Muc5ac

Summary

Gene Symbol: Muc5ac
Description: mucin 5AC, oligomeric mucus/gel-forming
Alias: LOW QUALITY PROTEIN: mucin-5AC, mucin 5, subtypes A and C, mucin 5, subtypes A and C, tracheobronchial/gastric
Species: rat
Products:     Muc5ac

Top Publications

  1. Souchier M, Buron N, Lafontaine P, Bron A, Baudouin C, Creuzot Garcher C. Trefoil factor family 1, MUC5AC and human leucocyte antigen-DR expression by conjunctival cells in patients with glaucoma treated with chronic drugs: could these markers predict the success of glaucoma surgery?. Br J Ophthalmol. 2006;90:1366-9 pubmed
    To evaluate conjunctival expression of trefoil factor family (TFF)1, MUC5AC and human leucocyte antigen (HLA)-DR in patients with glaucoma treated with topical drugs, and to determine whether these parameters can predict the outcome of ..
  2. Lee K, Liu T. Altered mucin gene expression in stone-containing intrahepatic bile ducts and cholangiocarcinomas. Dig Dis Sci. 2001;46:2166-72 pubmed
    ..bile ducts, cholangiocarcinomas, and normal controls to identify the expression of MUC2, MUC3, MUC4, MUC5B, and MUC5AC in nonneoplastic and neoplastic biliary epithelium...
  3. Nollet S, Forgue Lafitte M, Kirkham P, Bara J. Mapping of two new epitopes on the apomucin encoded by MUC5AC gene: expression in normal GI tract and colon tumors. Int J Cancer. 2002;99:336-43 pubmed
    ..These MAbs immunoreacted against a human recombinant protein encoded by the 3' region of the MUC5AC gene...
  4. Yu D, Chen Y, Han J, Zhang H, Chen X, Zou W, et al. MUC19 expression in human ocular surface and lacrimal gland and its alteration in Sjögren syndrome patients. Exp Eye Res. 2008;86:403-11 pubmed publisher
    ..Real-time PCR and immunohistochemistry were performed to determine the expression of MUC19 and MUC5AC in human cornea, conjunctiva, and lacrimal gland tissues...
  5. Boonla C, Wongkham S, Sheehan J, Wongkham C, Bhudhisawasdi V, Tepsiri N, et al. Prognostic value of serum MUC5AC mucin in patients with cholangiocarcinoma. Cancer. 2003;98:1438-43 pubmed
    The authors recently showed that MUC5AC mucin, which is expressed aberrantly in tumor tissue, is present in significant concentrations in serum from patients with cholangiocarcinoma...
  6. Lin Z, Liu X, Zhou T, Wang Y, Bai L, He H, et al. A mouse dry eye model induced by topical administration of benzalkonium chloride. Mol Vis. 2011;17:257-64 pubmed
    ..To develop a dry eye model of mouse induced by topical administration of benzalkonium chloride (BAC) and investigate the possible mechanisms...
  7. Kerschner J, Tripathi S, Khampang P, Papsin B. MUC5AC expression in human middle ear epithelium of patients with otitis media. Arch Otolaryngol Head Neck Surg. 2010;136:819-24 pubmed publisher
    To compare levels of middle ear (ME) MUC5AC expression in patients with otitis media (OM) with patients without OM...
  8. Yonezawa S, Horinouchi M, Osako M, Kubo M, Takao S, Arimura Y, et al. Gene expression of gastric type mucin (MUC5AC) in pancreatic tumors: its relationship with the biological behavior of the tumor. Pathol Int. 1999;49:45-54 pubmed
    ..The gastric type secretory mucin, MUC5AC, is strongly expressed in the surface mucous cells of gastric mucosa...
  9. Viau S, Maire M, Pasquis B, Gregoire S, Acar N, Bron A, et al. Efficacy of a 2-month dietary supplementation with polyunsaturated fatty acids in dry eye induced by scopolamine in a rat model. Graefes Arch Clin Exp Ophthalmol. 2009;247:1039-50 pubmed publisher
    ..Dietary GLA, EPA and DHA significantly interfered with lipid homeostasis in the exorbital LG and partially prevented the course of dry eye. In particular, our results demonstrate the efficacy of the combination of n-6 and n-3 PUFAs. ..

