Mmp14

Summary

Gene Symbol: Mmp14
Description: matrix metallopeptidase 14
Alias: Mt1-mmp, matrix metalloproteinase-14, MMP-14, MT-MMP 1, MT1MMP, MTMMP1, matrix metallopeptidase 14 (membrane-inserted), matrix metalloproteinase 14 membrane-inserted, membrane type 1-matrix metalloproteinase, membrane-type matrix metalloproteinase 1
Species: rat

Top Publications

  1. ncbi Enhanced expression of membrane type-1 matrix metalloproteinase in mesangial proliferative glomerulonephritis
    K Hayashi
    Department of Medicine, Juntendo University School of Medicine, Tokyo, Japan
    J Am Soc Nephrol 9:2262-71. 1998
  2. ncbi Expression of matrix metalloproteinases and their inhibitors by rat NK cells: inhibition of their expression by genistein
    M H Kim
    Department of Molecular Biology and Immunology, and Institute for Cancer Research, University of North Texas Health Science Center at Fort Worth, Texas, USA
    In Vivo 14:557-64. 2000
  3. ncbi Distinct roles for the catalytic and hemopexin domains of membrane type 1-matrix metalloproteinase in substrate degradation and cell migration
    Jian Cao
    Department of Medicine, School of Medicine, State University of New York, Stony Brook, New York 11794, USA
    J Biol Chem 279:14129-39. 2004
  4. pmc Increased expression and activity of matrix metalloproteinases characterize embolic cardiac myxomas
    Augusto Orlandi
    Department of Anatomic Pathology, Tor Vergata University of Rome Via Montpellier 1, Rome, Italy
    Am J Pathol 166:1619-28. 2005
  5. ncbi Extracellular matrix metalloproteinase inducer regulates matrix metalloproteinase activity in cardiovascular cells: implications in acute myocardial infarction
    Roland Schmidt
    Deutsches Herzzentrum und Medizinische Klinik I, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Circulation 113:834-41. 2006
  6. doi Early events of overused supraspinatus tendons involve matrix metalloproteinases and EMMPRIN/CD147 in the absence of inflammation
    Mohamed Attia
    Laboratoire CRRET CNRS EAC 7149, Université Paris Est Créteil, Creteil Cedex, France
    Am J Sports Med 41:908-17. 2013
  7. ncbi Early MT-1 MMP expression following elastase exposure is associated with increased cleaved MMP-2 activity in experimental rodent aortic aneurysms
    Indranil Sinha
    Jobst Vascular Research Laboratories, Section of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI 48109 0329, USA
    Surgery 136:176-82. 2004
  8. ncbi Proprotein convertases regulate insulin-like growth factor 1-induced membrane-type 1 matrix metalloproteinase in VSMCs via endoproteolytic activation of the insulin-like growth factor-1 receptor
    Philipp Stawowy
    Department of Medicine Cardiology, Deutsches Herzzentrum Berlin, Germany
    Biochem Biophys Res Commun 321:531-8. 2004
  9. ncbi Angiotensin type 1 receptor blockage improves ischemic injury following transient focal cerebral ischemia
    N Hosomi
    Second Department of Internal Medicine, Division of Stroke, Kagawa University School of Medicine, 1750 1 Ikenobe, Miki cho, Kagawa 761 0793, Japan
    Neuroscience 134:225-31. 2005
  10. ncbi Up-regulation of matrix metalloproteinase-2 and membrane-type 1-matrix metalloproteinase were coupled with that of type I procollagen in granulation tissue response after the onset of aortic dissection
    Masatoshi Akiyama
    Department of Cardiovascular Surgery, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Sendai 980 8574, Japan
    Virchows Arch 448:811-21. 2006

Research Grants

  1. Gene Expession in Conditioned Taste Aversion
    Louis Irwin; Fiscal Year: 2002
  2. The function of Runx1 in the ovary
    Misung Jo; Fiscal Year: 2007
  3. Extracellular Mechanisms For Thoracic Aortic Aneurysms
    John Ikonomidis; Fiscal Year: 2008

Scientific Experts

  • A Orlandi
  • Louis N Irwin
  • Elena Kaschina
  • Victor N Ierusalimsky
  • Kengo Furuichi
  • T L Haas
  • P Stawowy
  • W Schwab
  • Kengo Manase
  • He Wang
  • Paola Manduca
  • Naohisa Hosomi
  • John Ikonomidis
  • Erol Saygili
  • J T Peterson
  • Masatoshi Akiyama
  • Misung Jo
  • Chun Guo
  • Kristin Schram
