Gene Symbol: Mmp14
Description: matrix metallopeptidase 14
Alias: Mt1-mmp, matrix metalloproteinase-14, MMP-14, MT-MMP 1, MT1MMP, MTMMP1, matrix metallopeptidase 14 (membrane-inserted), matrix metalloproteinase 14 membrane-inserted, membrane type 1-matrix metalloproteinase, membrane-type matrix metalloproteinase 1
Species: rat
Products:     Mmp14

Top Publications

  1. Hayashi K, Osada S, Shofuda K, Horikoshi S, Shirato I, Tomino Y. Enhanced expression of membrane type-1 matrix metalloproteinase in mesangial proliferative glomerulonephritis. J Am Soc Nephrol. 1998;9:2262-71 pubmed
    ..Furthermore, the enhancement of MT1-MMP and MMP-2 expression associated with mesangial phenotypic change may contribute to the development of anti-Thy1.1 antibody-induced glomerulonephritis and remodeling of extracellular matrices. ..
  2. Kim M, Albertsson P, Xue Y, Kitson R, Nannmark U, Goldfarb R. Expression of matrix metalloproteinases and their inhibitors by rat NK cells: inhibition of their expression by genistein. In Vivo. 2000;14:557-64 pubmed
    ..Moreover, genistein greatly impaired the ability of RNK-16 cells to invade through a model basement membrane. This effect might be mediated by the observed down-regulation of MMP-13 and MT1-MMP. ..
  3. Cao J, Kozarekar P, Pavlaki M, Chiarelli C, Bahou W, Zucker S. Distinct roles for the catalytic and hemopexin domains of membrane type 1-matrix metalloproteinase in substrate degradation and cell migration. J Biol Chem. 2004;279:14129-39 pubmed
    ..These data demonstrated that each domain of MT1-MMP plays a distinct role in substrate degradation and cell migration. ..
  4. Orlandi A, Ciucci A, Ferlosio A, Pellegrino A, Chiariello L, Spagnoli L. Increased expression and activity of matrix metalloproteinases characterize embolic cardiac myxomas. Am J Pathol. 2005;166:1619-28 pubmed
    ..Our results strongly suggest that MMP overexpression may contribute to an excessive degradation of tumor ECM and increase the risk of embolism in cardiac myxomas. ..
  5. Schmidt R, Bültmann A, Ungerer M, Joghetaei N, Bülbül O, Thieme S, et al. Extracellular matrix metalloproteinase inducer regulates matrix metalloproteinase activity in cardiovascular cells: implications in acute myocardial infarction. Circulation. 2006;113:834-41 pubmed
    ..During cellular interactions, EMMPRIN stimulates MMP-9 in monocytes and MMP-2 in smooth muscle cells, indicating that EMMPRIN may display a key regulatory role for MMP activity in cardiovascular pathologies. ..
  6. Ikonomidis J, Jones J, Barbour J, Stroud R, Clark L, Kaplan B, et al. Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with Marfan syndrome. Circulation. 2006;114:I365-70 pubmed
    ..In addition, MFS samples showed evidence of increased TGF-beta signaling. These differences suggest disparate mechanisms of extracellular matrix remodeling between these 2 groups of patients. ..
  7. Otto S, Deussen A, Zatschler B, Müller B, Neisser A, Barth K, et al. A novel role of endothelium in activation of latent pro-membrane type 1 MMP and pro-MMP-2 in rat aorta. Cardiovasc Res. 2016;109:409-18 pubmed publisher
    ..of elastic fibres in aorta due to angiotensin II (ANGII)-stimulated overactivation of latent membrane type 1 matrix metalloproteinase (MT1MMP) and matrix metalloproteinase-2 (MMP2) is regarded to represent an important cause of ..
  8. Guo C, Piacentini L. Type I collagen-induced MMP-2 activation coincides with up-regulation of membrane type 1-matrix metalloproteinase and TIMP-2 in cardiac fibroblasts. J Biol Chem. 2003;278:46699-708 pubmed
    ..These results suggest that the migration and invasion of cardiac fibroblasts is furin-dependent and that the active species of MT1-MMP and MMP-2 may be involved in both events. ..