More Information

Publications72

  1. Cortijo J, Iranzo A, Milara X, Mata M, Cerda Nicolas M, Ruiz Sauri A, et al. Roflumilast, a phosphodiesterase 4 inhibitor, alleviates bleomycin-induced lung injury. Br J Pharmacol. 2009;156:534-44 pubmed publisher
    ..growth factor (TGFbeta), connective tissue growth factor, alphaI(I)collagen, endothelin-1 and the mucin, Muc5ac, in lung, and reduced bronchoalveolar lavage fluid levels of TNFalpha, interleukin-13, TGFbeta, Muc5ac, lipid ..
  2. Hasnain S, Wang H, Ghia J, Haq N, Deng Y, Velcich A, et al. Mucin gene deficiency in mice impairs host resistance to an enteric parasitic infection. Gastroenterology. 2010;138:1763-71 pubmed publisher
    ..Nevertheless, the precise role of mucins in host defense in nematode infection is not known. We investigated the role of the mucin (Muc2) in worm expulsion and host immunity in a model of nematode infection...
  3. Han F, An Y, Zhao C. [Alteration of cytokines and mucin in lower respiratory tract in allergic rhinitis model in rats]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2005;40:339-42 pubmed
    ..in bronchial alveolus lavage fluid (BALF) and the expression of intercellular adhesion molecule-1 (ICAM-1) and MUC5AC in nasal and lung tissue, respectively...
  4. Inatomi T, Tisdale A, Zhan Q, Spurr Michaud S, Gipson I. Cloning of rat Muc5AC mucin gene: comparison of its structure and tissue distribution to that of human and mouse homologues. Biochem Biophys Res Commun. 1997;236:789-97 pubmed
    The human mucin gene MUC5AC codes for a large mucin which has tandem repeat units and cysteine rich regions characteristic of several members of this class of glycoproteins...
  5. Liu W, Li H, Lu D, Liang J, Xing X, Liu A, et al. The tear fluid mucin 5AC change of primary angle-closure glaucoma patients after short-term medications and phacotrabeculectomy. Mol Vis. 2010;16:2342-6 pubmed
    This paper proposed to evaluate the tear fluid mucin 5AC (MUC5AC) change in Chinese primary angle-closure glaucoma and cataract patients after short-term medications and phacotrabeculectomy...
  6. Floyd A, Zhou X, Evans C, Rompala O, Zhu L, Wang M, et al. Mucin deficiency causes functional and structural changes of the ocular surface. PLoS ONE. 2012;7:e50704 pubmed publisher
    b>MUC5AC is the most abundant gel-forming mucin in the ocular system. However, the specific function is unknown...
  7. Sheehan J, Kirkham S, Howard M, Woodman P, Kutay S, Brazeau C, et al. Identification of molecular intermediates in the assembly pathway of the MUC5AC mucin. J Biol Chem. 2004;279:15698-705 pubmed
    b>MUC5AC mucins secreted by HT-29 cells in culture are oligomeric glycoproteins with characteristics similar to the MUC5AC mucins isolated from human airway sputum (Sheehan, J. K., Brazeau, C., Kutay, S., Pigeon, H., Kirkham, S., Howard, M...
  8. Balague C, Gambus G, Carrato C, Porchet N, Aubert J, Kim Y, et al. Altered expression of MUC2, MUC4, and MUC5 mucin genes in pancreas tissues and cancer cell lines. Gastroenterology. 1994;106:1054-61 pubmed
    ..Enhanced expression of MUC2, MUC4, and MUC5C genes is a frequent event in pancreas cancer and may contribute to the alterations in the biochemical structure of pancreas cancer mucins. ..
