Myc

Summary

Gene Symbol: Myc
Description: myelocytomatosis oncogene
Alias: RNCMYC, c-myc, mMyc, myc proto-oncogene protein, Avian myelocytomatosis viral (v-myc) oncogene homolog, myelocytomatosis viral oncogene homolog, proto-oncogene c-Myc, transcription factor p64, v-myc avian myelocytomatosis viral oncogene homolog
Species: rat

Top Publications

  1. ncbi Modulation of c-myc and c-fos gene expression in regenerating rat liver by 2-mercaptopropionylglycine
    Sujata Ohri
    Gene Regulation Laboratory, Centre for Biotechnology, Jawaharlal Nehru University, New Delhi, India
    Cell Biol Int 26:187-92. 2002
  2. pmc Synergistic role of c-Myc and ERK1/2 in the mitogenic response to TGF beta-1 in cultured rat nucleus pulposus cells
    Tomoko Nakai
    Division of Organogenesis, Research Center for Regenerative Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Arthritis Res Ther 10:R140. 2008
  3. pmc Angiotensin II reduces cardiac AdipoR1 expression through AT1 receptor/ROS/ERK1/2/c-Myc pathway
    Li Li
    Department of Physiology and Pathophysiology, Peking University Health Science Center, and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, China
    PLoS ONE 8:e49915. 2013
  4. ncbi Susceptibility of striatal neurons to excitotoxic injury correlates with basal levels of Bcl-2 and the induction of P53 and c-Myc immunoreactivity
    Zhong qin Liang
    Department of Pharmacology, Soochow University School of Medicine, Suzhou 215007, P R China
    Neurobiol Dis 20:562-73. 2005
  5. pmc c-MYC apoptotic function is mediated by NRF-1 target genes
    Fionnuala Morrish
    Fred Hutchinson Cancer Research Center, Division of Molecular Medicine, Seattle, Washington 98109, USA
    Genes Dev 17:240-55. 2003
  6. ncbi Prostatic neoplasia in transgenic mice with prostate-directed overexpression of the c-myc oncoprotein
    X Zhang
    Department of Urology, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Prostate 43:278-85. 2000
  7. pmc A functional screen for Myc-responsive genes reveals serine hydroxymethyltransferase, a major source of the one-carbon unit for cell metabolism
    Mikhail A Nikiforov
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Mol Cell Biol 22:5793-800. 2002
  8. pmc c-Myc functionally cooperates with Bax to induce apoptosis
    Philippe Juin
    University of California at San Francisco Cancer Center, San Francisco, California 94143 0128, USA
    Mol Cell Biol 22:6158-69. 2002
  9. ncbi Direct activation of RNA polymerase III transcription by c-Myc
    Natividad Gomez-Roman
    Institute of Biomedical and Life Sciences, Division of Biochemistry and Molecular Biology, University of Glasgow, Glasgow, G12 8QQ, UK
    Nature 421:290-4. 2003
  10. ncbi Myc-driven murine prostate cancer shares molecular features with human prostate tumors
    Katharine Ellwood-Yen
    Department of Medicine, and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Cancer Cell 4:223-38. 2003

Research Grants

  1. ETHANOL METABOLISM IN PREGNANCY--ROLE OF DIET
    Martin Ronis; Fiscal Year: 2005
  2. ETHANOL EFFECTS ON BONE FORMATION IN PREGNANCY
    Martin Ronis; Fiscal Year: 2006

Scientific Experts

Detail Information

Publications124 found, 100 shown here

  1. ncbi Modulation of c-myc and c-fos gene expression in regenerating rat liver by 2-mercaptopropionylglycine
    Sujata Ohri
    Gene Regulation Laboratory, Centre for Biotechnology, Jawaharlal Nehru University, New Delhi, India
    Cell Biol Int 26:187-92. 2002
    Expression of the two proto-oncogenes, c- myc and c- fos, in proliferating liver, and the modulation of their expression by 2-mercaptopropionylglycine (MPG) has been investigated...
  2. pmc Synergistic role of c-Myc and ERK1/2 in the mitogenic response to TGF beta-1 in cultured rat nucleus pulposus cells
    Tomoko Nakai
    Division of Organogenesis, Research Center for Regenerative Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Arthritis Res Ther 10:R140. 2008
    ..However, the precise cell cycle progression and molecular mechanisms by which TGFbeta1 stimulates cell growth remain unclear. The aim of this study was to elucidate a mechanism that enables cell proliferation with TGFbeta1 stimulation...
  3. pmc Angiotensin II reduces cardiac AdipoR1 expression through AT1 receptor/ROS/ERK1/2/c-Myc pathway
    Li Li
    Department of Physiology and Pathophysiology, Peking University Health Science Center, and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, China
    PLoS ONE 8:e49915. 2013
    ..Chromatin immunoprecipitation assay demonstrated that AngII provoked the recruitment of c-Myc onto the promoter region of AdipoR1, which was attenuated by PD98059...
  4. ncbi Susceptibility of striatal neurons to excitotoxic injury correlates with basal levels of Bcl-2 and the induction of P53 and c-Myc immunoreactivity
    Zhong qin Liang
    Department of Pharmacology, Soochow University School of Medicine, Suzhou 215007, P R China
    Neurobiol Dis 20:562-73. 2005
    The present studies evaluated the potential contribution of Bcl-2, p53, and c-Myc to the differential vulnerability of striatal neurons to the excitotoxin quinolinic acid (QA)...
  5. pmc c-MYC apoptotic function is mediated by NRF-1 target genes
    Fionnuala Morrish
    Fred Hutchinson Cancer Research Center, Division of Molecular Medicine, Seattle, Washington 98109, USA
    Genes Dev 17:240-55. 2003
    A detailed understanding of the signaling pathways by which c-Myc elicits apoptosis has proven elusive...
  6. ncbi Prostatic neoplasia in transgenic mice with prostate-directed overexpression of the c-myc oncoprotein
    X Zhang
    Department of Urology, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Prostate 43:278-85. 2000
    ..In order to test the in vivo effects of chronic overexpression of the mouse c-myc protooncogene on the prostate glands of transgenic mice, we created several lines of C(3)1-c-myc transgenic mice ..
