monoamine oxidase

Summary

Gene Symbol: monoamine oxidase
Description: monoamine oxidase A
Alias: Mao, amine oxidase [flavin-containing] A, MAO-A, monoamine oxidase type A
Species: rat
Products:     monoamine oxidase

Top Publications

  1. Gudkova O, Latyshko N, Shandrenko S. Amine oxidases as important agents of pathological processes of rhabdomyolysis in rats. Ukr Biochem J. 2016;88:79-87 pubmed publisher
  2. Wang J, Edmondson D. High-level expression and purification of rat monoamine oxidase A (MAO A) in Pichia pastoris: comparison with human MAO A. Protein Expr Purif. 2010;70:211-7 pubmed publisher
    ..expression in Pichia pastoris, purification and characterization of recombinant membrane-bound rat liver monoamine oxidase A (MAO A) are described. A 1-L culture of cells produces approximately 700 U of rat MAO A activity...
  3. Huang G, Zhu F, Chen Y, Chen S, Liu Z, Li X, et al. A spectrophotometric assay for monoamine oxidase activity with 2, 4-dinitrophenylhydrazine as a derivatized reagent. Anal Biochem. 2016;512:18-25 pubmed publisher
    A simple, rapid and reliable spectrophotometry was developed to determine monoamine oxidase (MAO)...
  4. Morishima M, Harada N, Hara S, Sano A, Seno H, Takahashi A, et al. Monoamine oxidase A activity and norepinephrine level in hippocampus determine hyperwheel running in SPORTS rats. Neuropsychopharmacology. 2006;31:2627-38 pubmed
    ..The protein expression and the activity levels of monoamine oxidase A (MAOA), a critical enzyme for the degradation of NE, were decreased in the hippocampus of SPORTS rats to ..
  5. Tsugeno Y, Ito A. A key amino acid responsible for substrate selectivity of monoamine oxidase A and B. J Biol Chem. 1997;272:14033-6 pubmed
    b>Monoamine oxidase (MAO) oxidizes biologically important amines including neurotransmitters and plays a central role in the regulation of intracellular level of these amines...
  6. Marquez C, Poirier G, Cordero M, Larsen M, Groner A, Marquis J, et al. Peripuberty stress leads to abnormal aggression, altered amygdala and orbitofrontal reactivity and increased prefrontal MAOA gene expression. Transl Psychiatry. 2013;3:e216 pubmed publisher
    ..Increased and sustained expression levels of the monoamine oxidase A (MAOA) gene were found in the prefrontal cortex but not in the amygdala of peripubertally stressed animals...
  7. Kaludercic N, Carpi A, Nagayama T, Sivakumaran V, Zhu G, Lai E, et al. Monoamine oxidase B prompts mitochondrial and cardiac dysfunction in pressure overloaded hearts. Antioxid Redox Signal. 2014;20:267-80 pubmed publisher
    ..b>MAO-A contributes to heart failure progression via enhanced norepinephrine catabolism and oxidative stress...
  8. Kuwahara T, Takamoto S, Ito A. Primary structure of rat monoamine oxidase A deduced from cDNA and its expression in rat tissues. Agric Biol Chem. 1990;54:253-7 pubmed
    The cDNA for rat monoamine oxidase A (MAO-A) mRNA was isolated from a liver cDNA library in lambda gt11 as the cDNA species cross-hybridizing with rat monoamine oxidase B (MAO-B) cDNA...
  9. Yáñez M, Fraiz N, Cano E, Orallo F. Inhibitory effects of cis- and trans-resveratrol on noradrenaline and 5-hydroxytryptamine uptake and on monoamine oxidase activity. Biochem Biophys Res Commun. 2006;344:688-95 pubmed
    ..5-hydroxytryptamine (5-HT) uptake by synaptosomes from rat brain, on 5-HT uptake by human platelets, and on monoamine oxidase (MAO) isoform activity...

