Mgp

Summary

Gene Symbol: Mgp
Description: matrix Gla protein
Alias: Mglap
Species: rat

Top Publications

  1. pmc Quercetin attenuates warfarin-induced vascular calcification in vitro independently from matrix Gla protein
    Kelly E Beazley
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 288:2632-40. 2013
  2. doi Decreased expression of γ-carboxylase in diabetes-associated arterial stiffness: impact on matrix Gla protein
    Marielle Doyon
    Faculty of Pharmacy, Universite de Montreal, 2900 Edouard Montpetit, Room 2143, P O Box 6128, Station Centre Ville, Montreal, Quebec H3C 3J7, Canada
    Cardiovasc Res 97:331-8. 2013
  3. ncbi Matrix GLA protein modulates branching morphogenesis in fetal rat lung
    Kirk A Gilbert
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, 500 Univ Drive, Hershey, PA 17033, USA
    Am J Physiol Lung Cell Mol Physiol 286:L1179-87. 2004
  4. ncbi Relationship between immunological rejection and matrix GLA protein in cryopreserved vascular allografts
    T Kiji
    Department of Surgery III, Nara Medical University, Nara, Japan
    Transplant Proc 36:2415-7. 2004
  5. ncbi Matrix Gla protein C-terminal region binds to vitronectin. Co-localization suggests binding occurs during tissue development
    Satoru K Nishimoto
    Department of Molecular Sciences, University of Tennessee Health Sciences Center, 858 Madison Avenue, Memphis, TN 38163, USA
    Matrix Biol 24:353-61. 2005
  6. ncbi Thyroid hormone targets matrix Gla protein gene associated with vascular smooth muscle calcification
    Yoji Sato
    Division of Cellular and Gene Therapy Products, National Institute of Health Sciences, Tokyo 158 8501, Japan
    Circ Res 97:550-7. 2005
  7. pmc Matrix Gla protein is associated with risk factors for atherosclerosis but not with coronary artery calcification
    Christopher J O'Donnell
    Framingham Heart Study, 73 Mt Wayte Ave, Suite 2, Framingham, MA 01702, USA
    Arterioscler Thromb Vasc Biol 26:2769-74. 2006
  8. ncbi Regression of warfarin-induced medial elastocalcinosis by high intake of vitamin K in rats
    Leon J Schurgers
    Cardiovascular Research Institute CARIM, Maastricht University, The Netherlands
    Blood 109:2823-31. 2007
  9. ncbi Gene expression profiling to identify markers associated with deregulated hTERT in HPV-transformed keratinocytes and cervical cancer
    Jillian de Wilde
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Int J Cancer 122:877-88. 2008
  10. doi Intermedin inhibits vascular calcification by increasing the level of matrix gamma-carboxyglutamic acid protein
    Yan Cai
    Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100191, China
    Cardiovasc Res 85:864-73. 2010

