Gene Symbol: Mlf1
Description: myeloid leukemia factor 1
Alias: myeloid leukemia factor 1
Grisendi S, Pandolfi P. NPM mutations in acute myelogenous leukemia. N Engl J Med. 2005;352:291-2 pubmed
Choudhury K, Bhattacharyya N. Chaperone protein HYPK interacts with the first 17 amino acid region of Huntingtin and modulates mutant HTT-mediated aggregation and cytotoxicity. Biochem Biophys Res Commun. 2015;456:66-73 pubmed publisher
..Deletion of HTT-N17 leads to formation of tinier, SDS-soluble nuclear aggregates formed by N-terminal mutant HTT. The increased cytotoxicity imparted by these tiny aggregates might be contributed due to loss of interaction with HYPK. ..
Rangrez A, Pott J, Kluge A, Frauen R, Stiebeling K, Hoppe P, et al
. Myeloid leukemia factor-1 is a novel modulator of neonatal rat cardiomyocyte proliferation. Biochim Biophys Acta Mol Cell Res. 2017;1864:634-644 pubmed publisher
..In this analysis, myeloid leukemia factor-1 (MLF1) was found to be significantly downregulated during the course of stretch...
Lim R, Winteringham L, Williams J, McCulloch R, Ingley E, Tiao J, et al
. MADM, a novel adaptor protein that mediates phosphorylation of the 14-3-3 binding site of myeloid leukemia factor 1. J Biol Chem. 2002;277:40997-1008 pubmed
A yeast two-hybrid screen was conducted to identify binding partners of Mlf1, an oncoprotein recently identified in a translocation with nucleophosmin that causes acute myeloid leukemia...
Williams J, Daly L, Ingley E, Beaumont J, Tilbrook P, Lalonde J, et al
. HLS7, a hemopoietic lineage switch gene homologous to the leukemia-inducing gene MLF1. EMBO J. 1999;18:5559-66 pubmed
..One of the genes isolated (HLS7) is homologous to the novel human oncogene myeloid leukemia factor 1 (MLF1) involved in the t(3;5)(q25.1;q34) translocation associated with acute myeloid leukemia...
Yoneda Kato N, Tomoda K, Umehara M, Arata Y, Kato J. Myeloid leukemia factor 1 regulates p53 by suppressing COP1 via COP9 signalosome subunit 3. EMBO J. 2005;24:1739-49 pubmed
b>Myeloid leukemia factor 1 (MLF1) was first identified as the leukemic fusion protein NPM-MLF1 generated by the t(3;5)(q25.1;q34) chromosomal translocation...
Winteringham L, Endersby R, Kobelke S, McCulloch R, Williams J, Stillitano J, et al
. Myeloid leukemia factor 1 associates with a novel heterogeneous nuclear ribonucleoprotein U-like molecule. J Biol Chem. 2006;281:38791-800 pubmed
b>Myeloid leukemia factor 1 (MLF1) is an oncoprotein associated with hemopoietic lineage commitment and acute myeloid leukemia...
Hoh R, Stowe T, Turk E, Stearns T. Transcriptional program of ciliated epithelial cells reveals new cilium and centrosome components and links to human disease. PLoS ONE. 2012;7:e52166 pubmed publisher
..We found that three genes associated with human disease states, Mdm1, Mlf1, and Dyx1c1, are upregulated during ciliogenesis and localize to centrioles and cilia...