Gene Symbol: Mical1
Description: microtubule associated monooxygenase, calponin and LIM domain containing 1
Alias: MICAL-1, Nical, [F-actin]-monooxygenase MICAL1, NEDD9 interacting protein with calponin homology and LIM domains, [F-actin]-methionine sulfoxide oxidase MICAL1, microtubule associated monoxygenase, calponin and LIM domain containing 1, molecule interacting with CasL protein 1, protein-methionine sulfoxide oxidase MICAL1
Lundquist M, Storaska A, Liu T, Larsen S, Evans T, Neubig R, et al
. Redox modification of nuclear actin by MICAL-2 regulates SRF signaling. Cell. 2014;156:563-76 pubmed publisher
..These data identify redox modification of nuclear actin as a regulatory switch that mediates SRF/MRTF-A-dependent gene transcription. ..
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T. The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions. Mol Biol Cell. 2008;19:971-83 pubmed
..These results suggest that the interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of AJs and TJs. ..
van Battum E, Gunput R, Lemstra S, Groen E, Yu K, Adolfs Y, et al
. The intracellular redox protein MICAL-1 regulates the development of hippocampal mossy fibre connections. Nat Commun. 2014;5:4317 pubmed publisher
Suzuki T, Nakamoto T, Ogawa S, Seo S, Matsumura T, Tachibana K, et al
. MICAL, a novel CasL interacting molecule, associates with vimentin. J Biol Chem. 2002;277:14933-41 pubmed
..Immunostaining revealed that MICAL localizes along with vimentin intermediate filaments. These results suggest that MICAL may be a cytoskeletal regulator that connects CasL to intermediate filaments. ..
Luo J, Xu Y, Zhu Q, Zhao F, Zhang Y, Peng X, et al
. Expression pattern of Mical-1 in the temporal neocortex of patients with intractable temporal epilepsy and pilocarpine-induced rat model. Synapse. 2011;65:1213-21 pubmed publisher
..Thus, as an effect factor participated in F-actin disassemble, Mical-1 may associate with inner pathophysiological modulation in epilepsy. ..
Zhou Y, Adolfs Y, Pijnappel W, Fuller S, van der Schors R, Li K, et al
. MICAL-1 is a negative regulator of MST-NDR kinase signaling and apoptosis. Mol Cell Biol. 2011;31:3603-15 pubmed publisher
..Our findings unveil a previously unknown biological role for MICAL-1 in apoptosis and define a novel negative regulatory mechanism of MST-NDR signaling. ..
Zucchini D, Caprini G, Pasterkamp R, Tedeschi G, Vanoni M. Kinetic and spectroscopic characterization of the putative monooxygenase domain of human MICAL-1. Arch Biochem Biophys. 2011;515:1-13 pubmed publisher
..7?M, under conditions that stabilize F-actin. The time-course of NADPH oxidation shows substrate recycling, indicating the possible reversibility of MICAL effect. ..
Lee B, Péterfi Z, Hoffmann F, Moore R, Kaya A, Avanesov A, et al
. MsrB1 and MICALs regulate actin assembly and macrophage function via reversible stereoselective methionine oxidation. Mol Cell. 2013;51:397-404 pubmed publisher
..Two methionine residues in actin are specifically converted to methionine-R-sulfoxide by Mical1 and Mical2 and reduced back to methionine by selenoprotein MsrB1, supporting actin disassembly and assembly, ..
Fischer J, Weide T, Barnekow A. The MICAL proteins and rab1: a possible link to the cytoskeleton?. Biochem Biophys Res Commun. 2005;328:415-23 pubmed
..Furthermore, we investigated the connection between MICAL proteins and the cytoskeleton. Using the microtubule depolymerizing drug nocodazole we detected a link between MICAL-1 and -3, and the microtubule cytoskeleton. ..