  9. Cao W, Adley B, Liao J, Lin X, Talamonti M, Bentrem D, et al. Mucinous nonneoplastic cyst of the pancreas: apomucin phenotype distinguishes this entity from intraductal papillary mucinous neoplasm. Hum Pathol. 2010;41:513-21 pubmed publisher
    ..Furthermore, apomucin immunostains of mucinous nonneoplastic cyst showed MUC1 expressed in 27% (4/15) cases, MUC5AC in 67% (10/15 cases), and MUC2 was were negative in all cases, whereas intraductal papillary mucinous neoplasm (n =..
  10. Li S, Zhang M, Li B, Zheng Q, Zhu H. [Toll-like receptor 2 and Toll-like receptor 4 participates in mediation of acute otitis media and mortality in pneumococcal infections in mice]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2011;46:1009-18 pubmed
    ..postchallenge, the mRNA accumulation levels of NF-?B, tumor necrosis factor alpha (TNF?), interleukin1?, MIP-1?, MUC5AC and MUC5B were significantly lower in the ears of TLR2(-/-) mice than that in WT and TLR4(-/-) mice...
  11. Hegab A, Sakamoto T, Nomura A, Ishii Y, Morishima Y, Iizuka T, et al. Niflumic acid and AG-1478 reduce cigarette smoke-induced mucin synthesis: the role of hCLCA1. Chest. 2007;131:1149-56 pubmed
    ..The CLCA1, epidermal growth factor receptor (EGFR), and MUC5AC expressions were increased in the trachea and lung tissues...
  12. Ferretti V, Segal Eiras A, Barbeito C, Croce M. Temporal and spatial expression of Muc2 and Muc5ac mucins during rat respiratory and digestive tracts development. Res Vet Sci. 2016;104:136-45 pubmed publisher
    ..respiratory and digestive epithelia, being MUC2/Muc2 the predominant gel-forming mucin of the intestine while MUC5AC/Muc5ac is one of the gel-forming mucins most expressed at the airways...
  13. Van De Bovenkamp J, Korteland Van Male A, Büller H, Einerhand A, Dekker J. Metaplasia of the duodenum shows a Helicobacter pylori-correlated differentiation into gastric-type protein expression. Hum Pathol. 2003;34:156-65 pubmed
    ..Expression was examined immunohistochemically of secretory mucins (MUC2, MUC5AC, MUC5B, and MUC6), trefoil peptides (TFF1, TFF2, and TFF3), and sucrase-isomaltase (SI)...
  14. Li R, Meng Z, Xie J. Effects of sulfur dioxide on the expressions of MUC5AC and ICAM-1 in airway of asthmatic rats. Regul Toxicol Pharmacol. 2007;48:284-91 pubmed
    ..The mRNA and protein levels of MUC5AC and ICAM-1 were analyzed in lungs and tracheas using real-time reverse transcription-polymerase chain reaction (..
  15. Wang W, Zheng M. Mucin 5 subtype AC expression and upregulation in the nasal mucosa of allergic rhinitis rats. Otolaryngol Head Neck Surg. 2012;147:1012-9 pubmed publisher
    ..the in vivo effects of an NF-?B inhibitor, ammonium pyrrolidine dithiocarbamate (PDTC), on mucin 5 subtype AC (MUC5AC) expression in the nasal mucosa of ovalbumin-sensitized rats. Randomized animal study. Academic medical center...
  16. Dogru M, Matsumoto Y, Okada N, Igarashi A, Fukagawa K, Shimazaki J, et al. Alterations of the ocular surface epithelial MUC16 and goblet cell MUC5AC in patients with atopic keratoconjunctivitis. Allergy. 2008;63:1324-34 pubmed publisher
    ..An increased understanding of the ocular surface at cellular level in the conjunctiva and the cornea may help explain the pathogenesis and the subsequent clinical appearance of atopic ocular allergies, which may be potentially blinding...
  17. Lü H, Guo Y, Dong Z. [Expression of MUC5AC in human nasal polyp and inferior turbinate epithelium]. Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2004;18:649-50 pubmed
    To examine the expression of MUC5AC in human nasal polyp and inferior turbinate epithelium, to evaluate the relationship between MUC5AC and the increased mucous secretions in polyps and chronic hypertrophy rhinitis...