Research Grants

Scientific Experts

  • Tatsuya Kiji
  • Christopher J O'Donnell
  • S M Herrmann
  • Paul Price
  • Shuichi Jono
  • L J Schurgers
  • Reidar Wallin
  • P B Munroe
  • A Farzaneh-Far
  • Kirk A Gilbert
  • Kelly E Beazley
  • Marielle Doyon
  • Francisco J Mendoza
  • Koba A Lomashvili
  • Yan Cai
  • Bing Gao
  • Erja Mustonen
  • Jillian de Wilde
  • Satoru K Nishimoto
  • Yoji Sato
  • Stephen R Rannels
  • A Sweatt
  • M Sato
  • SAMAN EGHTESAD
  • Maria V Nurminskaya
  • Patrick Mathieu
  • Pierre Moreau
  • C D Hough
  • H M Spronk
  • Mariano Rodriguez
  • Jose Carlos Estepa
  • Xiaonan Wang
  • Escolastico Aguilera-Tejero
  • Ignacio Lopez
  • Julio Martinez-Moreno
  • Maria E Rodriguez-Ortiz
  • Charles Henley
  • Yolanda Almaden
  • W CHARLES O'NEILL
  • Takahiro Yasui
  • Kenjiro Kohri
  • Chunling Xiao
  • Li Chen
  • Hongge Zhou
  • Ye Bo Zhou
  • Xiuli Lu
  • Xu Teng
  • Yi Zhu
  • Yong Fen Qi
  • Xian Wang
  • Ping Liu
  • Chao Shu Tang
  • Jian Liu
  • Atsushi Okada
  • Ming jiang Xu
  • Virva Pohjolainen
  • Jani Aro
  • Heikki Ruskoaho
  • Hanna Leskinen
  • Sampsa Pikkarainen
  • Jaana Rysa
  • Peter J F Snijders
  • Saskia M Wilting
  • T Yasui
  • Renske D M Steenbergen
  • Bauke Ylstra
  • Chris J L M Meijer
  • Mark A van de Wiel
  • M Sugimoto
  • Y Kitamura
  • S Hirota
  • S Nomura
  • Seiichi Ishida
  • Ryo Nakamura
  • Kazuhide Inoue
  • Taku Nagao
  • Kayoko Fujishita
  • Miyako Nishimoto
  • Mitsutoshi Satoh
  • Teruhide Yamaguchi
  • Satoko Mori
  • Yasuo Ohno
  • S M Hutson
  • D C Sane
  • H H Thijssen
  • J G De Mey
  • P J Morin
  • D R Schwartz
  • A B Zonderman
  • K R Cho

