blot and immunohistochemistry...
  34. Brown G, Herre J, Williams D, Willment J, Marshall A, Gordon S. Dectin-1 mediates the biological effects of beta-glucans. J Exp Med. 2003;197:1119-24 pubmed
    ..tail and immunoreceptor tyrosine activation motif of Dectin-1 as well as Toll-like receptor (TLR)-2 and Myd88. This is the first demonstration that the inflammatory response to pathogens requires recognition by a specific ..
  35. Fitzgerald K, Palsson McDermott E, Bowie A, Jefferies C, Mansell A, Brady G, et al. Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature. 2001;413:78-83 pubmed
    ..All TLRs have a Toll/IL-1 receptor (TIR) domain, which is responsible for signal transduction. MyD88 is one such protein that contains a TIR domain...
  36. Rosenzweig H, Jann M, Vance E, Planck S, Rosenbaum J, Davey M. Nucleotide-binding oligomerization domain 2 and Toll-like receptor 2 function independently in a murine model of arthritis triggered by intraarticular peptidoglycan. Arthritis Rheum. 2010;62:1051-9 pubmed publisher
    ..Mice deficient in TLR-2, myeloid differentiation factor 88 (MyD88), or NOD-2 and their wild-type controls were given an intraarticular injection of muramyl dipeptide (MDP), ..
  37. Wu W, Yu S, Feng S, Yang J, Lu X. Effect of the TLR2/MyD88/NF-κB axis on corneal allograft rejection after penetrating keratoplasty. J Recept Signal Transduct Res. 2016;36:45-52 pubmed publisher
    To evaluate the effect of the TLR2 (Toll-like receptor 2)/MyD88/NF-κB axis on the allograft rejection after penetrating keratoplasty (PK)...
  38. Sun Y, Hise A, Kalsow C, Pearlman E. Staphylococcus aureus-induced corneal inflammation is dependent on Toll-like receptor 2 and myeloid differentiation factor 88. Infect Immun. 2006;74:5325-32 pubmed
    ..study examined the role of TLR2, TLR4, and TLR9 and the common adaptor molecule myeloid differentiation factor 88 (MyD88) in a Staphylococcus aureus model of corneal inflammation...
  39. Li G, Zhang Y, Zhao J, Wu G, Su X, Hang C. Expression of myeloid differentiation primary response protein 88 (Myd88) in the cerebral cortex after experimental traumatic brain injury in rats. Brain Res. 2011;1396:96-104 pubmed publisher
    ..Myeloid differentiation primary response protein 88 (Myd88) is a critical adaptor protein that transmits signals for TLRs and IL-1 family...
  40. Liu Y, Li Y, Chen K, Zhou B, Lv Z, Zhou Z, et al. Knockdown of Myeloid Differentiation Factor 88 Attenuates Lipopolysaccharide-Induced Inflammatory Response in Pancreatic Ductal Cells. Pancreas. 2016;45:755-60 pubmed publisher
    The aim of the study was to explore the potential role of myeloid differentiation factor 88 (MyD88), which acts as an adaptor in the TLR4 signalling pathway, in immune responses of the pancreatic duct during acute pancreatitis...
  41. Li C, Ha T, Kelley J, Gao X, Qiu Y, Kao R, et al. Modulating Toll-like receptor mediated signaling by (1-->3)-beta-D-glucan rapidly induces cardioprotection. Cardiovasc Res. 2004;61:538-47 pubmed
    ..Toll-like receptor (TLR) mediated MyD88-dependent NFkappaB pathways play a role in the induction of innate immunity...
  42. Sun Q, Dai Y, Zhang X, Hu Y, Zhang D, Li W, et al. Expression and cell distribution of myeloid differentiation primary response protein 88 in the cerebral cortex following experimental subarachnoid hemorrhage in rats: a pilot study. Brain Res. 2013;1520:134-44 pubmed publisher
    ..Myeloid differentiation primary response protein 88 (MyD88) is essential to deliver TLRs signals down to NF-?B and pro-inflammatory factors...
