Gene Symbol: Ms4a2
Description: membrane spanning 4-domains A2
Alias: FCIGA, Fcer1b, Ms4a1, high affinity immunoglobulin epsilon receptor subunit beta, IgE Fc receptor subunit beta, Membrane-spanning 4-domains, subfamily A, member 1, beta polypeptide), fc epsilon receptor I beta-chain, fcERI, membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for, membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)
Species: rat
Products:     Ms4a2

Top Publications

  1. Davey A, Walvick R, Liu Y, Heikal A, Sheets E. Membrane order and molecular dynamics associated with IgE receptor cross-linking in mast cells. Biophys J. 2007;92:343-55 pubmed
    ..Our results suggest that fluorescence lifetime and, particularly, anisotropy permit us to correlate the recruitment of lipid molecules into more ordered domains that serve as platforms for IgE-mediated signaling. ..
  2. Sharma S, Ghosh B. Promoter polymorphism in the MS4A2 gene and asthma in the Indian population. Int Arch Allergy Immunol. 2009;149:208-18 pubmed publisher
    A previous study from our laboratory identified 3-locus risk and protective haplotypes of the MS4A2 gene, a prime candidate for asthma and atopy, that were associated with differential histamine release profiles from basophils and ..
  3. Ra C, Jouvin M, Kinet J. Complete structure of the mouse mast cell receptor for IgE (Fc epsilon RI) and surface expression of chimeric receptors (rat-mouse-human) on transfected cells. J Biol Chem. 1989;264:15323-7 pubmed
    ..The subunits are completely interchangeable upon transfection so that various chimeric mouse-rat-human receptors can be expressed. ..
  4. Shirakawa T, Li A, Dubowitz M, Dekker J, Shaw A, Faux J, et al. Association between atopy and variants of the beta subunit of the high-affinity immunoglobulin E receptor. Nat Genet. 1994;7:125-9 pubmed
    ..Our data indicate that Fc epsilon RI-beta, subject to maternal modification, may be the atopy-causing locus on chromosome 11q. ..
  5. Vonakis B, Gibbons S, Rotte M, Brothers E, Kim S, Chichester K, et al. Regulation of rat basophilic leukemia-2H3 mast cell secretion by a constitutive Lyn kinase interaction with the high affinity IgE receptor (Fc epsilon RI). J Immunol. 2005;175:4543-54 pubmed
  6. Hill M, Cookson W. A new variant of the beta subunit of the high-affinity receptor for immunoglobulin E (Fc epsilon RI-beta E237G): associations with measures of atopy and bronchial hyper-responsiveness. Hum Mol Genet. 1996;5:959-62 pubmed
    ..04), RAST to grass (p = 0.002) and bronchial reactivity to methacholine (p = 0.0009). The relative risk of individuals with E237G having asthma compared to subjects without the variant was 2.3 (95% CI 1.26-4.19; p = 0.005). ..
  7. Joubert B, Reif D, Edwards S, Leiner K, Hudgens E, Egeghy P, et al. Evaluation of genetic susceptibility to childhood allergy and asthma in an African American urban population. BMC Med Genet. 2011;12:25 pubmed publisher
    ..Statistically significant associations with asthma were observed for SNPs in GSTM1, MS4A2, and GSTP1 genes, after correction for multiple testing...
  8. Yamashita T, Yamaguchi T, Murakami K, Nagasawa S. Detergent-resistant membrane domains are required for mast cell activation but dispensable for tyrosine phosphorylation upon aggregation of the high affinity receptor for IgE. J Biochem. 2001;129:861-8 pubmed
    Aggregation of the high affinity receptor for IgE (FceRI) on mast cells results in the rapid phosphorylation of tyrosines on the beta and gamma chains of the receptor by the Src family kinase Lyn, which initiates the signaling cascades ..
  9. Sakurai D, Yamasaki S, Arase K, Park S, Arase H, Konno A, et al. Fc epsilon RI gamma-ITAM is differentially required for mast cell function in vivo. J Immunol. 2004;172:2374-81 pubmed
    ..These results indicate that FcepsilonRIgamma-mediated signals differentially regulate the receptor expression, activation, and survival of mast cells and systemic anaphylaxis. ..

