metallothionein

Summary

Gene Symbol: metallothionein
Description: metallothionein 1
Alias: Mt1a, metallothionein-1, MT-1, MT-I, metallothionein 1a, metallothionein-I
Species: rat
Products:     metallothionein

Top Publications

  1. Wörgötter E, Wagner G, Vasak M, Kägi J, Wuthrich K. Sequence-specific 1H-NMR assignments in rat-liver metallothionein-2. Eur J Biochem. 1987;167:457-66 pubmed
    ..chain, sequence-specific assignments were obtained for the 1H nuclear magnetic resonance (NMR) spectrum of metallothionein-2 from rat liver...
  2. Jakovac H, Grebić D, Tota M, Barac Latas V, Mrakovcic Sutic I, Milin C, et al. Time-course expression of metallothioneins and tissue metals in chronic relapsing form of experimental autoimmune encephalomyelitis. Histol Histopathol. 2011;26:233-45 pubmed publisher
    ..Concomitantly, in the brain and SC the concentration of copper increased. The data point to a neuroprotective role of MTs and to an important regulatory role of essential metals and hepatic MTs in the pathogenesis of CR-EAE. ..
  3. Tsuruma K, Shimazaki H, Ohno Y, Inoue Y, Honda A, Imai S, et al. Metallothionein-III deficiency exacerbates light-induced retinal degeneration. Invest Ophthalmol Vis Sci. 2012;53:7896-903 pubmed publisher
    ..We investigated the functional role of MT-III in light-induced retinal damage...
  4. Lanza C, Raimondo S, Vergani L, Catena N, Sénès F, Tos P, et al. Expression of antioxidant molecules after peripheral nerve injury and regeneration. J Neurosci Res. 2012;90:842-8 pubmed publisher
    ..The expression profiles of the following genes were investigated: three metallothionein isoforms (MT-1, MT-2, and MT-3), the main antioxidant enzymes (catalase, superoxide dismutase, and ..
  5. Rahman M, De Ley M. Metallothionein isogene transcription in red blood cell precursors from human cord blood. Eur J Biochem. 2001;268:849-56 pubmed
    The in vitro transcription patterns for 10 functional metallothionein (MT) isogenes have been investigated in red blood cell (RBC) precursors from human cord blood...
  6. Andersen R, Birren B, Taplitz S, Herschman H. Rat metallothionein-1 structural gene and three pseudogenes, one of which contains 5'-regulatory sequences. Mol Cell Biol. 1986;6:302-14 pubmed
    As shown by Southern blot analysis, the metallothionein-1 (MT-1) genes in rats comprise a multigene family. We present the sequence of the MT-1 structural gene and compare its features with other metallothionein genes...
  7. Scudiero R, Cigliano L, Verderame M. Age-related changes of metallothionein 1/2 and metallothionein 3 expression in rat brain. C R Biol. 2017;340:13-17 pubmed publisher
    ..These findings demonstrate an age-related expression of the MT3 gene. A possible link between the increasing amount of MT3 in brain aging and its different metal-binding behaviour is discussed. ..
  8. Kotani M, Kim K, Ishizaki N, Funaba M, Matsui T. Magnesium and calcium deficiencies additively increase zinc concentrations and metallothionein expression in the rat liver. Br J Nutr. 2013;109:425-32 pubmed publisher
    ..the effect of Mg deficiency on the expression of Zn-regulating factors such as Zn transporters and metallothionein (MT) in the rat liver...
  9. Brambila E, Muñoz Sánchez J, Albores A, Waalkes M. Early effects of surgery on zinc and metallothionein levels in female rats. Biol Trace Elem Res. 1999;70:173-82 pubmed
    Time-response effects of experimental surgery on zinc (Zn) and metallothionein (MT) homeostasis were investigated in female rats up to 24 h. Hepatic Zn content increased at 20 and 24 h postsurgery, whereas serum Zn levels decreased...

More Information

Publications62

  1. Suzuki Kurasaki M, Okabe M, Kurasaki M. Copper-metallothionein in the kidney of macular mice: a model for Menkes disease. J Histochem Cytochem. 1997;45:1493-501 pubmed
    ..Excess amounts of copper in the kidney of Macular mice, a model for this disease, were found as copper-metallothionein (Cu-MT) from kidney of the mice...
  2. Osier N, Pham L, Pugh B, Puccio A, Ren D, Conley Y, et al. Brain injury results in lower levels of melatonin receptors subtypes MT1 and MT2. Neurosci Lett. 2017;650:18-24 pubmed publisher
    ..TBI in rats resulted in lower levels of MT1 and MT2; replication of these findings is necessary as is evaluation of the consequences of lower receptor levels. ..
  3. Cai L, Chen S, Evans T, Cherian M, Chakrabarti S. Endothelin-1-mediated alteration of metallothionein and trace metals in the liver and kidneys of chronically diabetic rats. Int J Exp Diabetes Res. 2002;3:193-8 pubmed
    In the present study, the role of endothelin-1 (ET-1) on alterations of hepatic and renal metallothionein (MT) and trace metals (Zn, Cu, and Fe) were investigated in streptozotocin (STZ)-induced diabetic rats...
  4. