Musk

Summary

Gene Symbol: Musk
Description: muscle associated receptor tyrosine kinase
Alias: Nsk1, muscle, skeletal receptor tyrosine protein kinase, muscle specific kinase (neural fold/somite kinase 1), muscle, skeletal, receptor tyrosine kinase, muscle-specific kinase receptor, muscle-specific tyrosine kinase receptor MuSK, muscle-specific tyrosine protein kinase receptor
Species: rat
Products:     Musk

Top Publications

  1. Till J, Becerra M, Watty A, Lu Y, Ma Y, Neubert T, et al. Crystal structure of the MuSK tyrosine kinase: insights into receptor autoregulation. Structure. 2002;10:1187-96 pubmed
    Muscle-specific kinase (MuSK) is a receptor tyrosine kinase expressed selectively in skeletal muscle...
  2. Garcia Osta A, Tsokas P, Pollonini G, Landau E, Blitzer R, Alberini C. MuSK expressed in the brain mediates cholinergic responses, synaptic plasticity, and memory formation. J Neurosci. 2006;26:7919-32 pubmed
    Muscle-specific tyrosine kinase receptor (MuSK) has been believed to be mainly expressed and functional in muscle, in which it mediates the formation of neuromuscular junctions...
  3. Lu Z, Je H, Young P, Gross J, Lu B, Feng G. Regulation of synaptic growth and maturation by a synapse-associated E3 ubiquitin ligase at the neuromuscular junction. J Cell Biol. 2007;177:1077-89 pubmed
    ..ligase and have demonstrated that it regulates the surface expression of muscle-specific receptor tyrosine kinase (MuSK), the key organizer of postsynaptic development at the mammalian neuromuscular junction...
  4. Bowen D, Park J, Bodine S, Stark J, Valenzuela D, Stitt T, et al. Localization and regulation of MuSK at the neuromuscular junction. Dev Biol. 1998;199:309-19 pubmed
    The receptor tyrosine kinase, MuSK, is required for the formation of the neuromuscular junction (NMJ) where MuSK becomes phosphorylated when exposed to neuronally synthesized isoforms of agrin...
  5. Luo Z, Wang Q, Zhou J, Wang J, Luo Z, Liu M, et al. Regulation of AChR clustering by Dishevelled interacting with MuSK and PAK1. Neuron. 2002;35:489-505 pubmed
    ..Although MuSK is required for acetylcholine receptor (AChR) clustering at the neuromuscular junction (NMJ), the underlying ..
  6. Herbst R, Avetisova E, Burden S. Restoration of synapse formation in Musk mutant mice expressing a Musk/Trk chimeric receptor. Development. 2002;129:5449-60 pubmed
    Mice lacking Musk, a muscle-specific receptor tyrosine kinase that is activated by agrin, fail to form neuromuscular synapses and consequently die at birth because of their failure to move or breathe...
  7. Strochlic L, Cartaud A, Mejat A, Grailhe R, Schaeffer L, Changeux J, et al. 14-3-3 gamma associates with muscle specific kinase and regulates synaptic gene transcription at vertebrate neuromuscular synapse. Proc Natl Acad Sci U S A. 2004;101:18189-94 pubmed
    The muscle-specific receptor tyrosine kinase (MuSK) is part of a receptor complex, activated by neural agrin, that orchestrates the differentiation of the neuromuscular junction (NMJ)...
  8. Lin W, Burgess R, Dominguez B, Pfaff S, Sanes J, Lee K. Distinct roles of nerve and muscle in postsynaptic differentiation of the neuromuscular synapse. Nature. 2001;410:1057-64 pubmed
    ..Much evidence suggests that the nerve-derived protein agrin activates muscle-specific kinase (MuSK) to cluster AChRs through the synapse-specific cytoplasmic protein rapsyn...
  9. Valenzuela D, Stitt T, DiStefano P, Rojas E, Mattsson K, Compton D, et al. Receptor tyrosine kinase specific for the skeletal muscle lineage: expression in embryonic muscle, at the neuromuscular junction, and after injury. Neuron. 1995;15:573-84 pubmed
    ..Here we identify a receptor tyrosine kinase (RTK) specific to skeletal muscle, which we term "MuSK" for muscle-specific kinase...

