Gene Symbol: Mmp1
Description: matrix metallopeptidase 1
Alias: Clgn, MMP-1, Mmp1a, interstitial collagenase, fibroblast collagenase, matrix metallopeptidase 1a, matrix metalloproteinase 1, matrix metalloproteinase 1a (interstitial collagenase), myocardial collagenase
Species: rat
Products:     Mmp1

Top Publications

  1. Koullias G, Ravichandran P, Korkolis D, Rimm D, Elefteriades J. Increased tissue microarray matrix metalloproteinase expression favors proteolysis in thoracic aortic aneurysms and dissections. Ann Thorac Surg. 2004;78:2106-10; discussion 2110-1 pubmed
    ..The recognition of this pathophysiologic mechanism raises the potential for drug therapy to interrupt the cascade of events. ..
  2. Kowalewski R, Sobolewski K, Małkowski A, Wolańska M, Gacko M. Evaluation of enzymes involved in proteoglycan degradation in the wall of abdominal aortic aneurysms. J Vasc Res. 2006;43:95-100 pubmed
    ..Furthermore, increased expression of MMP1, MMP2 and MMP9 was also shown in the AAA wall...
  3. Shi Z, Ji X, Berardi D, Qazi H, Tarbell J. Interstitial flow induces MMP-1 expression and vascular SMC migration in collagen I gels via an ERK1/2-dependent and c-Jun-mediated mechanism. Am J Physiol Heart Circ Physiol. 2010;298:H127-35 pubmed publisher
  4. Shi Z, Ji X, Qazi H, Tarbell J. Interstitial flow promotes vascular fibroblast, myofibroblast, and smooth muscle cell motility in 3-D collagen I via upregulation of MMP-1. Am J Physiol Heart Circ Physiol. 2009;297:H1225-34 pubmed publisher
    ..Our findings shed light on the mechanism by which vascular SMCs and FBs/MFBs contribute to intimal thickening in regions of vascular injury where interstitial flow is elevated. ..
  5. Mossbock G, Weger M, Faschinger C, Zimmermann C, Schmut O, Renner W, et al. Role of functional single nucleotide polymorphisms of MMP1, MMP2, and MMP9 in open angle glaucomas. Mol Vis. 2010;16:1764-70 pubmed
    ..b>MMP1, MMP2, and MMP9 have previously been implicated in the pathogenesis of primary open angle glaucoma (POAG) and open ..
  6. Zhu Y, Spitz M, Lei L, Mills G, Wu X. A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter enhances lung cancer susceptibility. Cancer Res. 2001;61:7825-9 pubmed
    ..To our knowledge, these results report the first molecular epidemiological evidence of the MMP-1 promoter polymorphism associated with the development of lung cancer in the presence of continuing carcinogenic exposure. ..
  7. Herouy Y, May A, Pornschlegel G, Stetter C, Grenz H, Preissner K, et al. Lipodermatosclerosis is characterized by elevated expression and activation of matrix metalloproteinases: implications for venous ulcer formation. J Invest Dermatol. 1998;111:822-7 pubmed
    ..Furthermore, MMP-2 was imbalanced by locally reduced expression of TIMP-2 in the basement membrane zone of lesional skin. Our findings indicate lipodermatosclerosis to be characterized by elevated matrix turnover. ..
  8. Bradbury P, Zhai R, Hopkins J, Kulke M, Heist R, Singh S, et al. Matrix metalloproteinase 1, 3 and 12 polymorphisms and esophageal adenocarcinoma risk and prognosis. Carcinogenesis. 2009;30:793-8 pubmed publisher
    ..A total of 313 EA cases and 455 age and gender frequency-matched controls were genotyped for MMP1 1G/2G, MMP3 6A/5A, MMP12 -82A/G and MMP12 1082A/G...
  9. Lu Z, Cao Y, Wang Y, Zhang Q, Zhang X, Wang S, et al. Polymorphisms in the matrix metalloproteinase-1, 3, and 9 promoters and susceptibility to adult astrocytoma in northern China. J Neurooncol. 2007;85:65-73 pubmed

More Information


  1. Hirata H, Naito K, Yoshihiro S, Matsuyama H, Suehiro Y, Hinoda Y. A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter is associated with conventional renal cell carcinoma. Int J Cancer. 2003;106:372-4 pubmed
    ..Our present data suggest that the MMP-1 promoter polymorphism may be linked to susceptibility for conventional RCC. ..
  2. Yamaguchi S, Yamaguchi M, Yatsuyanagi E, Yun S, Nakajima N, Madri J, et al. Cyclic strain stimulates early growth response gene product 1-mediated expression of membrane type 1 matrix metalloproteinase in endothelium. Lab Invest. 2002;82:949-56 pubmed
    ..These results suggest that cyclic strain up-regulates the Egr-1-mediated expression of MT1-MMP in rat microvascular EC, emphasizing the importance of hemodynamic forces in the regulation of MT1-MMP in vivo. ..
