Mmp1a

Summary

Gene Symbol: Mmp1a
Description: matrix metallopeptidase 1a (interstitial collagenase)
Alias: matrix metallopeptidase 1a, matrix metalloproteinase 1a (interstitial collagenase)
Species: rat

Top Publications

  1. ncbi Increased tissue microarray matrix metalloproteinase expression favors proteolysis in thoracic aortic aneurysms and dissections
    George J Koullias
    Section of Cardiothoracic Surgery, Yale New Haven Hospital, New Haven, Connecticut 06510, USA
    Ann Thorac Surg 78:2106-10; discussion 2110-1. 2004
  2. ncbi Evaluation of enzymes involved in proteoglycan degradation in the wall of abdominal aortic aneurysms
    Radosław Kowalewski
    Department of Vascular Surgery and Transplantology, Medical University of Bialystok, Bialystok, Poland
    J Vasc Res 43:95-100. 2006
  3. ncbi Circulating matrix metalloproteinase-1 and -3 in patients with an acute coronary syndrome
    Teruo Inoue
    Department of Cardiology, Koshigaya Hospital, Dokkyo University School of Medicine, Koshigaya, Saitama, Japan
    Am J Cardiol 92:1461-4. 2003
  4. ncbi Polymorphisms in matrix metalloproteinase-1, -3, -9, and -12 genes in relation to subarachnoid hemorrhage
    B Zhang
    Human Genetics Research Division, Clinical Neurosciences Research Division, University of Southampton, School of Medicine, UK
    Stroke 32:2198-202. 2001
  5. ncbi Matrix metalloproteinase-1 and matrix metalloproteinase-3 gene promoter polymorphisms are associated with carotid artery stenosis
    Giorgio Ghilardi
    Dipartimento di Medicina, Chirurgia, e Odontoiatria, Clinica Chirurgica Generale, Università degli Studi di Milano Polo S Paolo, Milan, Italy
    Stroke 33:2408-12. 2002
  6. ncbi Lipodermatosclerosis is characterized by elevated expression and activation of matrix metalloproteinases: implications for venous ulcer formation
    Y Herouy
    Department of Dermatology, University Hospital, Freiburg, Germany
    J Invest Dermatol 111:822-7. 1998
  7. ncbi Enhanced angiotensin II-mediated effects in fibroblasts of patients with familial hypercholesterolemia
    Anna Solini
    Metabolism Section, Department of Internal Medicine University of Pisa, School of Medicine, Pisa, Italy
    J Hypertens 23:367-74. 2005
  8. ncbi Opposing effects of emphysema, hay fever, and select genetic variants on lung cancer risk
    Matthew B Schabath
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Epidemiol 161:412-22. 2005
  9. ncbi Inflammatory regulation of extracellular matrix remodeling in calcific aortic valve stenosis
    Jens J Kaden
    1st Department of Medicine Cardiology, Angiology, Pneumology, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Mannheim, Germany
    Cardiovasc Pathol 14:80-7. 2005
  10. ncbi Haplotype effect of the matrix metalloproteinase-1 gene on risk of myocardial infarction
    Eve Pearce
    Human Genetics Division, School of Medicine, University of Southampton, United Kingdom
    Circ Res 97:1070-6. 2005

