Myc

Summary

Gene Symbol: Myc
Description: MYC proto-oncogene, bHLH transcription factor
Alias: RNCMYC, c-myc, mMyc, myc proto-oncogene protein, Avian myelocytomatosis viral (v-myc) oncogene homolog, myelocytomatosis oncogene, myelocytomatosis viral oncogene homolog, proto-oncogene c-Myc, transcription factor p64, v-myc avian myelocytomatosis viral oncogene homolog
Species: rat
Products:     Myc

Top Publications

  1. Morrish F, Neretti N, Sedivy J, Hockenbery D. The oncogene c-Myc coordinates regulation of metabolic networks to enable rapid cell cycle entry. Cell Cycle. 2008;7:1054-66 pubmed
    The c-myc proto-oncogene is rapidly activated by serum and regulates genes involved in metabolism and cell cycle progression...
  2. Chen W, Chan D, Donald C, Lilly M, Kraft A. Pim family kinases enhance tumor growth of prostate cancer cells. Mol Cancer Res. 2005;3:443-51 pubmed
    ..We have found that the cellular levels of c-Myc were elevated in the Pim-1 and Pim-2 transfectants under these conditions...
  3. Popov N, Wanzel M, Madiredjo M, Zhang D, Beijersbergen R, Bernards R, et al. The ubiquitin-specific protease USP28 is required for MYC stability. Nat Cell Biol. 2007;9:765-74 pubmed
    The MYC proto-oncogene encodes a transcription factor that has been implicated in the genesis of many human tumours. Here, we used a bar-code short hairpin RNA (shRNA) screen to identify multiple genes that are required for MYC function...
  4. Sansom O, Meniel V, Muncan V, Phesse T, Wilkins J, Reed K, et al. Myc deletion rescues Apc deficiency in the small intestine. Nature. 2007;446:676-9 pubmed
    ..The proto-oncogene c-MYC has been identified as a target of the Wnt pathway in colorectal cancer cells in vitro, in normal crypts in vivo ..
  5. Knoepfler P, Zhang X, Cheng P, Gafken P, McMahon S, Eisenman R. Myc influences global chromatin structure. EMBO J. 2006;25:2723-34 pubmed
    The family of myc proto-oncogenes encodes transcription factors (c-, N-, and L-Myc) that regulate cell growth and proliferation and are involved in the etiology of diverse cancers...
  6. Remondini D, O Connell B, Intrator N, Sedivy J, Neretti N, Castellani G, et al. Targeting c-Myc-activated genes with a correlation method: detection of global changes in large gene expression network dynamics. Proc Natl Acad Sci U S A. 2005;102:6902-6 pubmed
    ..We discuss in detail the problem of finding targets of the c-myc protooncogene, which encodes a transcriptional regulator whose inappropriate expression has been correlated with a ..
  7. Schultz L, Albadine R, Hicks J, Jadallah S, DeMarzo A, Chen Y, et al. Expression status and prognostic significance of mammalian target of rapamycin pathway members in urothelial carcinoma of urinary bladder after cystectomy. Cancer. 2010;116:5517-26 pubmed publisher
    ..Immunohistochemistry was performed for Pten, c-myc, p27, phosphorylated (phos)Akt, phosS6, and 4E-BP1...
  8. Nikiforov M, Chandriani S, O Connell B, Petrenko O, Kotenko I, Beavis A, et al. A functional screen for Myc-responsive genes reveals serine hydroxymethyltransferase, a major source of the one-carbon unit for cell metabolism. Mol Cell Biol. 2002;22:5793-800 pubmed
    A cDNA library enriched with Myc-responsive cDNAs but depleted of myc cDNAs was used in a functional screen for growth enhancement in c-myc-null cells...
  9. Juin P, Hunt A, Littlewood T, Griffiths B, Swigart L, Korsmeyer S, et al. c-Myc functionally cooperates with Bax to induce apoptosis. Mol Cell Biol. 2002;22:6158-69 pubmed
    c-Myc promotes apoptosis by destabilizing mitochondrial integrity, leading to the release of proapoptotic effectors including holocytochrome c. Candidate mediators of c-Myc in this process are the proapoptotic members of the Bcl-2 family...
  10. Patel J, McMahon S. Targeting of Miz-1 is essential for Myc-mediated apoptosis. J Biol Chem. 2006;281:3283-9 pubmed
    The c-Myc oncoprotein plays a central role in human cancer via its ability to either activate or repress the transcription of essential downstream targets...