  3. Li W, Cui N, Mazzuca M, Mata K, Khalil R. Increased vascular and uteroplacental matrix metalloproteinase-1 and -7 levels and collagen type I deposition in hypertension in pregnancy: role of TNF-?. Am J Physiol Heart Circ Physiol. 2017;313:H491-H507 pubmed publisher
    ..The data suggest that targeting MMP-1 and MMP-7 and their upstream modulators, such as TNF-?, could provide a new approach in the management of hypertension in pregnancy and preeclampsia. ..
  4. Wang Y, Xu K, Su W, You Q, Hu Z, Wang Z, et al. Therapeutic effects of p75 tumor necrosis factor receptor monoclonal antibody on a rat model of traumatic arthritis. J Surg Res. 2014;186:234-9 pubmed publisher
    ..the surgery, rats were killed, and immunohistochemical staining was applied to detect the matrix metalloproteinase (MMP1 and MMP3) expression in the synovium...
  5. Nishioka Y, Sagae S, Nishikawa A, Ishioka S, Kudo R. A relationship between Matrix metalloproteinase-1 (MMP-1) promoter polymorphism and cervical cancer progression. Cancer Lett. 2003;200:49-55 pubmed
    ..These findings suggested that SNP of MMP-1 promoter might influence the ability in cervical cancer invasion via transcriptional activity of this gene. ..
  6. Schwartzkopff B, Fassbach M, Pelzer B, Brehm M, Strauer B. Elevated serum markers of collagen degradation in patients with mild to moderate dilated cardiomyopathy. Eur J Heart Fail. 2002;4:439-4 pubmed
    ..32; P=0.04 and r=-0.33; P=0.04, respectively) in patients with DCM. Serum markers of collagen degradation are elevated and might be valuable markers for progression of LV dilation in patients with DCM. ..
  7. Pradeepkumar Singh L, Vivek Sharma A, Swarnakar S. Upregulation of collagenase-1 and -3 in indomethacin-induced gastric ulcer in diabetic rats: role of melatonin. J Pineal Res. 2011;51:61-74 pubmed publisher
    ..Additionally, melatonin protects the gastric damage under diabetes via regulation of both MMP-1 and -13. ..
  8. Uchio K, Manabe N, Tamura K, Miyamoto M, Yamaguchi M, Ogura A, et al. Decreased matrix metalloproteinase activity in the kidneys of hereditary nephrotic mice (ICGN strain). Nephron. 2000;86:145-51 pubmed
    ..We biochemically measured interstitial collagenase (MMP-1), gelatinase (MMP-2 and MMP-9), and stromelysin (MMP-3) activities in the kidney tissues...
  9. Mairuae N, Connor J, Cheepsunthorn P. Increased cellular iron levels affect matrix metalloproteinase expression and phagocytosis in activated microglia. Neurosci Lett. 2011;500:36-40 pubmed publisher
    ..Thus, these findings further our understanding toward the consequences of iron accumulation by activated microglia in neurodegeneration and suggest a possible link between iron metabolism in activated microglia and neuroinflammation. ..
  10. Luczyszyn S, de Souza C, Braosi A, Dirschnabel A, Claudino M, Repeke C, et al. Analysis of the association of an MMP1 promoter polymorphism and transcript levels with chronic periodontitis and end-stage renal disease in a Brazilian population. Arch Oral Biol. 2012;57:954-63 pubmed publisher
    ..b>MMP1-1607 (1G/2G) is a functional polymorphism, as it alters MMP-1 expression...
  11. Ghilardi G, Biondi M, DeMonti M, Turri O, Guagnellini E, Scorza R. Matrix metalloproteinase-1 and matrix metalloproteinase-3 gene promoter polymorphisms are associated with carotid artery stenosis. Stroke. 2002;33:2408-12 pubmed
    ..Even if obtained from a relatively limited patient series, these results might have relevant implications for treatment of ICA stenosis and possibly prevention of carotid-related stroke. ..
  12. Lombardi F, Belletti S, Battezzati P, Pacciolla R, Biondi M. MMP-1 and MMP-3 polymorphism and arrhythmia recurrence after electrical cardioversion in patients with persistent atrial fibrillation. J Cardiovasc Med (Hagerstown). 2011;12:37-42 pubmed publisher
    ..These findings suggest that genetic factors contribute to determine arrhythmic recurrence rate in persistent atrial fibrillation. ..
  13. Tasci A, Tugcu V, Ozbek E, Ozbay B, Simsek A, Koksal V. A single-nucleotide polymorphism in the matrix metalloproteinase-1 promoter enhances bladder cancer susceptibility. BJU Int. 2008;101:503-7 pubmed
    ..001; odds ratio 3.21; 95% CI 1.33-5.60). These results suggest that the MMP-1 promoter polymorphism might be linked to susceptibility for bladder cancer. ..