More Information

Publications39

  1. Upadhyay A, Wang J, Edmondson D. Comparison of the structural properties of the active site cavities of human and rat monoamine oxidase A and B in their soluble and membrane-bound forms. Biochemistry. 2008;47:526-36 pubmed
  2. Wang J, Edmondson D. ²H kinetic isotope effects and pH dependence of catalysis as mechanistic probes of rat monoamine oxidase A: comparisons with the human enzyme. Biochemistry. 2011;50:7710-7 pubmed publisher
    b>Monoamine oxidase A (MAO A) is a mitochondrial outer membrane-bound flavoenzyme important in the regulation of serotonin and dopamine levels...
  3. De Colibus L, Li M, Binda C, Lustig A, Edmondson D, Mattevi A. Three-dimensional structure of human monoamine oxidase A (MAO A): relation to the structures of rat MAO A and human MAO B. Proc Natl Acad Sci U S A. 2005;102:12684-9 pubmed
    The three-dimensional structure of recombinant human monoamine oxidase A (hMAO A) as its clorgyline-inhibited adduct is described...
  4. Jones S, Gainetdinov R, Jaber M, Giros B, Wightman R, Caron M. Profound neuronal plasticity in response to inactivation of the dopamine transporter. Proc Natl Acad Sci U S A. 1998;95:4029-34 pubmed
  5. Ma J, Yoshimura M, Yamashita E, Nakagawa A, Ito A, Tsukihara T. Structure of rat monoamine oxidase A and its specific recognitions for substrates and inhibitors. J Mol Biol. 2004;338:103-14 pubmed
    b>Monoamine oxidase (MAO), a mitochondrial outer membrane enzyme, catalyzes the degradation of neurotransmitters in the central nervous system and is the target for anti-depression drug design...
  6. Pchejetski D, Kunduzova O, Dayon A, Calise D, Seguelas M, Leducq N, et al. Oxidative stress-dependent sphingosine kinase-1 inhibition mediates monoamine oxidase A-associated cardiac cell apoptosis. Circ Res. 2007;100:41-9 pubmed
    The mitochondrial enzyme monoamine oxidase (MAO), its isoform MAO-A, plays a major role in reactive oxygen species-dependent cardiomyocyte apoptosis and postischemic cardiac damage...
  7. Apostolov R, Yonezawa Y, Standley D, Kikugawa G, Takano Y, Nakamura H. Membrane attachment facilitates ligand access to the active site in monoamine oxidase A. Biochemistry. 2009;48:5864-73 pubmed publisher
    b>Monoamine oxidase membrane enzymes are responsible for the catalytic breakdown of extra- and intracellular neurotransmitters and are targets for the development of central nervous system drugs...
  8. Marziniak M, Mossner R, Benninghoff J, Syagailo Y, Lesch K, Sommer C. Association analysis of the functional monoamine oxidase A gene promotor polymorphism in migraine. J Neural Transm (Vienna). 2004;111:603-9 pubmed
    ..One of the key enzymes in the degradation of serotonin and to a lesser extent of dopamine is monoamine oxidase A (MAO-A)...
  9. Ma J, Kubota F, Yoshimura M, Yamashita E, Nakagawa A, Ito A, et al. Crystallization and preliminary crystallographic analysis of rat monoamine oxidase A complexed with clorgyline. Acta Crystallogr D Biol Crystallogr. 2004;60:317-9 pubmed
    b>Monoamine oxidase (MAO) is an FAD-containing mitochondrial outer-membrane protein which catalyzes the degradation of several neurotransmitters in the central nervous system...
  10. Umbarkar P, Singh S, Arkat S, Bodhankar S, Lohidasan S, Sitasawad S. Monoamine oxidase-A is an important source of oxidative stress and promotes cardiac dysfunction, apoptosis, and fibrosis in diabetic cardiomyopathy. Free Radic Biol Med. 2015;87:263-73 pubmed publisher
    ..The mitochondrial flavoenzyme monoamine oxidase A (MAO-A) is an important source of oxidative stress in the myocardium...
  11. Pizzinat N, Marchal Victorion S, Maurel A, Ordener C, Bompart G, Parini A. Substrate-dependent regulation of MAO-A in rat mesangial cells: involvement of dopamine D2-like receptors. Am J Physiol Renal Physiol. 2003;284:F167-74 pubmed
    ..In the present study, we investigated the existence of a back-regulation of the catecholamine-degrading enzyme monoamine oxidase (MAO)-A by dopamine in rat renal cells...
