Mtap

Summary

Gene Symbol: Mtap
Description: methylthioadenosine phosphorylase
Alias: Cc1-6, S-methyl-5'-thioadenosine phosphorylase, 5'-methylthioadenosine phosphorylase
Species: rat
Products:     Mtap

Top Publications

  1. Abbruzzese A, Della Pietra G, Porta R. Occurrence of 5'-deoxy-5'-methylthioadenosine phosphorylase in the mammalian CNS: distribution and kinetic studies on the rat brain enzyme. J Neurochem. 1983;40:487-92 pubmed
    ..4; a Km value for MTA of about 10 microM; an inhibitory effect of the MTA analog 5'-deoxy-5'-isobutylthioadenosine; and a remarkable resistance of the enzyme to heat treatment. ..
  2. Nicolette J, Wrobel N, Ferro A. The stimulatory effect of testosterone propionate and 17 beta-estradiol on 5'-methylthioadenosine phosphorylase activity in rat target tissues. Biochim Biophys Acta. 1980;627:190-8 pubmed
    ..The data suggest aht 5'-methylthioadenosine is not allowed to accumulate in rat target tissues even under conditions which are known to stimulate polyamine synthesis. ..
  3. Garbers D. Demonstration of 5'-methylthioadenosine phosphorylase activity in various rat tissues. Some properties of the enzyme from rat lung. Biochim Biophys Acta. 1978;523:82-93 pubmed
  4. Eloranta T, Khomutov A, Khomutov R, Hyvonen T. Aminooxy analogues of spermidine as inhibitors of spermine synthase and substrates of hepatic polyamine acetylating activity. J Biochem. 1990;108:593-8 pubmed
    ..The results suggest that compounds of this type are valuable tools in unraveling the physiology of polyamines. ..
  5. Hustinx S, Hruban R, Leoni L, Iacobuzio Donahue C, Cameron J, Yeo C, et al. Homozygous deletion of the MTAP gene in invasive adenocarcinoma of the pancreas and in periampullary cancer: a potential new target for therapy. Cancer Biol Ther. 2005;4:83-6 pubmed
    Methylthioadenosine phosphorylase (MTAP) plays an important role in the salvage pathway for the synthesis of adenosine. Novel chemotherapeutic strategies exploiting the selective loss of MTAP function in cancers have been proposed...
  6. Karikari C, Mullendore M, Eshleman J, Argani P, Leoni L, Chattopadhyay S, et al. Homozygous deletions of methylthioadenosine phosphorylase in human biliary tract cancers. Mol Cancer Ther. 2005;4:1860-6 pubmed
    ..in a subset of cases, homozygous deletions at this locus encompass the telomeric methylthioadenosine phosphorylase (MTAP) gene...
  7. Pang M, Bai X, Li Y, Bai J, Yuan L, Ren S, et al. Label-free LC-MS/MS shotgun proteomics to investigate the anti-inflammatory effect of rCC16. Mol Med Rep. 2016;14:4496-4504 pubmed publisher
    ..These protein profiles, and their interacting protein network, may facilitate the elucidation of the molecular mechanisms underlying the anti?inflammatory effects of CC16. ..
  8. Subhi A, Tang B, Balsara B, Altomare D, Testa J, Cooper H, et al. Loss of methylthioadenosine phosphorylase and elevated ornithine decarboxylase is common in pancreatic cancer. Clin Cancer Res. 2004;10:7290-6 pubmed
    Loss of the methylthioadenosine phosphorylase (MTAP) gene at 9p21 is observed frequently in a variety of human cancers...
  9. Belenky P, Christensen K, Gazzaniga F, Pletnev A, Brenner C. Nicotinamide riboside and nicotinic acid riboside salvage in fungi and mammals. Quantitative basis for Urh1 and purine nucleoside phosphorylase function in NAD+ metabolism. J Biol Chem. 2009;284:158-64 pubmed publisher
    ..Finally, we show that yeast nicotinic acid riboside utilization largely depends on uridine hydrolase and nicotinamide riboside kinase and that nicotinic acid riboside bioavailability is increased by ester modification. ..

More Information

Publications12

  1. Lu S, Mato J. S-adenosylmethionine in liver health, injury, and cancer. Physiol Rev. 2012;92:1515-42 pubmed publisher
    ..In experimental models, it is effective as a chemopreventive agent in HCC and perhaps other forms of cancer as well. ..
  2. Seidenfeld J, Wilson J, Williams Ashman H. Androgenic regulation of 5'-deoxy-5'-methylthioadenosine concentrations and methylthioadenosine phosphorylase activity in relation to polyamine metabolism of rat prostate. Biochem Biophys Res Commun. 1980;95:1861-8 pubmed
  3. Kim J, Deluna A, Mungrue I, Vu C, Pouldar D, Civelek M, et al. Effect of 9p21.3 coronary artery disease locus neighboring genes on atherosclerosis in mice. Circulation. 2012;126:1896-906 pubmed publisher
    ..We set out to investigate the potential role of the 9p21.3 locus neighboring genes, including Mtap, the 2 isoforms of Cdkn2a, p16Ink4a and p19Arf, and Cdkn2b, in atherosclerosis using knockout mice models...