  9. Stawowy P, Kallisch H, Kilimnik A, Margeta C, Seidah N, Chretien M, et al. Proprotein convertases regulate insulin-like growth factor 1-induced membrane-type 1 matrix metalloproteinase in VSMCs via endoproteolytic activation of the insulin-like growth factor-1 receptor. Biochem Biophys Res Commun. 2004;321:531-8 pubmed
    ..In conclusion, this study demonstrates that targeting furin-like PCs and thus inhibiting IGF-1R activation is a novel target to inhibit IGF-1-mediated signaling and cell functions, such as IGF-1-induced MT1-MMP/MMP-2 in VSMCs. ..

More Information


  1. Schram K, Wong M, Palanivel R, No E, Dixon I, Sweeney G. Increased expression and cell surface localization of MT1-MMP plays a role in stimulation of MMP-2 activity by leptin in neonatal rat cardiac myofibroblasts. J Mol Cell Cardiol. 2008;44:874-81 pubmed publisher
  2. Churchill J, Buraundi S, Farmer P, Li R, Southwell B, Hutson J, et al. Gubernaculum as icebreaker: do matrix metalloproteinases in rodent gubernaculum and inguinal fat pad permit testicular descent?. J Pediatr Surg. 2011;46:2353-7 pubmed publisher
    ..Disruption of these processes may cause cryptorchidism. ..
  3. Birukawa N, Murase K, Sato Y, Kosaka A, Yoneda A, Nishita H, et al. Activated hepatic stellate cells are dependent on self-collagen, cleaved by membrane type 1 matrix metalloproteinase for their growth. J Biol Chem. 2014;289:20209-21 pubmed publisher
    ..The intramolecular RGD motifs of collagen were exposed by cleavage with their own membrane type 1 matrix metalloproteinase (MT1-MMP). The following evidence supports this conclusion...
  4. Ceron C, Rizzi E, Guimaraes D, Martins Oliveira A, Cau S, Ramos J, et al. Time course involvement of matrix metalloproteinases in the vascular alterations of renovascular hypertension. Matrix Biol. 2012;31:261-70 pubmed publisher
    ..Using antioxidants or MMPs inhibitors in the early phase of hypertension may prevent the vascular alterations of hypertension. ..
  5. Boyd P, Doyle J, Gee E, Pallan S, Haas T. MAPK signaling regulates endothelial cell assembly into networks and expression of MT1-MMP and MMP-2. Am J Physiol Cell Physiol. 2005;288:C659-68 pubmed
  6. He J, Quan A, Xu Y, Teoh H, Wang G, Fish J, et al. Induction of matrix metalloproteinase-2 enhances systemic arterial contraction after hypoxia. Am J Physiol Heart Circ Physiol. 2007;292:H684-93 pubmed
    ..This may preserve the capacity to regulate the systemic circulation in the transition between the alterations in vascular tone and structural remodeling that occurs during prolonged hypoxic epochs. ..
  7. Boucher E, Mayer G, Londono I, Bendayan M. Expression and localization of MT1-MMP and furin in the glomerular wall of short- and long-term diabetic rats. Kidney Int. 2006;69:1570-7 pubmed
  8. Slongo M, Zampieri M, Onisto M. Expression of matrix metalloproteases (MMP-2, MT1 -MMP) and their tissue inhibitor (TIMP-2) by rat sertoli cells in culture: implications for spermatogenesis. Biol Chem. 2002;383:235-9 pubmed
  9. Lauer D, Slavic S, Sommerfeld M, Thone Reineke C, Sharkovska Y, Hallberg A, et al. Angiotensin type 2 receptor stimulation ameliorates left ventricular fibrosis and dysfunction via regulation of tissue inhibitor of matrix metalloproteinase 1/matrix metalloproteinase 9 axis and transforming growth factor ?1 in the rat heart. Hypertension. 2014;63:e60-7 pubmed publisher
  10. Furuichi K, Hisada Y, Shimizu M, Okumura T, Kitagawa K, Yoshimoto K, et al. Matrix metalloproteinase-2 (MMP-2) and membrane-type 1 MMP (MT1-MMP) affect the remodeling of glomerulosclerosis in diabetic OLETF rats. Nephrol Dial Transplant. 2011;26:3124-31 pubmed publisher
    ..These results suggest that MMP-2 and MT1-MMP are produced and activated in glomeruli through the progression of diabetic nephropathy and may have some effect on the remodeling of the glomerular matrix in diabetic nephropathy. ..
