MST2

Summary

Gene Symbol: MST2
Description: serine/threonine kinase 3
Alias: MST2, serine/threonine-protein kinase 3, MST-2, STE20-like kinase MST2, mammalian STE20-like protein kinase 2, serine/threonine kinase 3 (STE20 homolog, yeast)
Species: rat
Products:     MST2

Top Publications

  1. Creasy C, Chernoff J. Cloning and characterization of a member of the MST subfamily of Ste20-like kinases. Gene. 1995;167:303-6 pubmed
    We have identified a second human homology of the yeast Ste20 protein kinase family, which we designate MST2. MST2 is most similar to the previously identified MST1 protein kinase (78% identity, 88% similarity)...
  2. Praskova M, Khoklatchev A, Ortiz Vega S, Avruch J. Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras. Biochem J. 2004;381:453-62 pubmed
    MST1 (mammalian Sterile20-like 1) and MST2 are closely related Class II GC (protein Ser/Thr) kinases that initiate apoptosis when transiently overexpressed in mammalian cells...
  3. Chan E, Nousiainen M, Chalamalasetty R, Schäfer A, Nigg E, Sillje H. The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. Oncogene. 2005;24:2076-86 pubmed
    ..Little, however, is known about the function and regulation of human Lats kinases. Here we report that human Mst2, a STE20-family member and purported Hpo ortholog, phosphorylates and activates both Lats1 and Lats2...
  4. Lu L, Li Y, Kim S, Bossuyt W, Liu P, Qiu Q, et al. Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. Proc Natl Acad Sci U S A. 2010;107:1437-42 pubmed publisher
    ..of hippo signaling in regulation of mammalian organ size we have generated conditional alleles of Sav1, mst1, and mst2, orthologs of Drosophila Salvador and hippo, respectively...
  5. Song H, Mak K, Topol L, Yun K, Hu J, Garrett L, et al. Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. Proc Natl Acad Sci U S A. 2010;107:1431-6 pubmed publisher
    ..We found that Mst1 and Mst2, the two mouse homologs of the Drosophila Hpo, control the sizes of some, but not all organs, in mice, and Mst1 and ..
  6. Praskova M, Xia F, Avruch J. MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation. Curr Biol. 2008;18:311-21 pubmed publisher
    MST1 and MST2 are the mammalian Ste20-related protein kinases most closely related to Drosophila Hippo, a major regulator of cell proliferation and survival during development...
  7. Aurisicchio L, Di Lauro R, Zannini M. Identification of the thyroid transcription factor-1 as a target for rat MST2 kinase. J Biol Chem. 1998;273:1477-82 pubmed
    ..The cloning of this kinase revealed that we had identified the rat homolog of the human MST2 kinase...
  8. Du X, Dong Y, Shi H, Li J, Kong S, Shi D, et al. Mst1 and mst2 are essential regulators of trophoblast differentiation and placenta morphogenesis. PLoS ONE. 2014;9:e90701 pubmed publisher
    ..Mst1 and Mst2 (Mst1/2), key components of the mammalian hpo/Mst signaling pathway, encode two highly conserved Ser/Thr kinases ..
  9. Deng Y, Pang A, Wang J. Regulation of mammalian STE20-like kinase 2 (MST2) by protein phosphorylation/dephosphorylation and proteolysis. J Biol Chem. 2003;278:11760-7 pubmed
    Mammalian STE20-like kinase 2 (MST2), a member of the STE20-like kinase family, has been shown in previous studies to undergo proteolytic activation by caspase-3 during cell apoptosis...

More Information

Publications20

  1. Ni L, Li S, Yu J, Min J, Brautigam C, Tomchick D, et al. Structural basis for autoactivation of human Mst2 kinase and its regulation by RASSF5. Structure. 2013;21:1757-68 pubmed publisher
    ..Activation of the kinases Mst1 and Mst2 (Mst1/2) is a key upstream event in this pathway and remains poorly understood...
  2. Kwan J, Sczaniecka A, Heidary Arash E, Nguyen L, Chen C, Ratkovic S, et al. DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2. Genes Dev. 2016;30:2696-2709 pubmed publisher
    ..These data reveal a direct connection between cell polarity proteins and Hippo, which is essential for proper development of multicellular organisms. ..
  3. Cooper W, Hesson L, Matallanas D, Dallol A, von Kriegsheim A, Ward R, et al. RASSF2 associates with and stabilizes the proapoptotic kinase MST2. Oncogene. 2009;28:2988-98 pubmed publisher
    ..We identified the proapoptotic kinases, MST1 and MST2, as the most significant binding partners of RASSF2, confirmed the interactions at endogenous levels and showed ..
  4. Hirabayashi S, Nakagawa K, Sumita K, Hidaka S, Kawai T, Ikeda M, et al. Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1. Oncogene. 2008;27:4281-92 pubmed publisher
    ..Okadaic acid (OA), which activates MST2, facilitates the complex formation of MOB1, MST2 and NDR1 in HEK293FT cells...
  5. Callus B, Verhagen A, Vaux D. Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation. FEBS J. 2006;273:4264-76 pubmed
    ..Together these results show that hSav can bind to, and be phosphorylated by, Mst, and that the stabilizing effect of Mst on hSav requires its interaction with hSav but is probably not due to phosphorylation of hSav by Mst. ..
  6. Lee K, Ohyama T, Yajima N, Tsubuki S, Yonehara S. MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation. J Biol Chem. 2001;276:19276-85 pubmed
    ..In this study, we show that MST1 and MST2 are direct substrates of caspase-3 both in vivo and in vitro...
  7. Song H, Oh S, Oh H, Lim D. Role of the tumor suppressor RASSF2 in regulation of MST1 kinase activity. Biochem Biophys Res Commun. 2010;391:969-73 pubmed publisher
  8. Romano D, Matallanas D, Weitsman G, Preisinger C, Ng T, Kolch W. Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and Akt. Cancer Res. 2010;70:1195-203 pubmed publisher
    ..However, there is limited understanding about MST2 control by key regulators of cell division and survival...
  9. Kim D, Shu S, Coppola M, Kaneko S, Yuan Z, Cheng J. Regulation of proapoptotic mammalian ste20-like kinase MST2 by the IGF1-Akt pathway. PLoS ONE. 2010;5:e9616 pubmed publisher
    ..Its mammalian homolog MST2 has been shown to play similar role and be regulated by Raf-1 via a kinase-independent mechanism and by RASSF ..
  10. Park B, Kim D, Won G, Jeon H, Oh B, Lee Y, et al. Mammalian ste20-like kinase and SAV1 promote 3T3-L1 adipocyte differentiation by activation of PPAR?. PLoS ONE. 2012;7:e30983 pubmed publisher
    ..We sought to understand the role of MST2 kinase and Salvador homolog 1 (SAV1), a scaffolding protein that functions in the MST pathway, in adipocyte ..
  11. Lee K, Yonehara S. Phosphorylation and dimerization regulate nucleocytoplasmic shuttling of mammalian STE20-like kinase (MST). J Biol Chem. 2002;277:12351-8 pubmed