  7. pmc A functional screen for Myc-responsive genes reveals serine hydroxymethyltransferase, a major source of the one-carbon unit for cell metabolism
    Mikhail A Nikiforov
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Mol Cell Biol 22:5793-800. 2002
    A cDNA library enriched with Myc-responsive cDNAs but depleted of myc cDNAs was used in a functional screen for growth enhancement in c-myc-null cells...
  8. pmc c-Myc functionally cooperates with Bax to induce apoptosis
    Philippe Juin
    University of California at San Francisco Cancer Center, San Francisco, California 94143 0128, USA
    Mol Cell Biol 22:6158-69. 2002
    c-Myc promotes apoptosis by destabilizing mitochondrial integrity, leading to the release of proapoptotic effectors including holocytochrome c. Candidate mediators of c-Myc in this process are the proapoptotic members of the Bcl-2 family...
  9. ncbi Direct activation of RNA polymerase III transcription by c-Myc
    Natividad Gomez-Roman
    Institute of Biomedical and Life Sciences, Division of Biochemistry and Molecular Biology, University of Glasgow, Glasgow, G12 8QQ, UK
    Nature 421:290-4. 2003
    The proto-oncogene product c-Myc has a direct role in both metazoan cell growth and division...
  10. ncbi Myc-driven murine prostate cancer shares molecular features with human prostate tumors
    Katharine Ellwood-Yen
    Department of Medicine, and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Cancer Cell 4:223-38. 2003
    Increased Myc gene copy number is observed in human prostate cancer. To define Myc's functional role, we generated transgenic mice expressing human c-Myc in the mouse prostate...
  11. pmc Targeting c-Myc-activated genes with a correlation method: detection of global changes in large gene expression network dynamics
    D Remondini
    Dipartimento di Fisica and Galvani Center for Biocomplexity, Universita di Bologna, Bologna 40127, Italy
    Proc Natl Acad Sci U S A 102:6902-6. 2005
    ..We discuss in detail the problem of finding targets of the c-myc protooncogene, which encodes a transcriptional regulator whose inappropriate expression has been correlated with a ..
  12. ncbi Pim family kinases enhance tumor growth of prostate cancer cells
    Wei Wei Chen
    Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA
    Mol Cancer Res 3:443-51. 2005
    ..We have found that the cellular levels of c-Myc were elevated in the Pim-1 and Pim-2 transfectants under these conditions...
  13. pmc Myc influences global chromatin structure
    Paul S Knoepfler
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 4417, USA
    EMBO J 25:2723-34. 2006
    The family of myc proto-oncogenes encodes transcription factors (c-, N-, and L-Myc) that regulate cell growth and proliferation and are involved in the etiology of diverse cancers...
  14. pmc The oncogene c-Myc coordinates regulation of metabolic networks to enable rapid cell cycle entry
    Fionnuala Morrish
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Cell Cycle 7:1054-66. 2008
    The c-myc proto-oncogene is rapidly activated by serum and regulates genes involved in metabolism and cell cycle progression...
  15. pmc c-Myc activates multiple metabolic networks to generate substrates for cell-cycle entry
    F Morrish
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Oncogene 28:2485-91. 2009
    ..Many metabolic pathway genes are targets of the c-myc oncogene and cell-cycle regulator...
  16. doi The let-7a microRNA protects from growth of lung carcinoma by suppression of k-Ras and c-Myc in nude mice
    Xiao yan He
    Department of Cell Biology and Medical Genetics, Molecular Medicine and Cancer Research Center, Chongqing Medical University, No 1, Medical College Road, 400016 Chongqing, China
    J Cancer Res Clin Oncol 136:1023-8. 2010
    Down-regulation of let-7 microRNA (miRNA) plays an important role in the pathogenesis of lung cancer. k-Ras and c-Myc, two key oncogenes in lung cancer, have been found to be targeted by let-7 in vitro...
  17. pmc Expression status and prognostic significance of mammalian target of rapamycin pathway members in urothelial carcinoma of urinary bladder after cystectomy
    Luciana Schultz
    Department of Pathology, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Cancer 116:5517-26. 2010
    ..Identifying novel molecular prognostic factors and targets of therapy is crucial. Mammalian target of rapamycin (mTOR) pathway plays a pivotal role in establishing cell shape, migration, and proliferation...
  18. ncbi Targeting of Miz-1 is essential for Myc-mediated apoptosis
    Jagruti H Patel
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 281:3283-9. 2006
    The c-Myc oncoprotein plays a central role in human cancer via its ability to either activate or repress the transcription of essential downstream targets...
  19. ncbi Mithramycin inhibits myointimal proliferation after balloon injury of the rat carotid artery in vivo
    S J Chen
    Department of Medicine, University of Alabama at Birmingham
    Circulation 90:2468-73. 1994
    ..The immediate early-response gene c-myc is overexpressed in proliferating vascular smooth muscle cells in vitro, and c-myc antisense oligomers have been ..
  20. ncbi Malignant transformation of an epithelial cell by v-Src via tv-a-mediated retroviral infection: a new cell model for studying carcinogenesis
    Shu Ling Fu
    Institute of Traditional Medicine, National Yang Ming University, 155, Sec 2, Li Nong St, Taipei 11221, Taiwan
    Biochem Biophys Res Commun 338:830-8. 2005
    ..Furthermore, tv-a-mediated delivery of various oncogenes (v-src, H-ras, myc or akt) leads to malignant transformation...
  21. ncbi Prepubertal onset of diabetes prevents expression of renal cortical connective tissue growth factor
    William J Langer
    Department of Pediatrics, University of Nebraska Medical Center, Omaha, NE, USA
    Pediatr Nephrol 23:275-83. 2008
    ..Follistatin and avian myelocytomatosis viral oncogene homolog mRNA both showed a similar age-related pattern of response to DM, but protein levels did not ..
