Gene Symbol: Muc3
Description: mucin 3, intestinal
Alias: Muc3a, LOW QUALITY PROTEIN: mucin-12, mucin 3, intestinal, mucin-12, mucin-17, Mucin3, mucin 3A, cell surface associated
Species: rat

Top Publications

  1. Yamauchi J, Kawai Y, Yamada M, Uchikawa R, Tegoshi T, Arizono N. Altered expression of goblet cell- and mucin glycosylation-related genes in the intestinal epithelium during infection with the nematode Nippostrongylus brasiliensis in rat. APMIS. 2006;114:270-8 pubmed
    ..Seven days post-infection and thereafter, when the nematodes reached maturity, significant upregulation of MUC3, MUC4, resistin-like molecule beta (Relmbeta) and 3O-sulfotransferase (3ST)1 was observed, while 3ST2 expression ..
  2. Khatri I, Forstner G, Forstner J. The carboxyl-terminal sequence of rat intestinal mucin RMuc3 contains a putative transmembrane region and two EGF-like motifs. Biochim Biophys Acta. 1997;1326:7-11 pubmed
    ..technique was used to establish the nucleotide sequence encoding the C-terminal 379 amino acids of rat intestinal Muc3. Unlike the C-terminus of Muc2 and many secretory mucins, Muc3 contains two EGF motifs and a putative transmembrane ..
  3. Park H, Kim J, Kim G, Bae H, Crawley S, Yang S, et al. Aberrant expression of MUC3 and MUC4 membrane-associated mucins and sialyl Le(x) antigen in pancreatic intraepithelial neoplasia. Pancreas. 2003;26:e48-54 pubmed
    ..To examine the pattern of expression of membrane-associated mucins, MUC3 and MUC4, and a mucin-associated carbohydrate tumor antigen, sialyl Le(x), in these precursor lesions and ductal ..
  4. Lan A, Andriamihaja M, Blouin J, Liu X, Descatoire V, Desclée de Maredsous C, et al. High-protein diet differently modifies intestinal goblet cell characteristics and mucosal cytokine expression in ileum and colon. J Nutr Biochem. 2015;26:91-8 pubmed publisher
    ..cells at the epithelial surface but increased goblet cell number in colonic crypts together with an increased Muc3 and a slight reduction of Il-6 gene expression...
  5. Pelaseyed T, Gustafsson J, Gustafsson I, Ermund A, Hansson G. Carbachol-induced MUC17 endocytosis is concomitant with NHE3 internalization and CFTR membrane recruitment in enterocytes. Am J Physiol Cell Physiol. 2013;305:C457-67 pubmed publisher
    ..MUC17 and transmembrane mucins MUC3 and MUC12 are suggested to build the enterocyte apical glycocalyx...
  6. He Y, Li Y, Peng Z, Yu H, Zhang X, Chen L, et al. Role of N-glycosylation of the SEA module of rodent Muc3 in posttranslational processing of its carboxy-terminal domain. Glycobiology. 2009;19:1094-102 pubmed publisher
    A prominent feature of the rodent Muc3 SEA module is the precursor cleavage event that segregates the O-glycosylated N-terminal fragment and transmembrane domain into the noncovalently attached heterodimer...
  7. Tian F, Cheng L, Li D, Liu Z, Zeng Y, Xu J, et al. Downregulation of mucins in graft bile ducts after liver transplantation in rats. Transplantation. 2011;92:529-35 pubmed publisher
    ..Nonanastomotic biliary strictures represent a serious complication after orthotopic liver transplantation (OLT). This study investigates the potential role of mucins in bile duct injury after OLT...
  8. El Homsi M, Ducroc R, Claustre J, Jourdan G, Gertler A, Estienne M, et al. Leptin modulates the expression of secreted and membrane-associated mucins in colonic epithelial cells by targeting PKC, PI3K, and MAPK pathways. Am J Physiol Gastrointest Liver Physiol. 2007;293:G365-73 pubmed
    ..60 min) dose dependently increased the secretion of mucins (210 +/- 3% of controls) and the expression of Muc2, Muc3, and Muc4 (twofold basal level) but not of Muc1 and Muc5AC. Luminal perfusion of leptin (60 min, 0...
  9. Li F, Cheng N, Cheng J, Mao H, Zhou Y, Jiang L, et al. Proliferating cell nuclear antigen shRNA treatment attenuates chronic proliferative cholangitis in rats. J Gastroenterol Hepatol. 2009;24:920-6 pubmed publisher
    ..PCNA shRNA-1 treatment could effectively inhibit the hyperplastic behavior and lithogenic potentiality of CPC, which might facilitate the prevention of stone recurrence and biliary restenosis. ..