  11. Irwin L, Byers D. Novel odors affect gene expression for cytokines and proteinases in the rat amygdala and hippocampus. Brain Res. 2012;1489:1-7 pubmed publisher
    ..This suggests considerable variation in the way that olfactory information is processed at the cellular level in different brain regions and by the two sexes. ..
  12. Li R, Zhang J, CHURCHILL J, Sourial M, Southwell B, Hutson J. Is matrix metalloproteinase required in postnatal testicular tubules for germ cell maturation?. J Pediatr Surg. 2012;47:1724-9 pubmed publisher
    ..Increased knowledge about germ cell development may aid efforts to improve fertility in cryptorchidism. ..
  13. Akiyama M, Ohtani H, Sato E, Nagura H, Tabayashi K. Up-regulation of matrix metalloproteinase-2 and membrane-type 1-matrix metalloproteinase were coupled with that of type I procollagen in granulation tissue response after the onset of aortic dissection. Virchows Arch. 2006;448:811-21 pubmed
  14. Ueno H, Nakamura H, Inoue M, Imai K, Noguchi M, Sato H, et al. Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in human invasive breast carcinomas. Cancer Res. 1997;57:2055-60 pubmed
    ..These results suggest that MT1-MMP may play a key role in human breast carcinoma invasion and metastasis by being predominantly responsible for activation of proMMP-2. ..
  15. Camargo K, Gomes J, Loddi M, de Sordi R, Costa Ayub C, Soares M. MT1-MMP and its potential role in the vertebrate intestinal morphogenesis. Acta Histochem. 2016;118:729-735 pubmed publisher
    ..However, further studies are necessary to confirm the role of MT1-MMP in this cellular process. In addition, we performed validation of the primary antibody against human MT1-MMP for adult chickens. ..
  16. Marchant D, Bellac C, Moraes T, Wadsworth S, Dufour A, Butler G, et al. A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity. Nat Med. 2014;20:493-502 pubmed publisher
    ..These findings suggest that inhibiting extracellular MMP-12 could be a new avenue for the development of antiviral treatments...
  17. Overland A, Insel P. Heterotrimeric G proteins directly regulate MMP14/membrane type-1 matrix metalloprotease: a novel mechanism for GPCR-EGFR transactivation. J Biol Chem. 2015;290:9941-7 pubmed publisher
    ..occur by a membrane-delimited process: direct increase in the activity of membrane type-1 matrix metalloprotease (MMP14, MT1-MMP) by heterotrimeric G proteins, and in turn, the generation of heparin-binding epidermal growth factor (HB-..
  18. Manduca P, Castagnino A, Lombardini D, Marchisio S, Soldano S, Ulivi V, et al. Role of MT1-MMP in the osteogenic differentiation. Bone. 2009;44:251-65 pubmed publisher
    ..MT1-MMP has multiple functions and is implicated in multiple steps of the differentiation process, acting to regulate homeostasis of the osteogenic differentiation. ..
  19. Jin G, Zhang F, Chan K, Xavier Wong H, Liu B, Cheah K, et al. MT1-MMP cleaves Dll1 to negatively regulate Notch signalling to maintain normal B-cell development. EMBO J. 2011;30:2281-93 pubmed publisher
    ..Here, we show that loss of membrane-type 1 matrix metalloproteinase (MT1-MMP, MMP14), a cell surface protease expressed in bone marrow stromal cells (BMSCs), increases Notch signalling in HPCs and ..