  22. doi The PTEN regulator DJ-1 is associated with hTERT expression in clear cell renal cell carcinoma
    Raviprakash T Sitaram
    Department of Medical Biosciences, Pathology, Umea University, Umea, Sweden
    Int J Cancer 125:783-90. 2009
    ..Neither DJ-1, cMyc nor hTERT mRNA levels were associated with proliferation (S-phase fraction), telomere length or prognosis in ccRCC...
  23. pmc MYC overexpression induces prostatic intraepithelial neoplasia and loss of Nkx3.1 in mouse luminal epithelial cells
    Tsuyoshi Iwata
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 5:e9427. 2010
    Lo-MYC and Hi-MYC mice develop prostatic intraepithelial neoplasia (PIN) and prostatic adenocarcinoma as a result of MYC overexpression in the mouse prostate...
  24. pmc tPA is a potent mitogen for renal interstitial fibroblasts: role of beta1 integrin/focal adhesion kinase signaling
    Sha Hao
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Am J Pathol 177:1164-75. 2010
    ..by tPA was associated with an increased expression of numerous proliferation-related genes, including c-fos, c-myc, proliferating cell nuclear antigen, and cyclin D1...
  25. pmc B-cell activating factor and v-Myc myelocytomatosis viral oncogene homolog (c-Myc) influence progression of chronic lymphocytic leukemia
    Weizhou Zhang
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, Moores Cancer Center, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 107:18956-60. 2010
    Mice bearing a v-Myc myelocytomatosis viral oncogene homolog (c-Myc) transgene controlled by an Ig-alpha heavy-chain enhancer (iMyc(Cα) mice) rarely develop lymphomas but instead have increased rates of memory B-cell turnover and ..
  26. pmc Transgenic overexpression of Anks6(p.R823W) causes polycystic kidney disease in rats
    Sabine Neudecker
    Medical Research Center ZMF, Medical Faculty Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    Am J Pathol 177:3000-9. 2010
    ..Cyst development is accompanied by enhanced c-myc expression and continuous proliferation, apoptosis, and de-differentiation of the renal tubular epithelium as well ..
  27. pmc Kinetic profiling of the c-Myc transcriptome and bioinformatic analysis of repressed gene promoters
    Chui Sun Yap
    Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA
    Cell Cycle 10:2184-96. 2011
    Mammalian c-Myc is a member of a small family of three related proto-oncogenic transcription factors...
  28. doi Combined serum and tissue proteomic study applied to a c-Myc transgenic mouse model of hepatocellular carcinoma identified novel disease regulated proteins suitable for diagnosis and therapeutic intervention strategies
    Maria Stella Ritorto
    Department of Molecular Medicine and Medical Biotechnology, Fraunhofer ITEM, Hanover, Germany
    J Proteome Res 10:3012-30. 2011
    Hepatocellular carcinoma (HCC) is the third leading cause of cancer death in the U.S. Notably, most HCCs display c-Myc hyperactivity but this transcription factor participates in the regulation of as many as 15-20% of genes of the human ..
  29. pmc Immunoexpression status and prognostic value of mTOR and hypoxia-induced pathway members in primary and metastatic clear cell renal cell carcinomas
    Luciana Schultz
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Am J Surg Pathol 35:1549-56. 2011
    ..001). For phos-S6 and 4EBP1, levels were higher in primary ccRCC compared with benign tissues (P<0.001). c-MYC levels were higher in metastatic ccRCC (P<0...
  30. pmc cMyc is a principal upstream driver of beta-cell proliferation in rat insulinoma cell lines and is an effective mediator of human beta-cell replication
    Esra Karslioglu
    Division of Endocrinology, The University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA
    Mol Endocrinol 25:1760-72. 2011
    ..The cMyc pathway provides potential approaches, targets, and tools for driving and sustaining human β-cell replication...
  31. pmc CEBPD suppresses prolactin expression and prolactinoma cell proliferation
    Yunguang Tong
    Academic Affairs, Los Angeles, California 90048, USA
    Mol Endocrinol 25:1880-91. 2011
    ..CEBPD also suppresses expression of proliferation-related genes, including c-Myc, survivin, as well as cyclins B1, B2, and D1...
  32. doi Acinar-to-ductal metaplasia accompanies c-myc-induced exocrine pancreatic cancer progression in transgenic rodents
    Paul J Grippo
    Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Int J Cancer 131:1243-8. 2012
    ..The oncogenic transcription factor c-myc is associated with human pancreatic neoplasms...
  33. doi Differential pathotropism of non-immortalized and immortalized human neural stem cell lines in a focal demyelination model
    Daniela Ferrari
    Department of Biotechnology and Biosciences, Universita Milano Bicocca, Milan, Italy
    Cell Mol Life Sci 69:1193-210. 2012
    ..and to reduce the local inflammation after an acute injury, we transplanted GMP-grade non-immortalized hNSCs and v-myc (v-IhNSC), c-myc T58A (T-IhNSC) immortalized cells into the corpus callosum of adult rats after 5 days from focal ..
  34. ncbi Antioxidant N-acetyl-L-cysteine (NAC) supplementation reduces reactive oxygen species (ROS)-mediated hepatocellular tumor promotion of indole-3-carbinol (I3C) in rats
    Keisuke Shimamoto
    Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan
    J Toxicol Sci 36:775-86. 2011
    ..8-OHdG) as an oxidative DNA marker between the DEN-I3C-NAC and DEN-I3C groups, while mapkapk3 and Myc were decreased by the NAC treatment...
  35. pmc 1,25-dihydroxyvitamin D3 treatment shrinks uterine leiomyoma tumors in the Eker rat model
    Sunil K Halder
    Center for Women s Health Research, Department of Obstetrics and Gynecology, Meharry Medical College, Nashville, Tennessee 37208, USA
    Biol Reprod 86:116. 2012
    ..It also reduced leiomyoma size by suppressing cell growth and proliferation-related genes (Pcna, cyclin D1 [Ccnd1], Myc, Cdk1, Cdk2, and Cdk4), antiapoptotic genes (Bcl2 and Bcl2l1 [Bcl-x]), and estrogen and progesterone receptors...