Detail Information

Publications31

  1. pmc Quercetin attenuates warfarin-induced vascular calcification in vitro independently from matrix Gla protein
    Kelly E Beazley
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 288:2632-40. 2013
    ..vascular calcification in vitro via activation of β-catenin signaling and/or inhibition of matrix Gla protein (MGP) carboxylation...
  2. doi Decreased expression of γ-carboxylase in diabetes-associated arterial stiffness: impact on matrix Gla protein
    Marielle Doyon
    Faculty of Pharmacy, Universite de Montreal, 2900 Edouard Montpetit, Room 2143, P O Box 6128, Station Centre Ville, Montreal, Quebec H3C 3J7, Canada
    Cardiovasc Res 97:331-8. 2013
    ..VKOR) reduces the vitamin K required by γ-carboxylase to activate matrix γ-carboxyglutamic acid (Gla) protein (MGP), an inhibitor of vascular calcification...
  3. ncbi Matrix GLA protein modulates branching morphogenesis in fetal rat lung
    Kirk A Gilbert
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, 500 Univ Drive, Hershey, PA 17033, USA
    Am J Physiol Lung Cell Mol Physiol 286:L1179-87. 2004
    The regulation of matrix gamma-carboxyglutamic acid protein (MGP) expression during the process of lung branching morphogenesis and development was investigated...
  4. ncbi Relationship between immunological rejection and matrix GLA protein in cryopreserved vascular allografts
    T Kiji
    Department of Surgery III, Nara Medical University, Nara, Japan
    Transplant Proc 36:2415-7. 2004
    ..Recent attention has been focused on the inhibitory effect of matrix Gla protein (MGP) on ectopic vascular calcification, but the behavior of MGP in cryopreserved allografts is uncertain...
  5. ncbi Matrix Gla protein C-terminal region binds to vitronectin. Co-localization suggests binding occurs during tissue development
    Satoru K Nishimoto
    Department of Molecular Sciences, University of Tennessee Health Sciences Center, 858 Madison Avenue, Memphis, TN 38163, USA
    Matrix Biol 24:353-61. 2005
    Matrix Gla protein (MGP) regulates calcification in cartilage and arteries...
  6. ncbi Thyroid hormone targets matrix Gla protein gene associated with vascular smooth muscle calcification
    Yoji Sato
    Division of Cellular and Gene Therapy Products, National Institute of Health Sciences, Tokyo 158 8501, Japan
    Circ Res 97:550-7. 2005
    ..revealed that a physiological concentration of T3 (15 pmol/L free T3) increased mRNA level of matrix Gla protein (MGP), which acts as a potent inhibitor of vascular calcification in vivo, by 3-fold in RAOSMCs, as well as in cultured ..
  7. pmc Matrix Gla protein is associated with risk factors for atherosclerosis but not with coronary artery calcification
    Christopher J O'Donnell
    Framingham Heart Study, 73 Mt Wayte Ave, Suite 2, Framingham, MA 01702, USA
    Arterioscler Thromb Vasc Biol 26:2769-74. 2006
    ..Matrix Gla protein (MGP) is an inhibitor of calcification in vivo...
  8. ncbi Regression of warfarin-induced medial elastocalcinosis by high intake of vitamin K in rats
    Leon J Schurgers
    Cardiovascular Research Institute CARIM, Maastricht University, The Netherlands
    Blood 109:2823-31. 2007
    ..Matrix Gla protein (MGP) is a potent inhibitor of AC, and its activity depends on vitamin K (VK)...
  9. ncbi Gene expression profiling to identify markers associated with deregulated hTERT in HPV-transformed keratinocytes and cervical cancer
    Jillian de Wilde
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Int J Cancer 122:877-88. 2008
    ..For 2 of these genes, encoding AQP3 and MGP, altered expression in hTERT positive cervical carcinomas was confirmed by real-time RT-PCR and ..
  10. doi Intermedin inhibits vascular calcification by increasing the level of matrix gamma-carboxyglutamic acid protein
    Yan Cai
    Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100191, China
    Cardiovasc Res 85:864-73. 2010
    ..Here, we investigated the expression of the novel peptide intermedin (IMD) in the vasculature, tested its ability to prevent VC in vivo and in vitro, and examined the mechanism involved...
  11. doi Upregulation of cardiac matrix Gla protein expression in response to hypertrophic stimuli
    Erja Mustonen
    Institute of Biomedicine, Department of Pharmacology and Toxicology, Biocenter Oulu, University of Oulu, Oulu, Finland
    Blood Press 18:286-93. 2009
    Matrix Gla protein (MGP) expression is increased in cardiac hypertrophy, but the precise mechanisms regulating its expression are unknown...
  12. doi Matrix Gla protein expression in NRK-52E cells exposed to oxalate and calcium oxalate monohydrate crystals
    Bing Gao
    Department of Cell Biology and Genetics, Shenyang Medical College, Shenyang, China
    Urol Int 85:237-41. 2010
    Matrix Gla protein (MGP), a potent calcification inhibitor in extracellular matrix, is a molecular determinant regulating vascular calcification...
  13. doi Effect of calcium and the calcimimetic AMG 641 on matrix-Gla protein in vascular smooth muscle cells
    Francisco J Mendoza
    Departamento de Medicina y Cirugia Animal, Universidad de Cordoba, Campus Universitario Rabanales, Spain
    Calcif Tissue Int 88:169-78. 2011
    ..of calcium and the calcimimetic AMG 641 on arterial wall and isolated VSMC expression of matrix-Gla protein (MGP)...
  14. pmc Matrix Gla protein metabolism in vascular smooth muscle and role in uremic vascular calcification
    Koba A Lomashvili
    Department of Medicine, Renal Division, Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 286:28715-22. 2011
    Matrix Gla protein (MGP) is an inhibitor of vascular calcification but its mechanism of action and pathogenic role are unclear. This was examined in cultured rat aortas and in a model of vascular calcification in rats with renal failure...
  15. ncbi Matrix Gla protein is associated with coronary artery calcification as assessed by electron-beam computed tomography
    Shuichi Jono
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Thromb Haemost 91:790-4. 2004
    Matrix Gla protein (MGP) is an extracellular matrix protein with wide tissue distribution...
  16. ncbi Matrix Gla protein (MGP) and bone morphogenetic protein-2 in aortic calcified lesions of aging rats
    A Sweatt
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Thromb Haemost 1:178-85. 2003
    The vitamin K-dependent protein, matrix Gla protein (MGP) is a binding protein for bone morphogenetic protein-2 (BMP-2)...