  20. Nezi L, Greco D, Nitsch L, Garbi C. The role of proteases in fibronectin matrix remodeling in thyroid epithelial cell monolayer cultures. Biol Chem. 2002;383:167-76 pubmed
    ..These results indicate that in the FN remodeling process, occurring during FRT epithelium maturation, both plasmin-dependent (tPA activated) and plasmin-independent proteolytic activities are involved. ..
  21. Manase K, Endo T, Chida M, Nagasawa K, Honnma H, Yamazaki K, et al. Coordinated elevation of membrane type 1-matrix metalloproteinase and matrix metalloproteinase-2 expression in rat uterus during postpartum involution. Reprod Biol Endocrinol. 2006;4:32 pubmed
    ..These expression patterns indicate that MT1-MMP, MMP-2, MMP-9, TIMP-1 and TIMP-2 may play key roles in uterine postpartum involution and subsequent functional regenerative processes. ..
  22. Shinozaki S, Ohnishi H, Hama K, Kita H, Yamamoto H, Osawa H, et al. Indian hedgehog promotes the migration of rat activated pancreatic stellate cells by increasing membrane type-1 matrix metalloproteinase on the plasma membrane. J Cell Physiol. 2008;216:38-46 pubmed publisher
    ..These data indicate that Ihh promotes PSC migration by enhancing MT1-MMP localization on the plasma membrane but is negatively regulated by Gli-1. ..
  23. John M, Jaworski C, Chen Z, Subramanian S, Ma W, Sun F, et al. Matrix metalloproteinases are down-regulated in rat lenses exposed to oxidative stress. Exp Eye Res. 2004;79:839-46 pubmed
    ..Moreover, in our model system, MMP inhibition, not induction, is associated with cataractogenesis. ..
  24. Gomes J, Omar N, Dos Santos Neves J, Narvaes E, Novaes P. Increase of MT1-MMP, TIMP-2 and Ki-67 proteins in the odontogenic region of the rat incisor post-shortening procedure. J Mol Histol. 2010;41:333-41 pubmed publisher
    ..This suggests that MT1-MMP and TIMP-2 may have some role in cell proliferation during the eruption of the rat incisor tooth. ..
  25. Ji M, Zhang X, Shi P, Lu J, Wang S, Chang Q, et al. Downregulation of microRNA-193a-3p is involved in invertebral disc degeneration by targeting MMP14. J Mol Med (Berl). 2016;94:457-68 pubmed publisher
    ..Knockdown of MMP14 induced effects on NP cells similar to those induced by miR-193a-3p...
  26. Choi E, Kim D, Hong B, Kwon H, Song Y, Byun K, et al. Upregulation of extracellular matrix metalloproteinase inducer (EMMPRIN) and gelatinases in human atherosclerosis infected with Chlamydia pneumoniae: the potential role of Chlamydia pneumoniae infection in the progression of atherosclerosis. Exp Mol Med. 2002;34:391-400 pubmed
    ..The present study demonstrated upstream regulation of MMPs can be induced by C. pneumoniae within atheromatous plaque itself. These findings help to understand the potential role of C. pneumoniae in the progression of atherosclerosis. ..
  27. Di Gregoli K, Jenkins N, Salter R, White S, Newby A, Johnson J. MicroRNA-24 regulates macrophage behavior and retards atherosclerosis. Arterioscler Thromb Vasc Biol. 2014;34:1990-2000 pubmed publisher
  28. Schwab W, Harada H, Goetz W, Nowicki M, Witt M, Kasper M, et al. Immunocytochemical and biochemical detection of EMMPRIN in the rat tooth germ: differentiation-dependent co-expression with MMPs and co-localization with caveolin-1 in membrane rafts of dental epithelial cells. Histochem Cell Biol. 2007;128:195-203 pubmed
    ..The localization of EMMPRIN in membrane rafts provides a basis for further investigations on the role of caveolin-1 in EMMPRIN-mediated signal transduction cascades in ameloblasts. ..