  36. doi Cannabis exposure associated with weight reduction and β-cell protection in an obese rat model
    R A Levendal
    Department of Biochemistry and Microbiology, Nelson Mandela Metropolitan University, Port Elizabeth, South Africa
    Phytomedicine 19:575-82. 2012
    ..diet induced down-regulation of the following genes in the obese control group, relative to lean controls: UCP2, c-MYC and FLIP...
  37. pmc Mitochondrial structure, function and dynamics are temporally controlled by c-Myc
    J Anthony Graves
    Division of Hematology Oncology, Department of Pediatrics, Children s Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 7:e37699. 2012
    Although the c-Myc (Myc) oncoprotein controls mitochondrial biogenesis and multiple enzymes involved in oxidative phosphorylation (OXPHOS), the coordination of these events and the mechanistic underpinnings of their regulation remain ..
  38. doi Pro-inflammatory cytokine interleukin-1β promotes the development of intestinal stem cells
    Lei Wang
    Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA
    Inflamm Res 61:1085-92. 2012
    ..We investigated the effect of IL-1β on the development of intestinal epithelial stem cells...
  39. doi Mammary gland morphology and gene expression differ in female rats treated with 17β-estradiol or fed soy protein isolate
    Martin J J Ronis
    Arkansas Children s Nutrition Center, Little Rock, AR 72202, USA
    Endocrinology 153:6021-32. 2012
    ..and E2 altered expression of 422 genes and reversed E2 effects on many mRNAs, including those involved in the c-myc signaling pathway, cyclin D1, and Ki67...
  40. pmc Cross-species genome wide expression analysis during pluripotent cell determination in mouse and rat preimplantation embryos
    Elisa A Casanova
    Institute of Laboratory Animal Science, University of Zurich, Zurich, Switzerland
    PLoS ONE 7:e47107. 2012
    ..in ESCs, like for example Sox2 or Stat3, or play a role in reprogramming somatic cells to pluripotency like c-Myc, Klf4 and p53 and therefore represent interesting candidates to further analyze in vitro in the rat ESCs...
  41. pmc Distinct SNP combinations confer susceptibility to urinary bladder cancer in smokers and non-smokers
    Holger Schwender
    Mathematical Institute, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    PLoS ONE 7:e51880. 2012
    ..of cigarette smoke carcinogens were most relevant (GSTM1, rs11892031), in contrast to those in non-smokers with MYC and APOBEC3A near polymorphisms (rs9642880, rs1014971) being the most influential...
  42. pmc Burkitt's lymphoma-associated c-Myc mutations converge on a dramatically altered target gene response and implicate Nol5a/Nop56 in oncogenesis
    V H Cowling
    Department of Pharmacology, Geisel School of Medicine at Dartmouth, Norris Cotton Cancer Center, One Medical Center Drive, Lebanon, NH, USA
    Oncogene 33:3519-27. 2014
    Burkitt's lymphomas (BLs) acquire consistent point mutations in a conserved domain of Myc, Myc Box I...
  43. ncbi Upregulated Myc expression in N-methyl nitrosourea (MNU)- induced rat mammary tumours
    Rajamani Barathidasan
    Division of Pathology, Indian Veterinary Research Institute, Izatnagar, India E mail
    Asian Pac J Cancer Prev 14:4883-9. 2013
    The most common incident cancer and cause of cancer-related deaths in women is breast cancer. The Myc gene is upregulated in many cancer types including breast cancer, and it is considered as a potential anti-cancer drug target...
  44. pmc c-Myc programs fatty acid metabolism and dictates acetyl-CoA abundance and fate
    Lia R Edmunds
    From the Divisions of Hematology Oncology and
    J Biol Chem 289:25382-92. 2014
    b>myc(-/-) rat fibroblasts (KO cells) differ from myc(+/+) (WT) cells and KO cells with enforced Myc re-expression (KO-Myc cells) with respect to mitochondrial structure and function, utilization of glucose and glutamine as energy-..
  45. doi Pre-clinical analysis of changes in intra-cellular biochemistry of glioblastoma multiforme (GBM) cells due to c-Myc silencing
    Vishal Rajagopalan
    Department of Biochemistry, University of Madras, Guindy Campus, Chennai, 600025, India
    Cell Mol Neurobiol 34:1059-69. 2014
    ..JQ1 is essentially a Myc inhibitor. c-Myc is also known for altering the biochemistry of a tumor cell...
  46. pmc JNK1 Deficient Insulin-Producing Cells Are Protected against Interleukin-1β-Induced Apoptosis Associated with Abrogated Myc Expression
    Michala Prause
    Immuno Endocrinology Lab, Endocrinology Research Section, Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark Section of Cellular and Metabolic Research, Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark
    J Diabetes Res 2016:1312705. 2016
    ..INS-1 cell apoptosis associated with decreased 46 kDa isoform JNK protein phosphorylation and attenuated Myc expression. Transient knockdown of Myc also prevented IL-1β-induced apoptosis as well as caspase 3 cleavage...
  47. pmc Polycystic kidney disease in SBM transgenic mice: role of c-myc in disease induction and progression
    M Trudel
    Institut de Recherches Cliniques de Montreal, Faculte de Medecine de l Universite de Montreal, Quebec, Canada
    Am J Pathol 152:219-29. 1998
    SBM mouse is a unique transgenic model of polycystic kidney disease (PKD) produced by dysregulation of c-myc in the kidneys...
  48. pmc Chronic oxidative stress causes amplification and overexpression of ptprz1 protein tyrosine phosphatase to activate beta-catenin pathway
    Yu Ting Liu
    Department of Pathology and Biology of Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Am J Pathol 171:1978-88. 2007
    ..beta-catenin was translocated to nuclei, resulting in the expression of its target genes cyclin D1, c-myc, c-jun, fra-1, and CD44...
  49. doi New prognostic markers revealed by evaluation of genes correlated with clinical parameters in Wilms tumors
    Stefanie Wittmann
    Department of Physiological Chemistry I, Biocenter, University of Wuerzburg, Am Hubland, Wuerzburg, Germany
    Genes Chromosomes Cancer 47:386-95. 2008
    ..for multiple testing and multivariate analysis revealed potentially relevant alteration of CA9, DKK1, EGR1, HEY2, MYC, MYCN, TERT, TOP2A, TRIM22, and VEGF expression in association with CTNNB1 mutation status, histological risk, ..