  14. Collins J, Ramamoorthy K, Da Silveira A, Patston P, Mao J. Expression of matrix metalloproteinase genes in the rat intramembranous bone during postnatal growth and upon mechanical stresses. J Biomech. 2005;38:485-92 pubmed
    ..Taken together, these data suggest potentially important roles of MMP genes in the postnatal development of cranial sutures, and their susceptibility to mechanical stresses. ..
  15. Han J, Liang H, Yi J, Tan W, He S, Wang S, et al. Long-Term Selenium-Deficient Diet Induces Liver Damage by Altering Hepatocyte Ultrastructure and MMP1/3 and TIMP1/3 Expression in Growing Rats. Biol Trace Elem Res. 2017;175:396-404 pubmed publisher
    ..Furthermore, through immunohistochemistry (IHC) staining, higher expressions of metalloproteinases (MMP1/3) and their tissue inhibitors of metalloproteinases (TIMP1/3) were observed in the hepatic periportal of rats from ..
  16. Wang L, Huang Y, Yin M, Gershenwald J, Prieto V, Lee J, et al. Promoter polymorphisms in matrix metallopeptidase 1 and risk of cutaneous melanoma. Eur J Cancer. 2011;47:107-15 pubmed publisher
    Matrix metallopeptidase 1 (MMP1) is one of the interstitial collagens in the extracellular matrix metalloproteinase family and involved in tumour behaviours...
  17. Hu P, Chen W, Tang J, Bao J, Wu L. Protective effects of berberine in an experimental rat osteoarthritis model. Phytother Res. 2011;25:878-85 pubmed publisher
    ..These findings suggest that berberine may play a protective role in the development of OA and may be useful in the treatment of OA. ..
  18. Lin X, Jo H, Ishii T, Fujita M, Fu M, Tambara K, et al. Controlled release of matrix metalloproteinase-1 plasmid DNA prevents left ventricular remodeling in chronic myocardial infarction of rats. Circ J. 2009;73:2315-21 pubmed
    ..Gelatin microspheres for the controlled release of MMP-1 plasmid DNA are promising for improving cardiac remodeling and function when they are administered during the chronic phase of MI. ..
  19. Kaden J, Dempfle C, Grobholz R, Fischer C, Vocke D, Kiliç R, et al. Inflammatory regulation of extracellular matrix remodeling in calcific aortic valve stenosis. Cardiovasc Pathol. 2005;14:80-7 pubmed
    ..Activated leukocytes, by the secretion of TNFalpha, may stimulate valvular myofibroblasts to proliferate and express MMPs, thus regulating actively the matrix remodeling in calcific AS. ..
  20. So J, Song M, Kwon H, Lee C, Chae C, Sahoo A, et al. Lactobacillus casei enhances type II collagen/glucosamine-mediated suppression of inflammatory responses in experimental osteoarthritis. Life Sci. 2011;88:358-66 pubmed publisher
    ..IL-2, IL-6, IL-12, IL-17, tumor necrosis factor-? (TNF-?), and interferon-? (IFN-?)) and matrix metalloproteinases (MMP1, MMP3, and MMP13), while up-regulating anti-inflammatory cytokines (IL-4 and IL-10)...
  21. Grivas T, Vasiliadis E, Kaspiris A, Khaldi L, Kletsas D. Expression of matrix metalloproteinase-1 (MMP-1) in Wistar rat's intervertebral disc after experimentally induced scoliotic deformity. Scoliosis. 2011;6:9 pubmed publisher
  22. Wu L, Fan L, Chen L. [Precondition with doxycycline administration abates ischemia/reperfusion injury and reduces the expression of matrix metalloproteinase-1/9 in myocardium in rat in vivo]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2007;19:679-82 pubmed
    ..05 or P<0.01). Precondition with doxycycline could remarkably abate I/R injury of rat myocardium in vivo and inhibit the expressions of MMP-1 and MMP-9. ..
  23. Ohno T, Hirano S, Kanemaru S, Yamashita M, Umeda H, Suehiro A, et al. Expression of extracellular matrix proteins in the vocal folds and bone marrow derived stromal cells of rats. Eur Arch Otorhinolaryngol. 2008;265:669-74 pubmed
    ..Increased expression of Has2 and MMP-1 genes from BSCs may have a positive potential in the treatment of vocal fold scarring. ..
  24. Podesser B, Siwik D, Eberli F, Sam F, Ngoy S, Lambert J, et al. ET(A)-receptor blockade prevents matrix metalloproteinase activation late postmyocardial infarction in the rat. Am J Physiol Heart Circ Physiol. 2001;280:H984-91 pubmed
    ..Inhibition of ET(A) receptors prevents MMP activation and LV dilation, suggesting that ET, acting via the ET(A) receptor, contributes to chronic post-MI remodeling by its effects on MMP activity...
