Gene Symbol: Mtmr3
Description: myotubularin related protein 3
Alias: myotubularin-related protein 3, phosphatidylinositol-3,5-bisphosphate 3-phosphatase, phosphatidylinositol-3-phosphate phosphatase
Species: rat
Products:     Mtmr3

Top Publications

  1. Lorenzo O, Urbé S, Clague M. Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions. J Cell Sci. 2006;119:2953-9 pubmed
    ..all previously reported combinations and identified novel heteromeric interactions: MTMR8 with MTMR9, and MTMR3 with MTMR4, the first such combination of enzymatically active MTMs...
  2. Zhao R, Qi Y, Zhao Z. FYVE-DSP1, a dual-specificity protein phosphatase containing an FYVE domain. Biochem Biophys Res Commun. 2000;270:222-9 pubmed
    ..Finally, PCR analyses demonstrated that FYVE-DSP1 is widely distributed in human tissues but different spliced forms expressed differently. ..
  3. Taylor G, Maehama T, Dixon J. Myotubularin, a protein tyrosine phosphatase mutated in myotubular myopathy, dephosphorylates the lipid second messenger, phosphatidylinositol 3-phosphate. Proc Natl Acad Sci U S A. 2000;97:8910-5 pubmed
    ..Our findings provide evidence that myotubularin exerts its effects during myogenesis by regulating cellular levels of the inositol lipid PI(3)P. ..
  4. Walker D, Urbé S, Dove S, Tenza D, Raposo G, Clague M. Characterization of MTMR3. an inositol lipid 3-phosphatase with novel substrate specificity. Curr Biol. 2001;11:1600-5 pubmed
    ..Myotubularin-related protein 3 (MTMR3) shows extensive homology to Myotubularin, including the catalytic domain, but additionally possesses a C-terminal ..
  5. Vicinanza M, Korolchuk V, Ashkenazi A, Puri C, Menzies F, Clarke J, et al. PI(5)P regulates autophagosome biogenesis. Mol Cell. 2015;57:219-34 pubmed publisher