Mov10l1

Summary

Gene Symbol: Mov10l1
Description: Mov10 RISC complex RNA helicase like 1
Alias: Mov10 RISC complex RNA helicase like 1, RNA helicase Mov10l1, Moloney leukemia virus 10-like 1, Mov10l1, Moloney leukemia virus 10-like 1, homolog
Species: rat
Products:     Mov10l1

Top Publications

  1. Frost R, Hamra F, Richardson J, Qi X, Bassel Duby R, Olson E. MOV10L1 is necessary for protection of spermatocytes against retrotransposons by Piwi-interacting RNAs. Proc Natl Acad Sci U S A. 2010;107:11847-52 pubmed publisher
    ..Here we show that the putative DExD-box helicase MOV10-like-1 (MOV10L1) is essential for silencing retrotransposons in the mouse male germline...
  2. Zheng K, Xiol J, Reuter M, Eckardt S, Leu N, McLaughlin K, et al. Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway. Proc Natl Acad Sci U S A. 2010;107:11841-6 pubmed publisher
    ..Here we demonstrate that MOV10L1, a germ cell-specific putative RNA helicase, is associated with Piwi proteins...
  3. Liu Z, Olson E. Suppression of proliferation and cardiomyocyte hypertrophy by CHAMP, a cardiac-specific RNA helicase. Proc Natl Acad Sci U S A. 2002;99:2043-8 pubmed
    ..These findings identify CHAMP as a cardiac-specific suppressor of cardiomyocyte hypertrophy and cell cycle progression and suggest that CHAMP may suppress these processes through the regulation of p21(CIP1). ..
  4. Zheng K, Wang P. Blockade of pachytene piRNA biogenesis reveals a novel requirement for maintaining post-meiotic germline genome integrity. PLoS Genet. 2012;8:e1003038 pubmed publisher
    ..Here, we report that conditional inactivation of the putative RNA helicase MOV10L1 in mouse spermatocytes produces a specific loss of pachytene piRNAs, significant accumulation of pachytene ..
  5. Vourekas A, Zheng K, Fu Q, Maragkakis M, Alexiou P, Ma J, et al. The RNA helicase MOV10L1 binds piRNA precursors to initiate piRNA processing. Genes Dev. 2015;29:617-29 pubmed publisher
    ..Here we show that MOV10L1 exhibits 5'-to-3' directional RNA-unwinding activity in vitro and that a point mutation that abolishes this ..