  25. Yao J, Xiong M, Tang B, Chen G, Liang M, Ma X, et al. Simvastatin attenuates pulmonary vascular remodelling by down-regulating matrix metalloproteinase-1 and -9 expression in a carotid artery-jugular vein shunt pulmonary hypertension model in rats. Eur J Cardiothorac Surg. 2012;42:e121-7 pubmed publisher
    ..Simvastatin may play a role in the treatment of systemic-pulmonary shunt-induced PAH diseases, such as congenital heart disease. ..
  26. Alsaigh T, Pocock E, Bergan J, Schmid Schonbein G. Acute venous occlusion enhances matrix metalloprotease activity: Implications on endothelial dysfunction. Microvasc Res. 2011;81:108-16 pubmed publisher
    ..We conclude that venous pressure elevation increases enzymatic activity which may contribute to inflammation and endothelial dysfunction associated with this disease by influencing critical surface receptors. ..
  27. Wang Y, Wang W. Protective effect of ilomastat on trinitrobenzenesulfonic acid-induced ulcerative colitis in rats. World J Gastroenterol. 2008;14:5683-8 pubmed
    ..0001) . Expression of MMP-1 in protective group B was significantly lower than that in protective group A (P < 0.0001). Ilomastat improves TNB-induced UC in rats by inhibiting the MMP-1 activity. ..
  28. Kato R, Momiyama Y, Ohmori R, Taniguchi H, Nakamura H, Ohsuzu F. Levels of matrix metalloproteinase-1 in patients with and without coronary artery disease and relation to complex and noncomplex coronary plaques. Am J Cardiol. 2005;95:90-2 pubmed
    ..High serum levels of MMP-1 were associated with the presence of complex lesions in patients who had CAD. ..
  29. Xu H, Wu P, Shen Z, Chen X. Chemical analysis of Hericium erinaceum polysaccharides and effect of the polysaccharides on derma antioxidant enzymes, MMP-1 and TIMP-1 activities. Int J Biol Macromol. 2010;47:33-6 pubmed publisher
    ..It can be concluded that H. erinaceum polysaccharides possess anti-skin-aging activities. ..
  30. Jha P, Manickam B, Matta B, Bora P, Bora N. Proteolytic cleavage of type I collagen generates an autoantigen in autoimmune uveitis. J Biol Chem. 2009;284:31401-11 pubmed publisher
    ..Collectively, the evidence presented here suggests that MAA is an autoantigen in EAAU. These observations may extend to idiopathic human anterior uveitis and facilitate the development of antigen-specific therapy. ..
  31. Yang Q, Xie R, Geng X, Luo X, Han B, Cheng M. Effect of Danshao Huaxian capsule on expression of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 in fibrotic liver of rats. World J Gastroenterol. 2005;11:4953-6 pubmed
    ..DSHX enhances the expression of MMP-1 but decreases that of TIMP-1 in liver tissues of CCl(4)-induced hepatic fibrotic rats, which may result in its elevated activity that contributes to fighting against hepatic fibrosis. ..
  32. Tyagi S, Cleutjens J. Myocardial collagenase: purification and structural characterization. Can J Cardiol. 1996;12:165-71 pubmed
    b>Interstitial collagenase (matrix metalloproteinase-1 [MMP-1]) plays an important role in extracellular matrix turnover. Myocardial MMP-1 may contribute to tissue remodelling in the heart...
  33. Piccoli M, Figueira M, Andreoni C, Marumo J, Schor N, Bellini M. Lack of association between matrix metalloproteinase-1 (MMP-1) promoter polymorphism and risk of renal cell carcinoma. Int Braz J Urol. 2007;33:622-9 pubmed
    ..Our data suggest that the matrix metalloproteinase-1 (MMP-1) promoter polymorphism may not play a significant role in renal cell carcinoma patients in Brazil. ..
  34. Montes A, Valle Garay E, Suarez Zarracina T, Melon S, Martinez E, Carton J, et al. The MMP1 (-16071G/2G) single nucleotide polymorphism associates with the HAART-related lipodystrophic syndrome. AIDS. 2010;24:2499-506 pubmed publisher
    ..Serum MMPs (1, 2, 3, 8, 9, 10, 13) and TIMPs (1, 2, 4) were measured by ELISA microarrays. MMP1 (-16071G/2G) SNP was also genotyped...
  35. Tsai W, Hsu C, Chang H, Lin Y, Lin M, Pang J. Ibuprofen upregulates expressions of matrix metalloproteinase-1, -8, -9, and -13 without affecting expressions of types I and III collagen in tendon cells. J Orthop Res. 2010;28:487-91 pubmed publisher
    ..These findings suggest a molecular mechanism potentially accounting for the inhibition of tendon healing by ibuprofen. ..
  36. Leong D, Li Y, Gu X, Sun L, Zhou Z, Nasser P, et al. Physiological loading of joints prevents cartilage degradation through CITED2. FASEB J. 2011;25:182-91 pubmed publisher
    ..Together, these studies identify a novel regulatory pathway involving CITED2 and p38?, which may be critical for the maintenance of articular cartilage integrity under normal physical activity levels. ..
