Muc5b

Summary

Gene Symbol: Muc5b
Description: mucin 5B, oligomeric mucus/gel-forming
Alias: RGD1561983, mucin-5B
Species: rat
Products:     Muc5b

Top Publications

  1. Kirkham S, Kolsum U, Rousseau K, Singh D, Vestbo J, Thornton D. MUC5B is the major mucin in the gel phase of sputum in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2008;178:1033-9 pubmed publisher
    ..MUC5AC and MUC5B were the major mucins...
  2. Chen Y, Zhao Y, Wu R. In silico cloning of mouse Muc5b gene and upregulation of its expression in mouse asthma model. Am J Respir Crit Care Med. 2001;164:1059-66 pubmed
    ..a mouse expressed sequence tag (EST) clone (AA038672) showing great similarity to the 3' end of the human MUC5B gene...
  3. Li S, Zhang M, Li B, Zheng Q, Zhu H. [Toll-like receptor 2 and Toll-like receptor 4 participates in mediation of acute otitis media and mortality in pneumococcal infections in mice]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2011;46:1009-18 pubmed
    ..the mRNA accumulation levels of NF-?B, tumor necrosis factor alpha (TNF?), interleukin1?, MIP-1?, MUC5AC and MUC5B were significantly lower in the ears of TLR2(-/-) mice than that in WT and TLR4(-/-) mice...
  4. Elsheikh M, Mahfouz M. Up-regulation of MUC5AC and MUC5B mucin genes in nasopharyngeal respiratory mucosa and selective up-regulation of MUC5B in middle ear in pediatric otitis media with effusion. Laryngoscope. 2006;116:365-9 pubmed
    ..We investigated the expression of MUC5AC and MUC5B mucin gene messenger (m)RNAs in middle ear effusions as well as in tissue biopsies of the respiratory mucosa of ..
  5. Tang F, Duan C, Huang D, Wang W, Xie C, Meng J, et al. HSP70 and mucin 5B: novel protein targets of N,N'-dinitrosopiperazine-induced nasopharyngeal tumorigenesis. Cancer Sci. 2009;100:216-24 pubmed publisher
    ..The results showed that HSP70 and mucin 5B expression increased not only in rat NPC but also in atypical hyperplasia nasopharyngeal tissues, a precancer ..
  6. Henke M, John G, Germann M, Lindemann H, Rubin B. MUC5AC and MUC5B mucins increase in cystic fibrosis airway secretions during pulmonary exacerbation. Am J Respir Crit Care Med. 2007;175:816-21 pubmed
    ..is believed to be associated with mucus hypersecretion; thus, the principal airway gel-forming mucins, MUC5AC and MUC5B, are also expected to be increased relative to non-CF secretions...
  7. Floyd A, Zhou X, Evans C, Rompala O, Zhu L, Wang M, et al. Mucin deficiency causes functional and structural changes of the ocular surface. PLoS ONE. 2012;7:e50704 pubmed publisher
    ..But the tear volume was not changed. Despite the lack of Muc5ac expression in the conjunctiva of KO mice, Muc5b expression was significantly increased in these mice...
  8. Tian C, Yu H, Yang B, Han F, Zheng Y, Bartels C, et al. Otitis media in a new mouse model for CHARGE syndrome with a deletion in the Chd7 gene. PLoS ONE. 2012;7:e34944 pubmed publisher
    ..Gene expression profiling revealed up-regulation of Muc5ac, Muc5b and Tgf-?1 transcripts, the products of which are involved in mucin production and TGF pathway regulation...
  9. Kirkham S, Sheehan J, Knight D, Richardson P, Thornton D. Heterogeneity of airways mucus: variations in the amounts and glycoforms of the major oligomeric mucins MUC5AC and MUC5B. Biochem J. 2002;361:537-46 pubmed
    ..provides reliable and reproducible data and have employed it to determine the amounts of the MUC2, MUC5AC and MUC5B mucins in saline-induced sputa from healthy airways and spontaneous sputa from asthmatic airways...

