Gene Symbol: Mir126
Description: microRNA mir-126
Alias: rno-mir-126
Species: rat

Top Publications

  1. Wang Z, Zhang D, Hu Z, Cheng J, Zhuo C, Fang X, et al. MicroRNA-26a-modified adipose-derived stem cells incorporated with a porous hydroxyapatite scaffold improve the repair of bone defects. Mol Med Rep. 2015;12:3345-3350 pubmed publisher
    ..In conclusion, miR?26a transfection significantly improved the osteogenic potency of ASCs suggesting that modified ASCs incorporated with a HA scaffold may be used as a potential bone substitute. ..
  2. Luo Q, Guo D, Liu G, Chen G, Hang M, Jin M. Exosomes from MiR-126-Overexpressing Adscs Are Therapeutic in Relieving Acute Myocardial Ischaemic Injury. Cell Physiol Biochem. 2017;44:2105-2116 pubmed publisher
    ..The results suggested that the expression of miR-126-enhanced ADSC-derived exosomes prevented myocardial damage by protecting myocardial cells from apoptosis, inflammation, fibrosis, and increased angiogenesis. ..
  3. Ghorbanzadeh V, Mohammadi M, Dariushnejad H, Abhari A, Chodari L, Mohaddes G. Cardioprotective Effect of Crocin Combined with Voluntary Exercise in Rat: Role of Mir-126 and Mir-210 in Heart Angiogenesis. Arq Bras Cardiol. 2017;109:54-62 pubmed publisher
    ..O exercício voluntário e a suplementação dietética com crocina podem ter efeitos benéficos na prevenção de doenças cardiovasculares. ..
  4. Chen F, Du Y, Esposito E, Liu Y, Guo S, Wang X, et al. Effects of Focal Cerebral Ischemia on Exosomal Versus Serum miR126. Transl Stroke Res. 2015;6:478-84 pubmed publisher
    ..This proof-of-concept study suggests that changes in serum miR-126 may be able to distinguish severe permanent ischemia from milder injury after transient ischemia. ..
  5. Zhao R, Hou W, Zhang Z, Qian L, Jiang L. Differential Expression of Mir-1 26 and Vascular Endothelial Growth Factor in Retinal Cells of Metabolic Acidosis-Induced Neonatal Rats. J Nanosci Nanotechnol. 2015;15:2088-93 pubmed
    ..It is thus suggested that the miR-126 plays an important role in the development of acidosis-induced retinopathy. ..
  6. Meng Q, Wang W, Yu X, Li W, Kong L, Qian A, et al. Upregulation of MicroRNA-126 Contributes to Endothelial Progenitor Cell Function in Deep Vein Thrombosis via Its Target PIK3R2. J Cell Biochem. 2015;116:1613-23 pubmed publisher
    ..Overall, our findings demonstrated that miR-126 promoted EPCs function through suppressing PIK3R2 expression and modulation of miR-126 may represent a potential therapeutic intervention for treating DVT. ..
  7. Kim W, Noh H, Lee Y, Jeon J, Shanmugavadivu A, McPhie D, et al. MiR-126 Regulates Growth Factor Activities and Vulnerability to Toxic Insult in Neurons. Mol Neurobiol. 2016;53:95-108 pubmed publisher
  8. Zhang J, Zhang Z, Zhang D, Zhu J, Zhang T, Wang C. microRNA 126 inhibits the transition of endothelial progenitor cells to mesenchymal cells via the PIK3R2-PI3K/Akt signalling pathway. PLoS ONE. 2013;8:e83294 pubmed publisher
    ..miR-126 has the potential to be used as a biomarker for the early diagnosis of intimal hyperplasia in cardiovascular disease and can even be a therapeutic tool for treating cardiovascular diseases mediated by the EndMT process. ..
  9. Yang Y, Kan Q, Zhang P, Zhang X, Zhou X, Zhou X. [Bioinformatic analysis of target gene prediction and related signaling pathways of miRNA-126*]. Zhongguo Dang Dai Er Ke Za Zhi. 2013;15:227-32 pubmed
    ..The results suggest that miRNA-126(*) plays a certain role in fetal lung development and provide a basis for lung development research in the future. ..

