Muc4

Summary

Gene Symbol: Muc4
Description: mucin 4, cell surface associated
Alias: ASGP-1, Psmc, mucin-4, ASGP, MUC-4, ascites sialoglycoprotein, pancreatic adenocarcinoma mucin, pre-sialomucin complex, sialomucin ascites sialoglycoprotein-1, sialomucin complex, testis mucin
Species: rat
Products:     Muc4

Top Publications

  1. Saitou M, Goto M, Horinouchi M, Tamada S, Nagata K, Hamada T, et al. MUC4 expression is a novel prognostic factor in patients with invasive ductal carcinoma of the pancreas. J Clin Pathol. 2005;58:845-52 pubmed
    Many patients with invasive ductal carcinoma of the pancreas (IDC) have a poor outcome. MUC4 expression has been implicated as a marker for diagnosis and progression of IDC, but there are no studies of the relation between MUC4 expression ..
  2. Shibahara H, Tamada S, Higashi M, Goto M, Batra S, Hollingsworth M, et al. MUC4 is a novel prognostic factor of intrahepatic cholangiocarcinoma-mass forming type. Hepatology. 2004;39:220-9 pubmed
    ..for diagnosis and progression of pancreatic adenocarcinomas, but there is no study of the relationship between MUC4 expression and patient's prognosis in ICC-MF...
  3. Tamada S, Shibahara H, Higashi M, Goto M, Batra S, Imai K, et al. MUC4 is a novel prognostic factor of extrahepatic bile duct carcinoma. Clin Cancer Res. 2006;12:4257-64 pubmed
    Many of the patients with extrahepatic bile duct carcinoma (EHBDC) show a poor outcome. We have reported that MUC4 is a novel prognostic factor of pancreatic adenocarcinoma and intrahepatic cholangiocarcinoma...
  4. Zhang J, Perez A, Yasin M, Soto P, Rong M, Theodoropoulos G, et al. Presence of MUC4 in human milk and at the luminal surfaces of blood vessels. J Cell Physiol. 2005;204:166-77 pubmed
    b>MUC4 is a heterodimeric membrane mucin, composed of a mucin subunit ASGP-1 (MUC4alpha) and a transmembrane subunit ASGP-2 (MUC4beta), which has been implicated in the protection of epithelial cell surfaces...
  5. Andrianifahanana M, Moniaux N, Schmied B, Ringel J, Friess H, Hollingsworth M, et al. Mucin (MUC) gene expression in human pancreatic adenocarcinoma and chronic pancreatitis: a potential role of MUC4 as a tumor marker of diagnostic significance. Clin Cancer Res. 2001;7:4033-40 pubmed
    ..pancreatic tumor cell lines were analyzed by reverse transcription-PCR with primers specific for MUC1, MUC2, MUC3, MUC4, MUC5AC, MUC5B, MUC6, and MUC7 genes and by RNA slot blot analyses...
  6. Balague C, Gambus G, Carrato C, Porchet N, Aubert J, Kim Y, et al. Altered expression of MUC2, MUC4, and MUC5 mucin genes in pancreas tissues and cancer cell lines. Gastroenterology. 1994;106:1054-61 pubmed
    ..In pancreas cancer tissues and cell lines, increased expression of MUC2, MUC4, and MUC5C is shown...
  7. Chaturvedi P, Singh A, Moniaux N, Senapati S, Chakraborty S, Meza J, et al. MUC4 mucin potentiates pancreatic tumor cell proliferation, survival, and invasive properties and interferes with its interaction to extracellular matrix proteins. Mol Cancer Res. 2007;5:309-20 pubmed
    b>MUC4, a transmembrane mucin, is aberrantly expressed in pancreatic adenocarcinomas while remaining undetectable in the normal pancreas...
  8. Moniaux N, Chaturvedi P, Varshney G, Meza J, Rodriguez Sierra J, Aubert J, et al. Human MUC4 mucin induces ultra-structural changes and tumorigenicity in pancreatic cancer cells. Br J Cancer. 2007;97:345-57 pubmed
    b>MUC4 is a type-1 transmembrane glycoprotein and is overexpressed in many carcinomas. It is a heterodimeric protein of 930 kDa, composed of a mucin-type subunit, MUC4alpha, and a membrane-bound growth factor-like subunit, MUC4beta...
  9. Jung G, Helm R, Carraway C, Carraway K. Mechanism of concanavalin A-induced anchorage of the major cell surface glycoproteins to the submembrane cytoskeleton in 13762 ascites mammary adenocarcinoma cells. J Cell Biol. 1984;98:179-87 pubmed
    Concanavalin A (Con A)-induced anchorage of the major cell surface sialoglycoprotein component complex (ASGP-1/ASGP-2) was studied in 13762 rat mammary adenocarcinoma sublines with mobile (MAT-B1 subline) and immobile (MAT-C1 subline) ..

More Information

Publications57

  1. Rong M, Rossi E, Zhang J, McNeer R, Van Den Brande J, Yasin M, et al. Expression and localization of Muc4/sialomucin complex (SMC) in the adult and developing rat intestine: implications for Muc4/SMC function. J Cell Physiol. 2005;202:275-84 pubmed
    Muc4/sialomucin complex (SMC) is a high molecular mass heterodimeric membrane mucin, encoded by a single gene, and originally discovered in a highly metastatic ascites rat mammary adenocarcinoma...
  2. Fan├ža Berthon P, Michel C, Pagniez A, Rival M, Van Seuningen I, Darmaun D, et al. Intrauterine growth restriction alters postnatal colonic barrier maturation in rats. Pediatr Res. 2009;66:47-52 pubmed publisher
    ..After weaning, expression of mucin 2 (mRNA and protein) and mucin 4 (mRNA) were lower in colonic mucosa of rats with IUGR...
  3. Hanaoka J, Kontani K, Sawai S, Ichinose M, Tezuka N, Inoue S, et al. Analysis of MUC4 mucin expression in lung carcinoma cells and its immunogenicity. Cancer. 2001;92:2148-57 pubmed
    b>MUC4 has been cloned from tracheobronchial mucosa cDNA and reportedly is highly expressed in some human malignancies, including lung carcinoma. However, little is known about molecular and biologic characteristics...
  4. Miyahara N, Shoda J, Ishige K, Kawamoto T, Ueda T, Taki R, et al. MUC4 interacts with ErbB2 in human gallbladder carcinoma: potential pathobiological implications. Eur J Cancer. 2008;44:1048-56 pubmed publisher
    b>Muc4 interacts with erbB2 and potentiates tumourigenesis and/or tumour growth...
  5. Sheng Z, Wu K, Carraway K, Fregien N. Molecular cloning of the transmembrane component of the 13762 mammary adenocarcinoma sialomucin complex. A new member of the epidermal growth factor superfamily. J Biol Chem. 1992;267:16341-6 pubmed
    ..the 13762 rat mammary adenocarcinoma have a cell surface sialomucin complex composed of the sialomucin ascites sialoglycoprotein-1 (ASGP-1) and the membrane-associated glycoprotein ASGP-2...
  6. Yamauchi J, Kawai Y, Yamada M, Uchikawa R, Tegoshi T, Arizono N. Altered expression of goblet cell- and mucin glycosylation-related genes in the intestinal epithelium during infection with the nematode Nippostrongylus brasiliensis in rat. APMIS. 2006;114:270-8 pubmed
    ..Seven days post-infection and thereafter, when the nematodes reached maturity, significant upregulation of MUC3, MUC4, resistin-like molecule beta (Relmbeta) and 3O-sulfotransferase (3ST)1 was observed, while 3ST2 expression levels ..
  7. Sheng Z, Vanderpuye O, Hull S, Carraway C, Carraway K. Topography and microfilament core association of a cell surface glycoprotein of ascites tumor cell microvilli. J Cell Biochem. 1989;40:453-66 pubmed
    ..These microvilli are covered by a sialomucin complex, composed of the sialomucin ascites sialoglycoprotein-1 (ASGP-1) and the associated concanavalin A (Con A)-binding glycoprotein ASGP-2...
  8. Matull W, Andreola F, Loh A, Adiguzel Z, Deheragoda M, Qureshi U, et al. MUC4 and MUC5AC are highly specific tumour-associated mucins in biliary tract cancer. Br J Cancer. 2008;98:1675-81 pubmed publisher
    ..In pancreatic malignancy, MUC4 is a diagnostic and prognostic tumour marker, whereas MUC5AC has been proposed as a sensitive serological marker ..