  18. Balague C, Audie J, Porchet N, Real F. In situ hybridization shows distinct patterns of mucin gene expression in normal, benign, and malignant pancreas tissues. Gastroenterology. 1995;109:953-64 pubmed
    ..MUC2, MUC4, and MUC5AC are generally undetectable in all cells of normal pancreas tissue...
  19. Kania N, Setiawan B, Widjadjanto E, Nurdiana N, Widodo M, Kusuma H. Subchronic inhalation of coal dust particulate matter 10 induces bronchoalveolar hyperplasia and decreases MUC5AC expression in male Wistar rats. Exp Toxicol Pathol. 2014;66:383-9 pubmed publisher
    ..The purpose of the present study was to evaluate the effects of PM10 coal dust on lung histology, MUC5AC expression, epidermal growth factor (EGF) expression, and epidermal growth factor receptor (EGFR) expression...
  20. Kim D, Yang W. Panax ginseng ameliorates airway inflammation in an ovalbumin-sensitized mouse allergic asthma model. J Ethnopharmacol. 2011;136:230-5 pubmed publisher
    ..The expression of EMBP, Muc5ac, CD40, and CD40 ligand (CD40L) in lung tissues was investigated...
  21. Kim Y, Jung H, Ko T, Kim S. Up-regulation of MUC5AC mRNA expression in endotoxin-induced otitis media. Acta Otolaryngol. 2001;121:364-70 pubmed
    We investigated the expression levels of MUC5AC in endotoxin-induced otitis media with effusion (OME) in the rat using competitive polymerase chain reaction (PCR) and the morphology of middle ear mucosa using transmission electron ..
  22. Song J, Hyun S, Lillihoj E, Kim B. Mucin secretion in the rat tracheal epithelial cells by epidermal growth factor and Pseudomonas aeruginosa extracts. Korean J Intern Med. 2001;16:167-72 pubmed
    ..mucin secretion was also stimulated by either EGF or Pseudomonas extracts but more strong secretion of mucin and MUC5AC gene expression in the rat tracheal epithelial cell was done by Pseudomonas extracts...
  23. Sajjan U, Ganesan S, Comstock A, Shim J, Wang Q, Nagarkar D, et al. Elastase- and LPS-exposed mice display altered responses to rhinovirus infection. Am J Physiol Lung Cell Mol Physiol. 2009;297:L931-44 pubmed publisher
    ..hyperresponsiveness, increased lung volume, and sustained increases in expression of TNFalpha, IL-5, IL-13, and muc5AC (up to 14 days postinfection)...
  24. Yue T, Goldstein I, Hollingsworth M, Kaul K, Brand R, Haab B. The prevalence and nature of glycan alterations on specific proteins in pancreatic cancer patients revealed using antibody-lectin sandwich arrays. Mol Cell Proteomics. 2009;8:1697-707 pubmed publisher
    ..elevated in the cancer patients (65% of the patients) but showed no glycan alterations, whereas the MUC1 and MUC5AC proteins were less frequently elevated (30 and 35%, respectively) and showed highly prevalent (up to 65%) and ..
  25. Nam S, Kim N, Lee C, Choi K, Lee H, Jung H, et al. Gastric mucosal protection via enhancement of MUC5AC and MUC6 by geranylgeranylacetone. Dig Dis Sci. 2005;50:2110-20 pubmed
    ..protects tissues from the hazardous gastric environment; however, the role of each gastric MUC type, such as MUC1, MUC5AC, and MUC6, has not been evaluated...
  26. Gao F, Gao Y, Liu M, Liu Y. [Effects of chronic Aspergillus fumigatus exposure on the expression of mucin 5AC in the airways of asthmatic rats]. Zhonghua Jie He He Hu Xi Za Zhi. 2012;35:423-8 pubmed
    To explore the effects of chronic Aspergillus fumigatus (Af) exposure on the expression of mucin 5AC (MUC5AC) in the airways of asthmatic rats...