  29. Filippov S, Koenig G, Chun T, Hotary K, Ota I, Bugge T, et al. MT1-matrix metalloproteinase directs arterial wall invasion and neointima formation by vascular smooth muscle cells. J Exp Med. 2005;202:663-71 pubmed
    ..These studies suggest that therapeutic interventions designed to target MT1-MMP could prove beneficial in a range of human vascular disease states associated with the destructive remodeling of the vessel wall extracellular matrix. ..
  30. Sinha I, Hannawa K, Eliason J, Ailawadi G, Deogracias M, Bethi S, et al. Early MT-1 MMP expression following elastase exposure is associated with increased cleaved MMP-2 activity in experimental rodent aortic aneurysms. Surgery. 2004;136:176-82 pubmed
    The objective of this study was to determine the significance of membrane type 1 matrix metalloproteinase (MT1-MMP) activation of MMP-2 in experimental abdominal aortic aneurysms...
  31. Covington M, Burghardt R, Parrish A. Ischemia-induced cleavage of cadherins in NRK cells requires MT1-MMP (MMP-14). Am J Physiol Renal Physiol. 2006;290:F43-51 pubmed
    ..These results demonstrate that ischemia induces increased expression of active MT1-MMP and subsequent disruption of cadherin/catenin complexes, implying that MT1-MMP plays a role in ischemia-induced ARF. ..
  32. Takenaga K, Kozlova E. Role of intracellular S100A4 for migration of rat astrocytes. Glia. 2006;53:313-21 pubmed
    ..These findings indicate that S100A4 has a stabilizing function in reactive white matter astrocytes, a function that may contribute to the development of a rigid, growth-inhibitory glial scar. ..
  33. Norgauer J, Hildenbrand T, Idzko M, Panther E, Bandemir E, Hartmann M, et al. Elevated expression of extracellular matrix metalloproteinase inducer (CD147) and membrane-type matrix metalloproteinases in venous leg ulcers. Br J Dermatol. 2002;147:1180-6 pubmed
    ..These data suggest for the first time that membrane-bound MMPs may favour enhanced turnover of the extracellular matrix and support unrestrained MMP activity in venous leg ulcers. ..
  34. Attia M, Huet E, Gossard C, Menashi S, Tassoni M, Martelly I. Early events of overused supraspinatus tendons involve matrix metalloproteinases and EMMPRIN/CD147 in the absence of inflammation. Am J Sports Med. 2013;41:908-17 pubmed publisher
    ..A rat model of supraspinatus tendon overuse has been developed, which may be predictive of pathological tendon alterations...
  35. Haas T, Doyle J, Distasi M, Norton L, Sheridan K, Unthank J. Involvement of MMPs in the outward remodeling of collateral mesenteric arteries. Am J Physiol Heart Circ Physiol. 2007;293:H2429-37 pubmed
  36. Dahi S, Lee J, Lovett D, Sarkar R. Differential transcriptional activation of matrix metalloproteinase-2 and membrane type-1 matrix metalloproteinase by experimental deep venous thrombosis and thrombin. J Vasc Surg. 2005;42:539-45 pubmed
    ..These studies define new proteases potentially important to resolution of DVT and development of postthrombotic syndrome. ..
  37. Stehbens S, Paszek M, Pemble H, Ettinger A, Gierke S, Wittmann T. CLASPs link focal-adhesion-associated microtubule capture to localized exocytosis and adhesion site turnover. Nat Cell Biol. 2014;16:561-73 pubmed publisher
    ..We propose that CLASPs couple microtubule organization, vesicle transport and cell interactions with the ECM, establishing a local secretion pathway that facilitates FA turnover by severing cell-matrix connections...
  38. Guerra C, Carla Lara Pereira Y, Issa J, Luiz K, Guimarães E, Gerlach R, et al. Histological, histochemical, and protein changes after induced malocclusion by occlusion alteration of Wistar rats. Biomed Res Int. 2014;2014:563463 pubmed publisher
    ..This knowledge about morphology and molecular masticatory muscle remodeling following environmental interventions can be used to develop clinically successful treatments. ..
