Gene Symbol: Mir23a
Description: microRNA 23a
Farrell B, Power E, Mc Dermott K. Developmentally regulated expression of Sox9 and microRNAs 124, 128 and 23 in neuroepithelial stem cells in the developing spinal cord. Int J Dev Neurosci. 2011;29:31-6 pubmed publisher
Lin H, Qian J, Castillo A, Long B, Keyes K, Chen G, et al
. Effect of miR-23 on oxidant-induced injury in human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 2011;52:6308-14 pubmed publisher
..The protection of RPE cells against oxidative damage is afforded by miR-23a through regulation of Fas, which may be a novel therapeutic target in retinal degenerative diseases. ..
Nie Y, Han B, Liu X, Yang J, Wang F, Cong X, et al
. Identification of MicroRNAs involved in hypoxia- and serum deprivation-induced apoptosis in mesenchymal stem cells. Int J Biol Sci. 2011;7:762-8 pubmed
..In contrast, down-regulation of miR-21, miR-23a and miR-503 aggravated apoptosis of MSCs. It was indicated that these miRNAs may play important roles during MSC apoptosis induced by hypoxia/SD. ..
Mao J, Lv Z, Zhuang Y. MicroRNA-23a is involved in tumor necrosis factor-? induced apoptosis in mesenchymal stem cells and myocardial infarction. Exp Mol Pathol. 2014;97:23-30 pubmed publisher
..Our findings elucidate the etiology of MI and provide an alternative treatment strategy for patients with heart failure caused by MI who are not optimal candidates for surgical treatment. ..
Yang J, Nie Y, Wang F, Hou J, Cong X, Hu S, et al
. Reciprocal regulation of miR-23a and lysophosphatidic acid receptor signaling in cardiomyocyte hypertrophy. Biochim Biophys Acta. 2013;1831:1386-94 pubmed publisher
Li J, Aung L, Long B, Qin D, An S, Li P. miR-23a binds to p53 and enhances its association with miR-128 promoter. Sci Rep. 2015;5:16422 pubmed publisher
..miR-128 can downregulate prohibitin expression, and subsequently promote apoptosis. Our data provides novel evidence revealing that miR-23a can stimulate transcriptional activity of p53. ..
De Gasperi R, Graham Z, Harlow L, Bauman W, Qin W, Cardozo C. The Signature of MicroRNA Dysregulation in Muscle Paralyzed by Spinal Cord Injury Includes Downregulation of MicroRNAs that Target Myostatin Signaling. PLoS ONE. 2016;11:e0166189 pubmed publisher
Ryan B, Logan B, Abraham W, Williams J. MicroRNAs, miR-23a-3p and miR-151-3p, Are Regulated in Dentate Gyrus Neuropil following Induction of Long-Term Potentiation In Vivo. PLoS ONE. 2017;12:e0170407 pubmed publisher
Song Y, Joo H, Park I, Shen G, Lee Y, Shin J, et al
. Bone marrow mesenchymal stem cell-derived vascular endothelial growth factor attenuates cardiac apoptosis via regulation of cardiac miRNA-23a and miRNA-92a in a rat model of myocardial infarction. PLoS ONE. 2017;12:e0179972 pubmed publisher
..Our results indicate that the paracrine factor, VEGF, derived from transplanted BM-MSCs, regulated the expression of miRNAs such as miRNA-23a and miRNA-92a and exerted anti-apoptotic effects in cardiomyocytes after MI. ..