Scientific Experts

More Information


  1. Kim Y, Kim K, Lee H, Han S, Lee Y, Choe J, et al. Celastrol binds to ERK and inhibits FcepsilonRI signaling to exert an anti-allergic effect. Eur J Pharmacol. 2009;612:131-42 pubmed publisher
    ..Celastrol also showed an inhibitory effect on skin inflammation induced by phorbol myristate acetate (PMA) in Balb/c mice. In summary, celastrol binds to ERK and inhibits FcepsilonRI signaling to exert an anti-inflammatory effect. ..
  2. Asai K, Fujimoto K, Harazaki M, Kusunoki T, Korematsu S, Ide C, et al. Distinct aggregation of beta- and gamma-chains of the high-affinity IgE receptor on cross-linking. J Histochem Cytochem. 2000;48:1705-16 pubmed
    ..These findings suggest that high-affinity IgE receptor beta- and gamma-chains do not co-aggregate but for the most part form homogenous aggregates of beta-chains or gamma-chains after crosslinking. ..
  3. Saini S, Bloom D, Bieneman A, Vasagar K, Togias A, Schroeder J. Systemic effects of allergen exposure on blood basophil IL-13 secretion and FcepsilonRIbeta. J Allergy Clin Immunol. 2004;114:768-74 pubmed
  4. Kim Y, Park H, Yang J, Oh S, Chang Y, Shin E, et al. Association and functional relevance of E237G, a polymorphism of the high-affinity immunoglobulin E-receptor beta chain gene, to airway hyper-responsiveness. Clin Exp Allergy. 2007;37:592-8 pubmed
    ..In the Korean general population, AHR is significantly associated with the E237G polymorphism of FcepsilonRI-beta, which results in an intolerant amino acid substitution. ..
  5. Kinet J, Blank U, Ra C, White K, Metzger H, Kochan J. Isolation and characterization of cDNAs coding for the beta subunit of the high-affinity receptor for immunoglobulin E. Proc Natl Acad Sci U S A. 1988;85:6483-7 pubmed
    ..RNA transfer blots at high stringency failed to reveal mRNA for beta chains in a variety of cells (in particular, monocytes) that do not contain the high-affinity receptor for IgE. ..
  6. Li H, Xiaoyan D, Quanhua L, Jie L, Yixiao B. Single-nucleotide polymorphisms in genes predisposing to asthma in children of Chinese Han nationality. J Investig Allergol Clin Immunol. 2009;19:391-5 pubmed
    ..The 6 loci (IL-13 C-1112T, IL-13 C1923T, IL-4 C-590T, IL-4RA 175V, FcER1B E237G and 12-ADR Q27E) make little contribution to the development of asthma in children of Chinese Han ..
  7. Lee Y, Gilliland F, Wang J, Lee Y, Guo Y. Associations of FcepsilonRIbeta E237G polymorphism with wheezing in Taiwanese schoolchildren. Clin Exp Allergy. 2008;38:413-20 pubmed publisher
    ..The FcepsilonRIbeta E237G allele may have a protective role in wheezing illness among Taiwanese schoolchildren, depending on airway oxidative stress levels. ..
  8. Ott V, Tamir I, Niki M, Pandolfi P, Cambier J. Downstream of kinase, p62(dok), is a mediator of Fc gamma IIB inhibition of Fc epsilon RI signaling. J Immunol. 2002;168:4430-9 pubmed
    ..Taken together, these data suggest a role for p62(dok) as a mediator of Fc gamma RIIB inhibition of Fc epsilon RI signal transduction in mast cells. ..
  9. Costello P, Turner M, Walters A, Cunningham C, Bauer P, Downward J, et al. Critical role for the tyrosine kinase Syk in signalling through the high affinity IgE receptor of mast cells. Oncogene. 1996;13:2595-605 pubmed
    ..A similar mechanism is likely to apply to signal transduction through all members of the antigen receptor family. ..
  10. Amir Moazami O, Alexia C, Charles N, Launay P, Monteiro R, Benhamou M. Phospholipid scramblase 1 modulates a selected set of IgE receptor-mediated mast cell responses through LAT-dependent pathway. J Biol Chem. 2008;283:25514-23 pubmed publisher
    ..Altogether, these data identify PLSCR1 as a novel amplifier of FcepsilonRI signaling that acts selectively on the Lyn-initiated LAT/phospholipase Cgamma1/calcium axis, resulting in potentiation of a selected set of mast cell responses. ..
  11. Craig A, Greer P. Fer kinase is required for sustained p38 kinase activation and maximal chemotaxis of activated mast cells. Mol Cell Biol. 2002;22:6363-74 pubmed
    ..Further studies with mast cells derived from fps/fes-deficient mice will be required to provide insight into the role of Fps/Fes in mast cell activation. ..
  12. Kimura T, Kihara H, Bhattacharyya S, Sakamoto H, Appella E, Siraganian R. Downstream signaling molecules bind to different phosphorylated immunoreceptor tyrosine-based activation motif (ITAM) peptides of the high affinity IgE receptor. J Biol Chem. 1996;271:27962-8 pubmed
    ..Tyrosine phosphorylation of the ITAM of the gamma subunit recruits and activates Syk, whereas the beta subunit may be important for the Ras signaling pathway. ..
  13. Hálová I, Dráberová L, Bambousková M, Machyna M, Stegurová L, Smrz D, et al. Cross-talk between tetraspanin CD9 and transmembrane adaptor protein non-T cell activation linker (NTAL) in mast cell activation and chemotaxis. J Biol Chem. 2013;288:9801-14 pubmed publisher
    ..The combined data indicate that chemotaxis toward antigen is controlled in mast cells by a cross-talk among Fc?RI, tetraspanin CD9, transmembrane adaptor proteins NTAL and LAT, and cytoskeleton-regulatory proteins of the ERM family. ..