  50. doi Systems biology of autosomal dominant polycystic kidney disease (ADPKD): computational identification of gene expression pathways and integrated regulatory networks
    Xuewen Song
    Division of Nephrology, University Health Network, McMaster University, Hamilton, Ontario, Canada
    Hum Mol Genet 18:2328-43. 2009
    ..By integrating these pathways with a number of dysregulated networks of TFs (e.g. SRF, MYC, E2F1, CREB1, LEF1, TCF7, HNF1B/ HNF1A and HNF4A), our data suggest that epithelial dedifferentiation accompanied ..
  51. doi Intratracheal administration of p38α short-hairpin RNA plasmid ameliorates lung ischemia-reperfusion injury in rats
    Xiangqi Lv
    Department of Anesthesiology, Hei Long Jiang Province Key Lab of Research on Anesthesiology and Critical Care Medicine, and Second Affiliated hospital, Harbin Medical University, Harbin, China
    J Heart Lung Transplant 31:655-62. 2012
    ..The lungs have an extremely large surface area, which makes the absorption of shRNA highly effective. Therefore, we evaluated the therapeutic efficacy of p38α shRNA plasmids in a rat model of lung transplantation...
  52. doi Astilbin inhibits proliferation of rat aortic smooth muscle cells induced by angiotensin II and down-regulates expression of protooncogene
    Ping Li
    Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China
    J Huazhong Univ Sci Technolog Med Sci 32:181-5. 2012
    ..The expression of c-myc mRNA was assessed by using reverse transcription polymerase chain reaction (RT-PCR), and the expression of NF-κB ..
  53. doi Ginsenoside Rb₁ inhibits the carotid neointimal hyperplasia induced by balloon injury in rats via suppressing the phenotype modulation of vascular smooth muscle cells
    Shu Zhang
    Department of Pharmacology, Zunyi Medical College, 201 Dalian Rood, Zunyi, Guizhou, 563000, PR China
    Eur J Pharmacol 685:126-32. 2012
    ..kinase 1/2 (pERK1/2), smooth muscle α-actin (SM α-actin), and the mRNA expressions of proto-oncogene c-myc, SM α-actin, SM-emb (embryonic smooth muscle myosin heavy chain) and p38 MAPK were detected by ..
  54. doi Effects of pulsed electromagnetic fields on bone mass and Wnt/β-catenin signaling pathway in ovariectomized rats
    Jun Zhou
    Rehabilitation Key Laboratory of Sichuan Province, Department of Rehabilitation, West China Hospital, Sichuan University, Chengdu, People s Republic of China
    Arch Med Res 43:274-82. 2012
    ..This study aimed to systematically investigate the effects of PEMFs on bone mass and Wnt/β-catenin signaling pathway in ovariectomized rats...
  55. doi Amelioration of cisplatin-induced nephrotoxicity in peroxiredoxin I-deficient mice
    Kosuke Okada
    Division of Biomedical Science, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Cancer Chemother Pharmacol 71:503-9. 2013
    ..In the present study, we examined the role of Prx I against cisplatin-induced renal injury in vivo using Prx I-null mice...
  56. pmc The involvement of a Nanog, Klf4 and c-Myc transcriptional circuitry in the intertwining between neoplastic progression and reprogramming
    Ilaria Marzi
    Department of Experimental Pathology and Oncology, University of Florence, Florence, Italy
    Cell Cycle 12:353-64. 2013
    ..CD133(+) elements and pO(2)-dependent percentages of the three embryonic transcription factors Nanog, Klf4 and c-Myc. Once transferred into aerobic cultures, the minor cellular fraction expressing this triad generates various types ..
  57. pmc Mammalian target of rapamycin complex 1 (mTORC1) enhances bortezomib-induced death in tuberous sclerosis complex (TSC)-null cells by a c-MYC-dependent induction of the unfolded protein response
    Justin T Babcock
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 288:15687-98. 2013
    ..Here we report that control of c-MYC translation by mTORC1 plays a key role in determining whether TSC2-null Elt3 rat leiomyoma cells apoptose in ..
  58. ncbi The proto-oncogene c-myc acts through the cyclin-dependent kinase (Cdk) inhibitor p27(Kip1) to facilitate the activation of Cdk4/6 and early G(1) phase progression
    Alvaro J Obaya
    Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, 69 Brown Street, Providence, RI 02912, USA
    J Biol Chem 277:31263-9. 2002
    ..Cdk4/6 activity is promoted by D-type cyclins and opposed by Cdk inhibitor proteins. Loss of c-myc proto-oncogene function results in a defect in the activation of Cdk4/6...
  59. pmc Overexpression of PKD1 causes polycystic kidney disease
    Caroline Thivierge
    Institut de Recherches Cliniques de Montreal, Molecular Genetics and Development, 110 ave des Pins ouest, Montreal, Quebec, Canada H2W 1R7
    Mol Cell Biol 26:1538-48. 2006
    ..Our results also uncovered a striking increased renal c-myc expression in mice from all transgenic lines, indicating that c-myc is a critical in vivo downstream effector of ..
  60. ncbi c-Myc and ChREBP regulate glucose-mediated expression of the L-type pyruvate kinase gene in INS-1-derived 832/13 cells
    J Jason Collier
    Division of Endocrinology and Metabolism, University of Pittsburgh School of Medicine, E1147 BST, 200 Lothrop St, Pittsburgh, PA 15261, USA
    Am J Physiol Endocrinol Metab 293:E48-56. 2007
    ..Previously, we demonstrated a necessity in hepatocytes for c-Myc in the regulation of a prototypical glucose-responsive gene, L-type pyruvate kinase (L-PK) (Collier JJ, Doan TT, ..
  61. doi Polysaccharides from Capsosiphon fulvescens stimulate the growth of IEC-6 Cells by activating the MAPK signaling pathway
    Hiroe Go
    Food Science and Biotechnology, Pukyong National University, Busan, South Korea
    Mar Biotechnol (NY) 13:433-40. 2011
    ..of the Wnt signaling pathway, from the cytosol to the nucleus and increased the expression of cyclinD1 and c-myc. Cf-PS also induced ERK1/2 phosphorylation, which is activated by mitogenic and proliferative stimuli such as ..
