Mybpc1

Summary

Gene Symbol: Mybpc1
Description: myosin binding protein C, slow type
Alias: myosin-binding protein C, slow-type, C-protein, skeletal muscle slow isoform, muscle C-protein, slow MyBP-C
Species: rat
Products:     Mybpc1

Top Publications

  1. Ackermann M, Hu L, Bowman A, Bloch R, Kontrogianni Konstantopoulos A. Obscurin interacts with a novel isoform of MyBP-C slow at the periphery of the sarcomeric M-band and regulates thick filament assembly. Mol Biol Cell. 2009;20:2963-78 pubmed publisher
    ..Collectively, our experiments identify a new ligand of obscurin at the M-band, MyBP-C slow variant-1 and suggest that their interaction contributes to the assembly of M- and A-bands. ..
  2. Akopian A, Wood J. Peripheral nervous system-specific genes identified by subtractive cDNA cloning. J Biol Chem. 1995;270:21264-70 pubmed
    ..In addition, the DRG-specific clones provide probes to define the regulatory elements that specify peripheral nervous-system-specific gene expression. ..
  3. Schiaffino S, Reggiani C. Molecular diversity of myofibrillar proteins: gene regulation and functional significance. Physiol Rev. 1996;76:371-423 pubmed
    ..Both myosin and troponin isoforms contribute to the differences in the resistance to fatigue of muscle fibers...
  4. Winegrad S. Myosin-binding protein C (MyBP-C) in cardiac muscle and contractility. Adv Exp Med Biol. 2003;538:31-40; discussion 40-1 pubmed
    ..The normal interactions may be necessary to allow transitions in binding and filament structure that are associated with phosphorylation of the MyBP-C motif. ..
  5. Matsumoto Y, Kohyama K, Park I, Nakajima M, Hiraki K. Characterization of pathogenic T cells and autoantibodies in C-protein-induced autoimmune polymyositis. J Neuroimmunol. 2007;190:90-100 pubmed
    ..Further analysis of C-protein-induced EAM will provide useful information to elucidate the pathomechanisms of human polymyositis. ..
  6. Luther P, Bennett P, Knupp C, Craig R, PadrĂ³n R, Harris S, et al. Understanding the organisation and role of myosin binding protein C in normal striated muscle by comparison with MyBP-C knockout cardiac muscle. J Mol Biol. 2008;384:60-72 pubmed publisher
    ..However, in the MyBP-C-deficient hearts these extra meridional reflections are weak or absent, suggesting that they are due to MyBP-C itself or to MyBP-C in combination with a head perturbation brought about by the presence of MyBP-C. ..