  17. ncbi Glucocorticoid effects on vitamin K-dependent carboxylase activity and matrix Gla protein expression in rat lung
    Kirk A Gilbert
    Dept of Cellular and Molecular Physiology, H 166, The Pennsylvania State Univ College of Medicine, 500 Univ Dr, Hershey, PA 17033, USA
    Am J Physiol Lung Cell Mol Physiol 285:L569-77. 2003
    ..Matrix Gla protein (MGP), a vitamin K-dependent protein known to be synthesized in type II cells, was also found in fetal fibroblasts, ..
  18. ncbi Developmental expression and hormonal regulation of the rat matrix Gla protein (MGP) gene in chondrogenesis and osteogenesis
    L M Barone
    Department of Cell Biology, University of Massachusetts Medical Center, Worcester 01655
    J Cell Biochem 46:351-65. 1991
    Matrix Gla protein (MGP), a vitamin K dependent protein, has recently been identified in many tissues...
  19. pmc Molecular cloning of matrix Gla protein: implications for substrate recognition by the vitamin K-dependent gamma-carboxylase
    P A Price
    Department of Biology, University of California, San Diego, La Jolla 92093
    Proc Natl Acad Sci U S A 84:8335-9. 1987
    Matrix Gla protein (MGP), a low molecular weight protein found in bone, dentin, and cartilage, contains 5 residues of the vitamin K-dependent amino acid gamma-carboxyglutamic acid (Gla)...
  20. pmc Conserved phosphorylation of serines in the Ser-X-Glu/Ser(P) sequences of the vitamin K-dependent matrix Gla protein from shark, lamb, rat, cow, and human
    P A Price
    Department of Biology, University of California at San Diego, La Jolla 92093 0322
    Protein Sci 3:822-30. 1994
    The present studies demonstrate that matrix Gla protein (MGP), a 10-kDa vitamin K-dependent protein, is phosphorylated at 3 serine residues near its N-terminus...
  21. pmc High expression of genes for calcification-regulating proteins in human atherosclerotic plaques
    C M Shanahan
    Department of Medicine, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Clin Invest 93:2393-402. 1994
    ..and immunohistochemistry we show that two bone-associated proteins, osteopontin (OP) and matrix Gla protein (MGP), are highly expressed in human atheromatous plaques...
  22. ncbi Expression of bone matrix proteins mRNA during distraction osteogenesis
    M Sato
    Department of Orthopaedic Surgery, Osaka University Medical School, Suita, Japan
    J Bone Miner Res 13:1221-31. 1998
    ..the expression and localization of the mRNAs encoding osteopontin (OPN), osteocalcin (OC), matrix Gla protein (MGP), osteonectin (ON), and collagen type I and I during distraction osteogenesis were examined by in situ ..
  23. ncbi Mutations in the gene encoding the human matrix Gla protein cause Keutel syndrome
    P B Munroe
    Department of Paediatrics, Royal Free and University College Medical School, The Rayne Institute, London, UK
    Nat Genet 21:142-4. 1999
    ..b>Mglap-deficient mice (Mglap-/-) have been reported to have inappropriate calcification of cartilage...
  24. ncbi Expression of bone matrix proteins in urolithiasis model rats
    T Yasui
    Department of Urology, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Urol Res 27:255-61. 1999
    ..The expression of messenger (m) RNAs of osteopontin (OPN), matrix Gla protein (MGP), osteonectin (ON) and osteocalcin (OC) in bones and teeth has been described...
  25. ncbi Matrix Gla protein synthesis and gamma-carboxylation in the aortic vessel wall and proliferating vascular smooth muscle cells--a cell system which resembles the system in bone cells
    R Wallin
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Thromb Haemost 82:1764-7. 1999
    Matrix GLA protein (MGP) is an inhibitor of calcification in the arterial wall and its activity is dependent upon vitamin K-dependent gamma-carboxylation...
  26. ncbi Matrix gla protein is regulated by a mechanism functionally related to the calcium-sensing receptor
    A Farzaneh-Far
    Division of Cardiovascular Medicine, University of Cambridge, Addenbrooke s Hospital, ACCI level 6, Hills Road, Cambridge, CB2 2QQ, United Kingdom
    Biochem Biophys Res Commun 277:736-40. 2000
    Matrix Gla protein (MGP) is a mineral binding extra-cellular matrix protein which is thought to be a key inhibitor of tissue and vascular calcification...
  27. ncbi Polymorphisms of the human matrix gla protein (MGP) gene, vascular calcification, and myocardial infarction
    S M Herrmann
    Institut National de la Santé et de la Recherche Médicale Inserm SC7 U525, Paris, France
    Arterioscler Thromb Vasc Biol 20:2386-93. 2000
    The matrix Gla protein (MGP) is an important inhibitor of vessel and cartilage calcification that is strongly expressed in human calcified, atherosclerotic plaques and could modulate plaque calcification and coronary heart disease risk...
  28. ncbi Coordinately up-regulated genes in ovarian cancer
    C D Hough
    Laboratory of Cellular and Molecular Biology, National Institute on Aging, Baltimore, MD 21224, USA
    Cancer Res 61:3869-76. 2001
    ..A statistical analysis shows that genes commonly up-regulated in ovarian cancer may result from the aberrant activation of a limited number of pathways, providing promising targets for novel therapeutic strategies...
  29. ncbi Matrix Gla protein accumulates at the border of regions of calcification and normal tissue in the media of the arterial vessel wall
    H M Spronk
    Department of Biochemistry, Maastricht University, Maastricht, The Netherlands
    Biochem Biophys Res Commun 289:485-90. 2001
    Vitamin K-dependent matrix Gla protein (MGP) has been suggested to play a role in the inhibition of soft-tissue calcification...
  30. ncbi Biochemical characterization of the serum fetuin-mineral complex
    Paul A Price
    Division of Biology 0368, University of California San Diego, La Jolla, CA 92093 0368, USA
    J Biol Chem 278:22153-60. 2003
    ..FMC), a high molecular mass complex of calcium phosphate mineral and the proteins fetuin and matrix Gla protein (MGP) that was initially discovered in serum of rats treated with etidronate and appears to play a critical role in ..
  31. ncbi Expression of the matrix Gla protein in urogenital malignancies
    E N Levedakou
    Department of Medicine, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill 27599
    Int J Cancer 52:534-7. 1992
    Matrix Gla protein (MGP), is a vitamin-K-dependent protein which is synthesized in a variety of tissues such as lung, heart, kidney, cartilage and bone. The function of MGP in these tissues is unclear...

