Muc1

Summary

Gene Symbol: Muc1
Description: mucin 1, cell surface associated
Alias: mucin-1, Mucin1, mucin 1, transmembrane
Species: rat
Products:     Muc1

Top Publications

  1. Yamato T, Sasaki M, Watanabe Y, Nakanuma Y. Expression of MUC1 and MUC2 mucin core proteins and their messenger RNA in gall bladder carcinoma: an immunohistochemical and in situ hybridization study. J Pathol. 1999;188:30-7 pubmed
    Expression of mucin core protein MUC1 and MUC2 was examined at the protein and mRNA level in 55 cases of carcinoma and 20 of dysplasia, and in 15 non-dysplastic epithelia of the gall bladder...
  2. Kawaoka T, Oka M, Takashima M, Ueno T, Yamamoto K, Yahara N, et al. Adoptive immunotherapy for pancreatic cancer: cytotoxic T lymphocytes stimulated by the MUC1-expressing human pancreatic cancer cell line YPK-1. Oncol Rep. 2008;20:155-63 pubmed
    b>MUC1 is a tumor-associated antigen that is overexpressed in invasive ductal carcinomas of the pancreas (PC). MUC1-specific cytotoxic T lymphocytes (CTLs) recognize MUC1 molecules in a HLA-unrestricted manner...
  3. Kawasaki Y, Aoyagi Y, Abe Y, Go H, Imamura T, Kaneko M, et al. Serum KL-6 levels as a biomarker of lung injury in respiratory syncytial virus bronchiolitis. J Med Virol. 2009;81:2104-8 pubmed publisher
    ..These findings suggest that serum KL-6 is associated with the severity of RSV bronchiolitis and that it may be a useful biomarker for the severity of RSV bronchiolitis. ..
  4. Al Salmi Q, Walter J, Colasurdo G, Sockrider M, Smith E, Takahashi H, et al. Serum KL-6 and surfactant proteins A and D in pediatric interstitial lung disease. Chest. 2005;127:403-7 pubmed
    ..05). There was a direct relationship between SP-D and ILD score (p = 0.05). Serum KL-6, SP-D and SP-D levels are elevated in children with ILD. SP-A and SP-D levels appear to correlate with some measures of disease severity. ..
  5. Park S, Roh S, Kim Y, Kim S, Park H, Jang K, et al. Expression of MUC1, MUC2, MUC5AC and MUC6 in cholangiocarcinoma: prognostic impact. Oncol Rep. 2009;22:649-57 pubmed
    ..The aim of this study was to determine the relationship between the expression of MUC1, MUC2, MUC5AC and MUC6 in cholangiocarcinoma and clinicopathological parameters as well as patient survival...
  6. Guzman K, Bader T, Nettesheim P. Regulation of MUC5 and MUC1 gene expression: correlation with airway mucous differentiation. Am J Physiol. 1996;270:L846-53 pubmed
    ..Furthermore, we demonstrate the coordinate regulation of the expression of MUC5 and MUC1 (a membrane-bound mucin) and mucous differentiation...
  7. Imai T, Takase M, Takeda S, Kougo T. Serum KL-6 levels in pediatric patients: reference values for children and levels in pneumonia, asthma, and measles patients. Pediatr Pulmonol. 2002;33:135-41 pubmed
    ..However, in order to use serum KL-6 as a marker of interstitial lung diseases in children, a cutoff level should be determined separately. ..
  8. Ohshimo S, Bonella F, Grammann N, Starke K, Cui A, Bauer P, et al. Serum KL-6 as a novel disease marker in adolescent and adult cystic fibrosis. Sarcoidosis Vasc Diffuse Lung Dis. 2009;26:47-53 pubmed
    ..Serum levels of KL-6, high molecular weight human MUC1 mucin, are increased in the majority of patients with various interstitial lung disorders...