More Information

Publications35

  1. Zhang B, Luo S, Wang Q, Suzuki T, Xiong W, Mei L. LRP4 serves as a coreceptor of agrin. Neuron. 2008;60:285-97 pubmed publisher
    Neuromuscular junction (NMJ) formation requires agrin, a factor released from motoneurons, and MuSK, a transmembrane tyrosine kinase that is activated by agrin. However, how signal is transduced from agrin to MuSK remains unclear...
  2. Kong X, Barzaghi P, Ruegg M. Inhibition of synapse assembly in mammalian muscle in vivo by RNA interference. EMBO Rep. 2004;5:183-8 pubmed
    The formation of the vertebrate neuromuscular junction (NMJ) requires the receptor tyrosine kinase MuSK and the adaptor molecule rapsyn...
  3. Kim N, Stiegler A, Cameron T, Hallock P, Gomez A, Huang J, et al. Lrp4 is a receptor for Agrin and forms a complex with MuSK. Cell. 2008;135:334-42 pubmed publisher
    ..b>MuSK, a receptor tyrosine kinase that is expressed in skeletal muscle, and Agrin, a motor neuron-derived ligand that ..
  4. Okada K, Inoue A, Okada M, Murata Y, Kakuta S, Jigami T, et al. The muscle protein Dok-7 is essential for neuromuscular synaptogenesis. Science. 2006;312:1802-5 pubmed publisher
    The formation of the neuromuscular synapse requires muscle-specific receptor kinase (MuSK) to orchestrate postsynaptic differentiation, including the clustering of receptors for the neurotransmitter acetylcholine...
  5. DeChiara T, Bowen D, Valenzuela D, Simmons M, Poueymirou W, Thomas S, et al. The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vivo. Cell. 1996;85:501-12 pubmed
    ..We have generated mice with a targeted disruption of the gene encoding MuSK, a receptor tyrosine kinase selectively localized to the postsynaptic muscle surface...
  6. Yang X, Arber S, William C, Li L, Tanabe Y, Jessell T, et al. Patterning of muscle acetylcholine receptor gene expression in the absence of motor innervation. Neuron. 2001;30:399-410 pubmed
    ..Neurally derived Agrin is dispensable for this early phase of AChR expression, but MuSK, a receptor tyrosine kinase activated by Agrin, is required to establish this AChR prepattern...
  7. Luo Z, Je H, Wang Q, Yang F, Dobbins G, Yang Z, et al. Implication of geranylgeranyltransferase I in synapse formation. Neuron. 2003;40:703-17 pubmed
    Agrin activates the transmembrane tyrosine kinase MuSK to mediate acetylcholine receptor (AChR) clustering at the neuromuscular junction (NMJ). However, the intracellular signaling mechanism downstream of MuSK is poorly characterized...
  8. Bromann P, Weiner J, Apel E, Lewis R, Sanes J. A putative ariadne-like E3 ubiquitin ligase (PAUL) that interacts with the muscle-specific kinase (MuSK). Gene Expr Patterns. 2004;4:77-84 pubmed
    ..at the skeletal neuromuscular junction (NMJ) requires activation of the muscle-specific receptor tyrosine kinase (MuSK). Few intracellular mediators or modulators of MuSK actions are known...
  9. Tan Sindhunata M, Mathijssen I, Smit M, Baas F, de Vries J, van der Voorn J, et al. Identification of a Dutch founder mutation in MUSK causing fetal akinesia deformation sequence. Eur J Hum Genet. 2015;23:1151-7 pubmed publisher
    ..Here we identify MUSK as a novel cause of lethal FADS...
  10. Woller B, Luiskandl S, Popovic M, Prieler B, Ikonge G, Mutzl M, et al. Rin-like, a novel regulator of endocytosis, acts as guanine nucleotide exchange factor for Rab5a and Rab22. Biochim Biophys Acta. 2011;1813:1198-210 pubmed publisher
    ..novel RIN family member, Rin-like (Rinl), that represents a new interaction partner of the receptor tyrosine kinase MuSK, which is an essential key regulator of neuromuscular synapse development...
  11. Terrado J, Burgess R, DeChiara T, Yancopoulos G, Sanes J, Kato A. Motoneuron survival is enhanced in the absence of neuromuscular junction formation in embryos. J Neurosci. 2001;21:3144-50 pubmed
    ..e., null mutants for agrin, nerve-derived agrin, rapsyn, and MuSK)...
  12. Stiegler A, Burden S, Hubbard S. Crystal structure of the agrin-responsive immunoglobulin-like domains 1 and 2 of the receptor tyrosine kinase MuSK. J Mol Biol. 2006;364:424-33 pubmed
    Muscle-specific kinase (MuSK) is a receptor tyrosine kinase expressed exclusively in skeletal muscle, where it is required for formation of the neuromuscular junction...
  13. Xu K, Jha S, Hoch W, Dryer S. Delayed synapsing muscles are more severely affected in an experimental model of MuSK-induced myasthenia gravis. Neuroscience. 2006;143:655-9 pubmed
    Myasthenia gravis can be induced in mice by injecting the extracellular domain of rat muscle-specific kinase (MuSK), a transmembrane receptor tyrosine kinase involved in agrin signaling at the neuromuscular junction...
  14. Witzemann V, Chevessier F, Pacifici P, Yampolsky P. The neuromuscular junction: selective remodeling of synaptic regulators at the nerve/muscle interface. Mech Dev. 2013;130:402-11 pubmed publisher