  27. Cao L, Chen Y, Zhao Y, Zhang H, Wang S, Wang Z, et al. Effect of Myrtol standardized on mucus hypersecretion and clearance of Pseudomonas aeruginosa in a rat model of chronic obstructive pulmonary disease. Arzneimittelforschung. 2011;61:685-92 pubmed publisher
    ..g. muc5ac)...
  28. Choo D, Khwaja K, Nori K, Rewinski M, Zeff R, Perdrizet G. In vivo characterization of the molecular-genetic changes in gastric mucosa during the development of acute gastritis and stress ulceration. J Trauma. 2002;52:720-5; discussion 725-6 pubmed
    ..heat-shock gene (iHSP70) and an inhibition of the trefoil peptide, spasmolytic polypeptide (SP), and mucin (MUC5AC) gene expressions...
  29. Wang K, Feng Y, Wen F, Chen X, Ou X, Xu D, et al. Increased expression of human calcium-activated chloride channel 1 is correlated with mucus overproduction in the airways of Chinese patients with chronic obstructive pulmonary disease. Chin Med J (Engl). 2007;120:1051-7 pubmed
    ..of CaCC(1) and mucus overproduction in the airway of Chinese patients with COPD, the expressions of CaCC(1), MUC5AC and mucus in bronchial tissues were examined...
  30. Jankovic Velickovic L, Katic V, Hattori T, Kushima R, Marjanovic G, Stefanovic V. Differences in the expression of mucins in various forms of cystitis glandularis. Pathol Res Pract. 2007;203:653-8 pubmed
    ..For this examination, we used a panel of monoclonal-specific antibodies for MUC1, MUC2, MUC5AC, and MUC6...
  31. Song X, Li D, Farley W, Luo L, Heuckeroth R, Milbrandt J, et al. Neurturin-deficient mice develop dry eye and keratoconjunctivitis sicca. Invest Ophthalmol Vis Sci. 2003;44:4223-9 pubmed
    ..Neurturin-deficient (NRTN(-/-)) mice have defective parasympathetic innervation of their lacrimal glands. This study was conducted to evaluate tear function and ocular surface phenotype in NRTN(-/-) mice...
  32. Wu W, Zhen H, Gao M. [Effects of glucocorticoid on calcium-activated chloride channel expression in nasal mucosa in allergic rhinitis rats]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009;44:242-5 pubmed
    To investigate the expression of CLCA3 and Muc5ac in nasal mucosa in allergic rhinitis rats and the effects of glucocorticoid on its expression...
  33. Zoghbi S, Drouin E, Claustre J, Bara J, Scoazec J, Plaisancie P. Intestinal MUC2 and gastric M1/MUC5AC in preneoplastic lesions induced by 1,2-dimethylhydrazine in rat: a sequential analysis. Int J Oncol. 2007;30:489-97 pubmed
    ..Our study was performed to sequentially analyze the expression of the intestinal mucin MUC2 and of the gastric mucin MUC5AC as indicators during progression of preneoplastic biomarkers in rat colon...
  34. Chen L, Wang T, Zhang J, Zhang S, Liu D, Xu D, et al. Toll-like receptor 4 relates to lipopolysaccharide-induced mucus hypersecretion in rat airway. Arch Med Res. 2009;40:10-7 pubmed publisher
    ..Expressions of TLR4 and MUC5AC were evaluated with RT-PCR, in situ hybridization, immunohistochemistry and Alcian blue/Periodic acid-schiff (AB/..
  35. Shahzeidi S, Aujla P, Nickola T, Chen Y, Alimam M, Rose M. Temporal analysis of goblet cells and mucin gene expression in murine models of allergic asthma. Exp Lung Res. 2003;29:549-65 pubmed
    ..Increased Muc5ac and Muc2 mRNA expression occurred following ovalbumin or IL13, but not saline, exposure...
  36. Tian C, Yu H, Yang B, Han F, Zheng Y, Bartels C, et al. Otitis media in a new mouse model for CHARGE syndrome with a deletion in the Chd7 gene. PLoS ONE. 2012;7:e34944 pubmed publisher
    ..Gene expression profiling revealed up-regulation of Muc5ac, Muc5b and Tgf-?1 transcripts, the products of which are involved in mucin production and TGF pathway regulation...