More Information


  1. Lee K, Liu T. Altered mucin gene expression in stone-containing intrahepatic bile ducts and cholangiocarcinomas. Dig Dis Sci. 2001;46:2166-72 pubmed
    ..intrahepatic bile ducts, cholangiocarcinomas, and normal controls to identify the expression of MUC2, MUC3, MUC4, MUC5B, and MUC5AC in nonneoplastic and neoplastic biliary epithelium...
  2. Khatri I, Wang R, Forstner J. Evidence for a second peptide cleavage in the C-terminal domain of rodent intestinal mucin Muc3. Biochem J. 2004;378:207-12 pubmed
    Rat intestinal mucin Muc3 (rMuc3), like its human homologue (MUC3) and several other membrane mucins, contains a C-terminally located SEA (sea urchin sperm protein, enterokinase and agrin) module, with an intrinsic proteolytic site ..
  3. Algieri F, Zorrilla P, Rodríguez Nogales A, Garrido Mesa N, Banuelos O, González Tejero M, et al. Intestinal anti-inflammatory activity of hydroalcoholic extracts of Phlomis purpurea L. and Phlomis lychnitis L. in the trinitrobenzenesulphonic acid model of rat colitis. J Ethnopharmacol. 2013;146:750-9 pubmed publisher
    ..purpurea in the trinitrobenzenesulphonic acid (TNBS) model of rat colitis, a well characterized experimental model with some resemblance to human IBD...
  4. Ito H, Satsukawa M, Arai E, Sugiyama K, Sonoyama K, Kiriyama S, et al. Soluble fiber viscosity affects both goblet cell number and small intestine mucin secretion in rats. J Nutr. 2009;139:1640-7 pubmed publisher
    ..98; P < 0.01). In rats fed the HKM diet, ileal Muc2 gene expression was not affected, but that of Muc3 was lower than in those fed the control diet, indicating that the increase in luminal mucins after ingestion of HKM ..
  5. Khatri I, Ho C, Specian R, Forstner J. Characteristics of rodent intestinal mucin Muc3 and alterations in a mouse model of human cystic fibrosis. Am J Physiol Gastrointest Liver Physiol. 2001;280:G1321-30 pubmed
    Human mucin MUC3 and rodent Muc3 are widely assumed to represent secretory mucins expressed in columnar and goblet cells of the intestine...
  6. Li Y, Peng Z, He Y, Chen W, Bian X, Fang D, et al. Contribution of the conservative cleavage motif to posttranslational processing of the carboxyl terminal domain of rodent Muc3. Mol Cell Biochem. 2008;313:155-66 pubmed publisher
  7. Gum J, Hicks J, Lagace R, Byrd J, Toribara N, Siddiki B, et al. Molecular cloning of rat intestinal mucin. Lack of conservation between mammalian species. J Biol Chem. 1991;266:22733-8 pubmed
    ..Thus, the repetitive portions of intestinal mucin genes are apparently not well conserved between phylogenetically distant species. ..
  8. Xie Y, Liu S, Liu X, Luo Z, Zhu B, Li Z, et al. Intestinal microbiota and innate immunity-related gene alteration in cirrhotic rats with liver transplantation. Transplant Proc. 2011;43:3973-9 pubmed publisher
    ..05). Mucins (MUC2, MUC3) and Toll-like receptors (TLR2, TLR4) messenger RNA (mRNA) expression were significantly higher in the LC and LTC ..
  9. Dharmani P, Leung P, Chadee K. Tumor necrosis factor-? and Muc2 mucin play major roles in disease onset and progression in dextran sodium sulphate-induced colitis. PLoS ONE. 2011;6:e25058 pubmed publisher the expression of regulatory cytokines (40-fold for IL-10 and TGF?) and mucin genes (15-18 fold for Muc2 and Muc3) concomitant with depletion of goblet cell and adherent mucin...
  10. Amit Romach E, Reifen R, Uni Z. Mucosal function in rat jejunum and ileum is altered by induction of colitis. Int J Mol Med. 2006;18:721-7 pubmed
    ..The relative amount of MUC2 mRNA decreased in the jejunum, ileum and colon of colitis rat. However, MUC3 mRNA expression increased in the ileum and colon of these rats...
  11. Amit Romach E, Uni Z, Cheled S, Berkovich Z, Reifen R. Bacterial population and innate immunity-related genes in rat gastrointestinal tract are altered by vitamin A-deficient diet. J Nutr Biochem. 2009;20:70-7 pubmed publisher
    ..area relative to controls; decreased MUC2 mRNA expression in the jejunum, ileum and colon of VAD rats and increased MUC3 mRNA expression in the ileum and colon of these rats...
  12. Tsuboi Y, Kim Y, Paparella M, Chen N, Schachern P, Lin J. Pattern changes of mucin gene expression with pneumococcal otitis media. Int J Pediatr Otorhinolaryngol. 2001;61:23-30 pubmed
    ..Muc1, Muc3, Muc4, and Muc5 mucin genes were activated in the middle ear mucosa by pneumococci, which may contribute to hyper-..