  12. Ma J, Ito A. Tyrosine residues near the FAD binding site are critical for FAD binding and for the maintenance of the stable and active conformation of rat monoamine oxidase A. J Biochem. 2002;131:107-11 pubmed
    b>Monoamine oxidase is a flavin-containing enzyme located at the mitochondrial outer membrane that catalyzes the oxidative deamination of amines...
  13. Villeneuve C, Guilbeau Frugier C, Sicard P, Lairez O, Ordener C, Duparc T, et al. p53-PGC-1? pathway mediates oxidative mitochondrial damage and cardiomyocyte necrosis induced by monoamine oxidase-A upregulation: role in chronic left ventricular dysfunction in mice. Antioxid Redox Signal. 2013;18:5-18 pubmed publisher
    ..mRNA levels of monoamine oxidase-A (MAO-A), a mitochondrial enzyme that produces hydrogen peroxide (H(2)O(2)), increase in several models of ..
  14. De Marchi U, Mancon M, Battaglia V, Ceccon S, Cardellini P, Toninello A. Influence of reactive oxygen species production by monoamine oxidase activity on aluminum-induced mitochondrial permeability transition. Cell Mol Life Sci. 2004;61:2664-71 pubmed
    ..are generated by the interaction of aluminum with the inner membrane and the oxidation of tyramine by monoamine oxidase on the outer membrane...
  15. Wang J, Edmondson D. Topological probes of monoamine oxidases A and B in rat liver mitochondria: inhibition by TEMPO-substituted pargyline analogues and inactivation by proteolysis. Biochemistry. 2011;50:2499-505 pubmed publisher
    TEMPO-substituted pargyline analogues differentially inhibit recombinant human monoamine oxidase A (MAO A) and B (MAO B) in intact yeast mitochondria, suggesting these membrane-bound enzymes are located on differing faces of the ..
  16. Kozochkin D, Manukhina E, Downey H, Tseilikman O, Komelkova M, Vasilyeva M, et al. The role of microsomal oxidation in the regulation of monoamine oxidase activity in the brain and liver of rats. Gen Physiol Biophys. 2017;36:455-464 pubmed publisher
    It has been shown in our previous study that monoamine oxidase (MAO) activity in different brain regions are correlated with a microsomal oxidation phenotype...
  17. Park Y, Won S, Nam M, Chung J, Kwack K. Interaction between MAOA and FOXP2 in association with autism and verbal communication in a Korean population. J Child Neurol. 2014;29:NP207-11 pubmed publisher
    Expression levels of monoamine oxidase A (MAOA), the enzyme that related to monoamine neurotransmitters metabolism such as serotonin, are related to schizophrenia and autism spectrum disorder...
  18. Sherif F, Gottfries C, Alafuzoff I, Oreland L. Brain gamma-aminobutyrate aminotransferase (GABA-T) and monoamine oxidase (MAO) in patients with Alzheimer's disease. J Neural Transm Park Dis Dement Sect. 1992;4:227-40 pubmed
    Activities of Gamma-aminobutyrate aminotransferase (GABA-T) and Monoamine oxidase (MAO)-A and -B were estimated in postmortem brains from 6 control subjects without psychiatric or neurologic disorders and 8 histopathologically verified ..
  19. Bendre M, Comasco E, Nylander I, Nilsson K. Effect of voluntary alcohol consumption on Maoa expression in the mesocorticolimbic brain of adult male rats previously exposed to prolonged maternal separation. Transl Psychiatry. 2015;5:e690 pubmed publisher
    Discordant associations between monoamine oxidase A (MAOA) genotype and high alcohol drinking have been reported in human and non-human primates. Environmental influences likely moderate genetic susceptibility...
  20. Heron P, Cousins K, Boyd C, Daya S. Paradoxical effects of copper and manganese on brain mitochondrial function. Life Sci. 2001;68:1575-83 pubmed
    ..Cu2+ dose-dependently reduced flavin adenine dinucleotide (FAD)-dependent monoamine oxidase A (MAO-A) activity in a time-independent manner, with an IC50 value approximately 20 microM, whereas Mn2+ ..
  21. Meyers B, D Agostino A, Walker J, Kritzer M. Gonadectomy and hormone replacement exert region- and enzyme isoform-specific effects on monoamine oxidase and catechol-O-methyltransferase activity in prefrontal cortex and neostriatum of adult male rats. Neuroscience. 2010;165:850-62 pubmed publisher
