Gene Symbol: moat1
Description: solute carrier organic anion transporter family, member 2b1
Alias: Slc21a9, moat1, solute carrier organic anion transporter family member 2B1, multispecific organic anion transporter 1, organic anion transporter moatp1, solute carrier family 21 (organic anion transporter), member 9, solute carrier family 21 member 9
Ugele B, Bahn A, Rex Haffner M. Functional differences in steroid sulfate uptake of organic anion transporter 4 (OAT4) and organic anion transporting polypeptide 2B1 (OATP2B1) in human placenta. J Steroid Biochem Mol Biol. 2008;111:1-6 pubmed publisher
..OATP2B1 seems not to be involved in de novo synthesis of placental estrogens but may contribute to the clearance of estrogen sulfates from foetal circulation. ..
Maruyama H, Ogura J, Fujikawa A, Terada Y, Tsujimoto T, Koizumi T, et al
. Intestinal ischemia-reperfusion suppresses biliary excretion of hepatic organic anion transporting polypeptides substrate. J Pharm Pharm Sci. 2013;16:722-31 pubmed
..The decreases in these transporters cause alteration of pharmacokinetics of organic anion compound. The newly found influence of intestinal I/R on the expression and function of Oatps may be a key to perform appropriate drug therapy. ..
Nishio T, Adachi H, Nakagomi R, Tokui T, Sato E, Tanemoto M, et al
. Molecular identification of a rat novel organic anion transporter moat1, which transports prostaglandin D(2), leukotriene C(4), and taurocholate. Biochem Biophys Res Commun. 2000;275:831-8 pubmed
We have isolated a rat novel multispecific organic anion transporter, moat1. The isolated clones were originated by alternative splicing of the moat1 mRNA...
St Pierre M, Stallmach T, Freimoser Grundschober A, Dufour J, Serrano M, Marin J, et al
. Temporal expression profiles of organic anion transport proteins in placenta and fetal liver of the rat. Am J Physiol Regul Integr Comp Physiol. 2004;287:R1505-16 pubmed
..The placental expression of Oatp1a1, Oatp1a4, Oatp1a5, Oatp1b2, Oat, Ntcp, Mrp2, and Mrp6 was low. ..
Sakamoto K, Mikami H, Kimura J. Involvement of organic anion transporting polypeptides in the toxicity of hydrophilic pravastatin and lipophilic fluvastatin in rat skeletal myofibres. Br J Pharmacol. 2008;154:1482-90 pubmed publisher
..This is probably why hydrophilic pravastatin affects skeletal muscle, but not skeletal myoblasts. ..
Roberts L, Black D, Raman C, Woodford K, Zhou M, Haggerty J, et al
. Subcellular localization of transporters along the rat blood-brain barrier and blood-cerebral-spinal fluid barrier by in vivo biotinylation. Neuroscience. 2008;155:423-38 pubmed publisher
Yang Z, Xiang T, Zhang S, Zhan H, Chen Z, Sun B, et al
. Effect of polypeptide 2B1 on condition of dampness pattern in rats in terms of traditional Chinese medicine. J Tradit Chin Med. 2014;34:214-20 pubmed
..This study investigated how polypeptide 2B1 is involved in regulating and governing dampness in rat models with dampness pattern defined in terms of Traditional Chinese Medicine...