Detail Information

Publications62

  1. Morrish F, Neretti N, Sedivy J, Hockenbery D. The oncogene c-Myc coordinates regulation of metabolic networks to enable rapid cell cycle entry. Cell Cycle. 2008;7:1054-66 pubmed
    The c-myc proto-oncogene is rapidly activated by serum and regulates genes involved in metabolism and cell cycle progression...
  2. Chen W, Chan D, Donald C, Lilly M, Kraft A. Pim family kinases enhance tumor growth of prostate cancer cells. Mol Cancer Res. 2005;3:443-51 pubmed
    ..We have found that the cellular levels of c-Myc were elevated in the Pim-1 and Pim-2 transfectants under these conditions...
  3. Popov N, Wanzel M, Madiredjo M, Zhang D, Beijersbergen R, Bernards R, et al. The ubiquitin-specific protease USP28 is required for MYC stability. Nat Cell Biol. 2007;9:765-74 pubmed
    The MYC proto-oncogene encodes a transcription factor that has been implicated in the genesis of many human tumours. Here, we used a bar-code short hairpin RNA (shRNA) screen to identify multiple genes that are required for MYC function...
  4. Sansom O, Meniel V, Muncan V, Phesse T, Wilkins J, Reed K, et al. Myc deletion rescues Apc deficiency in the small intestine. Nature. 2007;446:676-9 pubmed
    ..The proto-oncogene c-MYC has been identified as a target of the Wnt pathway in colorectal cancer cells in vitro, in normal crypts in vivo ..
  5. Knoepfler P, Zhang X, Cheng P, Gafken P, McMahon S, Eisenman R. Myc influences global chromatin structure. EMBO J. 2006;25:2723-34 pubmed
    The family of myc proto-oncogenes encodes transcription factors (c-, N-, and L-Myc) that regulate cell growth and proliferation and are involved in the etiology of diverse cancers...
  6. Remondini D, O Connell B, Intrator N, Sedivy J, Neretti N, Castellani G, et al. Targeting c-Myc-activated genes with a correlation method: detection of global changes in large gene expression network dynamics. Proc Natl Acad Sci U S A. 2005;102:6902-6 pubmed
    ..We discuss in detail the problem of finding targets of the c-myc protooncogene, which encodes a transcriptional regulator whose inappropriate expression has been correlated with a ..
  7. Schultz L, Albadine R, Hicks J, Jadallah S, DeMarzo A, Chen Y, et al. Expression status and prognostic significance of mammalian target of rapamycin pathway members in urothelial carcinoma of urinary bladder after cystectomy. Cancer. 2010;116:5517-26 pubmed publisher
    ..Immunohistochemistry was performed for Pten, c-myc, p27, phosphorylated (phos)Akt, phosS6, and 4E-BP1...
  8. Nikiforov M, Chandriani S, O Connell B, Petrenko O, Kotenko I, Beavis A, et al. A functional screen for Myc-responsive genes reveals serine hydroxymethyltransferase, a major source of the one-carbon unit for cell metabolism. Mol Cell Biol. 2002;22:5793-800 pubmed
    A cDNA library enriched with Myc-responsive cDNAs but depleted of myc cDNAs was used in a functional screen for growth enhancement in c-myc-null cells...
  9. Juin P, Hunt A, Littlewood T, Griffiths B, Swigart L, Korsmeyer S, et al. c-Myc functionally cooperates with Bax to induce apoptosis. Mol Cell Biol. 2002;22:6158-69 pubmed
    c-Myc promotes apoptosis by destabilizing mitochondrial integrity, leading to the release of proapoptotic effectors including holocytochrome c. Candidate mediators of c-Myc in this process are the proapoptotic members of the Bcl-2 family...
  10. Patel J, McMahon S. Targeting of Miz-1 is essential for Myc-mediated apoptosis. J Biol Chem. 2006;281:3283-9 pubmed
    The c-Myc oncoprotein plays a central role in human cancer via its ability to either activate or repress the transcription of essential downstream targets...
  11. Ellwood Yen K, Graeber T, Wongvipat J, Iruela Arispe M, Zhang J, Matusik R, et al. Myc-driven murine prostate cancer shares molecular features with human prostate tumors. Cancer Cell. 2003;4:223-38 pubmed
    Increased Myc gene copy number is observed in human prostate cancer. To define Myc's functional role, we generated transgenic mice expressing human c-Myc in the mouse prostate...