  9. Kunert K, Keane Myers A, Spurr Michaud S, Tisdale A, Gipson I. Alteration in goblet cell numbers and mucin gene expression in a mouse model of allergic conjunctivitis. Invest Ophthalmol Vis Sci. 2001;42:2483-9 pubmed
    ..taken for relative quantitation of mRNA of the goblet cell mucin Muc5AC and the epithelial membrane-spanning mucin Muc4, by real-time RT-PCR...
  10. Tsutsumida H, Goto M, Kitajima S, Kubota I, Hirotsu Y, Wakimoto J, et al. MUC4 expression correlates with poor prognosis in small-sized lung adenocarcinoma. Lung Cancer. 2007;55:195-203 pubmed
    ..In this study, we evaluated the prognostic significance of the tracheal mucin MUC4 by immunohistochemical investigation of the expression profiles of MUC4, ErbB2, p27 and MUC1 in lung adenocarcinoma ..
  11. Price Schiavi S, Andrechek E, Idris N, Li P, Rong M, Zhang J, et al. Expression, location, and interactions of ErbB2 and its intramembrane ligand Muc4 (sialomucin complex) in rat mammary gland during pregnancy. J Cell Physiol. 2005;203:44-53 pubmed
    ..is a heterodimeric glycoprotein complex consisting of a peripheral O-glycosylated subunit ASGP-1 (ascites sialoglycoprotein-1) tightly but non-covalently bound to an N-glycosylated transmembrane subunit ASGP-2...
  12. Carraway K, Carvajal M, Li P, Carraway C. ErbB2 and its ligand Muc4 (sialomucin complex) in rat lacrimal gland. Adv Exp Med Biol. 2002;506:289-95 pubmed
    ..Though mucins are not generally considered a product of the lacrimal gland, our results clearly show Muc4/SMC is produced by the gland in soluble and membrane forms...
  13. Zhang J, Carraway C, Carraway K. Muc4 expression during blood vessel formation in damaged rat cornea. Curr Eye Res. 2006;31:1011-4 pubmed
    To determine the timing of Muc4 expression during the association of endothelial cells to form blood vessels in the rat corneal stroma after corneal wounding. Corneal damage was inflicted using brief cauterization with silver nitrite...
  14. Komatsu M, Carraway C, Fregien N, Carraway K. Reversible disruption of cell-matrix and cell-cell interactions by overexpression of sialomucin complex. J Biol Chem. 1997;272:33245-54 pubmed
    b>Sialomucin complex (SMC) is a large, heterodimeric glycoprotein complex composed of mucin (ASGP-1) and transmembrane (ASGP-2) subunits and expressed abundantly on the cell surface of ascites 13762 rat mammary adenocarcinoma cells...
  15. El Homsi M, Ducroc R, Claustre J, Jourdan G, Gertler A, Estienne M, et al. Leptin modulates the expression of secreted and membrane-associated mucins in colonic epithelial cells by targeting PKC, PI3K, and MAPK pathways. Am J Physiol Gastrointest Liver Physiol. 2007;293:G365-73 pubmed
    ..dose dependently increased the secretion of mucins (210 +/- 3% of controls) and the expression of Muc2, Muc3, and Muc4 (twofold basal level) but not of Muc1 and Muc5AC. Luminal perfusion of leptin (60 min, 0...
  16. Price Schiavi S, Carraway C, Fregien N, Carraway K. Post-transcriptional regulation of a milk membrane protein, the sialomucin complex (Ascites sialoglycoprotein (ASGP)-1/ASGP-2, rat muc4), by transforming growth factor beta. J Biol Chem. 1998;273:35228-37 pubmed
    ..complex (SMC, Rat Muc4) is a heterodimeric glycoprotein complex consisting of a mucin subunit ASGP-1 (ascites sialoglycoprotein-1) and a transmembrane subunit ASGP-2, which can act as a ligand for the receptor tyrosine kinase ErbB2...
  17. Kanno A, Satoh K, Kimura K, Hirota M, Umino J, Masamune A, et al. The expression of MUC4 and MUC5AC is related to the biologic malignancy of intraductal papillary mucinous neoplasms of the pancreas. Pancreas. 2006;33:391-6 pubmed
    ..Recently, MUC4 and MUC5AC expressions have been demonstrated to correlate with the unfavorable and the favorable prognosis of ..