  39. Peterson J, Li H, Dillon L, Bryant J. Evolution of matrix metalloprotease and tissue inhibitor expression during heart failure progression in the infarcted rat. Cardiovasc Res. 2000;46:307-15 pubmed
    ..The dissociation between LV MMP/TIMP mRNA and protein levels shows that post-translation processing occurs in the rat heart. ..
  40. Gu G, Zhao D, Yin Z, Liu P. BST-2 binding with cellular MT1-MMP blocks cell growth and migration via decreasing MMP2 activity. J Cell Biochem. 2012;113:1013-21 pubmed publisher
    ..Taken together, BST-2, as a membrane protein and a tetherin of enveloped viruses, was a novel inhibitor of MT1-MMP and could be considerable as an inhibitor of cancer cell growth and migration on clinic. ..
  41. Omar N, Gomes J, Neves J, Salmon C, Novaes P. MT1-MMP expression in the odontogenic region of rat incisors undergoing interrupted eruption. J Mol Histol. 2011;42:505-11 pubmed publisher
    ..Results indicate that MT1-MMP may have an important role in the process of dental eruption. ..
  42. Bruno G, Todor R, Lewis I, Chyatte D. Vascular extracellular matrix remodeling in cerebral aneurysms. J Neurosurg. 1998;89:431-40 pubmed
    ..This activity may contribute to focal degradation of the vascular extracellular matrix and may be related to aneurysm formation and growth. ..
  43. Kamioka M, Ishibashi T, Ohkawara H, Nagai R, Sugimoto K, Uekita H, et al. Involvement of membrane type 1-matrix metalloproteinase (MT1-MMP) in RAGE activation signaling pathways. J Cell Physiol. 2011;226:1554-63 pubmed publisher
  44. Annabi B, Shedid D, Ghosn P, Kenigsberg R, Desrosiers R, Bojanowski M, et al. Differential regulation of matrix metalloproteinase activities in abdominal aortic aneurysms. J Vasc Surg. 2002;35:539-46 pubmed
  45. Sung J, Park S, Lee C, Um J, Lee H, Kim J, et al. Proteolytic cleavage of extracellular secreted {alpha}-synuclein via matrix metalloproteinases. J Biol Chem. 2005;280:25216-24 pubmed
    ..The present study suggests that the extracellularly secreted alpha-synuclein could be processed via the activation of MMP-3 in a selective manner. ..
  46. Yan D, Liu X, Hua L, Wu K, Sha X, Zhao J, et al. MMP-14 promotes VSMC migration via up-regulating CD44 expression in cardiac allograft vasculopathy. Pathol Res Pract. 2016;212:1119-1125 pubmed publisher
    ..Our results elucidate the molecular mechanism of VSMC migration after cardiac transplantation and provide theoretical basis for seeking new specific drug targets for CAV prevention and treatment. ..
  47. Kitagawa Y, Kunimi K, Ito H, Sato H, Uchibayashi T, Okada Y, et al. Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in human urothelial carcinomas. J Urol. 1998;160:1540-5 pubmed
    ..In spite of the possible contribution to the invasive and metastatic phenotype, MT1-MMP mRNA and its product are thought to be expressed already in the clinical superficial stage in some cases of this tumor type. ..
  48. Laragione T, Brenner M, Mello A, Symons M, Gulko P. The arthritis severity locus Cia5d is a novel genetic regulator of the invasive properties of synovial fibroblasts. Arthritis Rheum. 2008;58:2296-306 pubmed publisher
    ..However, regulation of the FLS remains incompletely understood. The aim of this study was to determine whether the invasive properties of FLS are genetically regulated by arthritis severity loci...
  49. Miyata T, Ohnishi H, Suzuki J, Yoshikumi Y, Ohno H, Mashima H, et al. Involvement of syntaxin 4 in the transport of membrane-type 1 matrix metalloproteinase to the plasma membrane in human gastric epithelial cells. Biochem Biophys Res Commun. 2004;323:118-24 pubmed
    ..We suggest that syntaxin 4 is involved in the intracellular transport of MT1-MMP toward the plasma membrane. ..