  37. Kim D, Yeo S. Effects of normal saline and selenium-enriched hot spring water on experimentally induced rhinosinusitis in rats. Int J Pediatr Otorhinolaryngol. 2013;77:117-22 pubmed publisher
    ..This prospective, randomized, and controlled study examined the effects of normal saline and selenium-enriched hot spring water on experimentally induced rhinosinusitis in rats...
  38. Matull W, Andreola F, Loh A, Adiguzel Z, Deheragoda M, Qureshi U, et al. MUC4 and MUC5AC are highly specific tumour-associated mucins in biliary tract cancer. Br J Cancer. 2008;98:1675-81 pubmed publisher
    ..In pancreatic malignancy, MUC4 is a diagnostic and prognostic tumour marker, whereas MUC5AC has been proposed as a sensitive serological marker for BTC...
  39. Gao F, Gao Y, Liu M, Liu Y. Chronic Aspergillus fumigatus exposure upregulates the expression of mucin 5AC in the airways of asthmatic rats. Exp Lung Res. 2012;38:256-65 pubmed publisher
    ..The effects of chronic A. fumigatus exposure on the expression of airway mucin 5AC (MUC5AC) are unknown...
  40. Tsubokawa D, Goso Y, Nakamura T, Maruyama H, Yatabe F, Kurihara M, et al. Rapid and specific alterations of goblet cell mucin in rat airway and small intestine associated with resistance against Nippostrongylus brasiliensis reinfection. Exp Parasitol. 2012;130:209-17 pubmed publisher
    ..the challenge larvae were rejected during the pre-intestinal stage along with marked goblet cell hyperplasia and Muc5AC mucin hyperproduction on the bronchial mucosa, but not as a result of jejunal mucin alteration...
  41. Chang H, Kim S, Lee B, Hong E, Kim W. Phenotypic alterations of mucins and cytokeratins during gallbladder carcinogenesis. Pathol Int. 2004;54:576-84 pubmed
    ..mucin and cytokeratin during gallbladder carcinogenesis, we characterized the expressional profiles of MUC1, MUC2, MUC5AC, MUC6, CK7 and CK20 in 33 normal mucosa, 31 adenomas, 55 dysplasias and 131 carcinomas of the gallbladder...
  42. Hashimoto K, Graham B, Ho S, Adler K, Collins R, Olson S, et al. Respiratory syncytial virus in allergic lung inflammation increases Muc5ac and gob-5. Am J Respir Crit Care Med. 2004;170:306-12 pubmed
    ..We hypothesized that this increased mucus was associated with mucosal expression of Muc5ac, a mucus gene expression in airways, and gob-5, a member of the Ca(2)(+)-activated chloride channel family...
  43. Henke M, John G, Germann M, Lindemann H, Rubin B. MUC5AC and MUC5B mucins increase in cystic fibrosis airway secretions during pulmonary exacerbation. Am J Respir Crit Care Med. 2007;175:816-21 pubmed
    ..CF) is believed to be associated with mucus hypersecretion; thus, the principal airway gel-forming mucins, MUC5AC and MUC5B, are also expected to be increased relative to non-CF secretions...
  44. Caramori G, Casolari P, Di Gregorio C, Saetta M, Baraldo S, Boschetto P, et al. MUC5AC expression is increased in bronchial submucosal glands of stable COPD patients. Histopathology. 2009;55:321-31 pubmed publisher
    Mucus expectoration is a common feature of chronic obstructive pulmonary disease (COPD). MUC5AC and MUC5B, the major mucins, are released predominantly from submucosal glands in the central airways...
  45. Zhang J, Yan X, Li H. Analysis of the correlations of mucins, inflammatory markers, and clinical tests in dry eye. Cornea. 2013;32:928-32 pubmed publisher
    ..cytology specimens from all patients were immunolabeled with antibodies directed against human mucin 5AC (MUC5AC) and interleukin-6 (IL-6) and the staining density was measured...