  9. Kawamoto T, Shoda J, Miyahara N, Suzuki H, Furukawa M, Todoroki T, et al. Expression of MUC1 recognized by a monoclonal antibody MY.1E12 is a useful biomarker for tumor aggressiveness of carcinoma of the gallbladder. Clin Exp Metastasis. 2004;21:353-62 pubmed
    ..A high-level expression of MUC1 recognized by a monoclonal antibody (mAb), MY.1E12, is correlated with poor survival in several types of carcinomas...

More Information

Publications62

  1. Lepisto A, Moser A, Zeh H, Lee K, Bartlett D, McKolanis J, et al. A phase I/II study of a MUC1 peptide pulsed autologous dendritic cell vaccine as adjuvant therapy in patients with resected pancreatic and biliary tumors. Cancer Ther. 2008;6:955-964 pubmed
    ..b>MUC1 is an epithelial cell glycoprotein that is highly overexpressed and aberrantly glycosylated in many adenocarcinomas,..
  2. Dorai T, Fishman A, Ding C, Batinic Haberle I, Goldfarb D, Grasso M. Amelioration of renal ischemia-reperfusion injury with a novel protective cocktail. J Urol. 2011;186:2448-54 pubmed publisher
    ..According to histopathological and several molecular measures our unique renoprotective cocktail mitigated ischemia-reperfusion injury. ..
  3. Walter J, Fan L, Bag R, Zhang H, Doan M, Mallory G, et al. Serum KL-6 as a marker for bronchiolitis obliterans syndrome after lung transplantation. Transplantation. 2006;82:709-11 pubmed
    ..Our results indicate that serum KL-6 measurement has the potential to serve as a noninvasive diagnostic test for the detection of BO in lung transplant recipients. ..
  4. Kashiwagi H, Kijima H, Dowaki S, Ohtani Y, Tobita K, Yamazaki H, et al. MUC1 and MUC2 expression in human gallbladder carcinoma: a clinicopathological study and relationship with prognosis. Oncol Rep. 2001;8:485-9 pubmed
    ..To date, nine apomucins (MUC1-8, and MUC5B) have been identified...
  5. Yamasaki H, Ikeda S, Okajima M, Miura Y, Asahara T, Kohno N, et al. Expression and localization of MUC1, MUC2, MUC5AC and small intestinal mucin antigen in pancreatic tumors. Int J Oncol. 2004;24:107-13 pubmed
    ..We analyzed the expression and localization of MUC1, MUC2, MUC5AC and small intestinal mucin antigen (SIMA) in pancreatic tumors...
  6. Kardon R, Price R, Julian J, Lagow E, Tseng S, Gendler S, et al. Bacterial conjunctivitis in Muc1 null mice. Invest Ophthalmol Vis Sci. 1999;40:1328-35 pubmed
    In contrast to wild-type mice, genetically engineered Mucin1 (Muc1) null animals display a marked propensity for development of blepharitis and conjunctivitis...
  7. Wei X, Xu H, Kufe D. Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response. Cancer Cell. 2005;7:167-78 pubmed
    The MUC1 oncoprotein is aberrantly overexpressed by most human carcinomas. The present work demonstrates that MUC1 associates with the p53 tumor suppressor, and that this interaction is increased by genotoxic stress...
  8. Kondo H, Hazama S, Kawaoka T, Yoshino S, Yoshida S, Tokuno K, et al. Adoptive immunotherapy for pancreatic cancer using MUC1 peptide-pulsed dendritic cells and activated T lymphocytes. Anticancer Res. 2008;28:379-87 pubmed
    ..Pancreatic cancer has a poor prognosis. The clinical efficacy of immunotherapy using both dendritic cells pulsed with MUC1 peptide (MUC1-DC) and, cytotoxic T lymphocyte (CTL) sensitized with a pancreatic cancer, YPK-1, expressing MUC1 (..
  9. Beckerman R, Prives C. Transcriptional regulation by p53. Cold Spring Harb Perspect Biol. 2010;2:a000935 pubmed publisher
    ..How p53 is able to discriminate between these different loci is the subject of intense research. Here, we describe key aspects of the fundamentals of p53-mediated transcriptional regulation and target gene promoter selectivity. ..