Scientific Experts

  • T Inoue
  • A Solini
  • Bodo Schwartzkopff
  • Kenji Ueshima
  • Robert E Eckart
  • Jens J Kaden
  • G Ghilardi
  • Adviye Ergul
  • D L DeMeo
  • Shu Ye
  • Angharad R Morgan
  • Christopher J McAloon
  • Jaewwaew Klinchid
  • Chien Da Huang
  • Ivan O Rosas
  • Leanne E Felkin
  • Radosław Kowalewski
  • E Herpel
  • Eve Pearce
  • Matthew B Schabath
  • Ryuichi Kato
  • Yao zhong Kong
  • Per Eriksson
  • George J Koullias
  • Raffaella Lombardi
  • D L Gillespie
  • Ladina Joos
  • B Zhang
  • M Kouwenhoven
  • Chien Ying Liu
  • Ling Ling Hsieh
  • Wen Te Liu
  • Busyamas Chewaskulyoung
  • Robert A Stockley
  • Han Pin Kuo
  • Horng Chyuan Lin
  • Ratchada Cressey
  • Somchareon Saeteng
  • Watchara Kasinrerk
  • Alice M Wood
  • Shu Min Lin
  • Stephen C Gough
  • Nirush Lertprasertsuke
  • Chun Hua Wang
  • Po Jui Chang
  • Thomas J Richards
  • Jose Cisneros
  • Kevin Gibson
  • Frank Sciurba
  • Annie Pardo
  • Anna E Lokshin
  • James Dauber
  • Kathleen O Lindell
  • Moises Selman
  • Sandra D Macdonald
  • Kazuhisa Konishi
  • Yingze Zhang
  • Naftali Kaminski
  • Bernadette R Gochuico
  • M Pritsch
  • Emma J Birks
  • Ph A Schnabel
  • Paul J R Barton
  • Magdi H Yacoub
  • Asghar Khaghani
  • Krzysztof Sobolewski
  • Małgorzata Wolańska
  • Sissie Wong
  • Y Herouy
  • T J Dengler
  • Robert George
  • Andrzej Małkowski
  • A Koch
  • Marek Gacko
  • P Schirmacher
  • Yukihiko Momiyama
  • Charles Cox
  • Michael Bacher
  • Anders Hamsten
  • Xiao Ru Huang
  • David Alexandre Tregouet
  • David-Alexandre Tregouet
  • Marek M Martynowicz
  • Lin Leng
  • Wei Mu
  • Xiaosen Ouyang
  • Gunter Fingerle-Rowson
  • Xifeng Wu
  • Anthony J Greisinger
  • Haruo Nakamura