  • Ruili Li
  • Nádia Fayez Omar
  • Jose Rosa Gomes
  • K C Camargo
  • Sören Otto
  • Daliang Yan
  • Aaron C Overland
  • Naoko Kubo Birukawa
  • Carolina de Souza Guerra
  • Dilyara Lauer
  • Mohamed Attia
  • Carla S Ceron
  • Juliete A F Silva
  • John M Hutson
  • Bridget R Southwell
  • James A Churchill
  • Masashi Kamioka
  • Pedro Duarte Novaes
  • Juliana Dos Santos Neves
  • Eun Kyung No
  • Gary Sweeney
  • Teresina Laragione
  • K Hayashi
  • Eric Ispanovic
  • Satoshi Shinozaki
  • Jeff Z He
  • E Boucher
  • Keizo Takenaga
  • Marisa D Covington
  • Roland Schmidt
  • Sia Dahi
  • Sergey Filippov
  • Séverine Mazaud
  • Zamaneh Kassiri
  • Pamela J Boyd
  • Jesus Alvarez
  • Molykutty John
  • Indranil Sinha
  • Jian Cao
  • E Y Liao
  • Tzong Luen Wang
  • Tomoko Shofuda
  • Xiaojuan Liu
  • Lu Hua
  • M A de M Soares
  • Jiahai Shi
  • Jianhua Zhao
  • Birgit Zatschler
  • Anja Neisser
  • Kunpeng Wu
  • Xiang Wu
  • Xilin Sha
  • M M Loddi
  • Kathrin Barth
  • R de Sordi
  • Bianca Müller
  • J R Gomes
  • Henning Morawietz
  • Chen Yang
  • C L S Costa-Ayub
  • Andreas Deussen
  • Irakli Kopaliani
  • Chao Zhang
  • Ron Achong
  • Paul A Insel
  • Borhane Annabi
  • Kazuyuki Murase
  • Elaine A Del Bel Guimarães
  • Yusuke Nakashima
  • Keiko Kajiwara
  • Miyuki Nishimura

Detail Information

Publications67

  1. ncbi Enhanced expression of membrane type-1 matrix metalloproteinase in mesangial proliferative glomerulonephritis
    K Hayashi
    Department of Medicine, Juntendo University School of Medicine, Tokyo, Japan
    J Am Soc Nephrol 9:2262-71. 1998
    ..Furthermore, the enhancement of MT1-MMP and MMP-2 expression associated with mesangial phenotypic change may contribute to the development of anti-Thy1.1 antibody-induced glomerulonephritis and remodeling of extracellular matrices...
  2. ncbi Expression of matrix metalloproteinases and their inhibitors by rat NK cells: inhibition of their expression by genistein
    M H Kim
    Department of Molecular Biology and Immunology, and Institute for Cancer Research, University of North Texas Health Science Center at Fort Worth, Texas, USA
    In Vivo 14:557-64. 2000
    ..Moreover, genistein greatly impaired the ability of RNK-16 cells to invade through a model basement membrane. This effect might be mediated by the observed down-regulation of MMP-13 and MT1-MMP...
  3. ncbi Distinct roles for the catalytic and hemopexin domains of membrane type 1-matrix metalloproteinase in substrate degradation and cell migration
    Jian Cao
    Department of Medicine, School of Medicine, State University of New York, Stony Brook, New York 11794, USA
    J Biol Chem 279:14129-39. 2004
    ..These data demonstrated that each domain of MT1-MMP plays a distinct role in substrate degradation and cell migration...
  4. pmc Increased expression and activity of matrix metalloproteinases characterize embolic cardiac myxomas
    Augusto Orlandi
    Department of Anatomic Pathology, Tor Vergata University of Rome Via Montpellier 1, Rome, Italy
    Am J Pathol 166:1619-28. 2005
    ..Our results strongly suggest that MMP overexpression may contribute to an excessive degradation of tumor ECM and increase the risk of embolism in cardiac myxomas...
  5. ncbi Extracellular matrix metalloproteinase inducer regulates matrix metalloproteinase activity in cardiovascular cells: implications in acute myocardial infarction
    Roland Schmidt
    Deutsches Herzzentrum und Medizinische Klinik I, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Circulation 113:834-41. 2006
    ..Thus, we studied EMMPRIN expression on monocytes in acute myocardial infarction (MI) and its potential relevance for MMP activation...
  6. doi Early events of overused supraspinatus tendons involve matrix metalloproteinases and EMMPRIN/CD147 in the absence of inflammation
    Mohamed Attia
    Laboratoire CRRET CNRS EAC 7149, Université Paris Est Créteil, Creteil Cedex, France
    Am J Sports Med 41:908-17. 2013
    ..A rat model of supraspinatus tendon overuse has been developed, which may be predictive of pathological tendon alterations...