  10. Kitamura H, Yonezawa S, Tanaka S, Kim Y, Sato E. Expression of mucin carbohydrates and core proteins in carcinomas of the ampulla of Vater: their relationship to prognosis. Jpn J Cancer Res. 1996;87:631-40 pubmed
    ..in mucin glycosylation (Tn and sialosyl-Tn) and the expression of the mucin core protein antigens associated with MUC1 gene product (DF3 antigen) as well as MUC2 gene product (intestinal-MRP antigen) in tissues from 38 patients with ..
  11. Pierreux C, Poll A, Kemp C, Clotman F, Maestro M, Cordi S, et al. The transcription factor hepatocyte nuclear factor-6 controls the development of pancreatic ducts in the mouse. Gastroenterology. 2006;130:532-41 pubmed
    ..HNF-6 controls a network of genes involved in cilium formation and in hereditary polycystic diseases. Finally, HNF-6 deficiency represents a genetically defined model of pancreatic cystic disease. ..
  12. Imbert Y, Foulks G, Brennan M, Jumblatt M, John G, Shah H, et al. MUC1 and estrogen receptor alpha gene polymorphisms in dry eye patients. Exp Eye Res. 2009;88:334-8 pubmed publisher
    ..We reported that the frequency of non-Sjögren's aqueous-deficient dry eye patients expressing only the MUC1/A splice variant of the mucin MUC1 may be lower than that of a normal control group [Imbert, Y., Darling, D.S...
  13. Kirby A, Gnirke A, Jaffe D, Baresova V, Pochet N, Blumenstiel B, et al. Mutations causing medullary cystic kidney disease type 1 lie in a large VNTR in MUC1 missed by massively parallel sequencing. Nat Genet. 2013;45:299-303 pubmed publisher
    ..5-5 kb), GC-rich (>80%) coding variable-number tandem repeat (VNTR) sequence in the MUC1 gene encoding mucin 1. These results provide a cautionary tale about the challenges in identifying the genes responsible for mendelian, ..
  14. Kinoshita F, Hamano H, Harada H, Kinoshita T, Igishi T, Hagino H, et al. Role of KL-6 in evaluating the disease severity of rheumatoid lung disease: comparison with HRCT. Respir Med. 2004;98:1131-7 pubmed
    ..KL-6 is a useful marker to detect severe RA lung disease. It is also useful to distinguish non-fibrosis from fibrosis predominant cases. However, it sometimes could not detect early stage RA lung disease. ..
  15. Fança Berthon P, Michel C, Pagniez A, Rival M, Van Seuningen I, Darmaun D, et al. Intrauterine growth restriction alters postnatal colonic barrier maturation in rats. Pediatr Res. 2009;66:47-52 pubmed publisher
    ..The lack of an efficient colonic barrier induced by IUGR may predispose to colonic injury not only in neonatal life but also in later life. ..
  16. Janssen R, Grutters J, Sato H, van Velzen Blad H, Zanen P, Kohno N, et al. Analysis of KL-6 and SP-D as disease markers in bird fancier's lung. Sarcoidosis Vasc Diffuse Lung Dis. 2005;22:51-7 pubmed
    ..Since higher levels are associated with more severe lung function impairment at presentation, and better recovery over time, we postulate that in this disease they are especially markers of disease activity. ..
  17. Kaufman H, Kim Schulze S, Manson K, DeRaffele G, Mitcham J, Seo K, et al. Poxvirus-based vaccine therapy for patients with advanced pancreatic cancer. J Transl Med. 2007;5:60 pubmed
    ..1 vs 3.9 months, respectively; P = .002). Poxvirus vaccination is safe, well tolerated, and capable of generating antigen-specific immune responses in patients with advanced pancreatic cancer. ..