More Information


  1. Shi H, Chen L, Wang H, Zhu S, Dong C, Webster K, et al. Synergistic induction of miR-126 by hypoxia and HDAC inhibitors in cardiac myocytes. Biochem Biophys Res Commun. 2013;430:827-32 pubmed publisher
    ..The results suggest that miR-126 is a hypoxia-inducible target of HAT/HDAC and its activation in cardiac myocytes may contribute to cardioprotection by activating cell survival and pro-angiogenic pathways selectively during ischemia. ..
  2. Ishizaki T, Tamiya T, Taniguchi K, Morita R, Kato R, Okamoto F, et al. miR126 positively regulates mast cell proliferation and cytokine production through suppressing Spred1. Genes Cells. 2011;16:803-14 pubmed publisher
    ..Spred1 has also been implicated as the target of microRNA-126 (miR126), a miRNA located within the Egfl7 gene, and is involved in the regulation of vessel development through its role ..
  3. Gong X, Chen C, Hou P, Zhu S, Wu C, Song C, et al. Overexpression of miR-126 inhibits the activation and migration of HSCs through targeting CRK. Cell Physiol Biochem. 2014;33:97-106 pubmed publisher
    ..Our study showed that overexpression of miR-126 significantly inhibited the activation and migration of HSCs through targeting CRK which can also decrease miR-126 expression and promote HSCs activation. ..
  4. Guo C, Sah J, Beard L, Willson J, Markowitz S, Guda K. The noncoding RNA, miR-126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers. Genes Chromosomes Cancer. 2008;47:939-46 pubmed publisher
    ..Taken together, we propose that miR-126 regulates PI3K signaling partly by targeting p85beta, and that the loss of miR-126 may provide a selective growth advantage during colon carcinogenesis. ..
  5. Potus F, Ruffenach G, Dahou A, Thebault C, Breuils Bonnet S, Tremblay Ã, et al. Downregulation of MicroRNA-126 Contributes to the Failing Right Ventricle in Pulmonary Arterial Hypertension. Circulation. 2015;132:932-43 pubmed publisher
    ..More importantly, miR-126 upregulation in the RV improves microvessel density and RV function in experimental PAH. ..
  6. Chen L, Wang J, Wang B, Yang J, Gong Z, Zhao X, et al. MiR-126 inhibits vascular endothelial cell apoptosis through targeting PI3K/Akt signaling. Ann Hematol. 2016;95:365-74 pubmed publisher
    ..Overexpressed miR-126 inhibits apoptosis of VECs and DVT through targeting the anti-apoptotic pathway PI3K/Akt via PIK3R2. These findings may provide a new target for the therapy of DVT. ..
  7. Li B, Tao Y, Huang Q. Effect and mechanism of miR-126 in myocardial ischemia reperfusion. Genet Mol Res. 2015;14:18990-8 pubmed publisher
    ..These findings indicate that miR-126 is down-regulated in myocardial ischemia-reperfusion injury and that the inhibition of miR-126 may protect against myocardial cell apoptosis caused by ischemia-reperfusion. ..
  8. Tao H, Wang M, Zhang M, Zhang S, Wang C, Yuan W, et al. MiR-126 Suppresses the Glucose-Stimulated Proliferation via IRS-2 in INS-1 β Cells. PLoS ONE. 2016;11:e0149954 pubmed publisher
    ..MiR-126 may take part in the glucose homeostasis both through its target IRS-2 and IRS-1. The unbalance between IRS-1 and IRS-2 caused by miR-126 may play an important role in type 2 diabetes. ..
  9. Wang Y, Yan H. MicroRNA-126 contributes to Niaspan treatment induced vascular restoration after diabetic retinopathy. Sci Rep. 2016;6:26909 pubmed publisher
    ..These data are the first to show that Niaspan treatment ameliorates DR through its repair vascular and inhibits inflammatory effects, and also suggest that the miR-126 pathway may contribute to Niaspan treatment induced benefit effects. ..
  10. Yang Y, Kan Q, Qiu J, Pu X, Zhang P, Zhang X, et al. [Role of miRNA-126/miRNA-126* in the fetal lung development of rats]. Zhongguo Dang Dai Er Ke Za Zhi. 2012;14:708-12 pubmed
    ..05). miRNA-126(*) may play an important role in development of the fetal lung in rats. ..
  11. Xi T, Jin F, Zhu Y, Wang J, Tang L, Wang Y, et al. MicroRNA-126-3p attenuates blood-brain barrier disruption, cerebral edema and neuronal injury following intracerebral hemorrhage by regulating PIK3R2 and Akt. Biochem Biophys Res Commun. 2017;494:144-151 pubmed publisher
    ..In summary, our results suggest that exogenous miR-126-3p may alleviate BBB disruption, cerebral edema and neuronal injury following ICH by targeting PIK3R2 and the Akt signaling pathway in brain vascular endothelium...
  12. Ye P, Liu J, He F, Xu W, Yao K. Hypoxia-induced deregulation of miR-126 and its regulative effect on VEGF and MMP-9 expression. Int J Med Sci. 2014;11:17-23 pubmed publisher
    ..miR-126 is down-regulated under hypoxic condition both in vitro and in vivo and may halt the hypoxia-induce neovascularization by suspending the cell cycle progression and inhibiting the expression of VEGF and MMP-9. ..