  18. Soto P, Price Schiavi S, Carraway K. SMAD2 and SMAD7 involvement in the post-translational regulation of Muc4 via the transforming growth factor-beta and interferon-gamma pathways in rat mammary epithelial cells. J Biol Chem. 2003;278:20338-44 pubmed
    Muc4/sialomucin complex (SMC) is a heterodimeric glycoprotein complex derived from a single gene that is post-translationally processed into mucin (ASGP-1) and transmembrane (ASGP-2) subunits...
  19. Lin J, Tsuboi Y, Rimell F, Liu G, Toyama K, Kawano H, et al. Expression of mucins in mucoid otitis media. J Assoc Res Otolaryngol. 2003;4:384-93 pubmed
    ..In this study, we demonstrated that the MUC5B and MUC4 were major mucins in MOM that formed distinct treelike polymers (mucus strands)...
  20. Park H, Kim J, Kim G, Bae H, Crawley S, Yang S, et al. Aberrant expression of MUC3 and MUC4 membrane-associated mucins and sialyl Le(x) antigen in pancreatic intraepithelial neoplasia. Pancreas. 2003;26:e48-54 pubmed
    ..To examine the pattern of expression of membrane-associated mucins, MUC3 and MUC4, and a mucin-associated carbohydrate tumor antigen, sialyl Le(x), in these precursor lesions and ductal ..
  21. von Mensdorff Pouilly S, Gourevitch M, Kenemans P, Verstraeten A, Litvinov S, Van Kamp G, et al. Humoral immune response to polymorphic epithelial mucin (MUC-1) in patients with benign and malignant breast tumours. Eur J Cancer. 1996;32A:1325-31 pubmed
  22. Stringer A, Gibson R, Logan R, Bowen J, Yeoh A, Laurence J, et al. Irinotecan-induced mucositis is associated with changes in intestinal mucins. Cancer Chemother Pharmacol. 2009;64:123-32 pubmed publisher
    ..Goblet cells and mucin secretion were investigated, as well as mucin expression (Muc2 and Muc4) and kruppel-like factor (Klf) 4 using immunohistochemistry in the gastrointestinal tract...
  23. Tsuboi Y, Kim Y, Paparella M, Chen N, Schachern P, Lin J. Pattern changes of mucin gene expression with pneumococcal otitis media. Int J Pediatr Otorhinolaryngol. 2001;61:23-30 pubmed
    ..In the Eustachian tube, the Muc2, Muc4 and Muc5 mucin genes were expressed in both control and pneumococcal inoculation groups...
  24. Perez A, Barco R, Fernandez I, Price Schiavi S, Carraway K. PEA3 transactivates the Muc4/sialomucin complex promoter in mammary epithelial and tumor cells. J Biol Chem. 2003;278:36942-52 pubmed
    ..complex (SMC, rat Muc4) is a heterodimeric glycoprotein composed of two subunits, the mucin component ascites sialoglycoprotein ASGP-1 and the transmembrane subunit ASGP-2, which is aberrantly expressed on the surfaces of a variety ..
  25. Komatsu M, Tatum L, Altman N, Carothers Carraway C, Carraway K. Potentiation of metastasis by cell surface sialomucin complex (rat MUC4), a multifunctional anti-adhesive glycoprotein. Int J Cancer. 2000;87:480-6 pubmed
    b>Sialomucin complex (SMC), a rat homologue of the human mucin MUC4, is a large membrane-bound mucin complex, originally isolated from highly metastatic ascites 13762 mammary adenocarcinoma cells...
  26. McNeer R, Carraway C, Fregien N, Carraway K. Characterization of the expression and steroid hormone control of sialomucin complex in the rat uterus: implications for uterine receptivity. J Cell Physiol. 1998;176:110-9 pubmed
    ..sublines of a highly metastatic mammary adenocarcinoma, consists of a high Mr mucin subunit (ASGP-1, ascites sialoglycoprotein) and a transmembrane subunit (ASGP-2) with two epidermal growth factor-like domains...
  27. Rossi E, Komatsu M, Price Schiavi S, Huang D, Guy P, Carvajal M, et al. An intramembrane modulator of the ErbB2 receptor tyrosine kinase that potentiates neuregulin signaling. J Biol Chem. 1999;274:5263-6 pubmed
    ..These observations point to a novel intramembrane mechanism for the modulation of receptor tyrosine kinase activity. ..
  28. Mimeault M, Johansson S, Senapati S, Momi N, Chakraborty S, Batra S. MUC4 down-regulation reverses chemoresistance of pancreatic cancer stem/progenitor cells and their progenies. Cancer Lett. 2010;295:69-84 pubmed publisher
    The present study was undertaken to estimate the therapeutic benefit to down-regulate the MUC4 mucin for reversing chemoresistance of pancreatic cancer (PC) stem/progenitor cells and their progenies...
  29. Hu Y, Carvajal M, Carraway K. Sialomucin complex (rMuc4) expression during development of the rat cornea. Curr Eye Res. 2000;21:820-3 pubmed
    To determine changes in sialomucin complex (SMC, rat Muc4) expression in rat ocular surface tissue during development from birth to adult...
  30. Bharathan S, Moriarty J, Moody C, Sherblom A. Effect of tunicamycin on sialomucin and natural killer susceptibility of rat mammary tumor ascites cells. Cancer Res. 1990;50:5250-6 pubmed
    ..adenocarcinoma contain a dominant cell surface "complex" consisting of two glycoproteins: ascites sialoglycoprotein (ASGP)-1, a Mr 600,000-700,000 peanut agglutinin-binding sialomucin, and ASGP-2, a Mr 120,000 ..
  31. Song X, Li D, Farley W, Luo L, Heuckeroth R, Milbrandt J, et al. Neurturin-deficient mice develop dry eye and keratoconjunctivitis sicca. Invest Ophthalmol Vis Sci. 2003;44:4223-9 pubmed
    ..Neurturin-deficient (NRTN(-/-)) mice have defective parasympathetic innervation of their lacrimal glands. This study was conducted to evaluate tear function and ocular surface phenotype in NRTN(-/-) mice...
  32. Komatsu M, Arango M, Carraway K. Synthesis and secretion of Muc4/sialomucin complex: implication of intracellular proteolysis. Biochem J. 2002;368:41-8 pubmed
    Muc4/sialomucin complex (SMC) is a heterodimeric glycoprotein complex implicated in epithelial protection and overexpressed in some tumours...
  33. Tei M, Spurr Michaud S, Tisdale A, Gipson I. Vitamin A deficiency alters the expression of mucin genes by the rat ocular surface epithelium. Invest Ophthalmol Vis Sci. 2000;41:82-8 pubmed
    To study effects of depletion of retinoic acid on expression of the mucins ASGP (rMuc4), rMuc5AC, and rMuc1, by the corneal and conjunctival epithelia of the rat...
  34. Komatsu M, Yee L, Carraway K. Overexpression of sialomucin complex, a rat homologue of MUC4, inhibits tumor killing by lymphokine-activated killer cells. Cancer Res. 1999;59:2229-36 pubmed
    Sialomucin complex (SMC) is a large heterodimeric glycoprotein complex composed of a mucin subunit ascites sialoglycoprotein-1 and a transmembrane subunit ascites sialoglycoprotein-2...
  35. Lomako J, Lomako W, Decker S, Carraway C, Carraway K. Non-apoptotic desquamation of cells from corneal epithelium: putative role for Muc4/sialomucin complex in cell release and survival. J Cell Physiol. 2005;202:115-24 pubmed
    Muc4/sialomucin complex (SMC), a large heterodimeric mucin composed of an extracellular mucin subunit ASGP-1 and a transmembrane subunit ASGP-2, is present at the rat ocular surface localized mainly to the most superficial layers of the ..
  36. Wasserberg N, Salgar S, Yang D, Ruiz P, Ho S, De Faria W, et al. Expression of MUC2 and MUC4 proteins and cytokines: early markers of intestinal graft rejection. Transplantation. 2003;75:1249-55 pubmed
    ..HP was performed on hematoxylin-eosin and periodic acid Schiff-stained sections. Expression of MUC2 and MUC4 proteins and of mRNA was detected by immunohistochemistry and Northern analysis, respectively...
  37. Zhu X, Price Schiavi S, Carraway K. Extracellular regulated kinase (ERK)-dependent regulation of sialomucin complex/rat Muc4 in mammary epithelial cells. Oncogene. 2000;19:4354-61 pubmed
    b>Sialomucin complex (SMC, rat Muc4) is a membrane mucin implicated in the protection of epithelia and the metastasis of some tumors...