  12. Gomez Roman N, Grandori C, Eisenman R, White R. Direct activation of RNA polymerase III transcription by c-Myc. Nature. 2003;421:290-4 pubmed
    The proto-oncogene product c-Myc has a direct role in both metazoan cell growth and division...
  13. He X, Chen J, Zhang Z, Li C, Peng Q, Peng H. The let-7a microRNA protects from growth of lung carcinoma by suppression of k-Ras and c-Myc in nude mice. J Cancer Res Clin Oncol. 2010;136:1023-8 pubmed publisher
    Down-regulation of let-7 microRNA (miRNA) plays an important role in the pathogenesis of lung cancer. k-Ras and c-Myc, two key oncogenes in lung cancer, have been found to be targeted by let-7 in vitro...
  14. Maclean K, Keller U, Rodriguez Galindo C, Nilsson J, Cleveland J. c-Myc augments gamma irradiation-induced apoptosis by suppressing Bcl-XL. Mol Cell Biol. 2003;23:7256-70 pubmed
    Alterations in MYC and p53 are hallmarks of cancer. p53 coordinates the response to gamma irradiation (gamma-IR) by either triggering apoptosis or cell cycle arrest...
  15. Morrish F, Isern N, Sadilek M, Jeffrey M, Hockenbery D. c-Myc activates multiple metabolic networks to generate substrates for cell-cycle entry. Oncogene. 2009;28:2485-91 pubmed publisher
    ..Many metabolic pathway genes are targets of the c-myc oncogene and cell-cycle regulator...
  16. Zhang X, Lee C, Ng P, Rubin M, Shabsigh A, Buttyan R. Prostatic neoplasia in transgenic mice with prostate-directed overexpression of the c-myc oncoprotein. Prostate. 2000;43:278-85 pubmed
    ..In order to test the in vivo effects of chronic overexpression of the mouse c-myc protooncogene on the prostate glands of transgenic mice, we created several lines of C(3)1-c-myc transgenic mice ..
  17. Paice A, Hesketh J, Towner P, Hirako M, Peters T, Preedy V. Alcohol increases c-myc mRNA and protein in skeletal and cardiac muscle. Metabolism. 2002;51:1285-90 pubmed
    ..Therefore, we investigated the responses of skeletal muscle c-myc protein and mRNA to a standard acute ethanol dosage regimen (75 mmol/kg/body weight [BW]) for 2.5 to 24 hours...
  18. Ritorto M, Borlak J. Combined serum and tissue proteomic study applied to a c-Myc transgenic mouse model of hepatocellular carcinoma identified novel disease regulated proteins suitable for diagnosis and therapeutic intervention strategies. J Proteome Res. 2011;10:3012-30 pubmed publisher
    Hepatocellular carcinoma (HCC) is the third leading cause of cancer death in the U.S. Notably, most HCCs display c-Myc hyperactivity but this transcription factor participates in the regulation of as many as 15-20% of genes of the human ..
  19. KINNEY E, Tanida S, Rodrigue A, Johnson J, Tompkins V, Sakamuro D. Adenovirus E1A oncoprotein liberates c-Myc activity to promote cell proliferation through abating Bin1 expression via an Rb/E2F1-dependent mechanism. J Cell Physiol. 2008;216:621-31 pubmed publisher
    Adenovirus E1A oncogene transforms primary rodent fibroblasts in cooperation with activated Ras. Conversely, the c-Myc oncoprotein-binding tumor suppressor, Bin1, inhibits Ras/E1A-mediated cell transformation...
  20. Klefstrom J, Verschuren E, Evan G. c-Myc augments the apoptotic activity of cytosolic death receptor signaling proteins by engaging the mitochondrial apoptotic pathway. J Biol Chem. 2002;277:43224-32 pubmed
    Activation of c-Myc sensitizes cells to apoptosis induction by ligand-activated death receptors...
  21. Urbanek Olejnik K, Liszewska M, Winczura A, Kostka G. Changes of c-Myc and DNMT1 mRNA and protein levels in the rat livers induced by dibutyl phthalate treatment. Toxicol Ind Health. 2016;32:801-8 pubmed publisher
    We investigated the relationship between dibutyl phthalate (DBP)-induced hypomethylation of the c-Myc promoter region (as evident in our early study) and the expression of c-Myc and DNMT1 genes (at messenger RNA (mRNA) and protein level) ..