  18. Ye Q, Yan Z, Liao X, Li Y, Yang J, Sun J, et al. MUC1 induces metastasis in esophageal squamous cell carcinoma by upregulating matrix metalloproteinase 13. Lab Invest. 2011;91:778-87 pubmed publisher
    ..Given the associations of MUC1 with ESCC and tumor metastasis, we explored a potential role of MUC1 in ESCC metastasis...
  19. Wesseling J, van der Valk S, Vos H, Sonnenberg A, Hilkens J. Episialin (MUC1) overexpression inhibits integrin-mediated cell adhesion to extracellular matrix components. J Cell Biol. 1995;129:255-65 pubmed
    Episialin (MUC1) is a transmembrane molecule with a large mucin-like extracellular domain protruding high above the cell surface...
  20. Tang W, Inagaki Y, Kokudo N, Guo Q, Seyama Y, Nakata M, et al. KL-6 mucin expression in carcinoma of the ampulla of Vater: association with cancer progression. World J Gastroenterol. 2005;11:5450-4 pubmed
    ..010). Survival analysis showed that positive expression of KL-6 was related to a poorer prognosis (P = 0.029). The aberrant expression of KL-6 mucin is significantly related to unfavorable behaviors of carcinoma of the ampulla of Vater. ..
  21. Sirica A, Zhang Z, Lai G, Asano T, Shen X, Ward D, et al. A novel "patient-like" model of cholangiocarcinoma progression based on bile duct inoculation of tumorigenic rat cholangiocyte cell lines. Hepatology. 2008;47:1178-90 pubmed
    ..b>Mucin 1 (MUC1) messenger RNA (mRNA), an indicator of cholangiocarcinoma cell progression, was also significantly ..
  22. Mukherjee P, Basu G, Tinder T, Subramani D, Bradley J, Arefayene M, et al. Progression of pancreatic adenocarcinoma is significantly impeded with a combination of vaccine and COX-2 inhibition. J Immunol. 2009;182:216-24 pubmed
    ..In this study, we show that a novel Mucin-1 (MUC1)-based vaccine in combination with a cyclooxygenase-2 inhibitor (celecoxib), and low-dose chemotherapy (gemcitabine)..
  23. Chen J, Liu J, An J. [Expressions of Sca-1, CD24 and Muc1 in quiescent mammary glands of female rats]. Nan Fang Yi Ke Da Xue Xue Bao. 2007;27:488-91 pubmed
    To investigate the expressions of the stem cell antigen-1 (Sca-1), Mucin1 (Muc1) and CD24 in quiescent mammary glands of female rats...
  24. Tian F, Cheng L, Li D, Liu Z, Zeng Y, Xu J, et al. Downregulation of mucins in graft bile ducts after liver transplantation in rats. Transplantation. 2011;92:529-35 pubmed publisher
    ..Nonanastomotic biliary strictures represent a serious complication after orthotopic liver transplantation (OLT). This study investigates the potential role of mucins in bile duct injury after OLT...
  25. Ghosh S, Uchida M, Yoo B, Ross A, Gendler S, Gong J, et al. Targeted imaging of breast tumor progression and therapeutic response in a human uMUC-1 expressing transgenic mouse model. Int J Cancer. 2013;132:1860-7 pubmed publisher
    ..Our study could provide a very sensitive molecular imaging approach for monitoring tumor progression and therapeutic response. ..
  26. Janssen R, Sato H, Grutters J, Bernard A, van Velzen Blad H, du Bois R, et al. Study of Clara cell 16, KL-6, and surfactant protein-D in serum as disease markers in pulmonary sarcoidosis. Chest. 2003;124:2119-25 pubmed
    ..Both CC16 and KL-6 may be of value in reflecting disease severity, and KL-6 tends to associate with pulmonary disease outcome. ..
  27. Kim D, Kim H, Shim S, Lee J, Choi C, Kim E, et al. Cord blood KL-6, a specific lung injury marker, correlates with the subsequent development and severity of atypical bronchopulmonary dysplasia. Neonatology. 2008;93:223-9 pubmed
    ..502, p = 0.024). The present study shows that cord plasma KL-6, a specific lung injury marker, is increased and objectively reflects disease severity in atypical BPD. ..
