Mtmr1

Summary

Gene Symbol: Mtmr1
Description: myotubularin related protein 1
Alias: myotubularin-related protein 1
Species: rat
Products:     Mtmr1

Top Publications

  1. Kim S, Taylor G, Torgersen K, Dixon J. Myotubularin and MTMR2, phosphatidylinositol 3-phosphatases mutated in myotubular myopathy and type 4B Charcot-Marie-Tooth disease. J Biol Chem. 2002;277:4526-31 pubmed
    ..Furthermore, the MTM-related phosphatases MTMR1, MTMR3, and MTMR6 also dephosphorylate PI(3)P, suggesting that activity toward this substrate is common to all ..
  2. Buj Bello A, Furling D, Tronchère H, Laporte J, Lerouge T, Butler Browne G, et al. Muscle-specific alternative splicing of myotubularin-related 1 gene is impaired in DM1 muscle cells. Hum Mol Genet. 2002;11:2297-307 pubmed
    The myotubularin-related 1 (MTMR1) gene belongs to a highly conserved family of eucaryotic phosphatases, with at least 11 members in humans...
  3. Lorenzo O, Urbé S, Clague M. Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions. J Cell Sci. 2006;119:2953-9 pubmed
    ..Despite this, only MTMR4 exerts any effect on EGF receptor trafficking and degradation, which is more pronounced with a phosphatase inactive form of MTMR4 and requires an intact FYVE domain. ..
  4. Bong S, Son K, Yang S, Park J, Cho J, Kim K, et al. Crystal Structure of Human Myotubularin-Related Protein 1 Provides Insight into the Structural Basis of Substrate Specificity. PLoS ONE. 2016;11:e0152611 pubmed publisher
    Myotubularin-related protein 1 (MTMR1) is a phosphatase that belongs to the tyrosine/dual-specificity phosphatase superfamily...