  22. Mizukami Y, Iwamatsu A, Aki T, Kimura M, Nakamura K, Nao T, et al. ERK1/2 regulates intracellular ATP levels through alpha-enolase expression in cardiomyocytes exposed to ischemic hypoxia and reoxygenation. J Biol Chem. 2004;279:50120-31 pubmed
    ..The induction of alpha-enolase by ERK1/2 appears to be mediated by c-Myc. The introduction of the alpha-enolase protein into the cells restores ATP levels and prevents cell death during ..
  23. Van De Casteele M, Kefas B, Cai Y, Heimberg H, Scott D, Henquin J, et al. Prolonged culture in low glucose induces apoptosis of rat pancreatic beta-cells through induction of c-myc. Biochem Biophys Res Commun. 2003;312:937-44 pubmed
    ..rat islets, culture in the presence of 3 or 5mM (G3-G5) instead of 10mM glucose (G10) induces a large increase in c-myc expression before onset of a caspase-dependent apoptosis...
  24. Dendelé B, Tekpli X, Sergent O, Dimanche Boitrel M, Holme J, Huc L, et al. Identification of the couple GSK3?/c-Myc as a new regulator of hexokinase II in benzo[a]pyrene-induced apoptosis. Toxicol In Vitro. 2012;26:94-101 pubmed publisher
    ..level, glycogen synthase kinase 3 alpha (GSK3?) was involved in B[a]P-induced apoptosis via a decrease in c-Myc expression...
  25. Yap C, Peterson A, Castellani G, Sedivy J, Neretti N. Kinetic profiling of the c-Myc transcriptome and bioinformatic analysis of repressed gene promoters. Cell Cycle. 2011;10:2184-96 pubmed
    Mammalian c-Myc is a member of a small family of three related proto-oncogenic transcription factors...
  26. Couillard M, Trudel M. C-myc as a modulator of renal stem/progenitor cell population. Dev Dyn. 2009;238:405-14 pubmed publisher
    The role of c-myc has been well-studied in gene regulation and oncogenesis but remains elusive in murine development from midgestation...
  27. Yano T, Sander C, Clark H, Dolezal M, Jaffe E, Raffeld M. Clustered mutations in the second exon of the MYC gene in sporadic Burkitt's lymphoma. Oncogene. 1993;8:2741-8 pubmed
    ..from 15 untreated patients with Burkitt's lymphoma were analysed for abnormalities in the coding region of the MYC gene by single stranded conformational polymorphism (SSCP) analysis followed by DNA sequencing...
  28. Grippo P, Sandgren E. Acinar-to-ductal metaplasia accompanies c-myc-induced exocrine pancreatic cancer progression in transgenic rodents. Int J Cancer. 2012;131:1243-8 pubmed publisher
    ..The oncogenic transcription factor c-myc is associated with human pancreatic neoplasms...
  29. Widlund H, Horstmann M, Price E, Cui J, Lessnick S, Wu M, et al. Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor. J Cell Biol. 2002;158:1079-87 pubmed
    ..Thus, beta-catenin regulation of MITF expression represents a tissue-restricted pathway that significantly influences the growth and survival behavior of this notoriously treatment-resistant neoplasm. ..
  30. Brenner C, Deplus R, Didelot C, Loriot A, Viré E, De Smet C, et al. Myc represses transcription through recruitment of DNA methyltransferase corepressor. EMBO J. 2005;24:336-46 pubmed
    The Myc transcription factor is an essential mediator of cell growth and proliferation through its ability to both positively and negatively regulate transcription...
  31. Zeng L, Liao H, Liu Y, Lee T, Zhu M, Wang X, et al. Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism. J Biol Chem. 2004;279:48801-7 pubmed
    ..Thus, this SREBP-regulated mechanism may control the efflux of cholesterol, which is a newly defined function of SREBP2 in ECs in addition to its role in cholesterol uptake and biosynthesis...
  32. Barathidasan R, Pawaiya R, Rai R, Dhama K. Upregulated Myc expression in N-methyl nitrosourea (MNU)- induced rat mammary tumours. Asian Pac J Cancer Prev. 2013;14:4883-9 pubmed
    The most common incident cancer and cause of cancer-related deaths in women is breast cancer. The Myc gene is upregulated in many cancer types including breast cancer, and it is considered as a potential anti-cancer drug target...