  7. ncbi Early MT-1 MMP expression following elastase exposure is associated with increased cleaved MMP-2 activity in experimental rodent aortic aneurysms
    Indranil Sinha
    Jobst Vascular Research Laboratories, Section of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI 48109 0329, USA
    Surgery 136:176-82. 2004
    The objective of this study was to determine the significance of membrane type 1 matrix metalloproteinase (MT1-MMP) activation of MMP-2 in experimental abdominal aortic aneurysms.
  8. ncbi Proprotein convertases regulate insulin-like growth factor 1-induced membrane-type 1 matrix metalloproteinase in VSMCs via endoproteolytic activation of the insulin-like growth factor-1 receptor
    Philipp Stawowy
    Department of Medicine Cardiology, Deutsches Herzzentrum Berlin, Germany
    Biochem Biophys Res Commun 321:531-8. 2004
    ..In conclusion, this study demonstrates that targeting furin-like PCs and thus inhibiting IGF-1R activation is a novel target to inhibit IGF-1-mediated signaling and cell functions, such as IGF-1-induced MT1-MMP/MMP-2 in VSMCs...
  9. ncbi Angiotensin type 1 receptor blockage improves ischemic injury following transient focal cerebral ischemia
    N Hosomi
    Second Department of Internal Medicine, Division of Stroke, Kagawa University School of Medicine, 1750 1 Ikenobe, Miki cho, Kagawa 761 0793, Japan
    Neuroscience 134:225-31. 2005
    ..Angiotensin type 1 receptor stimulation may be one of the important factors that cause cerebral edema following cerebral ischemia, and that its inhibition may be of therapeutic advantage in cerebral ischemia...
  10. ncbi Up-regulation of matrix metalloproteinase-2 and membrane-type 1-matrix metalloproteinase were coupled with that of type I procollagen in granulation tissue response after the onset of aortic dissection
    Masatoshi Akiyama
    Department of Cardiovascular Surgery, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Sendai 980 8574, Japan
    Virchows Arch 448:811-21. 2006
    ....
  11. pmc Coordinated elevation of membrane type 1-matrix metalloproteinase and matrix metalloproteinase-2 expression in rat uterus during postpartum involution
    Kengo Manase
    Department of Obstetrics and Gynecology, Sapporo Medical University School of Medicine, South 1 West 16, Chuou ku, Sapporo 060 8543, Japan
    Reprod Biol Endocrinol 4:32. 2006
    ..To understand the expression patterns of matrix metalloproteinases (MMPs) in the rat uterus, we analyzed their activities in postpartum uterine involution...
  12. doi Indian hedgehog promotes the migration of rat activated pancreatic stellate cells by increasing membrane type-1 matrix metalloproteinase on the plasma membrane
    Satoshi Shinozaki
    Division of Gastroenterology, Department of Internal Medicine, Jichi Medical University, Tochigi, Japan
    J Cell Physiol 216:38-46. 2008
    ..These data indicate that Ihh promotes PSC migration by enhancing MT1-MMP localization on the plasma membrane but is negatively regulated by Gli-1...
  13. doi Cdc42 and RhoA have opposing roles in regulating membrane type 1-matrix metalloproteinase localization and matrix metalloproteinase-2 activation
    Eric Ispanovic
    School of Kinesiology and Health Sciences, York University, Toronto, Ontario, Canada M3J 1P3
    Am J Physiol Cell Physiol 295:C600-10. 2008
    ..Furthermore, VEGF-dependent activation of MMP-2 was reduced by inhibition of Cdc42. These results suggest that Cdc42 and RhoA have opposing roles in regulating cell surface localization of MT1-MMP and MMP-2 activation...
  14. doi Involvement of membrane type 1-matrix metalloproteinase (MT1-MMP) in RAGE activation signaling pathways
    Masashi Kamioka
    Department of Cardiology and Hematology, Fukushima Medical University, Fukushima, Japan
    J Cell Physiol 226:1554-63. 2011
    ....
  15. ncbi Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in human invasive breast carcinomas
    H Ueno
    Department of Molecular Immunology, School of Medicine, Kanazawa University, Ishikawa, Japan
    Cancer Res 57:2055-60. 1997
    ..These results suggest that MT1-MMP may play a key role in human breast carcinoma invasion and metastasis by being predominantly responsible for activation of proMMP-2...
  16. doi Type 1 metalloproteinase is selectively expressed in adult rat brain and can be rapidly up-regulated by kainate
    Victor N Ierusalimsky
    Institute of Higher Nervous Activity and Neurophysiology RAS, 5A Butlerova Street, Moscow 117485, Russia Electronic address
    Acta Histochem 115:816-26. 2013
    ..Thus, MMP-1 is present in several brain areas in normal conditions at a detectable level, and its expression increases after kainate-induced seizures...