Detail Information

Publications29

  1. ncbi Increased tissue microarray matrix metalloproteinase expression favors proteolysis in thoracic aortic aneurysms and dissections
    George J Koullias
    Section of Cardiothoracic Surgery, Yale New Haven Hospital, New Haven, Connecticut 06510, USA
    Ann Thorac Surg 78:2106-10; discussion 2110-1. 2004
    ..We applied tissue microarray analysis to determine MMP profiles in a large group of surgically resected thoracic aneurysms and dissections...
  2. ncbi Evaluation of enzymes involved in proteoglycan degradation in the wall of abdominal aortic aneurysms
    Radosław Kowalewski
    Department of Vascular Surgery and Transplantology, Medical University of Bialystok, Bialystok, Poland
    J Vasc Res 43:95-100. 2006
    ....
  3. ncbi Circulating matrix metalloproteinase-1 and -3 in patients with an acute coronary syndrome
    Teruo Inoue
    Department of Cardiology, Koshigaya Hospital, Dokkyo University School of Medicine, Koshigaya, Saitama, Japan
    Am J Cardiol 92:1461-4. 2003
    ..Serum MMP levels appear to be a marker of plaque instability in patients with acute coronary syndrome...
  4. ncbi Polymorphisms in matrix metalloproteinase-1, -3, -9, and -12 genes in relation to subarachnoid hemorrhage
    B Zhang
    Human Genetics Research Division, Clinical Neurosciences Research Division, University of Southampton, School of Medicine, UK
    Stroke 32:2198-202. 2001
    ..The possible impact of MMP gene polymorphisms on susceptibility to intracranial aneurysms is still controversial, with conflicting data from different reported studies...
  5. ncbi Matrix metalloproteinase-1 and matrix metalloproteinase-3 gene promoter polymorphisms are associated with carotid artery stenosis
    Giorgio Ghilardi
    Dipartimento di Medicina, Chirurgia, e Odontoiatria, Clinica Chirurgica Generale, Università degli Studi di Milano Polo S Paolo, Milan, Italy
    Stroke 33:2408-12. 2002
    ..The aim of this study was to investigate a possible association between MMP polymorphisms and increased risk of internal carotid artery (ICA) stenosis...
  6. ncbi Lipodermatosclerosis is characterized by elevated expression and activation of matrix metalloproteinases: implications for venous ulcer formation
    Y Herouy
    Department of Dermatology, University Hospital, Freiburg, Germany
    J Invest Dermatol 111:822-7. 1998
    ..Furthermore, MMP-2 was imbalanced by locally reduced expression of TIMP-2 in the basement membrane zone of lesional skin. Our findings indicate lipodermatosclerosis to be characterized by elevated matrix turnover...
  7. ncbi Enhanced angiotensin II-mediated effects in fibroblasts of patients with familial hypercholesterolemia
    Anna Solini
    Metabolism Section, Department of Internal Medicine University of Pisa, School of Medicine, Pisa, Italy
    J Hypertens 23:367-74. 2005
    ..We sought to determine whether AngII promotes proliferative and pro-atherogenic responses in FH patients...
  8. ncbi Opposing effects of emphysema, hay fever, and select genetic variants on lung cancer risk
    Matthew B Schabath
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Epidemiol 161:412-22. 2005
    ..19, 0.66) protective genotypes as compared with none (OR = 0.69, 95% CI: 0.30, 1.59). The biologic role of respiratory disease in lung cancer is unclear. Further study may yield new insights for identification of susceptible subgroups...
  9. ncbi Inflammatory regulation of extracellular matrix remodeling in calcific aortic valve stenosis
    Jens J Kaden
    1st Department of Medicine Cardiology, Angiology, Pneumology, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Mannheim, Germany
    Cardiovasc Pathol 14:80-7. 2005
    ....
  10. ncbi Haplotype effect of the matrix metalloproteinase-1 gene on risk of myocardial infarction
    Eve Pearce
    Human Genetics Division, School of Medicine, University of Southampton, United Kingdom
    Circ Res 97:1070-6. 2005
    ..Haplotype-specific differences in MMP1 mRNA level in atherosclerotic tissues were also detected. The data indicate that MMP1 gene variation is a genetic factor contributing to interindividual differences in MI risk...
  11. ncbi Interstitial fibrosis in the heart: differences in extracellular matrix proteins and matrix metalloproteinases in end-stage dilated, ischaemic and valvular cardiomyopathy
    E Herpel
    Department of Pathology, University of Heidelberg, Heidelberg, Germany
    Histopathology 48:736-47. 2006