    ..in mouse models by specifically targeting endplate receptors or the activity of synaptic regulators such as MuSK. Both regulators have multiple functions and acetylcholine receptors are not just signal transducers but regulate ..
  15. Linnoila J, Wang Y, Yao Y, Wang Z. A mammalian homolog of Drosophila tumorous imaginal discs, Tid1, mediates agrin signaling at the neuromuscular junction. Neuron. 2008;60:625-41 pubmed publisher
    ..identify a protein, tumorous imaginal discs (Tid1), that binds to the cytoplasmic domain of muscle-specific kinase (MuSK), a major component of the agrin receptor...
  16. Sigoillot S, Bourgeois F, Lambergeon M, Strochlic L, Legay C. ColQ controls postsynaptic differentiation at the neuromuscular junction. J Neurosci. 2010;30:13-23 pubmed publisher
    ..Moreover, ColQ interacts with perlecan/dystroglycan and the muscle-specific receptor tyrosine kinase (MuSK), key molecules in the NMJ formation...
  17. Cheusova T, Khan M, Enz R, Hashemolhosseini S. Identification of developmentally regulated expression of MuSK in astrocytes of the rodent retina. J Neurochem. 2006;99:450-7 pubmed
    ..the master regulators of postsynaptic neuromuscular synaptogenesis is the muscle-specific receptor tyrosine kinase (MuSK). In mammals prominent MuSK expression is believed to be restricted to skeletal muscle...
  18. Bianchetta M, Betensky R, Cohen J. Cell-surface MuSK self-association: a crucial role for the putative signal sequence. Biochemistry. 2005;44:16229-38 pubmed
    The receptor tyrosine kinase MuSK plays a crucial role-both as a signaling molecule and structurally-in the process of clustering nicotinic acetylcholine receptors at the neuromuscular junction...
  19. Mazhar S, Herbst R. The formation of complex acetylcholine receptor clusters requires MuSK kinase activity and structural information from the MuSK extracellular domain. Mol Cell Neurosci. 2012;49:475-86 pubmed publisher
    ..It was proposed that the formation of complex AChR clusters is regulated by a MuSK-dependent muscle intrinsic program...
  20. Macpherson P, Suhr S, Goldman D. Activity-dependent gene regulation in conditionally-immortalized muscle precursor cell lines. J Cell Biochem. 2004;91:821-39 pubmed
    ..for all genes tested, including subunits of the nicotinic acetylcholine receptor (nAChR), muscle specific kinase (MuSK), and myogenin, is reproduced in RMT lines...
  21. Bergamin E, Hallock P, Burden S, Hubbard S. The cytoplasmic adaptor protein Dok7 activates the receptor tyrosine kinase MuSK via dimerization. Mol Cell. 2010;39:100-9 pubmed publisher
    ..proteins, Agrin, a neuronally derived ligand, and the following muscle proteins: LRP4, the receptor for Agrin; MuSK, a receptor tyrosine kinase (RTK); and Dok7 (or Dok-7), a cytoplasmic adaptor protein...
  22. Stiegler A, Burden S, Hubbard S. Crystal structure of the frizzled-like cysteine-rich domain of the receptor tyrosine kinase MuSK. J Mol Biol. 2009;393:1-9 pubmed publisher
    Muscle-specific kinase (MuSK) is an essential receptor tyrosine kinase for the establishment and maintenance of the neuromuscular junction (NMJ)...
  23. Osman A, Schrader A, Hawkes A, Akil O, Bergeron A, Lustig L, et al. Muscle-like nicotinic receptor accessory molecules in sensory hair cells of the inner ear. Mol Cell Neurosci. 2008;38:153-69 pubmed publisher
    Nothing is known about the regulation of nicotinic acetylcholine receptors (nAChRs) in hair cells of the inner ear. MuSK, rapsyn and RIC-3 are accessory molecules associated with muscle and brain nAChR function...
  24. Cheusova T, Khan M, Schubert S, Gavin A, Buchou T, Jacob G, et al. Casein kinase 2-dependent serine phosphorylation of MuSK regulates acetylcholine receptor aggregation at the neuromuscular junction. Genes Dev. 2006;20:1800-16 pubmed
    The release of Agrin by motoneurons activates the muscle-specific receptor tyrosine kinase (MuSK) as the main organizer of subsynaptic specializations at the neuromuscular junction. MuSK downstream signaling is largely undefined...
  25. Lee Y, Rudell J, Yechikhov S, Taylor R, Swope S, Ferns M. Rapsyn carboxyl terminal domains mediate muscle specific kinase-induced phosphorylation of the muscle acetylcholine receptor. Neuroscience. 2008;153:997-1007 pubmed publisher
    ..localization of the acetylcholine receptor (AChR) is regulated by agrin signaling via the muscle specific kinase (MuSK) and requires an intracellular scaffolding protein called rapsyn...
  26. Gautam M, DeChiara T, Glass D, Yancopoulos G, Sanes J. Distinct phenotypes of mutant mice lacking agrin, MuSK, or rapsyn. Brain Res Dev Brain Res. 1999;114:171-8 pubmed
    Differentiation of the postsynaptic membrane at the neuromuscular junction requires agrin, a nerve-derived signal; MuSK, a critical component of the agrin receptor in muscle; and rapsyn, a protein that interacts with acetylcholine ..