Gene Symbol: Mir223
Description: microRNA 223
Alias: rno-mir-223
Species: rat

Top Publications

  1. Song L, Duan P, Guo P, Li D, Li S, Xu Y, et al. Downregulation of miR-223 and miR-153 mediates mechanical stretch-stimulated proliferation of venous smooth muscle cells via activation of the insulin-like growth factor-1 receptor. Arch Biochem Biophys. 2012;528:204-11 pubmed publisher
    ..Thus, miR-153 and miR-223 may be viable therapeutic targets for mechanical stretch-induced neointimal hyperplasia in vein grafts. ..
  2. Dai G, Ma P, Song X, Liu N, Zhang T, Wu B. MicroRNA-223-3p inhibits the angiogenesis of ischemic cardiac microvascular endothelial cells via affecting RPS6KB1/hif-1a signal pathway. PLoS ONE. 2014;9:e108468 pubmed publisher
    ..It is highly possible that mir-223-3p becomes a novel intervention core target in the treatment of angiogenesis of ischemic heart diseases. ..
  3. Wang Y, Zhou J, Hong K, Cheng X, Li Y. MicroRNA-223 displays a protective role against cardiomyocyte hypertrophy by targeting cardiac troponin I-interacting kinase. Cell Physiol Biochem. 2015;35:1546-56 pubmed publisher
    ..By direct targeting TNNI3K, miR-223 could suppress CMs hypertrophy via downregulating cTnI phosphorylation, reducing intracellular Ca(2+) and contractility of CMs. miR-223 / TNNI3K axis may thus be major players of CMs hypertrophy. ..
  4. Wang Q, Zhao D, Xu H, Zhou H, Yang Q, Liu F, et al. Down-regulation of microRNA-223 promotes degranulation via the PI3K/Akt pathway by targeting IGF-1R in mast cells. PLoS ONE. 2015;10:e0123575 pubmed publisher
    ..IGF-1R was identified as a direct target of miR-223. These findings suggest that down-regulation of miR-223 promotes degranulation via the PI3K/Akt pathway by targeting IGF-1R in mast cells. ..
  5. Yang L, Li Y, Wang X, Mu X, Qin D, Huang W, et al. Overexpression of miR-223 Tips the Balance of Pro- and Anti-hypertrophic Signaling Cascades toward Physiologic Cardiac Hypertrophy. J Biol Chem. 2016;291:15700-13 pubmed publisher
    ..Thus, our study suggests that the ultimate phenotype outcome of a miRNA may be decided by the secondary net effects of the whole target network rather than by several primary direct targets in an organ/tissue. ..
  6. Liu X, Zhang Y, Du W, Liang H, He H, Zhang L, et al. MiR-223-3p as a Novel MicroRNA Regulator of Expression of Voltage-Gated K+ Channel Kv4.2 in Acute Myocardial Infarction. Cell Physiol Biochem. 2016;39:102-14 pubmed publisher
  7. Guclu A, Koçak C, Koçak F, Akcılar R, Dodurga Y, Akcılar A, et al. MicroRNA-125b as a new potential biomarker on diagnosis of renal ischemia-reperfusion injury. J Surg Res. 2017;207:241-248 pubmed publisher
    ..BM reduces miR-21 and miR-125b in case of IR injury and makes functional and histopathologic repairs. ..
  8. Brianza Padilla M, Carbó R, Arana J, Vázquez Palacios G, Ballinas Verdugo M, Cardoso Saldaña G, et al. Inflammation Related MicroRNAs Are Modulated in Total Plasma and in Extracellular Vesicles from Rats with Chronic Ingestion of Sucrose. Biomed Res Int. 2016;2016:2489479 pubmed publisher
    ..05). Overall, our results show that high carbohydrate ingestion modulates circulating miRNAs levels related to an inflammatory response. ..
  9. Moen A, Jacobsen D, Phuyal S, Legfeldt A, Haugen F, Røe C, et al. MicroRNA-223 demonstrated experimentally in exosome-like vesicles is associated with decreased risk of persistent pain after lumbar disc herniation. J Transl Med. 2017;15:89 pubmed publisher
    ..Dysregulation of miR-223 may predict chronic lumbar radicular pain. Trial registration/ethics REK 2014/1725. ..

More Information


  1. Uemura R, Murakami Y, Hashimoto A, Sawada A, Otani K, Taira K, et al. Expression of Serum Exosomal and Esophageal MicroRNA in Rat Reflux Esophagitis. Int J Mol Sci. 2017;18: pubmed publisher
    ..Esophageal miR-223-3p expression was higher compared with controls, and gradually decreased from acute to chronic phase in esophagitis. In conclusion, exosomal miR-29a-3p and esophageal miR-223-3p might play roles in GERD. ..