  33. Frank S, Parisi T, Taubert S, Fernandez P, Fuchs M, Chan H, et al. MYC recruits the TIP60 histone acetyltransferase complex to chromatin. EMBO Rep. 2003;4:575-80 pubmed
    The transcription factor MYC binds specific DNA sites in cellular chromatin and induces the acetylation of histones H3 and H4...
  34. Collier J, Doan T, Daniels M, Schurr J, Kolls J, Scott D. c-Myc is required for the glucose-mediated induction of metabolic enzyme genes. J Biol Chem. 2003;278:6588-95 pubmed
    Glucose exerts powerful effects on hepatocyte gene transcription by mechanisms that are incompletely understood. c-Myc regulates hepatic glucose metabolism by increasing glycolytic enzyme gene transcription while concomitantly decreasing ..
  35. Amente S, Bertoni A, Morano A, Lania L, Avvedimento E, Majello B. LSD1-mediated demethylation of histone H3 lysine 4 triggers Myc-induced transcription. Oncogene. 2010;29:3691-702 pubmed publisher
    b>Myc is a transcription factor that significantly contributes to cancer progression by modulating the expression of important genes through binding to a DNA sequence, CACGTG, called E-box...
  36. Tong Y, Zheng Y, Zhou J, Oyesiku N, Koeffler H, Melmed S. Genomic characterization of human and rat prolactinomas. Endocrinology. 2012;153:3679-91 pubmed publisher
    ..human prolactinoma and pituitaries of estrogen-treated ACI rat, 145 concordantly expressed genes, including E2F1, Myc, Igf1, and CEBPD, were identified...
  37. Zhang W, Xiong Y, Zhu T, Xiong A, Bao H, Cheng X. MicroRNA let-7g inhibited hypoxia-induced proliferation of PASMCs via G0/G1 cell cycle arrest by targeting c-myc. Life Sci. 2017;170:9-15 pubmed publisher
    ..MTS and EDU were performed to evaluate PASMCs proliferation. The mRNA and protein expression of c-myc, Bmi-1 and p16 were determined by qRT-PCR and Western blotting, respectively...
  38. Rogulski K, Cohen D, Corcoran D, Benos P, Prochownik E. Deregulation of common genes by c-Myc and its direct target, MT-MC1. Proc Natl Acad Sci U S A. 2005;102:18968-73 pubmed
    In addition to its role in cancer, the c-Myc oncoprotein controls many normal cellular processes as a consequence of its function as a basic helix-loop-helix leucine zipper transcription factor...
  39. Trudel M, Barisoni L, Lanoix J, D AGATI V. Polycystic kidney disease in SBM transgenic mice: role of c-myc in disease induction and progression. Am J Pathol. 1998;152:219-29 pubmed
    SBM mouse is a unique transgenic model of polycystic kidney disease (PKD) produced by dysregulation of c-myc in the kidneys...
  40. Fu D, Wang S, Zhou D, Ma Y, Jin L, Zu L. [Effects of Huoxue Qianyang Formula on expressions of proto-oncogenes c-fos and c-myc in spontaneous hypertensive rats with ventricular hypertrophy]. Zhong Xi Yi Jie He Xue Bao. 2008;6:387-91 pubmed publisher
    ..hypertensive rats (SHRs) by analyzing the expressions of mRNAs and proteins of proto-oncogenes c-fos and c-myc in left ventricular muscle...
  41. Hou Y, Okamoto C, Okada K, Kawao N, Kawata S, Ueshima S, et al. c-Myc is essential for urokinase plasminogen activator expression on hypoxia-induced vascular smooth muscle cells. Cardiovasc Res. 2007;75:186-94 pubmed
    The purpose of this study was to investigate whether c-Myc regulates expression of urokinase plasminogen activator (uPA) on hypoxia-induced vascular smooth muscle cells (VSMCs)...
  42. Alter Koltunoff M, Goren S, Nousbeck J, Feng C, Sher A, Ozato K, et al. Innate immunity to intraphagosomal pathogens is mediated by interferon regulatory factor 8 (IRF-8) that stimulates the expression of macrophage-specific Nramp1 through antagonizing repression by c-Myc. J Biol Chem. 2008;283:2724-33 pubmed
    ..Nramp1 expression in activated macrophages is accompanied by a promoter shift from a repression state elicited by c-Myc to an activation state elicited by the induction of IRF-8 in activated macrophages...