  28. Tsutsumida H, Swanson B, Singh P, Caffrey T, Kitajima S, Goto M, et al. RNA interference suppression of MUC1 reduces the growth rate and metastatic phenotype of human pancreatic cancer cells. Clin Cancer Res. 2006;12:2976-87 pubmed
    b>MUC1 is a highly glycosylated, type I transmembrane protein expressed by normal ductal epithelial cells of the pancreas, breast, lung, and gastrointestinal tract, and overexpressed in many cases of adenocarcinoma...
  29. Xu H, Inagaki Y, Tang W, Guo Q, Wang F, Seyama Y, et al. Elevation of serum KL-6 mucin levels in patients with cholangiocarcinoma. Hepatogastroenterology. 2008;55:2000-4 pubmed
    KL-6 mucin is a type of MUC1 mucin. Previous immunohistochemical studies by the authors revealed that, in liver cancer tissues, KL-6 mucin expressed only in intrahepatic cholangiocarcinoma (CC) but not in hepatocellular carcinoma (HCC)...
  30. Lederer D, Jelic S, Basner R, Ishizaka A, Bhattacharya J. Circulating KL-6, a biomarker of lung injury, in obstructive sleep apnoea. Eur Respir J. 2009;33:793-6 pubmed publisher
    ..Circulating KL-6 levels are elevated in some patients with obstructive sleep apnoea, possibly reflecting increased alveolar wall permeability. ..
  31. Tsuboi Y, Kim Y, Paparella M, Chen N, Schachern P, Lin J. Pattern changes of mucin gene expression with pneumococcal otitis media. Int J Pediatr Otorhinolaryngol. 2001;61:23-30 pubmed
    ..the Muc2 mucin gene was expressed in middle ear mucosa of the control rats. Following pneumococcal inoculation, Muc1-Muc5 mucin genes were expressed in the middle ear mucosa in a time-dependent manner...
  32. Aubert S, Fauquette V, Hemon B, Lepoivre R, Briez N, Bernard D, et al. MUC1, a new hypoxia inducible factor target gene, is an actor in clear renal cell carcinoma tumor progression. Cancer Res. 2009;69:5707-15 pubmed publisher
    The hypoxia inducible factor (HIF) signaling pathway is known as the main renal carcinogenetic pathway. MUC1, an O-glycoprotein membrane-bound mucin, is overexpressed in clear renal cell carcinomas (cRCC) with correlation to two major ..
  33. Nguyen G, Hwang B, Zhang Y, Monahan J, Davis G, Lee Y, et al. Novel biomarkers of arterial and venous ischemia in microvascular flaps. PLoS ONE. 2013;8:e71628 pubmed publisher
    ..qRT-PCR was used to identify five candidate genes Prol1, Muc1, Fcnb, Il1b, and Vcsa1 to serve as biomarkers for flap failure in both arterial ischemia and venous congestion...
  34. Kohlgraf K, Gawron A, Higashi M, Meza J, Burdick M, Kitajima S, et al. Contribution of the MUC1 tandem repeat and cytoplasmic tail to invasive and metastatic properties of a pancreatic cancer cell line. Cancer Res. 2003;63:5011-20 pubmed
    b>MUC1 is a polymorphic, highly glycosylated, type I transmembrane protein expressed by ductal epithelial cells of many organs including pancreas, breast, gastrointestinal tract, and airway...
  35. von Mensdorff Pouilly S, Gourevitch M, Kenemans P, Verstraeten A, Litvinov S, Van Kamp G, et al. Humoral immune response to polymorphic epithelial mucin (MUC-1) in patients with benign and malignant breast tumours. Eur J Cancer. 1996;32A:1325-31 pubmed
  36. Jan Y, Yeh T, Yeh J, Yang H, Chen M. Expression of epidermal growth factor receptor, apomucins, matrix metalloproteinases, and p53 in rat and human cholangiocarcinoma: appraisal of an animal model of cholangiocarcinoma. Ann Surg. 2004;240:89-94 pubmed
    ..Expression of epidermal growth factor receptor (EGFR), MUC1, MUC2, MUC5AC, MMP-2, MMP-9, and p53 in both human and experimental rat cholangiocarcinoma was examined using ..