  37. Micheal S, Yousaf S, Khan M, Akhtar F, Islam F, Khan W, et al. Polymorphisms in matrix metalloproteinases MMP1 and MMP9 are associated with primary open-angle and angle closure glaucoma in a Pakistani population. Mol Vis. 2013;19:441-7 pubmed
    ..A significant difference in the genotype frequencies of MMP1 rs1799750 (-1607 1G/2G) was observed between the patients with POAG and the control subjects (p = 0.001)...
  38. Wojciechowski R, Bailey Wilson J, Stambolian D. Association of matrix metalloproteinase gene polymorphisms with refractive error in Amish and Ashkenazi families. Invest Ophthalmol Vis Sci. 2010;51:4989-95 pubmed publisher
    ..Statistically significant genetic associations of ocular refraction to polymorphisms near MMP1 and within MMP2 were identified in the AMISH but not among the ASHK families...
  39. Yang E, Boire A, Agarwal A, Nguyen N, O Callaghan K, Tu P, et al. Blockade of PAR1 signaling with cell-penetrating pepducins inhibits Akt survival pathways in breast cancer cells and suppresses tumor survival and metastasis. Cancer Res. 2009;69:6223-31 pubmed publisher
    ..Together, these findings indicate that blockade of MMP1-PAR1 signaling may provide a benefit beyond treatment with Taxotere alone in advanced, metastatic breast cancer.
  40. McAloon C, Wood A, Gough S, Stockley R. Matrix metalloprotease polymorphisms are associated with gas transfer in alpha 1 antitrypsin deficiency. Ther Adv Respir Dis. 2009;3:23-30 pubmed publisher assess the role of polymorphism of MMP1, MMP3 and MMP12 in AATD phenotypes...
  41. Al Mubarak R, Da Silveira A, Mao J. Expression and mechanical modulation of matrix metalloproteinase-1 and -2 genes in facial and cranial sutures. Cell Tissue Res. 2005;321:465-71 pubmed
  42. Abdel Aziz M, Badary D, Hussein M. Renal damage following Alloxan-induced diabetes is associated with generation of reactive oxygen species, alterations of p53, TGF-?1, and extracellular matrix metalloproteinases in rats. Cell Biol Int. 2017;41:525-533 pubmed publisher
    ..Alterations of TGF-?, p53, and extracellular matrix metalloproteinases contribute to the pathogenesis of Alloxan-induced renal damage. ..
  43. Itagaki M, Kubota T, Tai H, Shimada Y, Morozumi T, Yamazaki K. Matrix metalloproteinase-1 and -3 gene promoter polymorphisms in Japanese patients with periodontitis. J Clin Periodontol. 2004;31:764-9 pubmed
  44. Urtasun R, Cubero F, Vera M, Nieto N. Reactive nitrogen species switch on early extracellular matrix remodeling via induction of MMP1 and TNFalpha. Gastroenterology. 2009;136:1410-22, e1-4 pubmed publisher
    ..There was a time- and dose-dependent down-regulation of collagen I and alpha-Sma proteins and up-regulation of MMP1 and TNFalpha, indicating decreased HSC activation. These effects were blocked by ONOO- scavengers...
  45. Ben David D, Livne E, Reznick A. The involvement of oxidants and NF-?B in cytokine-induced MMP-9 synthesis by bone marrow-derived osteoprogenitor cells. Inflamm Res. 2012;61:673-88 pubmed publisher
  46. Nothnick W, Keeble S, Curry T. Collagenase, gelatinase, and proteoglycanase messenger ribonucleic acid expression and activity during luteal development, maintenance, and regression in the pseudopregnant rat ovary. Biol Reprod. 1996;54:616-24 pubmed
  47. Lin C, Yang W, Chung M, Lee P. Functional polymorphisms in matrix metalloproteinases-1, -3, -9 are associated with arteriovenous fistula patency in hemodialysis patients. Clin J Am Soc Nephrol. 2010;5:1805-14 pubmed publisher
    ..001). Specific genotypes of MMP-1, MMP-3 and MMP-9 with lower transcriptional activity are associated with higher frequencies of AVF failure, which may result from more accumulation of extracellular matrix, leading to AVF stenosis. ..
  48. Keeling J, Herrera G. Matrix metalloproteinases and mesangial remodeling in light chain-related glomerular damage. Kidney Int. 2005;68:1590-603 pubmed
    ..Zymography was used to assess activity demonstrating increased MMP-2 in AL-Am. Altered expressions of MMPs play a key role in the pathogenesis of AL-Am and LCDD. MMPs were more highly expressed in AL-Am compared to LCDD. ..
  49. Ryu H, Park Y, Park S, Lee J, Cho S, Lee W, et al. KITENIN is associated with tumor progression in human gastric cancer. Anticancer Res. 2010;30:3479-86 pubmed
    ..These results indicate that KITENIN plays an important role in human gastric cancer progression by AP-1 activation. ..
