Gene Symbol: Mvk
Description: mevalonate kinase
Alias: Lrbp, mevalonate kinase, LHR mRNA binding protein
Species: rat
Products:     Mvk

Top Publications

  1. Wang L, Gulappa T, Menon K. Identification and characterization of proteins that selectively interact with the LHR mRNA binding protein (LRBP) in rat ovaries. Biochim Biophys Acta. 2010;1803:591-7 pubmed publisher
    Luteinizing hormone receptor (LHR) mRNA binding protein (LRBP), identified as mevalonate kinase, has been shown to be a trans factor mediating the post-transcriptional regulation of LHR mRNA expression in ovaries...
  2. Schafer B, Bishop R, Kratunis V, Kalinowski S, Mosley S, Gibson K, et al. Molecular cloning of human mevalonate kinase and identification of a missense mutation in the genetic disease mevalonic aciduria. J Biol Chem. 1992;267:13229-38 pubmed
    ..biosynthetic pathway in humans, and it is presumed to be caused by a mutation in the gene coding for mevalonate kinase. To elucidate the molecular basis of this inherited disorder, a 2...
  3. Biardi L, Sreedhar A, Zokaei A, Vartak N, Bozeat R, Shackelford J, et al. Mevalonate kinase is predominantly localized in peroxisomes and is defective in patients with peroxisome deficiency disorders. J Biol Chem. 1994;269:1197-205 pubmed
    We reported recently that mevalonate kinase (EC; ATP:mevalonate 5-phosphotransferase) that was isolated from rat liver and believed to be a cytosolic protein was localized in rat liver peroxisomes...
  4. Fu Z, Voynova N, Herdendorf T, Miziorko H, KIM J. Biochemical and structural basis for feedback inhibition of mevalonate kinase and isoprenoid metabolism. Biochemistry. 2008;47:3715-24 pubmed publisher
    b>Mevalonate kinase (MK), which catalyzes a key reaction in polyisoprenoid and sterol metabolism in many organisms, is subject to feedback regulation by farnesyl diphosphate and related compounds...
  5. Menon K, Nair A, Wang L, Peegel H. Regulation of luteinizing hormone receptor mRNA expression by a specific RNA binding protein in the ovary. Mol Cell Endocrinol. 2007;260-262:109-16 pubmed
    ..A specific binding protein, identified as mevalonate kinase, binds to the open reading frame of LH receptor mRNA...
  6. Menon B, Peegel H, Menon K. Evidence for the association of luteinizing hormone receptor mRNA-binding protein with the translating ribosomes during receptor downregulation. Biochim Biophys Acta. 2009;1793:1787-94 pubmed publisher
    ..This process involves interaction of LHR mRNA with a specific mRNA-binding protein (LRBP), identified as mevalonate kinase (MVK), resulting in inhibition of translation followed by targeting the ribonucleoprotein complex to ..
  7. Fu Z, Wang M, Potter D, Miziorko H, KIM J. The structure of a binary complex between a mammalian mevalonate kinase and ATP: insights into the reaction mechanism and human inherited disease. J Biol Chem. 2002;277:18134-42 pubmed
    b>Mevalonate kinase catalyzes the ATP-dependent phosphorylation of mevalonic acid to form mevalonate 5-phosphate, a key intermediate in the pathways of isoprenoids and sterols...
  8. Nair A, Menon K. Regulation of luteinizing hormone receptor expression: evidence of translational suppression in vitro by a hormonally regulated mRNA-binding protein and its endogenous association with luteinizing hormone receptor mRNA in the ovary. J Biol Chem. 2005;280:42809-16 pubmed
    ..The identity of LRBP was later established as mevalonate kinase (MVK). The present study examined if LRBP binding to LHR mRNA impairs translation...
  9. Gupta S, Mehan R, Tansey T, Chen H, Goping G, Goldberg I, et al. Differential binding of proteins to peroxisomes in rat hepatoma cells: unique association of enzymes involved in isoprenoid metabolism. J Lipid Res. 1999;40:1572-84 pubmed
    ..For instance, mevalonate kinase and phosphomevalonate kinase are almost totally released (95% and 91%, respectively), whereas 3-hydroxy-3-..

More Information


  1. Chu X, Li D. Expression, purification, and characterization of His20 mutants of rat mevalonate kinase. Protein Expr Purif. 2003;32:75-82 pubmed
    b>Mevalonate kinase plays a key role in regulating the biosynthesis of cholesterol in animal cells...
  2. Nair A, Menon K. Isolation and characterization of a novel trans-factor for luteinizing hormone receptor mRNA from ovary. J Biol Chem. 2004;279:14937-44 pubmed
    ..LRBP was subjected to N-terminal microsequencing followed by homology search, which revealed its identity as mevalonate kinase. Purified rat mevalonate kinase antibody recognized the gel-purified LRBP on Western blots performed with ..
  3. Houten S, Kuis W, Duran M, de Koning T, van Royen Kerkhof A, Romeijn G, et al. Mutations in MVK, encoding mevalonate kinase, cause hyperimmunoglobulinaemia D and periodic fever syndrome. Nat Genet. 1999;22:175-7 pubmed
    ..Subsequent analysis of cells from four unrelated HIDS patients revealed reduced activities of mevalonate kinase (MK; encoded by the gene MVK), a key enzyme of isoprenoid biosynthesis...
  4. Waterham H. Defects of cholesterol biosynthesis. FEBS Lett. 2006;580:5442-9 pubmed
    ..The etiology of the underlying pathophysiology may involve multiple affected processes due to lowered cholesterol and/or the elevated, teratogenic levels of the intermediate sterol precursors. ..
  5. Menon B, Sinden J, Franzo Romain M, Botta R, Menon K. Regulation of LH receptor mRNA binding protein by miR-122 in rat ovaries. Endocrinology. 2013;154:4826-34 pubmed publisher
    LH receptor (LHR) expression in the ovary is regulated by the RNA binding protein, (LHR mRNA binding protein [LRBP]), which has been identified as being mevalonate kinase...
  6. Lachmann H, Goodman H, Andrews P, Gallagher H, Marsh J, Breuer S, et al. AA amyloidosis complicating hyperimmunoglobulinemia D with periodic fever syndrome: a report of two cases. Arthritis Rheum. 2006;54:2010-4 pubmed
    ..We report 2 further cases of patients with AA amyloidosis in HIDS, both of whom developed dialysis-dependent renal failure, and we describe the outcome of the first renal transplant in this setting. ..
  7. Hogenboom S, Wanders R, Waterham H. Cholesterol biosynthesis is not defective in peroxisome biogenesis defective fibroblasts. Mol Genet Metab. 2003;80:290-5 pubmed
    ..five enzymes all have been reported to be partly or exclusively peroxisomal and include HMG-CoA reductase, mevalonate kinase, phosphomevalonate kinase, mevalonate pyrophosphate decarboxylase, and isopentenyl pyrophosphate isomerase...
  8. Kovacs W, Tape K, Shackelford J, Duan X, Kasumov T, Kelleher J, et al. Localization of the pre-squalene segment of the isoprenoid biosynthetic pathway in mammalian peroxisomes. Histochem Cell Biol. 2007;127:273-90 pubmed several reports concluding that three of the peroxisomal cholesterol biosynthetic enzymes, namely mevalonate kinase, phosphomevalonate kinase, and mevalonate diphosphate decarboxylase, do not localize to peroxisomes in human ..
  9. Tanaka R, Lee L, Schafer B, Kratunis V, Mohler W, Robinson G, et al. Molecular cloning of mevalonate kinase and regulation of its mRNA levels in rat liver. Proc Natl Acad Sci U S A. 1990;87:2872-6 pubmed
    b>Mevalonate kinase [ATP:(R)-mevalonate 5-phosphotransferase, EC 2.7.1...
  10. Stamellos K, Shackelford J, Tanaka R, Krisans S. Mevalonate kinase is localized in rat liver peroxisomes. J Biol Chem. 1992;267:5560-8 pubmed
    ..In this study we have investigated the subcellular localization of mevalonate kinase (EC; ATP:mevalonate-5-phosphotransferase)...
  11. Menon B, Sinden J, Menon K. Association of luteinizing hormone receptor (LHR) mRNA with its binding protein leads to decapping and degradation of the mRNA in the p bodies. Biochim Biophys Acta. 2013;1833:1173-9 pubmed publisher
    ..Luteinizing hormone surge through a post-transcriptional mechanism involving an RNA binding protein designated as LRBP. The present study examined the mechanism by which LRBP induces the degradation of Luteinizing hormone receptor ..
  12. Hogenboom S, Tuyp J, Espeel M, Koster J, Wanders R, Waterham H. Mevalonate kinase is a cytosolic enzyme in humans. J Cell Sci. 2004;117:631-9 pubmed
    ..In this study we have studied the subcellular localisation of human mevalonate kinase (MK) using a variety of biochemical and microscopical techniques...
  13. Chu X, Yu W, Wu L, Liu X, Li N, Li D. Effect of a disulfide bond on mevalonate kinase. Biochim Biophys Acta. 2007;1774:1571-81 pubmed
    b>Mevalonate kinase is one of ATP-dependent enzymes in the mevalonate pathway and catalyzes the phosphorylation of mevalonate to form mevalonate 5-phosphate...
  14. Hogenboom S, Romeijn G, Houten S, Baes M, Wanders R, Waterham H. Absence of functional peroxisomes does not lead to deficiency of enzymes involved in cholesterol biosynthesis. J Lipid Res. 2002;43:90-8 pubmed
    ..Our results show that the previously reported deficiencies of mevalonate kinase and phosphomevalonate kinase activity in livers from human Zellweger patients reflect the bad condition of ..
  15. Ramachandran C, Shah S. Studies on mevalonate kinase, phosphomevalonate kinase and pyrophosphomevalonate decarboxylase in developing rat brain. J Neurochem. 1977;28:751-7 pubmed