  17. doi Angiotensin type 2 receptor stimulation ameliorates left ventricular fibrosis and dysfunction via regulation of tissue inhibitor of matrix metalloproteinase 1/matrix metalloproteinase 9 axis and transforming growth factor β1 in the rat heart
    Dilyara Lauer
    Center for Cardiovascular Research and Institute of Pharmacology, Charite Universitatsmedizin, Berlin, Hessische Strasse 3 4, D 10115 Berlin, Germany
    Hypertension 63:e60-7. 2014
    ....
  18. pmc Activated hepatic stellate cells are dependent on self-collagen, cleaved by membrane type 1 matrix metalloproteinase for their growth
    Naoko Kubo Birukawa
    From the Department of Molecular Target Exploration
    J Biol Chem 289:20209-21. 2014
    ..The intramolecular RGD motifs of collagen were exposed by cleavage with their own membrane type 1 matrix metalloproteinase (MT1-MMP). The following evidence supports this conclusion...
  19. pmc Histological, histochemical, and protein changes after induced malocclusion by occlusion alteration of Wistar rats
    Carolina de Souza Guerra
    Department of Morphology, Physiology and Basic Pathology, Ribeirao Preto School of Dentistry, University of Sao Paulo, FORP USP, P O Box 14040 904, Ribeirao Preto, SP, Brazil
    Biomed Res Int 2014:563463. 2014
    ..This knowledge about morphology and molecular masticatory muscle remodeling following environmental interventions can be used to develop clinically successful treatments. ..
  20. pmc Heterotrimeric G proteins directly regulate MMP14/membrane type-1 matrix metalloprotease: a novel mechanism for GPCR-EGFR transactivation
    Aaron C Overland
    From the Departments of Pharmacology and
    J Biol Chem 290:9941-7. 2015
    ..occur by a membrane-delimited process: direct increase in the activity of membrane type-1 matrix metalloprotease (MMP14, MT1-MMP) by heterotrimeric G proteins, and in turn, the generation of heparin-binding epidermal growth factor (HB-..
  21. doi A novel role of endothelium in activation of latent pro-membrane type 1 MMP and pro-MMP-2 in rat aorta
    Sören Otto
    Department of Physiology, Faculty of Medicine, Technische Universitat Dresden, Germany
    Cardiovasc Res 109:409-18. 2016
    ..of elastic fibres in aorta due to angiotensin II (ANGII)-stimulated overactivation of latent membrane type 1 matrix metalloproteinase (MT1MMP) and matrix metalloproteinase-2 (MMP2) is regarded to represent an important cause of ..
  22. doi MT1-MMP and its potential role in the vertebrate intestinal morphogenesis
    K C Camargo
    Department of Structural and Molecular Biology and Genetic Electronic address
    Acta Histochem 118:729-735. 2016
    ..However, further studies are necessary to confirm the role of MT1-MMP in this cellular process. In addition, we performed validation of the primary antibody against human MT1-MMP for adult chickens...
  23. doi MMP-14 promotes VSMC migration via up-regulating CD44 expression in cardiac allograft vasculopathy
    Daliang Yan
    Department of Thoracic Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, PR China Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Medical College, Nantong University, Nantong, Jiangsu 226001, PR China
    Pathol Res Pract 212:1119-1125. 2016
    ..Our results elucidate the molecular mechanism of VSMC migration after cardiac transplantation and provide theoretical basis for seeking new specific drug targets for CAV prevention and treatment...
  24. ncbi Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in human urothelial carcinomas
    Y Kitagawa
    Department of Urology, Kanazawa University School of Medicine, Japan
    J Urol 160:1540-5. 1998
    ..We examined the mRNA expression of MT-MMPs and the tissue immunolocalization of MT1-MMP in human urothelial carcinomas...
  25. ncbi Membrane type 1-matrix metalloproteinase (MMP)-associated MMP-2 activation increases in the rat ovary in response to an ovulatory dose of human chorionic gonadotropin
    Misung Jo
    Department of Obstetrics and Gynecology, Chandler Medical Center, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    Biol Reprod 70:1024-32. 2004
    ..The increase in MT1-MMP mRNA may be an important part of the mechanism necessary for the efficient generation of active MMP-2 during the ovulatory process...
  26. ncbi Membrane type (MT) 1-matrix metalloproteinase (MMP) and MMP-2 expression in ligature-induced periodontitis in the rat
    Ron Achong
    Department of Oral and Maxillofacial Surgery, Louisiana State University School of Dentistry, New Orleans, LA, USA
    J Periodontol 74:494-500. 2003
    ..This study aims to elucidate the presence and localization of MT1-MMP and MMP-2 in periodontitis in a rat model...