    ..of these systems could be related to gonadal steroid effects on catechol-O-methyltransferase and monoamine oxidase which are principal enzymatic controllers of forebrain dopamine, serotonin and norepinephrine levels...
  22. Maurel A, Hernandez C, Kunduzova O, Bompart G, Cambon C, Parini A, et al. Age-dependent increase in hydrogen peroxide production by cardiac monoamine oxidase A in rats. Am J Physiol Heart Circ Physiol. 2003;284:H1460-7 pubmed
    ..In the present study, we investigated the role of the catecholamine-degrading enzyme monoamine oxidase (MAO) in H(2)O(2) production in the hearts of young, adult, and old rats...
  23. Bianchi P, Kunduzova O, Masini E, Cambon C, Bani D, Raimondi L, et al. Oxidative stress by monoamine oxidase mediates receptor-independent cardiomyocyte apoptosis by serotonin and postischemic myocardial injury. Circulation. 2005;112:3297-305 pubmed
    ..5-HT]), released by activated platelets during cardiac ischemia, is metabolized by the mitochondrial enzyme monoamine oxidase A (MAO-A)...
  24. Kaplan A, Keenan T, Scott R, Zhou X, Bourchouladze R, McRiner A, et al. Identification of 5-(1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)thiophene-2-Carboxamides as Novel and Selective Monoamine Oxidase B Inhibitors Used to Improve Memory and Cognition. ACS Chem Neurosci. 2017;8:2746-2758 pubmed publisher
    ..suggested that the CREB activation by HT-0411 is attributed to its specific and selective inhibition of monoamine oxidase B (MAO-B)...
  25. Liu Y, Meng F, Wang L, Zhang L, Cheng X, Zhou J. Apolipoprotein E influences melatonin biosynthesis by regulating NAT and MAOA expression in C6 cells. J Pineal Res. 2012;52:397-402 pubmed publisher
    ..Further study suggested that mRNA expression of monoamine oxidase A (MAOA) and monoamine oxidase B (MAOB) decreased in ApoE4-C6 cells...
  26. Morais M, Santos P, Mateus Pinheiro A, Patrício P, Pinto L, Sousa N, et al. The effects of chronic stress on hippocampal adult neurogenesis and dendritic plasticity are reversed by selective MAO-A inhibition. J Psychopharmacol. 2014;28:1178-83 pubmed publisher
    ..However, the effects of antidepressants that act through the selective inhibition of monoamine oxidase subtype A (MAO-A) in these phenomena are still largely unknown...
  27. Maron E, Lang A, Tasa G, Liivlaid L, Tõru I, Must A, et al. Associations between serotonin-related gene polymorphisms and panic disorder. Int J Neuropsychopharmacol. 2005;8:261-6 pubmed
    ..between PD phenotype and five candidate polymorphisms including 5-HT transporter (5-HTTLPR and VNTR), monoamine oxidase A (MAOA promoter region), tryptophan hydroxylase 1 (TPH1 218A/C) and 5-HT1B receptor (5-HT1BR 861G/C) genes...
  28. Tseilikman V, Kozochkin D, Manukhina E, Downey H, Tseilikman O, Misharina M, et al. Duration of hexobarbital-induced sleep and monoamine oxidase activities in rat brain: Focus on the behavioral activity and on the free-radical oxidation. Gen Physiol Biophys. 2016;35:175-83 pubmed publisher
    The present study is focused on the relationship between monoamine oxidase (MAO) activity and hepatic content of cytochrome P450 (CYP), which reflects the status of microsomal oxidation...
  29. Kabayama M, Sakoori K, Yamada K, Ornthanalai V, Ota M, Morimura N, et al. Rines E3 ubiquitin ligase regulates MAO-A levels and emotional responses. J Neurosci. 2013;33:12940-53 pubmed publisher
    b>Monoamine oxidase A (MAO-A), the catabolic enzyme of norepinephrine and serotonin, plays a critical role in emotional and social behavior. However, the control and impact of endogenous MAO-A levels in the brain remains unknown...
  30. Guindalini C, Scivoletto S, Ferreira R, Nishimura A, Zilberman M, Peluso M, et al. Association of MAO A polymorphism and alcoholism in Brazilian females. Psychiatr Genet. 2005;15:141-4 pubmed
    Among the different possible genes involved in the alcoholism etiology, the X-linked monoamine oxidase A gene is a good candidate...