  50. Laragione T, Brenner M, Sherry B, Gulko P. CXCL10 and its receptor CXCR3 regulate synovial fibroblast invasion in rheumatoid arthritis. Arthritis Rheum. 2011;63:3274-83 pubmed publisher
    ..These observations suggest that the CXCL10/CXCR3 axis is a potential new target for therapies aimed at reducing FLS invasion and its associated joint damage and pannus invasion and destruction in RA. ..
  51. Yang S, Lee S, Choi E, Lee K, Kim S, Shin M, et al. Matrix metalloproteinase-1 induces cleavage of exogenous alphaB-crystallin transduced by a cell-penetrating peptide. J Cell Biochem. 2011;112:2454-62 pubmed publisher
    ..These results suggest that MMP-1 is responsible for proteolytic cleavage of TAT-?B-crystallin during its intracellular transduction in H9c2 cells. ..
  52. Zhang B, Cai W, Weng H, Hu Z, Lu J, Zheng M, et al. Diagnostic value of platelet derived growth factor-BB, transforming growth factor-beta1, matrix metalloproteinase-1, and tissue inhibitor of matrix metalloproteinase-1 in serum and peripheral blood mononuclear cells for hepatic fibrosis. World J Gastroenterol. 2003;9:2490-6 pubmed
    ..The combination of serum PDGF-BB, TIMP-1mRNA and TIMP-1mRNA/MMP-1mRNA in PBMCs is even more efficient in screening liver fibrosis. ..
  53. Yang L, Zou X, Gao X, Chen H, Luo J, Wang Z, et al. Sodium tanshinone IIA sulfonate attenuates angiotensin II-induced collagen type I expression in cardiac fibroblasts in vitro. Exp Mol Med. 2009;41:508-16 pubmed publisher
    ..In conclusion, the current studies demonstrate that anti-fibrotic effects of STS are mediated by interfering with the modulation of ROS. ..
  54. Babaei S, Bayat M. Pentoxifylline Accelerates Wound Healing Process by Modulating Gene Expression of MMP-1, MMP-3, and TIMP-1 in Normoglycemic Rats. J Invest Surg. 2015;28:196-201 pubmed publisher
    ..There was a significant increase in TIMP-1 gene expression. Systemic administration of PTX significantly accelerated the wound healing process in NG rats. ..
  55. Xu J, Zhang Y, Zhang X, Ma Y. [Anti-angiogenic effects of genistein on synovium in a rat model of type II collagen-induced arthritis]. Zhong Xi Yi Jie He Xue Bao. 2011;9:186-93 pubmed
    ..The anti-angiogenic activity of genistein may correlate to its inhibitory effect on the expressions of VEGF and MMP-1, 2 and 9 in serum of CIA rats; genistein plus MTX are superior to single agents in treating rheumatoid arthritis. ..
  56. Niebroj Dobosz I, Janik P, Sokołowska B, Kwiecinski H. Matrix metalloproteinases and their tissue inhibitors in serum and cerebrospinal fluid of patients with amyotrophic lateral sclerosis. Eur J Neurol. 2010;17:226-31 pubmed publisher
    ..Although the role of changed MMPs/TIMPs level in the pathogenesis of ALS is not clear their analysis in serum may be used as prognostic factor and a potential marker for monitoring treatment effects. ..
  57. Volman T, Goris R, Lomme R, DeGroot J, Verhofstad A, Hendriks T. Increased expression of matrix metalloproteinases in the murine zymosan-induced multiple organ dysfunction syndrome. J Pathol. 2004;203:968-75 pubmed
    ..For both MMPs, staining appeared to be limited to phagocytes. In conclusion, the data suggest a role for MMPs, especially MMP-9, in the pathogenesis of MODS. ..
  58. Sun J, Zhang P, Zhang B, Li K, Li Z, Li J, et al. Budesonide ameliorates lung function of the cigarette smoke-exposed rats through reducing matrix metalloproteinase-1 content. Int J Clin Exp Pathol. 2015;8:5137-44 pubmed
    ..05). Inhaled budesonide mitigates the ongoing inflammatory process in the smoked lungs and ameliorates declining lung function through reducing MMP-1 content. ..
  59. Cleutjens J, Kandala J, Guarda E, Guntaka R, Weber K. Regulation of collagen degradation in the rat myocardium after infarction. J Mol Cell Cardiol. 1995;27:1281-92 pubmed
    ..TIMP mRNA synthesis is regulated by the activation of MMPs with the balance between collagenase activation and TIMP inhibition determining the amount of collagenolysis in infarcted tissue. ..
