Mgll

Summary

Gene Symbol: Mgll
Description: monoglyceride lipase
Alias: MAGL, monoglyceride lipase, MGL, monoacylglycerol lipase
Species: rat
Products:     Mgll

Top Publications

  1. Blankman J, Simon G, Cravatt B. A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol. Chem Biol. 2007;14:1347-56 pubmed
    ..about the inactivation of 2-AG, which can be hydrolyzed by multiple enzymes in vitro, including FAAH and monoacylglycerol lipase (MAGL)...
  2. Lau B, Drew G, Mitchell V, Vaughan C. Endocannabinoid modulation by FAAH and monoacylglycerol lipase within the analgesic circuitry of the periaqueductal grey. Br J Pharmacol. 2014;171:5225-36 pubmed publisher
    ..hydrolase (FAAH) inhibitor, URB597, whereas a 2-AG-induced suppression of inhibition was unmasked by the monoacylglycerol lipase (MGL) inhibitor, JZL184...
  3. Jiang S, Zhang M, Tian Z, Wang M, Zhao R, Wang L, et al. The monoacylglycerol lipase inhibitor JZL184 decreases inflammatory response in skeletal muscle contusion in rats. Eur J Pharmacol. 2015;761:1-10 pubmed publisher
    Muscle wound healing process is a typical inflammation-evoked event. The monoacylglycerol lipase (MAGL) inhibitor (4-nitrophenyl)4-[bis(1,3-benzodioxol -5-yl)-hydroxymethyl]piperidine-1-carboxylate (JZL184) has been previously reported ..
  4. Marrs W, Blankman J, Horne E, Thomazeau A, Lin Y, Coy J, et al. The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors. Nat Neurosci. 2010;13:951-7 pubmed publisher
    ..Enzymes that hydrolyze 2-AG, such as monoacylglycerol lipase, regulate the accumulation and efficacy of 2-AG at cannabinoid receptors...
  5. Schlosburg J, Blankman J, Long J, Nomura D, Pan B, Kinsey S, et al. Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system. Nat Neurosci. 2010;13:1113-9 pubmed publisher
    ..We found that a similar form of functional antagonism was produced by sustained inactivation of monoacylglycerol lipase (MAGL), the principal degradative enzyme for the endocannabinoid 2-arachidonoylglycerol...
  6. Hinojos C, Boerwinkle E, Fornage M, Doris P. Combined genealogical, mapping, and expression approaches to identify spontaneously hypertensive rat hypertension candidate genes. Hypertension. 2005;45:698-704 pubmed
    ..The present approach identifies a number of genes that may influence blood pressure in SHR by virtue of allelic effects on gene expression. ..
  7. Kouchi Z. Monoacylglycerol lipase promotes Fcγ receptor-mediated phagocytosis in microglia but does not regulate LPS-induced upregulation of inflammatory cytokines. Biochem Biophys Res Commun. 2015;464:603-10 pubmed publisher
    b>Monoacylglycerol lipase (MAGL) is important for neuroinflammation. However, the regulatory mechanisms underlying its expression and function remain unknown...
  8. Keimpema E, Tortoriello G, Alpar A, Capsoni S, Arisi I, Calvigioni D, et al. Nerve growth factor scales endocannabinoid signaling by regulating monoacylglycerol lipase turnover in developing cholinergic neurons. Proc Natl Acad Sci U S A. 2013;110:1935-40 pubmed publisher
    ..In doing so, NGF limits the sorting of monoacylglycerol lipase (MGL), rate limiting 2-AG bioavailability, to proximal neurites, allowing cell-autonomous 2-AG signaling ..
  9. Keimpema E, Barabas K, Morozov Y, Tortoriello G, Torii M, Cameron G, et al. Differential subcellular recruitment of monoacylglycerol lipase generates spatial specificity of 2-arachidonoyl glycerol signaling during axonal pathfinding. J Neurosci. 2010;30:13992-4007 pubmed publisher
    ..Therefore, we hypothesized that local 2-AG degradation by monoacylglycerol lipase (MGL) must play a role...

More Information

Publications20

  1. Carloni S, Alonso Alconada D, Girelli S, Duranti A, Tontini A, Piomelli D, et al. Pretreatment with the monoacylglycerol lipase inhibitor URB602 protects from the long-term consequences of neonatal hypoxic-ischemic brain injury in rats. Pediatr Res. 2012;72:400-6 pubmed publisher
    ..assess whether preventing the deactivation of the endocannabinoid 2-arachidonoylglycerol (2-AG) with the monoacylglycerol lipase (MAGL) inhibitor URB602 can provide neuroprotective effects in hypoxia-ischemia (HI)-induced brain injury...
  2. Berdan C, Erion K, Burritt N, Corkey B, Deeney J. Inhibition of Monoacylglycerol Lipase Activity Decreases Glucose-Stimulated Insulin Secretion in INS-1 (832/13) Cells and Rat Islets. PLoS ONE. 2016;11:e0149008 pubmed publisher
    ..have determined effects of increasing intracellular MAG in the β-cell by inhibiting mono-acyl-glycerol lipase (MGL) activity, which catalyzes the final step in triacylglycerol breakdown, namely the hydrolysis of MAG to glycerol ..
  3. Karlsson M, Contreras J, Hellman U, Tornqvist H, Holm C. cDNA cloning, tissue distribution, and identification of the catalytic triad of monoglyceride lipase. Evolutionary relationship to esterases, lysophospholipases, and haloperoxidases. J Biol Chem. 1997;272:27218-23 pubmed
    b>Monoglyceride lipase catalyzes the last step in the hydrolysis of stored triglycerides in the adipocyte and presumably also complements the action of lipoprotein lipase in degrading triglycerides from chylomicrons and very low density ..
  4. Jiang S, Zhang M, Tian Z, Wang L, Zhao R, Li S, et al. The distribution and time-dependent expression of MAGL during skeletal muscle wound healing in rats. Histol Histopathol. 2015;30:1243-54 pubmed publisher
    b>Monoacylglycerol lipase (MAGL) is widely distributed in mammals and largely responsible for metabolizing 2-arachidonoylglycerol (2-AG). Little is known about its expression in skeletal muscles after trauma...
  5. Navia Paldanius D, Savinainen J, Laitinen J. Biochemical and pharmacological characterization of human ?/?-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12). J Lipid Res. 2012;53:2413-24 pubmed publisher
    ..From these, monoacylglycerol lipase (MAGL) is well characterized and, on a quantitative basis, is the main 2-AG hydrolase...
  6. Suarez J, Rivera P, Llorente R, Romero Zerbo S, Bermudez Silva F, de Fonseca F, et al. Early maternal deprivation induces changes on the expression of 2-AG biosynthesis and degradation enzymes in neonatal rat hippocampus. Brain Res. 2010;1349:162-73 pubmed publisher
    ..to analyze the impact of MD on the enzymes involved in 2-AG biosynthesis (DAGLalpha and DAGLbeta) and degradation (MAGL) in relevant areas (DG, CA1, CA3) of the hippocampus in 13-day-old neonatal rats...
  7. Comelli F, Giagnoni G, Bettoni I, Colleoni M, Costa B. The inhibition of monoacylglycerol lipase by URB602 showed an anti-inflammatory and anti-nociceptive effect in a murine model of acute inflammation. Br J Pharmacol. 2007;152:787-94 pubmed
    ..2-AG) is an endocannabinoid whose hydrolysis is predominantly catalysed by the enzyme monoacylglycerol lipase (MAGL)...
  8. Duncan M, Thomas A, Cluny N, Patel A, Patel K, Lutz B, et al. Distribution and function of monoacylglycerol lipase in the gastrointestinal tract. Am J Physiol Gastrointest Liver Physiol. 2008;295:G1255-65 pubmed publisher
    ..Here, we describe the presence and localization of monoacylglycerol lipase (MGL), the major enzyme responsible for the degradation of 2-arachidonoylglycerol...
  9. Ho W, Randall M. Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol. Br J Pharmacol. 2007;150:641-51 pubmed
    ..and 2-arachidonoylglycerol (2-AG) are rapidly degraded by fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MGL)...
  10. Dinh T, Carpenter D, Leslie F, Freund T, Katona I, Sensi S, et al. Brain monoglyceride lipase participating in endocannabinoid inactivation. Proc Natl Acad Sci U S A. 2002;99:10819-24 pubmed
    ..Here we tested the hypothesis that monoglyceride lipase (MGL), a serine hydrolase that converts monoglycerides to fatty acid and glycerol, participates in 2-AG ..
  11. Labar G, Bauvois C, Borel F, Ferrer J, Wouters J, Lambert D. Crystal structure of the human monoacylglycerol lipase, a key actor in endocannabinoid signaling. Chembiochem. 2010;11:218-27 pubmed publisher
    2-Arachidonoylglycerol plays a major role in endocannabinoid signaling, and is tightly regulated by the monoacylglycerol lipase (MAGL). Here we report the crystal structure of human MAGL...