  46. Wagner J, Harkema J, Jiang Q, Illek B, Ames B, Peden D. Gamma-tocopherol attenuates ozone-induced exacerbation of allergic rhinosinusitis in rats. Toxicol Pathol. 2009;37:481-91 pubmed publisher
    ..and analyzed by reverse transcriptase polymerase chain reaction (RT-PCR) for mucin glycoprotein 5AC (MUC5AC) expression levels...
  47. Dogru M, Asano Kato N, Tanaka M, Igarashi A, Shimmura S, Shimazaki J, et al. Ocular surface and MUC5AC alterations in atopic patients with corneal shield ulcers. Curr Eye Res. 2005;30:897-908 pubmed
    To describe MUC5AC alterations and the ocular surface disorder in atopic patients with or without corneal ulcers. Atopic patients' eyes were divided into two groups according to the presence and absence of corneal ulceration...
  48. Tan Y, Zhang W, Yang L, Jiang S. The effect of formoterol on airway goblet cell hyperplasia and protein Muc5ac expression in asthmatic mice. Eur Rev Med Pharmacol Sci. 2011;15:743-50 pubmed
    ..the effect of long-acting beta2-adrenoceptor agonist formoterol on airway goblet cell hyperplasia and protein Muc5ac expression in asthmatic mice. Forty female BABL/c mice were randomly divided into four groups with 10 mice in each...
  49. Guzman K, Bader T, Nettesheim P. Regulation of MUC5 and MUC1 gene expression: correlation with airway mucous differentiation. Am J Physiol. 1996;270:L846-53 pubmed
    ..These studies demonstrate that expression of MUC1 and MUC5 is coordinately regulated with airway mucous cell differentiation. These cDNAs should provide useful tools to study mucin synthesis during differentiation and disease...
  50. Li Q, Li N, Liu C, Xu R, Kolosov V, Perelman J, et al. Ezrin/Exocyst complex regulates mucin 5AC secretion induced by neutrophil elastase in human airway epithelial cells. Cell Physiol Biochem. 2015;35:326-38 pubmed publisher
    ..In the present study, we examined whether Ezrin is involved in mucin 5AC (MUC5AC) secretion after neutrophil elastase (NE) attack, and we investigated the role of the exocyst complex docking ..
  51. Wang K, Wen F, Feng Y, Ou X, Xu D, Yang J, et al. Increased expression of human calcium-activated chloride channel 1 gene is correlated with mucus overproduction in Chinese asthmatic airway. Cell Biol Int. 2007;31:1388-95 pubmed
    ..channel 1 (CaCC1) and mucus overproduction in Chinese asthmatic airway, the expression of CaCC1, mucin 5AC (MUC5AC) and mucus in bronchial tissues were examined...
  52. Gomi A, Harima Mizusawa N, Shibahara Sone H, Kano M, Miyazaki K, Ishikawa F. Effect of Bifidobacterium bifidum BF-1 on gastric protection and mucin production in an acute gastric injury rat model. J Dairy Sci. 2013;96:832-7 pubmed publisher
    ..Interestingly, mucin 5ac (muc5ac) gene expression in gastric corpus samples and gastric mucin production in stomach samples from the BF-1 group, ..
  53. Tei M, Spurr Michaud S, Tisdale A, Gipson I. Vitamin A deficiency alters the expression of mucin genes by the rat ocular surface epithelium. Invest Ophthalmol Vis Sci. 2000;41:82-8 pubmed
    ..Both the membrane-spanning mucin ASGP (rMuc4) and the secretory mucin rMuc5AC are directly or indirectly regulated by vitamin A in the ocular surface epithelium, whereas the membrane-spanning mucin rMuc1 is not. ..
  54. Yuan B, Dan Q, Zhao S, Wang S, Meng B, Zhang Y. [Effects of acrolein exposure on the expression of Muc5ac in the airway of rats]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2010;41:994-7 pubmed
    To explore the changes of Muc5ac expression in a rat model of mucus hypersecretion induced by acrolein. The rat model of mucus hypersceretion was established by acrolein exposure...
