Gene Symbol: Mir181a-1
Description: microRNA mir-181a-1
Liu Y, Zhao Z, Yang F, Gao Y, Song J, Wan Y. microRNA-181a is involved in insulin-like growth factor-1-mediated regulation of the transcription factor CREB1. J Neurochem. 2013;126:771-80 pubmed publisher
..Repressed expression of miR-181a is involved in IGF-1-mediated up-regulation of CREB1 in vivo and in vitro. These findings indicate that miR-181a could be a potential target for preventing neurodegenerative diseases. ..
Wang L, Huang H, Fan Y, Kong B, Hu H, Hu K, et al
. Effects of downregulation of microRNA-181a on H2O2-induced H9c2 cell apoptosis via the mitochondrial apoptotic pathway. Oxid Med Cell Longev. 2014;2014:960362 pubmed publisher
..MiR-181a may represent a potential therapeutic target for the treatment of oxidative stress-associated cardiovascular diseases...
Huang Y, Liu X, Liao Y, Luo C, Zou D, Wei X, et al
. MiR-181a influences the cognitive function of epileptic rats induced by pentylenetetrazol. Int J Clin Exp Pathol. 2015;8:12861-8 pubmed
Chandrasekar V, Dreyer J. microRNAs miR-124, let-7d and miR-181a regulate cocaine-induced plasticity. Mol Cell Neurosci. 2009;42:350-62 pubmed publisher
Sengupta J, Pochiraju S, Pochiraju S, Kannampalli P, Bruckert M, Addya S, et al
. MicroRNA-mediated GABA A?-1 receptor subunit down-regulation in adult spinal cord following neonatal cystitis-induced chronic visceral pain in rats. Pain. 2013;154:59-70 pubmed publisher
..These results support an integral role for miRNA-mediated transcriptional deregulation of the GABAergic system in neonatal cystitis-induced chronic pelvic pain. ..
Remus E, Lyle A, Weiss D, LandÃ zuri N, Weber M, SEARLES C, et al
. miR181a protects against angiotensin II-induced osteopontin expression in vascular smooth muscle cells. Atherosclerosis. 2013;228:168-74 pubmed publisher
..p < 0.05) CONCLUSIONS: These results demonstrate that miR181a regulates OPN expression and that altering miR181a expression may be a novel therapeutic approach to modulate OPN protein expression. ..
Deng M, Tufan T, Raza M, Jones T, Zhu M. MicroRNAs 29b and 181a down-regulate the expression of the norepinephrine transporter and glucocorticoid receptors in PC12 cells. J Neurochem. 2016;139:197-207 pubmed publisher
..Also, exposure of cells to corticosterone significantly reduced miR-29b levels through a GR-independent way. ..