  27. ncbi Type I collagen-induced MMP-2 activation coincides with up-regulation of membrane type 1-matrix metalloproteinase and TIMP-2 in cardiac fibroblasts
    Chun Guo
    School of Pharmacy and Pharmaceutical Sciences, De Montfort University, Leicester LE1 9BH, United Kingdom
    J Biol Chem 278:46699-708. 2003
    ..These results suggest that the migration and invasion of cardiac fibroblasts is furin-dependent and that the active species of MT1-MMP and MMP-2 may be involved in both events...
  28. doi Matrix metalloproteinase-2 (MMP-2) and membrane-type 1 MMP (MT1-MMP) affect the remodeling of glomerulosclerosis in diabetic OLETF rats
    Kengo Furuichi
    Division of Blood Purification, Kanazawa University Hospital, Kanazawa Japan
    Nephrol Dial Transplant 26:3124-31. 2011
    ....
  29. doi Sequential IL-23 and IL-17 and increased Mmp8 and Mmp14 expression characterize the progression of an experimental model of periodontal disease in type 1 diabetes
    Juliete A F Silva
    Department of Anatomy, Cell Biology, Physiology and Biophysics, State University of Campinas UNICAMP, Campinas, Sao Paulo, Brazil
    J Cell Physiol 227:2441-50. 2012
    ..Cytokine profile and expression levels of collagenases, Mmp14, and tissue inhibitors were determined, as were the numbers of neutrophils and macrophages in combined ..
  30. doi MT1-MMP expression in the odontogenic region of rat incisors undergoing interrupted eruption
    Nádia Fayez Omar
    Department of Morphology, Faculty Odontology of Piracicaba, State University of Campinas, Piracicaba, SP, Brazil
    J Mol Histol 42:505-11. 2011
    ..Results indicate that MT1-MMP may have an important role in the process of dental eruption...
  31. doi Gubernaculum as icebreaker: do matrix metalloproteinases in rodent gubernaculum and inguinal fat pad permit testicular descent?
    James A Churchill
    Murdoch Childrens Research Institute, Parkville, Victoria 3052, Australia
    J Pediatr Surg 46:2353-7. 2011
    ....
  32. doi Time course involvement of matrix metalloproteinases in the vascular alterations of renovascular hypertension
    Carla S Ceron
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, 14049 900, Brazil
    Matrix Biol 31:261-70. 2012
    ..Using antioxidants or MMPs inhibitors in the early phase of hypertension may prevent the vascular alterations of hypertension...
  33. doi Is matrix metalloproteinase required in postnatal testicular tubules for germ cell maturation?
    Ruili Li
    F Douglas Stephens Surgical Research Laboratory, Murdoch Childrens Research Institute, Melbourne 3052, Australia
    J Pediatr Surg 47:1724-9. 2012
    ..We aimed to investigate neonatal rodent testis matrix metalloproteinase (MMP) production to see whether MMPs loosen extracellular matrix between Sertoli cells to facilitate gonocyte movement...
  34. ncbi Expression of matrix metalloproteases (MMP-2, MT1 -MMP) and their tissue inhibitor (TIMP-2) by rat sertoli cells in culture: implications for spermatogenesis
    M Liliana Slongo
    Department of Experimental Biomedical Sciences, University of Padua, Italy
    Biol Chem 383:235-9. 2002
    ....
  35. doi Regulation of MT1-MMP and MMP-2 by leptin in cardiac fibroblasts involves Rho/ROCK-dependent actin cytoskeletal reorganization and leads to enhanced cell migration
    Kristin Schram
    Department of Biology, York University, Toronto, Ontario, Canada
    Endocrinology 152:2037-47. 2011
    ..Subsequent pro-MMP-2 activation then contributes to stimulation of cell migration...
  36. ncbi Elevated expression of extracellular matrix metalloproteinase inducer (CD147) and membrane-type matrix metalloproteinases in venous leg ulcers
    J Norgauer
    Department of Dermatology, University Medical Center, Hauptstrasse 7, D 79104 Freiburg, Germany
    Br J Dermatol 147:1180-6. 2002
    ..Extracellular MMP inducer (EMMPRIN; CD147) has been reported to increase MMP expression, and membrane type 1 MMP (MT1-MMP) has been implicated in the activation of MMPs...