Research Grants27

  1. MATRIX GLA PROTEIN AND CARTILAGE CALCIFICATION
    Paul Price; Fiscal Year: 2001
    ..Adapted from the Applicant's Abstract): The three objectives of this investigation are to understand the role of MGP in preventing calcification of growth plate cartilage, to establish the role of MGP as a calcification inhibitor in ..
  2. VITAMIN K, METABOLISM AND FUNCTION
    Reidar Wallin; Fiscal Year: 2001
    ..specific gene 6 product Gas6 and the bone and cartilage resident proteins, osteocalsin and matrix GLA protein (MGP)...
  3. MATRIX GLA PROTEIN AND ARTERY CALCIFICATION
    Paul Price; Fiscal Year: 2002
    ..These experiments are being done to establish the importance of vitamin K deficiency and of warfarin treatment as risk factors for the calcification of human arteries. ..
  4. Vitamin K, Bone, and Arterial Calcification
    Reidar Wallin; Fiscal Year: 2006
    ..main focus of this grant is to understand the involvement of the vitamin K-dependent protein, Matrix Gla protein (MGP), in bone formation...
  5. Initiation and Inhibition of Medial Artery Calcification
    Paul Price; Fiscal Year: 2007
    ..prevented by the opposing action of calcification inhibitors such as the vitamin K-dependent matrix Gla protein (MGP), an inhibitor which is secreted by smooth muscle cells adjacent to the elastic lamellae in the artery media...
  6. REGULATION AND BIOSYNTHESIS OF K-DEPENDENT BONE PROTEINS
    Paul Price; Fiscal Year: 1990
    ..These studies should help to define the clinical and biological significance of the Gla protein of bone and may provide a useful and unique biochemical marker for the assessment of bone turnover and skeletal status...
  7. REGULATION OF VITAMIN K-DEPENDENT BONE PROTEINS
    Paul Price; Fiscal Year: 1993
    ..out an integrated series of experiments designed to understand the regulation and function of Matrix Gla Protein (MGP)...