  43. Chowdhury M, Montgomery M, Morris M, Cognard E, Shepherd P, Smith G. Glucagon phosphorylates serine 552 of β-catenin leading to increased expression of cyclin D1 and c-Myc in the isolated rat liver. Arch Physiol Biochem. 2015;121:88-96 pubmed publisher
    ..catenin on serine 552 that is associated with increased expression of genes cyclin D1 (CCND1) and c-Myc (MYC), which are known to be involved in liver cancer...
  44. Zhang Q, Spears E, Boone D, Li Z, Gregory M, Hann S. Domain-specific c-Myc ubiquitylation controls c-Myc transcriptional and apoptotic activity. Proc Natl Acad Sci U S A. 2013;110:978-83 pubmed publisher
    The oncogenic transcription factor c-Myc causes transformation and tumorigenesis, but it can also induce apoptotic cell death...
  45. Malekinejad H, Janbaz Acyabar H, Razi M, Varasteh S. Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression. Phytomedicine. 2012;19:1077-84 pubmed publisher
    ..The expression of c-myc at mRNA level also was analyzed. SMN in preventive and protective forms significantly (p<0...
  46. Tinel M, Berson A, Elkahwaji J, Cresteil T, Beaune P, Pessayre D. Downregulation of cytochromes P450 in growth-stimulated rat hepatocytes: role of c-Myc induction and impaired C/EBP binding to DNA. J Hepatol. 2003;39:171-8 pubmed
    ..EGF increased c-myc mRNA and protein, and decreased CYP mRNAs and proteins; both effects were prevented by two agents blocking c-myc ..
  47. Chen S, Qiong Y, Gardner D. A role for p38 mitogen-activated protein kinase and c-myc in endothelin-dependent rat aortic smooth muscle cell proliferation. Hypertension. 2006;47:252-8 pubmed
    ..mitogenic activity requires an intact p38 mitogen-activated protein kinase (p38 MAPK) system and increased c-myc gene expression. ET increased [3H]-thymidine incorporation in rat aortic smooth muscle cells approximately 5-fold...
  48. Adhikary S, Peukert K, Karsunky H, Beuger V, Lutz W, Elsässer H, et al. Miz1 is required for early embryonic development during gastrulation. Mol Cell Biol. 2003;23:7648-57 pubmed
    Miz1 is a member of the POZ domain/zinc finger transcription factor family. In vivo, Miz1 forms a complex with the Myc oncoprotein and recruits Myc to core promoter elements. Myc represses transcription through Miz1 binding sites...
  49. Jian B, Yang S, Chaudry I, Raju R. Resveratrol improves cardiac contractility following trauma-hemorrhage by modulating Sirt1. Mol Med. 2012;18:209-14 pubmed publisher
    ..Our recent studies, based on the reported interrelationship between c-Myc and Sirt1 (mammalian orthologue of yeast sir2 [silent information regulator 2]) expression and their role in ..
  50. Liu L, Guo X, Rao J, Zou T, Xiao L, Yu T, et al. Polyamines regulate E-cadherin transcription through c-Myc modulating intestinal epithelial barrier function. Am J Physiol Cell Physiol. 2009;296:C801-10 pubmed publisher
    ..study was performed to determine whether polyamines induce E-cadherin expression through the transcription factor c-Myc and whether polyamine-regulated E-cadherin plays a role in maintenance of the epithelial barrier integrity...
  51. Ernens I, Goodfellow S, Innes F, Kenneth N, Derblay L, White R, et al. Hypoxic stress suppresses RNA polymerase III recruitment and tRNA gene transcription in cardiomyocytes. Nucleic Acids Res. 2006;34:286-94 pubmed
    ..that the pol III-specific transcription factor IIIB (TFIIIB) is bound and regulated by the proto-oncogene product c-Myc, the mitogen-activated protein kinase ERK and the retinoblastoma tumour suppressor protein, RB...
  52. Thivierge C, Kurbegovic A, Couillard M, Guillaume R, Côté O, Trudel M. Overexpression of PKD1 causes polycystic kidney disease. Mol Cell Biol. 2006;26:1538-48 pubmed
    ..Our results also uncovered a striking increased renal c-myc expression in mice from all transgenic lines, indicating that c-myc is a critical in vivo downstream effector of ..