  43. Huang C, Pan L, Lin F, Qian W, Li W. [Alveolar macrophage TLR4/MyD88 signaling pathway contributes to ventilator-induced lung injury in rats]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2015;31:182-5, 189 pubmed
    To investigate the role of alveolar macrophages Toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88) signaling in ventilator-induced lung injury (VILI) in rat model...
  44. Feng Y, Chen H, Cai J, Zou L, Yan D, Xu G, et al. Cardiac RNA induces inflammatory responses in cardiomyocytes and immune cells via Toll-like receptor 7 signaling. J Biol Chem. 2015;290:26688-98 pubmed publisher
    ..Deletion of myeloid differentiation primary response protein 88 (MyD88), a downstream adapter of TLRs including TLR7, abolished the RNA-induced MIP-2 production...
  45. Milanski M, Degasperi G, Coope A, Morari J, Denis R, Cintra D, et al. Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity. J Neurosci. 2009;29:359-70 pubmed publisher
  46. Chiou Y, Lin C. Der p2 activates airway smooth muscle cells in a TLR2/MyD88-dependent manner to induce an inflammatory response. J Cell Physiol. 2009;220:311-8 pubmed publisher
    ..Der p2 activated the MyD88 signaling pathway through toll-like receptor (TLR) 2, not through TLR4...
  47. Monnerat Cahli G, Alonso H, Gallego M, Alarcón M, Bassani R, Casis O, et al. Toll-like receptor 4 activation promotes cardiac arrhythmias by decreasing the transient outward potassium current (Ito) through an IRF3-dependent and MyD88-independent pathway. J Mol Cell Cardiol. 2014;76:116-25 pubmed publisher
    ..We conclude that TLR4 activation decreased Ito, which increased AP duration via a MyD88-independent, IRF3-dependent pathway...
  48. Sonego F, Castanheira F, Czaikoski P, Kanashiro A, Souto F, França R, et al. MyD88-, but not Nod1- and/or Nod2-deficient mice, show increased susceptibility to polymicrobial sepsis due to impaired local inflammatory response. PLoS ONE. 2014;9:e103734 pubmed publisher
    ..Here, we evaluated the role of Nod1, Nod2 and MyD88-dependent signaling in the chemokine production and neutrophil recruitment to the infectious site during sepsis ..
  49. Ha T, Hua F, Li Y, Ma J, Gao X, Kelley J, et al. Blockade of MyD88 attenuates cardiac hypertrophy and decreases cardiac myocyte apoptosis in pressure overload-induced cardiac hypertrophy in vivo. Am J Physiol Heart Circ Physiol. 2006;290:H985-94 pubmed
    In this study, we evaluated whether blocking myeloid differentiation factor-88 (MyD88) could decrease cardiac myocyte apoptosis following pressure overload...
  50. Kumar H, Kawai T, Akira S. Pathogen recognition by the innate immune system. Int Rev Immunol. 2011;30:16-34 pubmed publisher
    ..In this review, we comprehensively review the recent progress in the field of PAMP recognition by PRRs and the signaling pathways activated by PRRs. ..
  51. Chandrasekar B, Mummidi S, Valente A, Patel D, Bailey S, Freeman G, et al. The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88, interleukin-1 receptor-associated kinase, tumor necrosis factor receptor-associated factor 6, c-Src, phosphatidylinositol 3-kinase, Akt. J Biol Chem. 2005;280:26263-77 pubmed
    ..LY294002, Akt inhibitor, the c-Jun N-terminal kinase (JNK) inhibitor SP600125, antisense JNK and dominant negative MyD88, interleukin-1 receptor-associated kinase (IRAK)-1, IRAK4, and phosphatidylinositol 3-kinase expression all ..