  37. doi Increase of MT1-MMP, TIMP-2 and Ki-67 proteins in the odontogenic region of the rat incisor post-shortening procedure
    Jose Rosa Gomes
    Departamento de Biologia Estrutural Molecular e Genética, UEPG, Carlos Cavalcanti Avenue, 4748 Ponta Grossa, PR 84030 900, Brazil
    J Mol Histol 41:333-41. 2010
    ..This suggests that MT1-MMP and TIMP-2 may have some role in cell proliferation during the eruption of the rat incisor tooth...
  38. doi Sympathetic neurons express and secrete MMP-2 and MT1-MMP to control nerve sprouting via pro-NGF conversion
    Erol Saygili
    Department of Cardiology, Medical Clinic I, RWTH Aachen University, Germany
    Cell Mol Neurobiol 31:17-25. 2011
    ..In summary, specific MMP-2 blockade prevents sympathetic nerve sprouting (SNS) by inhibition of pro-NGF conversion while losartan abolishes HFES-induced SNS by reducing total NGF, MMP-2 and MT1-MMP expression...
  39. doi Role of MT1-MMP in the osteogenic differentiation
    Paola Manduca
    Genetics, DIBIO, University of Genoa, 26, C Europa, Genoa 16132, Italy
    Bone 44:251-65. 2009
    ..MT1-MMP has multiple functions and is implicated in multiple steps of the differentiation process, acting to regulate homeostasis of the osteogenic differentiation...
  40. pmc The arthritis severity locus Cia5d is a novel genetic regulator of the invasive properties of synovial fibroblasts
    Teresina Laragione
    Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    Arthritis Rheum 58:2296-306. 2008
    ..However, regulation of the FLS remains incompletely understood. The aim of this study was to determine whether the invasive properties of FLS are genetically regulated by arthritis severity loci...
  41. ncbi Immunocytochemical and biochemical detection of EMMPRIN in the rat tooth germ: differentiation-dependent co-expression with MMPs and co-localization with caveolin-1 in membrane rafts of dental epithelial cells
    W Schwab
    Institute of Anatomy, Medical Faculty Carl Gustav Carus, Technical University Dresden, Fiedlerstr 42, 01307, Dresden, Germany
    Histochem Cell Biol 128:195-203. 2007
    ..The localization of EMMPRIN in membrane rafts provides a basis for further investigations on the role of caveolin-1 in EMMPRIN-mediated signal transduction cascades in ameloblasts...
  42. ncbi The role of proteases in fibronectin matrix remodeling in thyroid epithelial cell monolayer cultures
    Luigi Nezi
    Centro di Endocrinologia ed Oncologia Sperimentale, CNR, Dpt Biologia e Patologia Cellulare e Molecolare, Napoli, Italy
    Biol Chem 383:167-76. 2002
    ..These results indicate that in the FN remodeling process, occurring during FRT epithelium maturation, both plasmin-dependent (tPA activated) and plasmin-independent proteolytic activities are involved...
  43. ncbi Differential regulation of matrix metalloproteinase activities in abdominal aortic aneurysms
    Borhane Annabi
    Laboratoire de Medecine Moleculaire, Centre de cancérologie Charles Bruneau, Hôpital Sainte Justine UQAM, Montreal, PQ, Canada
    J Vasc Surg 35:539-46. 2002
    ..In this study, we assessed the expression levels and the functional regulation of several MMPs in the pathogenesis of AAAs...
  44. ncbi Macrophage-derived MT1-MMP and increased MMP-2 activity are associated with glomerular damage in crescentic glomerulonephritis
    K Hayashi
    Division of Nephrology, Department of Medicine, Juntendo University School of Medicine, Tokyo, Japan
    J Pathol 191:299-305. 2000
    ....
  45. ncbi Evolution of matrix metalloprotease and tissue inhibitor expression during heart failure progression in the infarcted rat
    J T Peterson
    Department of Cardiovascular Therapeutics, Parke Davis Pharmaceutical Research, Division of Warner Lambert Company, 2800 Plymouth Road, Ann Arbor, MI 48105, USA
    Cardiovasc Res 46:307-15. 2000
    ....
  46. ncbi Vascular extracellular matrix remodeling in cerebral aneurysms
    G Bruno
    Cerebrovascular Research Laboratory, The Cleveland Clinic Foundation, Ohio 44195, USA
    J Neurosurg 89:431-40. 1998
    ..The purpose of the present study was to determine whether active extracellular matrix remodeling occurs within cerebral aneurysms...
  47. pmc Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas
    A Okada
    Institut de Génétique et de Biologie Moléculaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur Collège de France, Illkirch
    Proc Natl Acad Sci U S A 92:2730-4. 1995
    ....