  62. doi Evaluation of the potential toxicity of dibromoacetonitrile-induced apoptosis and tumor-initiating activity in rat liver
    Naglaa Assaf
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, MISR for Science and Technology University, Cairo, Egypt
    Food Chem Toxicol 49:3055-62. 2011
    ..erythrocytes and changes in the expression of hepatocyte growth factor gene and proto-oncogenes (c-met and c-myc) in liver tissues...
  63. doi Effects of Ganoderma lucidum polysaccharides on IEC-6 cell proliferation, migration and morphology of differentiation benefiting intestinal epithelium healing in vitro
    Li Xin Sun
    Department of Pharmacology, Basic Medical School, Peking University Health Science Center, Beijing Affiliated Hospital of Chengde Medical College, Chengde, Hebei Province, China
    J Pharm Pharmacol 63:1595-603. 2011
    ..To identify potential effects, a non-transformed small-intestinal epithelial cell line, IEC-6 cells, was used...
  64. pmc Resveratrol improves cardiac contractility following trauma-hemorrhage by modulating Sirt1
    Bixi Jian
    Center for Surgical Research, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    Mol Med 18:209-14. 2012
    ..Our recent studies, based on the reported interrelationship between c-Myc and Sirt1 (mammalian orthologue of yeast sir2 [silent information regulator 2]) expression and their role in ..
  65. pmc Von Willebrand Factor permeates small vessels in CADASIL and inhibits smooth muscle gene expression
    XiaoJie Zhang
    Departments of Neurology X Z, H M, M M W, Molecular and Integrative, Physiology J S, M M W, and Pathology M B, University of Michigan Medical School, Ann Arbor, MI 48109 Department of Neurology, Veterans Administration Ann Arbor Healthcare, System, Ann Arbor, MI 48105 M M W Institute for Neuropathology, Universitatsspital, CH 8091 Zurich E J R Department of Pathology and Center for Alzheimer s Disease and Related Disorders, Southern Illinois University School of Medicine, Springfield, IL 62794 B E M Departments of Pathology M B S L, Neurology B B W, and Public Health Sciences B B W, University of Virginia, Charlottesville, VA 22908
    Transl Stroke Res 3:138-45. 2012
    ..We tested whether endothelial von Willebrand factor (vWF) accumulates in CADASIL vessels and whether exposure of smooth muscle cells to vWF alters the expression of smooth muscle gene expression...
  66. ncbi Transmural pressure loading enhances gastric mucosal cell proliferation
    Hiromasa Nakamizo
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Dig Dis Sci 57:2545-54. 2012
    ..The aims of this study were to determine whether exposure to transmural pressure would affect the proliferation of gastric mucosal cells and to elucidate the intracellular signaling pathways involved...
  67. doi Mechanisms of prostate atrophy after LHRH antagonist cetrorelix injection: an experimental study in a rat model of benign prostatic hyperplasia
    Dong Yang
    Department of Urology, Huazhong University of Science and Technology, Wuhan, China
    J Huazhong Univ Sci Technolog Med Sci 32:389-95. 2012
    ..TGF-β1 and c-Myc expression were measured by qRT-PCR and Western blotting in the proximal and distal region of ventral prostatic ..
  68. doi Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression
    H Malekinejad
    Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
    Phytomedicine 19:1077-84. 2012
    ..The expression of c-myc at mRNA level also was analyzed. SMN in preventive and protective forms significantly (p<0...
  69. ncbi Rat alpha-fetoprotein heterogeneity. Comparative chemical study of the two electrophoretic variants and their Ricinus lectin-binding properties
    J P Kerckaert
    Biochim Biophys Acta 493:293-303. 1977
    ..The slow moving alpha-fetoprotein could be further fractionated on RCAI-sepharose column in two components, AFPA1 and AFPA2 differing by their sialic acid content...
  70. ncbi Nucleotide sequence of the first exon of the rat c-myc gene: proviral insertions in murine leukemia virus-induced lymphomas do not affect exon 1
    D L Steffen
    Cell Biology Group, Worcester Foundation for Experimental Biology, Shrewsbury, Massachusetts 01545
    Virology 164:55-63. 1988
    We have previously reported that proviruses are integrated adjacent to the c-myc gene in rat thymomas induced by murine leukemia viruses...
  71. pmc Characterization of rat c-myc and adjacent regions
    K Hayashi
    Nucleic Acids Res 15:6419-36. 1987
    Rat genomic regions covering c-myc were cloned from the DNA of both normal liver and two lines of Morris hepatomas, one of which had c-myc amplification. The three restriction maps showed perfect agreement within the overlapping regions...
  72. ncbi Point mutations in the c-Myc transactivation domain are common in Burkitt's lymphoma and mouse plasmacytomas
    K Bhatia
    Pediatric Branch, Clinical Oncology Program, NCI NIH, Bethesda, Maryland 20892
    Nat Genet 5:56-61. 1993
    We have screened the entire coding region of c-myc in a panel of Burkitt's lymphomas (BLs) and mouse plasmacytomas (PCTs)...
  73. ncbi Expression and subcellular localization of the Myc superfamily proteins: c-Myc, Max, Mad1 and Mxi1 in the epiphyseal plate cartilage chondrocytes of growing rats
    Y Wang
    INSERM U120 alliée CNRS, Hopital Robert Debre, Paris, France
    Cell Mol Biol (Noisy-le-grand) 43:175-88. 1997
    The changes in the expressions of the protooncogene protein c-Myc, its dimerization partner Max and the competitive inhibitors Mad1 and Mxi1 during the terminal differentiation of chondrocytes in vivo were investigated by ..
  74. ncbi Coordinated regulation of iron-controlling genes, H-ferritin and IRP2, by c-MYC
    K J Wu
    Division of Oncology, Department of Pathology, Columbia University, New York, NY 10032, USA an
    Science 283:676-9. 1999
    The protein encoded by the c-MYC proto-oncogene is a transcription factor that can both activate and repress the expression of target genes, but few of its transcriptional targets have been identified...