  38. Wu K, Fregien N, Carraway K. Molecular cloning and sequencing of the mucin subunit of a heterodimeric, bifunctional cell surface glycoprotein complex of ascites rat mammary adenocarcinoma cells. J Biol Chem. 1994;269:11950-5 pubmed
    ..amounts of a heterodimeric cell surface glycoprotein complex composed of a mucin subunit ASGP-1 (ascites sialoglycoprotein-1) and a transmembrane subunit (ASGP-2)...
  39. Hasnain S, Thornton D, Grencis R. Changes in the mucosal barrier during acute and chronic Trichuris muris infection. Parasite Immunol. 2011;33:45-55 pubmed publisher
    ..muris, with an increase in Muc4, Muc13 and Muc17...
  40. Lomako J, Lomako W, Carothers Carraway C, Carraway K. Regulation of the membrane mucin Muc4 in corneal epithelial cells by proteosomal degradation and TGF-beta. J Cell Physiol. 2010;223:209-14 pubmed publisher
    b>MUC4 is a heterodimeric membrane mucin, composed of a mucin subunit ASGP-1 (MUC4alpha) and a transmembrane subunit ASGP-2 (MUC4beta), which has been implicated in the protection of epithelial cell surfaces...
  41. Tian F, Cheng L, Li D, Liu Z, Zeng Y, Xu J, et al. Downregulation of mucins in graft bile ducts after liver transplantation in rats. Transplantation. 2011;92:529-35 pubmed publisher
    ..Nonanastomotic biliary strictures represent a serious complication after orthotopic liver transplantation (OLT). This study investigates the potential role of mucins in bile duct injury after OLT...
  42. Moehle C, Ackermann N, Langmann T, Aslanidis C, Kel A, Kel Margoulis O, et al. Aberrant intestinal expression and allelic variants of mucin genes associated with inflammatory bowel disease. J Mol Med (Berl). 2006;84:1055-66 pubmed
    ..003) polymorphism with CD and for MUC4-A585S (P = 0.025), as well as MUC13-R502S (P = 0.0003) with UC...
  43. Lomako W, Lomako J, Soto P, Carraway C, Carraway K. TGFbeta regulation of membrane mucin Muc4 via proteosome degradation. J Cell Biochem. 2009;107:797-802 pubmed publisher
    b>Muc4 is a heterodimeric membrane mucin implicated in epithelial differentiation and tumor progression. It is expressed from a single gene as a 300 kDa precursor protein which is cleaved in the endoplasmic reticulum to its two subunits...
  44. Price Schiavi S, Perez A, Barco R, Carraway K. Cloning and characterization of the 5' flanking region of the sialomucin complex/rat Muc4 gene: promoter activity in cultured cells. Biochem J. 2000;349:641-9 pubmed
    Sialomucin complex (SMC/Muc4) is a heterodimeric glycoprotein complex consisting of a mucin subunit ascites sialoglycoprotein-1 (ASGP-1) and a transmembrane subunit (ASGP-2), which is aberrantly expressed on the surfaces of a variety of ..
  45. Workman H, Sweeney C, Carraway K. The membrane mucin Muc4 inhibits apoptosis induced by multiple insults via ErbB2-dependent and ErbB2-independent mechanisms. Cancer Res. 2009;69:2845-52 pubmed publisher
    The aberrant expression of membrane mucins such as Muc1 and Muc4 by tumor cells has been shown to engage signaling pathways that promote cellular properties associated with tumor progression...
  46. Yeh C, Pang S, Wu R, Chen T, Jan Y, Chen M. Prognostic value of MUC4 for mass-forming intrahepatic cholangiocarcinoma after hepatectomy. Oncol Rep. 2009;21:49-56 pubmed
    ..Fifteen clinicopathological variables (including MUC4 staining status) were used for survival analysis. MUC 4 is overexpressed in rat CCA...
  47. Dogru M, Okada N, Asano Kato N, Igarashi A, Fukagawa K, Shimazaki J, et al. Alterations of the ocular surface epithelial mucins 1, 2, 4 and the tear functions in patients with atopic keratoconjunctivitis. Clin Exp Allergy. 2006;36:1556-65 pubmed
  48. Li X, Xiong J, Wang C. [Clinical significance of the expression of MUC4 mRNA in peripheral blood mononuclear cells of pancreatic cancer patients]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2005;27:624-7 pubmed
    To explore the expression and clinical significance of MUC4 mRNA in peripheral blood mononuclear cells of pancreatic cancer patients...