  37. Laes J, Ravoet M, Quan X, Van Vooren P, Szpirer J, Szpirer C. Improved radiation hybrid map of rat chromosome 2: colocalization of the genes encoding corticotropin-releasing hormone and IL6-receptor with quantitative trait loci regulating the inflammatory response. Cytogenet Cell Genet. 2001;92:130-3 pubmed
    ..Our data show that they reside within regions that were genetically defined as QTLs controlling the inflammatory response. These genes are thus both functional and positional candidates. ..
  38. Hant F, Ludwicka Bradley A, Wang H, Li N, Elashoff R, Tashkin D, et al. Surfactant protein D and KL-6 as serum biomarkers of interstitial lung disease in patients with scleroderma. J Rheumatol. 2009;36:773-80 pubmed publisher
    ..quot; Serum SP-D and KL-6 may serve as noninvasive serological means of assessing interstitial lung disease in patients with SSc. ..
  39. Ogihara T, Hirano K, Morinobu T, Ogawa S, Hiroi M, Ban R, et al. KL-6, a mucinous glycoprotein, as an indicator of chronic lung disease of the newborn. J Pediatr. 2000;137:280-2 pubmed
    ..04). KL-6 correlated with the alveolar-arterial oxygen tension difference on day 10 and day 30. Plasma KL-6 may be useful as an early marker of chronic lung disease and an indicator of severity. ..
  40. Ho S, Niehans G, Lyftogt C, Yan P, Cherwitz D, Gum E, et al. Heterogeneity of mucin gene expression in normal and neoplastic tissues. Cancer Res. 1993;53:641-51 pubmed
    ..neoplastic tissue, antibodies and cDNA probes that recognize the core tandem repeat sequences of membrane-bound (MUC1) and secreted (MUC2 and MUC3) mucins were used for immunohistochemical and RNA Northern and slot-blot analysis...
  41. Zhu Y, Fu J, You K, Jin L, Wang M, Lu D, et al. Changes in pulmonary tissue structure and KL-6/MUC1 expression in a newborn rat model of hyperoxia-induced bronchopulmonary dysplasia. Exp Lung Res. 2013;39:417-26 pubmed publisher
    Following preterm birth, levels of Krebs von den Lungen-6/mucin 1 (KL-6/MUC1) in serum correlate closely with the development of advanced bronchopulmonary dysplasia (BPD), but the role of KL-6/MUC1 in the development of BPD is unclear...
  42. Kase S, Kitaichi N, Namba K, Miyazaki A, Yoshida K, Ishikura K, et al. Elevation of serum Krebs von den Lunge-6 levels in patients with tubulointerstitial nephritis and uveitis syndrome. Am J Kidney Dis. 2006;48:935-41 pubmed
    ..Serum KL-6 may be a potential laboratory parameter for the diagnosis and follow-up of patients with TINU syndrome that could complement urinary beta(2)-microglobulin measurements. ..
  43. Shimamoto T, Tani M, Kawai M, Hirono S, Ina S, Miyazawa M, et al. MUC1 is a useful molecular marker for malignant intraductal papillary mucinous neoplasms in pancreatic juice obtained from endoscopic retrograde pancreatography. Pancreas. 2010;39:879-83 pubmed publisher
    ..chain reaction was performed for pancreatic juice by a LightCycler instrument focused on carcinoembryonic antigen, MUC1, and human telomerase reverse transcriptase...
  44. Tinder T, Subramani D, Basu G, Bradley J, Schettini J, Million A, et al. MUC1 enhances tumor progression and contributes toward immunosuppression in a mouse model of spontaneous pancreatic adenocarcinoma. J Immunol. 2008;181:3116-25 pubmed
    b>MUC1, a membrane tethered mucin glycoprotein, is overexpressed and aberrantly glycosylated in >80% of human ductal pancreatic adenocarcinoma...