  75. ncbi A comprehensive analysis of cytokine-induced and nuclear factor-kappa B-dependent genes in primary rat pancreatic beta-cells
    A K Cardozo
    Diabetes Research Center, Vrije Universiteit Brussel, Laarbeeklaan 103, B 1090 Brussels, Belgium
    J Biol Chem 276:48879-86. 2001
    ..Cytokine-induced NF-kappa B activation decreased Pdx-1 and increased c-Myc expression...
  76. ncbi Induction of c-Myc expression suppresses insulin gene transcription by inhibiting NeuroD/BETA2-mediated transcriptional activation
    Hideaki Kaneto
    Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    J Biol Chem 277:12998-3006. 2002
    ..We have found that hyperglycemia induces the expression of the basic helix-loop-helix transcription factor c-Myc in islets in several different diabetic models...
  77. ncbi Identification of Myc-mediated death response pathways by microarray analysis
    Qiang Yu
    Advanced Technology Center, Center for Cancer Research, NCI National Institutes of Health, Gaithersburg, MD 20877, USA
    J Biol Chem 277:13059-66. 2002
    To understand the mechanisms of Myc-mediated apoptosis induced by DNA damage, we have characterized the death kinetics of three Rat-1 fibroblast cell lines that either overexpress Myc or lack Myc and their parental wild-type cells ..
  78. ncbi Expression of c-Fos and c-Myc and deposition of beta-APP in neurons in the adult rat brain as a result of exposure to short-lasting impulse noise
    Annette Säljö
    Department of Anatomy and Cell Biology, University of Goteborg, Sweden
    J Neurotrauma 19:379-85. 2002
    ..Here, rat brains were investigated immunohistochemically for the expression of c-Fos, c-Myc, and beta-APP during the first 3 weeks postexposure to impulse noise of 198 or 202 dB...
  79. ncbi c-Myc augments the apoptotic activity of cytosolic death receptor signaling proteins by engaging the mitochondrial apoptotic pathway
    Juha Klefstrom
    University of California, San Francisco Comprehensive Cancer Center, San Francisco, Calfornia 94115, USA
    J Biol Chem 277:43224-32. 2002
    Activation of c-Myc sensitizes cells to apoptosis induction by ligand-activated death receptors...
  80. ncbi c-Myc is required for the glucose-mediated induction of metabolic enzyme genes
    James J Collier
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Biol Chem 278:6588-95. 2003
    Glucose exerts powerful effects on hepatocyte gene transcription by mechanisms that are incompletely understood. c-Myc regulates hepatic glucose metabolism by increasing glycolytic enzyme gene transcription while concomitantly decreasing ..
  81. pmc Loss of protooncogene c-Myc function impedes G1 phase progression both before and after the restriction point
    Christoph Schorl
    Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, Rhode Island 02912, USA
    Mol Biol Cell 14:823-35. 2003
    c-myc is an important protooncogene whose misregulation is believed to causally affect the development of numerous human cancers. c-myc null rat fibroblasts are viable but display a severe (two- to threefold) retardation of proliferation...
  82. ncbi Heterogeneous pattern of chromosomal breakpoints involving the MYC locus in multiple myeloma
    Sonia Fabris
    Laboratorio di Ematologia Sperimentale e Genetica Molecolare, U O Ematologia 1, Dipartimento di Scienze Mediche, Universita degli Studi di Milano, Ospedale Maggiore IRCCS, Italy
    Genes Chromosomes Cancer 37:261-9. 2003
    Chromosomal rearrangements of the MYC locus, which often involve the IG loci, are recurrent events in multiple myeloma (MM) and plasma cell leukemia (PCL)...
  83. pmc MYC recruits the TIP60 histone acetyltransferase complex to chromatin
    Scott R Frank
    DNAX Research Institute, 901 California Avenue, Palo Alto, CA 94304, USA
    EMBO Rep 4:575-80. 2003
    The transcription factor MYC binds specific DNA sites in cellular chromatin and induces the acetylation of histones H3 and H4...
  84. ncbi Prolonged culture in low glucose induces apoptosis of rat pancreatic beta-cells through induction of c-myc
    Mark Van De Casteele
    Diabetes Research Center, Brussels Free University VUB, Brussels, Belgium
    Biochem Biophys Res Commun 312:937-44. 2003
    ..rat islets, culture in the presence of 3 or 5mM (G3-G5) instead of 10mM glucose (G10) induces a large increase in c-myc expression before onset of a caspase-dependent apoptosis...
  85. ncbi Loss of MYC confers resistance to doxorubicin-induced apoptosis by preventing the activation of multiple serine protease- and caspase-mediated pathways
    Emanuela Grassilli
    Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    J Biol Chem 279:21318-26. 2004
    c-Myc plays an essential role in proliferation, differentiation, and apoptosis. Because of its relevance to cancer, most studies have focused on the cellular consequences of c-Myc overexpression...
  86. ncbi Activation of cell cycle regulatory proteins in the apoptosis of terminally differentiated oligodendrocytes
    M Strazza
    Istituto di Fisiologia Clinica, Sez di Siena, 53100 Siena, Italy
    Neurochem Res 29:923-31. 2004
    ..Although at the time of induction of cell death the oligodendrocytes are postmitotic, activation of c-myc and translocation of Cdc25A into the nucleus can be demonstrated...
  87. pmc Myc represses transcription through recruitment of DNA methyltransferase corepressor
    Carmen Brenner
    Free University of Brussels, Faculty of Medicine, Laboratory of Molecular Virology, Brussels, Belgium
    EMBO J 24:336-46. 2005
    The Myc transcription factor is an essential mediator of cell growth and proliferation through its ability to both positively and negatively regulate transcription...
  88. ncbi Nucleolar localization of hepatic c-Myc: a potential mechanism for c-Myc regulation
    Jennifer A Sanders
    Department of Pediatrics, Rhode Island Hospital and Brown University, Providence, RI 02903, USA
    Biochim Biophys Acta 1743:141-50. 2005
    The c-myc proto-oncogene encodes a transcription factor that is involved in cell proliferation, growth, differentiation, and apoptosis...