  50. Oblander S, Zhou Z, Galvez B, Starcher B, Shannon J, Durbeej M, et al. Distinctive functions of membrane type 1 matrix-metalloprotease (MT1-MMP or MMP-14) in lung and submandibular gland development are independent of its role in pro-MMP-2 activation. Dev Biol. 2005;277:255-69 pubmed
    ..Instead, in the lung, it is essential for postnatal development of alveolar septae. Lung development in Mmp14-/- mice is arrested at the prealveolar stage with compensatory hyperinflation of immature saccules...
  51. Alvarez J, Costales L, Serra R, Balbin M, López J. Expression patterns of matrix metalloproteinases and vascular endothelial growth factor during epiphyseal ossification. J Bone Miner Res. 2005;20:1011-21 pubmed
    ..MMPs were widely expressed during ossification of the secondary center, whereas expression of VEGF was restricted to later stages...
  52. Hosomi N, Nishiyama A, Ban C, Naya T, Takahashi T, Kohno M, et al. Angiotensin type 1 receptor blockage improves ischemic injury following transient focal cerebral ischemia. Neuroscience. 2005;134:225-31 pubmed
    ..Angiotensin type 1 receptor stimulation may be one of the important factors that cause cerebral edema following cerebral ischemia, and that its inhibition may be of therapeutic advantage in cerebral ischemia. ..
  53. Saygili E, Schauerte P, Pekassa M, Saygili E, Rackauskas G, Schwinger R, et al. Sympathetic neurons express and secrete MMP-2 and MT1-MMP to control nerve sprouting via pro-NGF conversion. Cell Mol Neurobiol. 2011;31:17-25 pubmed publisher
    ..In summary, specific MMP-2 blockade prevents sympathetic nerve sprouting (SNS) by inhibition of pro-NGF conversion while losartan abolishes HFES-induced SNS by reducing total NGF, MMP-2 and MT1-MMP expression. ..
  54. Wang T, Yang Y, Chang H, Hung C. Angiotensin II signals mechanical stretch-induced cardiac matrix metalloproteinase expression via JAK-STAT pathway. J Mol Cell Cardiol. 2004;37:785-94 pubmed
    ..These findings indicate that cyclical stretch induces MMP-14 and -2 expression in neonatal rat cardiomyocytes and that the induction is mediated by the angiotensin II-JAK-STAT1 pathway. ..
  55. Jo M, Thomas L, Wheeler S, Curry T. Membrane type 1-matrix metalloproteinase (MMP)-associated MMP-2 activation increases in the rat ovary in response to an ovulatory dose of human chorionic gonadotropin. Biol Reprod. 2004;70:1024-32 pubmed
    ..The increase in MT1-MMP mRNA may be an important part of the mechanism necessary for the efficient generation of active MMP-2 during the ovulatory process. ..
  56. Hayashi K, Horikoshi S, Osada S, Shofuda K, Shirato I, Tomino Y. Macrophage-derived MT1-MMP and increased MMP-2 activity are associated with glomerular damage in crescentic glomerulonephritis. J Pathol. 2000;191:299-305 pubmed
  57. Shi J, Son M, Yamada S, Szabova L, Kahan S, Chrysovergis K, et al. Membrane-type MMPs enable extracellular matrix permissiveness and mesenchymal cell proliferation during embryogenesis. Dev Biol. 2008;313:196-209 pubmed
    ..These defects are directly tied to loss of indispensable collagenolytic activities required in collagen-rich mesenchymal tissues for extracellular matrix remodeling and cell proliferation during embryogenesis. ..
  58. Kassiri Z, Oudit G, Sanchez O, Dawood F, Mohammed F, Nuttall R, et al. Combination of tumor necrosis factor-alpha ablation and matrix metalloproteinase inhibition prevents heart failure after pressure overload in tissue inhibitor of metalloproteinase-3 knock-out mice. Circ Res. 2005;97:380-90 pubmed
    ..Notably, combining TNFalpha ablation with MMP inhibition completely rescued heart disease in timp-3(-/-)-AB mice. This study provides a basis for anti-TNFalpha and MMP inhibitor combination therapy in heart disease. ..