    ..To investigate whether or not there are differences in the distribution of extracellular matrix (ECM) proteins and matrix metalloproteinases (MMPs) in end-stage heart failure underlying different cardiomyopathies...
  12. ncbi A quantitative gene expression profile of matrix metalloproteinases (MMPS) and their inhibitors (TIMPS) in the myocardium of patients with deteriorating heart failure requiring left ventricular assist device support
    Leanne E Felkin
    National Heart and Lung Institute, Imperial College London, Heart Science Centre, Harefield, Middlesex
    J Heart Lung Transplant 25:1413-9. 2006
    ..Matrix metalloproteinases (MMPs) and the tissue inhibitors of metalloproteinases (TIMPs) play a key role in myocardial remodelling and heart failure. We hypothesized that MMP and TIMP expression would be altered in these patients...
  13. ncbi Genetic determinants of emphysema distribution in the national emphysema treatment trial
    Dawn L DeMeo
    Channing Laboratory, Pulmonary and Critical Care Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 176:42-8. 2007
    ....
  14. ncbi MMP1 and MMP7 as potential peripheral blood biomarkers in idiopathic pulmonary fibrosis
    Ivan O Rosas
    Dorothy P and Richard P Simmons Center for Interstitial Lung Diseases, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School ofMedicine, Pittsburgh, Pennsylvania, United States of America
    PLoS Med 5:e93. 2008
    ..The objective of this study was to determine whether there is a peripheral blood protein signature in IPF and whether components of this signature may serve as biomarkers for disease presence and progression...
  15. ncbi Matrix metalloproteinase-1 polymorphism is associated with persistent airway obstruction in asthma in the Taiwanese population
    Chien Da Huang
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan
    J Asthma 46:41-6. 2009
    ..We investigated whether MMP-1 polymorphism is associated with persistent airway obstruction in asthma in the Taiwanese population...
  16. ncbi Matrix metalloprotease polymorphisms are associated with gas transfer in alpha 1 antitrypsin deficiency
    Christopher J McAloon
    Lung Investigation Unit, University Hospital Birmingham, Birmingham, UK
    Ther Adv Respir Dis 3:23-30. 2009
    ..Matrix metalloproteinases [MMPs] are believed to be important in the pathophysiology of COPD, and may therefore confer susceptibility to this phenotype in patients with AATD...
  17. ncbi Evidence for vascular macrophage migration inhibitory factor in destabilization of human atherosclerotic plaques
    Yao zhong Kong
    The First People s Foshan Hospital, Foshan, Guangdong, China
    Cardiovasc Res 65:272-82. 2005
    ..The aim of this study is to investigate the potential role of MIF in the destabilization of atherosclerotic plaques by stimulation of vascular MMP-1 expression...
  18. ncbi Levels of matrix metalloproteinase-1 in patients with and without coronary artery disease and relation to complex and noncomplex coronary plaques
    Ryuichi Kato
    First Department of Internal Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan
    Am J Cardiol 95:90-2. 2005
    ..High serum levels of MMP-1 were associated with the presence of complex lesions in patients who had CAD...
  19. ncbi Matrix metalloproteinase and cytokine profiles in monocytes over the course of stroke
    M Kouwenhoven
    J Clin Immunol 21:365-75. 2001
    ..Such changes may contribute to the influx of blood-borne cells into the ischemic lesions during the acute phase of stroke...
  20. ncbi The role of matrix metalloproteinase polymorphisms in the rate of decline in lung function
    Ladina Joos
    University of British Columbia McDonald Research Laboratories iCAPTURE Center, St Paul s Hospital, 1081 Burrard Street, Vancouver, British Columbia V6Z 1Y6, Canada
    Hum Mol Genet 11:569-76. 2002
    ..0007). These data suggest that polymorphisms in the MMP1 and MMP12 genes, but not MMP9, are either causative factors in smoking-related lung injury or are in linkage disequilibrium with causative polymorphisms...
  21. ncbi Elevated serum markers of collagen degradation in patients with mild to moderate dilated cardiomyopathy
    Bodo Schwartzkopff
    Department of Cardiology, Angiology and Pneumology, Heinrich Heine University Dusseldorf, Moorenstrasse 5, Germany
    Eur J Heart Fail 4:439-4. 2002
    ..In the present study, serological markers of collagen metabolism were investigated...
  22. ncbi Varicose veins possess greater quantities of MMP-1 than normal veins and demonstrate regional variation in MMP-1 and MMP-13
    D L Gillespie