More Information

Publications19

  1. Lin J, Tsuboi Y, Rimell F, Liu G, Toyama K, Kawano H, et al. Expression of mucins in mucoid otitis media. J Assoc Res Otolaryngol. 2003;4:384-93 pubmed
    ..In this study, we demonstrated that the MUC5B and MUC4 were major mucins in MOM that formed distinct treelike polymers (mucus strands)...
  2. Ahn E, Kim W, Kwon J, Choi P, Kim W, Sunwoo Y, et al. Variants of MUC5B minisatellites and the susceptibility of bladder cancer. DNA Cell Biol. 2009;28:169-76 pubmed publisher
    The human MUC5B gene, which is primarily expressed in the tracheobronchial tract, is clustered to chromosome 11p15.5 with three other secreted gel-forming mucins, MUC6, MUC2, and MUC5AC...
  3. Roy M, Livraghi Butrico A, Fletcher A, McElwee M, Evans S, Boerner R, et al. Muc5b is required for airway defence. Nature. 2014;505:412-6 pubmed publisher
    ..MUC5AC and MUC5B are evolutionarily conserved genes that encode structurally related mucin glycoproteins, the principal ..
  4. Guzman K, Randell S, Nettesheim P. Epidermal growth factor regulates expression of the mucous phenotype of rat tracheal epithelial cells. Biochem Biophys Res Commun. 1995;217:412-8 pubmed
    ..Following tissue injury and during inflammation the release of EGF and its functional analogue TGF alpha have been observed and may be involved in the mucus hypersecretion characteristic of many airway diseases. ..
  5. Viswanathan H, Brownlee I, Pearson J, Carrie S. MUC5B secretion is up-regulated in sinusitis compared with controls. Am J Rhinol. 2006;20:554-7 pubmed
    ..Biophysical properties of the mucus were measured by rheometry. ELISA was done to estimate MUC5AC and MUC5B mucin content in comparison with standards, i.e., porcine gastric mucin (MUC5AC) and human salivary mucin (MUC5B)...
  6. Lee K, Liu T. Altered mucin gene expression in stone-containing intrahepatic bile ducts and cholangiocarcinomas. Dig Dis Sci. 2001;46:2166-72 pubmed
    ..intrahepatic bile ducts, cholangiocarcinomas, and normal controls to identify the expression of MUC2, MUC3, MUC4, MUC5B, and MUC5AC in nonneoplastic and neoplastic biliary epithelium...
  7. Balague C, Audie J, Porchet N, Real F. In situ hybridization shows distinct patterns of mucin gene expression in normal, benign, and malignant pancreas tissues. Gastroenterology. 1995;109:953-64 pubmed
    ..Acinar cells express only MUC1. Normal pancreatic ducts show homogeneous expression of MUC1 and MUC5B and heterogenous expression of MUC3...
  8. Kamio K, Matsushita I, Hijikata M, Kobashi Y, Tanaka G, Nakata K, et al. Promoter analysis and aberrant expression of the MUC5B gene in diffuse panbronchiolitis. Am J Respir Crit Care Med. 2005;171:949-57 pubmed
    ..We analyzed nucleotide sequences of regulatory region of six mucin genes--MUC1, MUC2, MUC4, MUC5AC, MUC5B, and MUC7--and detected their promoter polymorphisms...
  9. Shori D, Genter T, Hansen J, Koch C, Wyatt H, Kariyawasam H, et al. Altered sialyl- and fucosyl-linkage on mucins in cystic fibrosis patients promotes formation of the sialyl-Lewis X determinant on salivary MUC-5B and MUC-7. Pflugers Arch. 2001;443 Suppl 1:S55-61 pubmed
    ..We have hypothesized that changes in the glycosylation of key tracheal mucins such as MUC5B and MUC7 might increase the risk of pulmonary disease in CF patients...
  10. Guzman K, Bader T, Nettesheim P. Regulation of MUC5 and MUC1 gene expression: correlation with airway mucous differentiation. Am J Physiol. 1996;270:L846-53 pubmed
    ..These studies demonstrate that expression of MUC1 and MUC5 is coordinately regulated with airway mucous cell differentiation. These cDNAs should provide useful tools to study mucin synthesis during differentiation and disease...