  48. pmc MT1-matrix metalloproteinase directs arterial wall invasion and neointima formation by vascular smooth muscle cells
    Sergey Filippov
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan, Ann Arbor, 48109, USA
    J Exp Med 202:663-71. 2005
    ..These studies suggest that therapeutic interventions designed to target MT1-MMP could prove beneficial in a range of human vascular disease states associated with the destructive remodeling of the vessel wall extracellular matrix...
  49. ncbi Cleavage of focal adhesion kinase in vascular smooth muscle cells overexpressing membrane-type matrix metalloproteinases
    Tomoko Shofuda
    Division of Vascular Surgery, Department of Surgery, University of Washington School of Medicine, Seattle, Wash 98195 6410, USA
    Arterioscler Thromb Vasc Biol 24:839-44. 2004
    ..Because integrin-mediated cell adhesion regulates these events, we have investigated the functional relationship between MT-MMPs and focal adhesion assembly...
  50. ncbi Membrane-type matrix metalloproteinase-1 (MT1-MMP) is down-regulated in estrogen-deficient rat osteoblast in vivo
    E Y Liao
    Institute of Endocrinology and Metabolism, The Second Xiangya Hospital of Central South University, Changsha, Hunan, PR China
    J Endocrinol Invest 27:1-5. 2004
    ..There is evidence suggesting a role for MT1-MMP in the process of bone loss during the pathogenesis of osteoporosis...
  51. ncbi Angiotensin II signals mechanical stretch-induced cardiac matrix metalloproteinase expression via JAK-STAT pathway
    Tzong Luen Wang
    Department of Emergency Department, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    J Mol Cell Cardiol 37:785-94. 2004
    ..The objective of this study was to test the hypothesis that angiotensin II is a potential mediator of stretch-induced activation of matrix metalloproteinases (MMP)...
  52. ncbi MAPK signaling regulates endothelial cell assembly into networks and expression of MT1-MMP and MMP-2
    Pamela J Boyd
    School of Kinesiology and Health Sciences, Farquharson Bldg, Rm 341, York University, 4700 Keele St, Toronto, Ontario, Canada M3J 1P3
    Am J Physiol Cell Physiol 288:C659-68. 2005
    ....
  53. ncbi Basal membrane remodeling during follicle histogenesis in the rat ovary: contribution of proteinases of the MMP and PA families
    Séverine Mazaud
    Laboratoire de Physiologie et Physiopathologie, CNRS UMR 7079, Universite Paris VI, Paris, France
    Dev Biol 277:403-16. 2005
    ....
  54. ncbi Matrix metalloproteinases are down-regulated in rat lenses exposed to oxidative stress
    Molykutty John
    Section of Molecular Therapeutics, National Eye Institute, National Institutes of Health, Building 7, Room 202, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Exp Eye Res 79:839-46. 2004
    ..Moreover, in our model system, MMP inhibition, not induction, is associated with cataractogenesis...
  55. ncbi Expression patterns of matrix metalloproteinases and vascular endothelial growth factor during epiphyseal ossification
    Jesus Alvarez
    Departamento de Morfologia y Biologia Celular, Instituto Universitario de Oncologia del Principado de Asturias IUOPA, Universidad de Oviedo, Oviedo, Asturias, Spain
    J Bone Miner Res 20:1011-21. 2005
    ..MMPs were widely expressed during ossification of the secondary center, whereas expression of VEGF was restricted to later stages...
  56. ncbi Combination of tumor necrosis factor-alpha ablation and matrix metalloproteinase inhibition prevents heart failure after pressure overload in tissue inhibitor of metalloproteinase-3 knock-out mice
    Zamaneh Kassiri
    Ontario Cancer Institute, University of Toronto, University Health Network, Canada
    Circ Res 97:380-90. 2005
    ..Notably, combining TNFalpha ablation with MMP inhibition completely rescued heart disease in timp-3(-/-)-AB mice. This study provides a basis for anti-TNFalpha and MMP inhibitor combination therapy in heart disease...
  57. ncbi Ischemia-induced cleavage of cadherins in NRK cells requires MT1-MMP (MMP-14)
    Marisa D Covington
    Department of Medical Pharmacology and Toxicology, College of Medicine, Texas A and M University System Health Science Center, College Station, Texas, USA
    Am J Physiol Renal Physiol 290:F43-51. 2006
    ..These results demonstrate that ischemia induces increased expression of active MT1-MMP and subsequent disruption of cadherin/catenin complexes, implying that MT1-MMP plays a role in ischemia-induced ARF...
  58. doi Increased expression and cell surface localization of MT1-MMP plays a role in stimulation of MMP-2 activity by leptin in neonatal rat cardiac myofibroblasts
    Kristin Schram
    York University, Toronto, Ontario, Canada
    J Mol Cell Cardiol 44:874-81. 2008
    ....