  60. Ueshima K, Shibata M, Suzuki T, Endo S, Hiramori K. Extracellular matrix disturbances in acute myocardial infarction: relation between disease severity and matrix metalloproteinase-1, and effects of magnesium pretreatment on reperfusion injury. Magnes Res. 2003;16:120-6 pubmed
  61. Levin J, Giese A, Boetzel K, Israel L, Högen T, Nübling G, et al. Increased alpha-synuclein aggregation following limited cleavage by certain matrix metalloproteinases. Exp Neurol. 2009;215:201-8 pubmed publisher
  62. Gerometta R, Spiga M, BORRAS T, Candia O. Treatment of sheep steroid-induced ocular hypertension with a glucocorticoid-inducible MMP1 gene therapy virus. Invest Ophthalmol Vis Sci. 2010;51:3042-8 pubmed publisher
    To investigate whether intracameral injection of the adenovirus vector AdhGRE.MMP1 would reduce or prevent elevated intraocular pressure (IOP) induced by corticosteroids in living animals.
  63. Morgan A, Rerkasem K, Gallagher P, Zhang B, Morris G, Calder P, et al. Differences in matrix metalloproteinase-1 and matrix metalloproteinase-12 transcript levels among carotid atherosclerotic plaques with different histopathological characteristics. Stroke. 2004;35:1310-5 pubmed
    ..027 and P=0.001, respectively), and than in those from patients with transient ischemic attack (P=0.046 and P=0.008, respectively). These data support a role of MMP-1 and -12 in determining atherosclerotic plaque stability. ..
  64. Nam S, Yu G, Kim H, Park K, Chung J, Ha E, et al. A polymorphism at -1607 2G in the matrix metalloproteinase-1 (MMP-1) increased risk of sudden deafness in Korean population but not at -519A/G in MMP-1. Laryngoscope. 2011;121:171-5 pubmed publisher
    ..0003). The 2G allele was found to increase the risk of SD compared with the G allele (P = .002). At MMP1 -519A/G, there was no statistically significant increase in the risk of SD...
  65. Roghani M, Becherer J, Moss M, Atherton R, Erdjument Bromage H, Arribas J, et al. Metalloprotease-disintegrin MDC9: intracellular maturation and catalytic activity. J Biol Chem. 1999;274:3531-40 pubmed
  66. Sung J, Park S, Lee C, Um J, Lee H, Kim J, et al. Proteolytic cleavage of extracellular secreted {alpha}-synuclein via matrix metalloproteinases. J Biol Chem. 2005;280:25216-24 pubmed
    ..The present study suggests that the extracellularly secreted alpha-synuclein could be processed via the activation of MMP-3 in a selective manner. ..
  67. Silva S, Jerônimo M, Silva Pereira I, Bocca A, Sousa J. Expression of metalloproteinases and interleukins on anastomoses in septic rats. J Surg Res. 2013;183:777-82 pubmed publisher
    ..A colonic segment containing anastomosis was removed for analysis of the expression of MMP1a, MMP8, MMP13, IL1?, IL6, IL10, TNF?, and IFN? genes...
  68. Ghose Roy S, Mishra S, Ghosh G, Bandyopadhyay A. Thyroid hormone induces myocardial matrix degradation by activating matrix metalloproteinase-1. Matrix Biol. 2007;26:269-79 pubmed
    ..The results suggest that accelerated breakdown of collagens-I and -III by MMP-1 due to suppression of the endogenous TIMPs plays an important role in regulating the ECM in myocardium of hyperthyroid rat. ..
  69. Zhang L, Li X, Bi L. Alterations of collagen-I, MMP-1 and TIMP-1 in the periodontal ligament of diabetic rats under mechanical stress. J Periodontal Res. 2011;46:448-55 pubmed publisher
    ..Diabetes affects proteins involved in remodeling of periodontal ligament during mechanical pressure. This may delay the reconstruction and remodeling of periodontal ligament in diabetic individuals. ..
  70. Peng B, Cao L, Wang W, Xian L, Jiang D, Zhao J, et al. Polymorphisms in the promoter regions of matrix metalloproteinases 1 and 3 and cancer risk: a meta-analysis of 50 case-control studies. Mutagenesis. 2010;25:41-8 pubmed publisher
    ..Many studies have been carried out on the association between polymorphisms of MMP1 -1607 1G>2G and MMP3 -1171 5A>6A and cancer risk. However, results from these studies remain inconclusive...
  71. Malinsky R, Valera F, Cavallari F, Küpper D, Milaneze C, Silva J, et al. Matrix metalloproteinases and their impact on sinusal extension in chronic rhinosinusitis with nasal polyps. Eur Arch Otorhinolaryngol. 2013;270:1345-8 pubmed publisher
    ..However, no correlation was observed between MMPs gene expression and sinonasal CT scan extension. 2c. ..
  72. HANDY J, Saxena N, Fu P, Lin S, Mells J, Gupta N, et al. Adiponectin activation of AMPK disrupts leptin-mediated hepatic fibrosis via suppressors of cytokine signaling (SOCS-3). J Cell Biochem. 2010;110:1195-207 pubmed publisher
    ..We therefore conclude that the protective effects of adiponectin against liver fibrosis require AMPK activation, and may occur through inhibition of the Jak-Stat signal transduction pathway. ..