  89. ncbi [The study on the relationship between the tumor-like proliferation of synoviocytes and the expression of c-myc and ODC genes in adjuvant arthritis rats]
    Ming Meng
    Department of Immunology, Beijing University of Chinese Medicine, Beijing 100029, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 21:411-4. 2005
    ..To investigate the mechanism of the tumor-like proliferation of synoviocytes in adjuvant arthritis (AA) rats...
  90. ncbi Coordinated regulation of c-Myc and Max in rat liver development
    Jennifer A Sanders
    Department of Pediatrics, Rhode Island Hospital and Brown University, Providence, RI 02903, USA
    Am J Physiol Gastrointest Liver Physiol 290:G145-55. 2006
    ..processes of liver development and regeneration involve regulation of a key network of transcription factors, the c-myc/max/mad network...
  91. pmc Deregulation of common genes by c-Myc and its direct target, MT-MC1
    Kenneth R Rogulski
    Section of Hematology Oncology, Children s Hospital of Pittsburgh, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15213, USA
    Proc Natl Acad Sci U S A 102:18968-73. 2005
    In addition to its role in cancer, the c-Myc oncoprotein controls many normal cellular processes as a consequence of its function as a basic helix-loop-helix leucine zipper transcription factor...
  92. pmc Hypoxic stress suppresses RNA polymerase III recruitment and tRNA gene transcription in cardiomyocytes
    Isabelle Ernens
    Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    Nucleic Acids Res 34:286-94. 2006
    ..that the pol III-specific transcription factor IIIB (TFIIIB) is bound and regulated by the proto-oncogene product c-Myc, the mitogen-activated protein kinase ERK and the retinoblastoma tumour suppressor protein, RB...
  93. ncbi Transforming growth factor beta suppresses human telomerase reverse transcriptase (hTERT) by Smad3 interactions with c-Myc and the hTERT gene
    He Li
    Department of Immunology and Monash Institute of Medical Research, Monash University, Melbourne, Victoria 3181, Australia
    J Biol Chem 281:25588-600. 2006
    ..In response to TGF-beta, Smad3 binds to c-Myc; knocking down c-Myc, Smad3 does not bind to the TERT gene, suggesting that c-Myc recruits Smad3 to the TERT ..
  94. ncbi Downregulation of the PI3K/Akt survival pathway in cells with deregulated expression of c-Myc
    Kerstin Bellmann
    Centre de recherche en cancérologie de l Université Laval, L Hôtel Dieu de Québec, 9 rue McMahon, Quebec, Canada, G1R 2J6
    Apoptosis 11:1311-9. 2006
    ..We previously showed that a deregulated expression of c-Myc in cells treated with toxic agents caused an enhanced activation of p38 that acts in a death-promoting pathway...
  95. ncbi [Expression of c-myc protein on rats' brains after brain concussion]
    Wei hua Fang
    Department of Forensic Medicine, Wannan Medical College, Wuhu 241001, China
    Fa Yi Xue Za Zhi 22:333-4. 2006
    To study the changes of expression of c-myc protein on rats' brains after brain concussion.
  96. ncbi [Study of the possible mechanism of effects of carbon disulfide on c-myc expression in rat testicles]
    Yanying Duan
    Department of Environmental and Occupational Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Wei Sheng Yan Jiu 36:401-3. 2007
    To survey the expression of c-myc of teticles in rats exposed to carbon disulfide (CS2) and the possible mechanism of effects on it.
  97. doi Oncogenicity of DNA in vivo: tumor induction with expression plasmids for activated H-ras and c-myc
    Li Sheng
    Division of Viral Products, OVRR, CBER, FDA, Building 29A, Room 3D08, 29 Lincoln Drive, Bethesda, MD 20892, USA
    Biologicals 36:184-97. 2008
    ..this issue, we have generated expression plasmids for the activated human H-ras oncogene and for the murine c-myc proto-oncogene. Their oncogenic activity was confirmed in vitro using the focus-formation transformation assay...
  98. doi [Effects of Huoxue Qianyang Formula on expressions of proto-oncogenes c-fos and c-myc in spontaneous hypertensive rats with ventricular hypertrophy]
    De yu Fu
    Department of Cardiology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China
    Zhong Xi Yi Jie He Xue Bao 6:387-91. 2008
    ..Chinese herbal medicine, in reversing the left ventricular hypertrophy (LVH) of spontaneous hypertensive rats (SHRs) by analyzing the expressions of mRNAs and proteins of proto-oncogenes c-fos and c-myc in left ventricular muscle.
  99. doi Myc-mediated transcriptional repression by recruitment of histone deacetylase
    John F Kurland
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
    Cancer Res 68:3624-9. 2008
    b>Myc is a transcription factor that features prominently in cancer. The oncogenicity of Myc stems from its ability to regulate expression of genes required for cell growth and proliferation...
  100. doi Regulation of calpain activity by c-Myc through calpastatin and promotion of transformation in c-Myc-negative cells by calpastatin suppression
    Maryam Niapour
    Arthritis and Immune Disorder Research Centre, University Health Network and the Department of Immunology, University of Toronto, Toronto, Ontario, Canada
    J Biol Chem 283:21371-81. 2008
    The c-Myc transcription factor is commonly dysregulated in cancer. c-Myc also sensitizes cells to apoptosis induced by a variety of toxic events. c-Myc turnover is rapid and mediated by the proteasome and intracellular calpains...
  101. pmc Global regulation of nucleotide biosynthetic genes by c-Myc
    Yen Chun Liu
    Program in Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 3:e2722. 2008
    The c-Myc transcription factor is a master regulator and integrates cell proliferation, cell growth and metabolism through activating thousands of target genes...

Research Grants2

  1. ETHANOL METABOLISM IN PREGNANCY--ROLE OF DIET
    Martin Ronis; Fiscal Year: 2005
    ....
  2. ETHANOL EFFECTS ON BONE FORMATION IN PREGNANCY
    Martin Ronis; Fiscal Year: 2006
    ..The role of CYP2E1 and free radicals in the skeletal toxicity of ethanol during these periods will also be studied. ..