  53. Rodriguez J, Sandoval J, Serviddio G, Sastre J, Morante M, Perrelli M, et al. Id2 leaves the chromatin of the E2F4-p130-controlled c-myc promoter during hepatocyte priming for liver regeneration. Biochem J. 2006;398:431-7 pubmed
    ..Id2 forms a complex with E2F4, p130 and mSin3A in quiescent liver and all these components are present at the c-myc promoter as shown using ChIP (chromatin immunoprecipitation)...
  54. Wang J, Kim J, Roh M, Franco O, Hayward S, Wills M, et al. Pim1 kinase synergizes with c-MYC to induce advanced prostate carcinoma. Oncogene. 2010;29:2477-87 pubmed publisher
    The oncogenic PIM1 kinase has been implicated as a cofactor for c-MYC in prostate carcinogenesis. In this study, we show that in human prostate tumors, coexpression of c-MYC and PIM1 is associated with higher Gleason grades...
  55. Boone D, Qi Y, Li Z, Hann S. Egr1 mediates p53-independent c-Myc-induced apoptosis via a noncanonical ARF-dependent transcriptional mechanism. Proc Natl Acad Sci U S A. 2011;108:632-7 pubmed publisher
    c-Myc is frequently deregulated in human cancers. Although deregulated c-Myc leads to tumor growth, it also triggers apoptosis in partnership with tumor suppressors such as ARF and p53...
  56. Calaf G, Echiburu Chau C. Synergistic effect of malathion and estrogen on mammary gland carcinogenesis. Oncol Rep. 2012;28:640-6 pubmed publisher
    ..Furthermore, markers for cancer detection such as mutant p53, c-myc, c-fos and CYPs proteins were overexpressed after treatments...
  57. Okada K, Ma D, Warabi E, Morito N, Akiyama K, Murata Y, et al. Amelioration of cisplatin-induced nephrotoxicity in peroxiredoxin I-deficient mice. Cancer Chemother Pharmacol. 2013;71:503-9 pubmed publisher
    ..We suggest the enhanced transcriptional activity of c-Myc in Prx I-null mice may partly contribute the enhanced expression of renal efflux transporters...
  58. Lin S, Elledge S. Multiple tumor suppressor pathways negatively regulate telomerase. Cell. 2003;113:881-9 pubmed
    ..We discovered three tumor suppressor/oncogene pathways involved in hTERT repression. One, the Mad1/c-Myc pathway, had been previously implicated in hTERT regulation...
  59. Kaneto H, Sharma A, Suzuma K, Laybutt D, Xu G, Bonner Weir S, et al. Induction of c-Myc expression suppresses insulin gene transcription by inhibiting NeuroD/BETA2-mediated transcriptional activation. J Biol Chem. 2002;277:12998-3006 pubmed
    ..We have found that hyperglycemia induces the expression of the basic helix-loop-helix transcription factor c-Myc in islets in several different diabetic models...
  60. Kurabe N, Katagiri K, Komiya Y, Ito R, Sugiyama A, Kawasaki Y, et al. Deregulated expression of a novel component of TFTC/STAGA histone acetyltransferase complexes, rat SGF29, in hepatocellular carcinoma: possible implication for the oncogenic potential of c-Myc. Oncogene. 2007;26:5626-34 pubmed
    c-Myc N-terminal conserved domains, MbI and MbII, are essential for c-Myc-mediated transformation and transactivation...
  61. Strom A, Bonal C, Ashery Padan R, Hashimoto N, Campos M, Trumpp A, et al. Unique mechanisms of growth regulation and tumor suppression upon Apc inactivation in the pancreas. Development. 2007;134:2719-25 pubmed
    ..Expression of a target of beta-catenin, the proto-oncogene c-myc (Myc), was increased in acinar cells lacking Apc, suggesting that c-myc expression is essential for hyperplasia...
  62. Guerra L, Albihn A, Tronnersjö S, Yan Q, Guidi R, Stenerlow B, et al. Myc is required for activation of the ATM-dependent checkpoints in response to DNA damage. PLoS ONE. 2010;5:e8924 pubmed publisher
    The MYC protein controls cellular functions such as differentiation, proliferation, and apoptosis. In response to genotoxic agents, cells overexpressing MYC undergo apoptosis...