  59. Mazaud S, Guyot R, Guigon C, Coudouel N, le Magueresse Battistoni B, Magre S. Basal membrane remodeling during follicle histogenesis in the rat ovary: contribution of proteinases of the MMP and PA families. Dev Biol. 2005;277:403-16 pubmed
  60. Wang H, Olszewski B, Rosebury W, Wang D, Robertson A, Keiser J. Impaired angiogenesis in SHR is associated with decreased KDR and MT1-MMP expression. Biochem Biophys Res Commun. 2004;315:363-8 pubmed
    ..Significantly, expression of kinase-insert domain-containing receptor (KDR) and membrane type 1 matrix metalloproteinase (MT1-MMP) was reduced in SHRs compared to controls...
  61. Okada A, Bellocq J, Rouyer N, Chenard M, Rio M, Chambon P, et al. Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas. Proc Natl Acad Sci U S A. 1995;92:2730-4 pubmed
  62. Ispanovic E, Serio D, Haas T. Cdc42 and RhoA have opposing roles in regulating membrane type 1-matrix metalloproteinase localization and matrix metalloproteinase-2 activation. Am J Physiol Cell Physiol. 2008;295:C600-10 pubmed publisher
    ..Furthermore, VEGF-dependent activation of MMP-2 was reduced by inhibition of Cdc42. These results suggest that Cdc42 and RhoA have opposing roles in regulating cell surface localization of MT1-MMP and MMP-2 activation. ..
  63. Liao E, Liao H, Guo L, Zhou H, Wu X, Dai R, et al. Membrane-type matrix metalloproteinase-1 (MT1-MMP) is down-regulated in estrogen-deficient rat osteoblast in vivo. J Endocrinol Invest. 2004;27:1-5 pubmed
    ..There is evidence suggesting a role for MT1-MMP in the process of bone loss during the pathogenesis of osteoporosis. ..
  64. Ierusalimsky V, Balaban P. Type 1 metalloproteinase is selectively expressed in adult rat brain and can be rapidly up-regulated by kainate. Acta Histochem. 2013;115:816-26 pubmed publisher
    ..Thus, MMP-1 is present in several brain areas in normal conditions at a detectable level, and its expression increases after kainate-induced seizures. ..
  65. Kojima A, Konishi M, Akizawa T. Prion fragment peptides are digested with membrane type matrix metalloproteinases and acquire enzyme resistance through Cu²?-binding. Biomolecules. 2014;4:510-26 pubmed publisher
    ..The C-terminal peptides had higher resistance than the central region. The data obtained from this study suggest that MT-MMPs expressed in the brain might possess PrPC-degrading activity. ..
  66. Pang L, Wei C, Duan J, Zou H, Cao W, Qi Y, et al. TGF-?1/Smad signaling, MMP-14, and MSC markers in arterial injury: discovery of the molecular basis of restenosis. Int J Clin Exp Pathol. 2014;7:2915-24 pubmed
  67. Shofuda T, Shofuda K, Ferri N, Kenagy R, Raines E, Clowes A. Cleavage of focal adhesion kinase in vascular smooth muscle cells overexpressing membrane-type matrix metalloproteinases. Arterioscler Thromb Vasc Biol. 2004;24:839-44 pubmed
    ..This study provides the first evidence that MT-MMPs are not only important in matrix degradation but also may affect the function of focal adhesions through FAK cleavage. ..
  68. Schram K, Ganguly R, No E, Fang X, Thong F, Sweeney G. Regulation of MT1-MMP and MMP-2 by leptin in cardiac fibroblasts involves Rho/ROCK-dependent actin cytoskeletal reorganization and leads to enhanced cell migration. Endocrinology. 2011;152:2037-47 pubmed publisher
    ..Subsequent pro-MMP-2 activation then contributes to stimulation of cell migration. ..