  59. ncbi Differential transcriptional activation of matrix metalloproteinase-2 and membrane type-1 matrix metalloproteinase by experimental deep venous thrombosis and thrombin
    Sia Dahi
    Division of Vascular Surgery, University of California San Francisco, USA
    J Vasc Surg 42:539-45. 2005
    ..We hypothesized that MMP-2 and its membrane-bound activator membrane type-1 matrix metalloproteinase (MT1-MMP) expression would be expressed and activated during the resolution of DVT...
  60. ncbi Role of intracellular S100A4 for migration of rat astrocytes
    Keizo Takenaga
    Division of Chemotherapy, Chiba Cancer Center Research Institute, Chiba, Japan
    Glia 53:313-21. 2006
    ..These findings indicate that S100A4 has a stabilizing function in reactive white matter astrocytes, a function that may contribute to the development of a rigid, growth-inhibitory glial scar...
  61. ncbi Expression and localization of MT1-MMP and furin in the glomerular wall of short- and long-term diabetic rats
    E Boucher
    Department of Pathology and Cell Biology, University of Montreal, Montreal, Quebec, Canada
    Kidney Int 69:1570-7. 2006
    ....
  62. ncbi Upregulation of extracellular matrix metalloproteinase inducer (EMMPRIN) and gelatinases in human atherosclerosis infected with Chlamydia pneumoniae: the potential role of Chlamydia pneumoniae infection in the progression of atherosclerosis
    Eui Young Choi
    Yonsei Cardiovascular Center, Cardiovascular Research Institute, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
    Exp Mol Med 34:391-400. 2002
    ..The present study demonstrated upstream regulation of MMPs can be induced by C. pneumoniae within atheromatous plaque itself. These findings help to understand the potential role of C. pneumoniae in the progression of atherosclerosis...
  63. ncbi Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with Marfan syndrome
    John S Ikonomidis
    Cardiothoracic Surgical Research, Division of Cardiothoracic Surgery, Medical University of South Carolina, Ralph H Johnson Veterans Affairs Medical Center, Suite 409 CSB, 96 Jonathan Lucas St, Charleston, SC 29425, USA
    Circulation 114:I365-70. 2006
    ..Whether and to what degree MMP, TIMP, and TGF-beta signaling profiles are altered in ATAAs in MFS compared with non-MFS patients remains unknown...
  64. ncbi Induction of matrix metalloproteinase-2 enhances systemic arterial contraction after hypoxia
    Jeff Z He
    Dept of Critical Care, Rm 4 015, St Michael s Hospital, 30 Bond St, Toronto, ON, Canada
    Am J Physiol Heart Circ Physiol 292:H684-93. 2007
    ..This may preserve the capacity to regulate the systemic circulation in the transition between the alterations in vascular tone and structural remodeling that occurs during prolonged hypoxic epochs...
  65. ncbi Involvement of MMPs in the outward remodeling of collateral mesenteric arteries
    Tara L Haas
    School of Kinesiology and Health Sciences, Rm 341 Farquharson, York Univ, 4700 Keele St, Toronto, ON Canada M3J 1P3
    Am J Physiol Heart Circ Physiol 293:H2429-37. 2007
    ....
  66. ncbi Impaired angiogenesis in SHR is associated with decreased KDR and MT1-MMP expression
    He Wang
    Human Biomarker Center, Translational Medicine and Technology, GlaxoSmithKline, USA
    Biochem Biophys Res Commun 315:363-8. 2004
    ..Significantly, expression of kinase-insert domain-containing receptor (KDR) and membrane type 1 matrix metalloproteinase (MT1-MMP) was reduced in SHRs compared to controls...
  67. ncbi Decreased vascular matrix metalloproteinase abundance in diabetic patients with symptomatic macroangiopathy
    J Sheppard Mondy
    Ethn Dis 12:S3-18-22. 2002
    ..Decreased MMP activity may contribute to pathological remodeling leading to increased incidence of amputations in African-American patients...

Research Grants3

  1. Gene Expession in Conditioned Taste Aversion
    Louis Irwin; Fiscal Year: 2002
    ..As such, it represents a more realistic view of the way in which a system as complex as the brain likely processes and encodes experiential information. ..
  2. The function of Runx1 in the ovary
    Misung Jo; Fiscal Year: 2007
    ..Such knowledge can be applied for promoting or inhibiting these critical facets of ovarian physiology, thereby allowing us to better manage fertility, infertility, and ovarian-based disorders. [unreadable] [unreadable]..
  3. Extracellular Mechanisms For Thoracic Aortic Aneurysms
    John Ikonomidis; Fiscal Year: 2008
    ..abstract_text> ..