  55. Fortin M, Wagner J, Brault J, Harkema J, Renzi P, Paquet L, et al. Spatial and temporal expression of CCR3 and the common beta chain of the IL-3, IL-5 and GM-CSF receptor in the nasal epithelium and lymphoid tissues in a rat model of allergic rhinitis. Cytokine. 2010;52:194-202 pubmed publisher
    ..In contrast, IL-13 and MUC5AC mRNA, as well as production of mucosubstances were maximal at 24h...
  56. Hewson C, Haas J, Bartlett N, Message S, Laza Stanca V, Kebadze T, et al. Rhinovirus induces MUC5AC in a human infection model and in vitro via NF-?B and EGFR pathways. Eur Respir J. 2010;36:1425-35 pubmed publisher
    ..b>MUC5AC is the major mucin produced by bronchial epithelial cells...
  57. Mata M, Ruiz A, Cerda M, Martinez Losa M, Cortijo J, Santangelo F, et al. Oral N-acetylcysteine reduces bleomycin-induced lung damage and mucin Muc5ac expression in rats. Eur Respir J. 2003;22:900-5 pubmed
    ..of this antioxidant was examined on bleomycin-induced lung damage, mucus secretory cells hyperplasia and mucin Muc5ac gene expression in rats...
  58. Yamasaki H, Ikeda S, Okajima M, Miura Y, Asahara T, Kohno N, et al. Expression and localization of MUC1, MUC2, MUC5AC and small intestinal mucin antigen in pancreatic tumors. Int J Oncol. 2004;24:107-13 pubmed
    ..We analyzed the expression and localization of MUC1, MUC2, MUC5AC and small intestinal mucin antigen (SIMA) in pancreatic tumors...
  59. Wang Y, Ogawa Y, Dogru M, Kawai M, Tatematsu Y, Uchino M, et al. Ocular surface and tear functions after topical cyclosporine treatment in dry eye patients with chronic graft-versus-host disease. Bone Marrow Transplant. 2008;41:293-302 pubmed
    ..staining scores, goblet cells density, conjunctival squamous metaplasia grade, inflammatory cell numbers and the MUC5AC expression. Our study suggests that 0...
  60. Wang Y, Gao J, Li Z, Jin Z, Gong Y, Man X. Diagnostic value of mucins (MUC1, MUC2 and MUC5AC) expression profile in endoscopic ultrasound-guided fine-needle aspiration specimens of the pancreas. Int J Cancer. 2007;121:2716-22 pubmed
    ..We immunohistochemically tested mucins expression (MUC1, MUC2 and MUC5AC) in EUS-FNA samples from pancreatic occupying lesions for the diagnostic utility...
  61. Kim J, Jung K, Han J, Shim J, In K, Kang K, et al. Relation of epidermal growth factor receptor expression to mucus hypersecretion in diffuse panbronchiolitis. Chest. 2004;126:888-95 pubmed
    ..blue/periodic acid-Schiff (AB/PAS) staining for mucous glycoconjugates, and by immunohistochemical staining for MUC5AC, EGFR, tumor necrosis factor-alpha, and CD16 on neutrophils...
  62. Cho H, Hotchkiss J, Harkema J. Inflammatory and epithelial responses during the development of ozone-induced mucous cell metaplasia in the nasal epithelium of rats. Toxicol Sci. 1999;51:135-45 pubmed
    ..Ozone-induced MCM may be dependent on these important pre-metaplastic responses (i.e., mucin mRNA upregulation, neutrophilic inflammation, and epithelial proliferation). ..
  63. Aishima S, Kuroda Y, Nishihara Y, Taguchi K, Taketomi A, Maehara Y, et al. Gastric mucin phenotype defines tumour progression and prognosis of intrahepatic cholangiocarcinoma: gastric foveolar type is associated with aggressive tumour behaviour. Histopathology. 2006;49:35-44 pubmed
    ..We examined the expression profile of MUC2, MUC5AC and MUC6 by immunohistochemical staining in 100 ICCs and compared the clinicopathological factors and the ..