  52. Verstrepen L, Bekaert T, Chau T, Tavernier J, Chariot A, Beyaert R. TLR-4, IL-1R and TNF-R signaling to NF-kappaB: variations on a common theme. Cell Mol Life Sci. 2008;65:2964-78 pubmed publisher
    ..In this review, we will discuss our current knowledge of NF-kappaB signaling in response to TLR-4, TNF-R and IL-1R stimulation, with a special focus on the similarities and dissimilarities among these pathways. ..
  53. Zhu C, Xu H, Zhang G, Lu C, Ji M, Wu W. Myeloid differentiation factor 88-silenced bone marrow-derived dendritic cells exhibit enhanced tolerogenicity in intestinal transplantation in rats. Transplant Proc. 2008;40:1625-8 pubmed publisher
    Myeloid differentiation factor 88 (MyD88) is a key adaptor of Toll-like receptor signaling, which plays a critical role in dendritic cell (DC) function...
  54. Patel R, Myers L, Kurundkar A, Maheshwari A, Nusrat A, Lin P. Probiotic bacteria induce maturation of intestinal claudin 3 expression and barrier function. Am J Pathol. 2012;180:626-35 pubmed publisher
    ..Neonatal mice raised on antibiotics or lacking the toll-like receptor adaptor protein MyD88 exhibit impaired barrier function and decreased claudin 3 expression...
  55. Nagpal K, Plantinga T, Wong J, Monks B, Gay N, Netea M, et al. A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling. J Biol Chem. 2009;284:25742-8 pubmed publisher
    The adapter protein MyD88 adapter-like (Mal), encoded by TIR-domain containing adapter protein (Tirap) (MIM 606252), is the most polymorphic of the five adapter proteins involved in Toll-like receptor signaling, harboring eight non-..
  56. Gardoni F, Boraso M, Zianni E, Corsini E, Galli C, Cattabeni F, et al. Distribution of interleukin-1 receptor complex at the synaptic membrane driven by interleukin-1? and NMDA stimulation. J Neuroinflammation. 2011;8:14 pubmed publisher
    ..and recruiting a signalling core complex consisting of the myeloid differentiation primary response protein 88 (MyD88) and the IL-1R accessory protein (IL-1RAcP)...
  57. Chen Y, Chen J, Wang H, Shi J, Wu K, Liu S, et al. HCV-induced miR-21 contributes to evasion of host immune system by targeting MyD88 and IRAK1. PLoS Pathog. 2013;9:e1003248 pubmed publisher
    ..that miR-21 targets two important factors in the TLR signaling pathway, myeloid differentiation factor 88 (MyD88) and interleukin-1 receptor-associated kinase 1 (IRAK1), which are involved in HCV-induced type I IFN production...
  58. Weber A, Wasiliew P, Kracht M. Interleukin-1 (IL-1) pathway. Sci Signal. 2010;3:cm1 pubmed publisher
    ..Of note, most intracellular components that participate in the cellular response to IL-1 also mediate responses to other cytokines (IL-18 and IL-33), Toll-like-receptors (TLRs), and many forms of cytotoxic stresses. ..
  59. Dai P, Jeong S, Yu Y, Leng T, Wu W, Xie L, et al. Modulation of TLR signaling by multiple MyD88-interacting partners including leucine-rich repeat Fli-I-interacting proteins. J Immunol. 2009;182:3450-60 pubmed publisher
    ..Previously we utilized a dual-tagging quantitative proteomics approach to uncover MyD88 interactions in LPS-stimulated cells and described the function of Fliih, a leucine-rich repeat (LRR) protein that ..
  60. Kuo C, Liang C, Lai C, Liang S. Involvement of heat shock protein (Hsp)90 beta but not Hsp90 alpha in antiapoptotic effect of CpG-B oligodeoxynucleotide. J Immunol. 2007;178:6100-8 pubmed
    ..The CpG-B ODN-induced Hsp90beta expression depended on TLR9, MyD88, and PI3K...