  45. Briassoulis G, Mavrikiou M, Margeli A, Lazaropoulou C, Natsi L, Papassotiriou I, et al. Circulating levels of KL-6 in acute respiratory distress syndrome sepsis or traumatic brain injury in critically ill children. Pediatr Pulmonol. 2006;41:790-5 pubmed
    ..Only in patients with ARDS, plasma KL-6 levels were higher in non-survivors than survivors (P < 0.03). Plasma KL-6 levels have possible prognostic significance and may provide a useful marker for ARDS in critically ill children. ..
  46. Gipson I, Spurr Michaud S, Senchyna M, Ritter R, Schaumberg D. Comparison of mucin levels at the ocular surface of postmenopausal women with and without a history of dry eye. Cornea. 2011;30:1346-52 pubmed publisher
    To determine if levels of the glycocalyx membrane mucins, MUC1 and MUC16, and the secreted goblet cell mucin MUC5AC are altered in conjunctival cells and tears of postmenopausal women presenting with a history of non-Sjögren dry eye and ..
  47. Lacunza E, Ferretti V, Barbeito C, Segal Eiras A, Croce M. Immunohistochemical evidence of Muc1 expression during rat embryonic development. Eur J Histochem. 2010;54:e49 pubmed
    During embryonic development, studies on mouse and human embryos have established that Muc1/MUC1 expression coincides with the onset of epithelial sheet and glandular formation...
  48. Yovchev M, Grozdanov P, Joseph B, Gupta S, Dabeva M. Novel hepatic progenitor cell surface markers in the adult rat liver. Hepatology. 2007;45:139-49 pubmed
    ..Moreover, study of progenitor cells purified with Ep-CAM antibodies from D-galactosamine injured rat liver, a noncarcinogenic model of progenitor cell activation, verified that progenitor cells expressed these markers...
  49. Simms M, Hughes O, Limb M, Price M, Bishop M. MUC1 mucin as a tumour marker in bladder cancer. BJU Int. 1999;84:350-2 pubmed
    To evaluate serum MUC1 levels (a high molecular weight glycoprotein which is upregulated and abnormally glycosylated in bladder cancer and other carcinomas) in patients with a variety of stages and grades of transitional cell carcinoma (..
  50. Fujita K, Denda K, Yamamoto M, Matsumoto T, Fujime M, Irimura T. Expression of MUC1 mucins inversely correlated with post-surgical survival of renal cell carcinoma patients. Br J Cancer. 1999;80:301-8 pubmed
    ..tissues at different stages of progression and of various histological grades were examined for the expression of MUC1 mucins with sialylated carbohydrates (sialylated MUC1 mucins) using a monoclonal antibody MY.1E12...
  51. Isaacs J, Murphy C. Ultrastructural localisation of Muc-1 on the plasma membrane of uterine epithelial cells. Acta Histochem. 2003;105:239-43 pubmed
    ..Ultrastructural localisation also revealed that Muc-1 was not present on the outer surface of the plasma membrane during the receptive phase. ..
  52. Seregni E, Botti C, Lombardo C, Cantoni A, Bogni A, Cataldo I, et al. Pattern of mucin gene expression in normal and neoplastic lung tissues. Anticancer Res. 1996;16:2209-13 pubmed
    This work evaluates the expression in lung cancer of the most well characterized mucin genes (MUC1, MUC2, MUC3) and of the recently described MUC4 in lung tissues, to check a correlation between the expression of any particular gene and ..
  53. Ishikawa N, Hattori N, Tanaka S, Horimasu Y, Haruta Y, Yokoyama A, et al. Levels of surfactant proteins A and D and KL-6 are elevated in the induced sputum of chronic obstructive pulmonary disease patients: a sequential sputum analysis. Respiration. 2011;82:10-8 pubmed publisher
    ..However, sputum fractionation itself had a relatively minor effect on the levels of these proteins. ..