    Department of Surgery, Uniformed Services University, Bethesda, Maryland 20854, USA
    J Surg Res 106:233-8. 2002
    ..In addition we hypothesized that there may be regional variation in the expression of these enzymes within the leg...
  23. ncbi Extracellular matrix disturbances in acute myocardial infarction: relation between disease severity and matrix metalloproteinase-1, and effects of magnesium pretreatment on reperfusion injury
    Kenji Ueshima
    Second Department of Internal Medicine, Iwate Medical University, Morioka, Japan
    Magnes Res 16:120-6. 2003
    ..Additionally, to investigate whether magnesium (Mg) sulfate pretreatment inhibits myocardial damage in coronary reperfusion therapy for patients with AMI...
  24. ncbi Myocardial collagen turnover in hypertrophic cardiomyopathy
    Raffaella Lombardi
    Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Federico II University School of Medicine, Naples, Italy
    Circulation 108:1455-60. 2003
    ..Myocardial interstitial fibrosis is a characteristic of hypertrophic cardiomyopathy (HCM). This study evaluates the collagen turnover in HCM and its impact on left ventricular (LV) diastolic function...
  25. ncbi Variation in the matrix metalloproteinase-1 gene and risk of coronary heart disease
    Shu Ye
    Human Genetics Division, University of Southampton School of Medicine, Southampton General Hospital, Southampton SO16 6YD, UK
    Eur Heart J 24:1668-71. 2003
    ..In addition, we examined a polymorphism in the human MMP-3 gene that was previously reported to be associated with progression of coronary atherosclerosis...
  26. ncbi Matrix metalloproteinases in patients with myocardial infarction and percutaneous revascularization
    Robert E Eckart
    Cardiology Service ATTN MCHE MDC, Brooke Army Medical Center, 3851 Roger Brooke Drive, Fort Sam Houston, San Antonio, TX 78234 6200, USA
    J Interv Cardiol 17:27-31. 2004
    ..Matrix metalloproteinases (MMPs) are enzymes involved in extracellular matrix degradation. The extrapolation of the role MMPs play in the clinical setting of acute coronary syndromes has not yet been defined...
  27. ncbi Differences in matrix metalloproteinase-1 and matrix metalloproteinase-12 transcript levels among carotid atherosclerotic plaques with different histopathological characteristics
    Angharad R Morgan
    Human Genetics Division, School of Medicine, University of Southampton, UK
    Stroke 35:1310-5. 2004
    ..Here we investigated whether transcript levels of MMP-1, -3, -7, -9, and -12 in carotid atherosclerotic plaques were correlated with histological features and clinical manifestations...
  28. ncbi Downregulation of vascular matrix metalloproteinase inducer and activator proteins in hypertensive patients
    Adviye Ergul
    Program in Clinical and Experimental Therapeutics, University of Georgia College of Pharmacy, Medical College of Georgia, Augusta, Georgia 30912, USA
    Am J Hypertens 17:775-82. 2004
    ..However, the expression pattern of the vascular MMP system in human hypertension remained unknown...
  29. ncbi Effect of combined genetic polymorphisms on lung cancer risk in northern Thai women
    Jaewwaew Klinchid
    Division of Clinical Chemistry, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand
    Cancer Genet Cytogenet 195:143-9. 2009
    ..Confirmation would require further investigations with larger sample sizes...

Research Grants12

  1. Mechanism of Endothelial Dysfunction in Diabetes
    Adviye Ergul; Fiscal Year: 2004
    ..The results will lead to the development of novel therapeutic targets for the high-risk diabetic patients and may identify subgroups of patients that would be more suitable for these new treatment strategies. ..
  2. Vascular Protection & Endothelin B Receptors in Diabetes
    Adviye Ergul; Fiscal Year: 2007
    ..abstract_text> ..
  3. Asthma Candidate Genes in Alpha 1-Antitrypsin Deficiency
    Dawn DeMeo; Fiscal Year: 2007
    ..The identification of modifying factors of COPD in AAT deficiency may have significant public health relevance to COPD patients without AAT deficiency. ..
  4. Cerebrovascular mechanisms of ischemic injury in diabetes
    Adviye Ergul; Fiscal Year: 2007
    ..Identification of causal factors and molecular mechanisms responsible for disruption of vascular integrity in diabetes will advance stroke treatment by reducing the risk of hemorrhage and improve stroke outcome. ..
  5. Vascular Protection & Endothelin B Receptors in Diabetes
    Adviye Ergul; Fiscal Year: 2009
    ..abstract_text> ..