  73. Gilliver S, Ruckshanthi J, Atkinson S, Ashcroft G. Androgens influence expression of matrix proteins and proteolytic factors during cutaneous wound healing. Lab Invest. 2007;87:871-81 pubmed
  74. DeMeo D, Hersh C, Hoffman E, Litonjua A, Lazarus R, Sparrow D, et al. Genetic determinants of emphysema distribution in the national emphysema treatment trial. Am J Respir Crit Care Med. 2007;176:42-8 pubmed
    ..GSTP1, EPHX1, and MMP1 polymorphisms were associated with the densitometric, apical-predominant distribution of emphysema (p value range = ..
  75. Klinchid J, Chewaskulyoung B, Saeteng S, Lertprasertsuke N, Kasinrerk W, Cressey R. Effect of combined genetic polymorphisms on lung cancer risk in northern Thai women. Cancer Genet Cytogenet. 2009;195:143-9 pubmed publisher
    ..CYP1A1 (Ile462Val), CYP2E1 (PstI), CYP2E1 (DraI), GSTM1, GSTT1, MPO (AciI), OGG1 (Ser326Cys), TP53 (Arg72Pro), and MMP1(AluI). The 173 subjects were 91 lung cancer patients and 82 healthy volunteers...
  76. Won H, Park J, Park E, Riew K. Effect of hyperglycemia on apoptosis of notochordal cells and intervertebral disc degeneration in diabetic rats. J Neurosurg Spine. 2009;11:741-8 pubmed publisher
    ..Understanding the mechanism by which diabetes affects disc degeneration is the first step in designing therapeutic modalities to delay or prevent disc degeneration caused by diabetes mellitus. ..
  77. Li H, Zhang Y, Ma J. [Effects of yiqi huoxue compound combined with exercise therapy on MMP-1 and collagen type III expressions of cardiac muscle in chronic heart failure rats]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2011;31:955-60 pubmed
    ..Its mechanism might be to inhibit the MMP-1 expression, improve the expression of collagen type III, thus alleviating and even reversing myocardial fibrosis. ..
  78. Pearce E, Tregouet D, Samnegard A, Morgan A, Cox C, Hamsten A, et al. Haplotype effect of the matrix metalloproteinase-1 gene on risk of myocardial infarction. Circ Res. 2005;97:1070-6 pubmed
    ..Several single nucleotide polymorphisms in the MMP1 gene promoter were identified following sequencing DNA samples from 30 individuals...
  79. Eckart R, Uyehara C, Shry E, Furgerson J, Krasuski R. Matrix metalloproteinases in patients with myocardial infarction and percutaneous revascularization. J Interv Cardiol. 2004;17:27-31 pubmed
    ..Results of this study indicate that MMP subtypes may play differing roles in the manifestation of acute coronary syndromes and response to revascularization. ..
  80. Gillespie D, Patel A, Fileta B, Chang A, Barnes S, Flagg A, et al. Varicose veins possess greater quantities of MMP-1 than normal veins and demonstrate regional variation in MMP-1 and MMP-13. J Surg Res. 2002;106:233-8 pubmed
    ..These data suggest that posttranscriptional regulatory controls could be responsible for the observed differences. ..
  81. Felkin L, Birks E, George R, Wong S, Khaghani A, Yacoub M, et al. A quantitative gene expression profile of matrix metalloproteinases (MMPS) and their inhibitors (TIMPS) in the myocardium of patients with deteriorating heart failure requiring left ventricular assist device support. J Heart Lung Transplant. 2006;25:1413-9 pubmed
    ..The data show that high myocardial collagenase (MMP1 and MMP8) expression without compensatory changes in collagen or TIMP expression is a feature of ..
  82. Liu H, Wei Q, Gershenwald J, Prieto V, Lee J, Duvic M, et al. Influence of single nucleotide polymorphisms in the MMP1 promoter region on cutaneous melanoma progression. Melanoma Res. 2012;22:169-75 pubmed publisher
    Recently, we reported on the associations of seven single nucleotide polymorphisms (SNPs) in the promoter region of MMP1 gene with susceptibility to cutaneous melanoma (CM)...
  83. HANDY J, Fu P, Kumar P, Mells J, Sharma S, Saxena N, et al. Adiponectin inhibits leptin signalling via multiple mechanisms to exert protective effects against hepatic fibrosis. Biochem J. 2011;440:385-95 pubmed publisher
  84. Ghilardi G, Biondi M, Mangoni J, Leviti S, DeMonti M, Guagnellini E, et al. Matrix metalloproteinase-1 promoter polymorphism 1G/2G is correlated with colorectal cancer invasiveness. Clin Cancer Res. 2001;7:2344-6 pubmed
    ..52). Our results suggest that the presence of 2G polymorphism at the MMP-1 promoter region may favor the growth and the metastatic process in CRC patients and could be looked at as a risk factor for a worse prognosis. ..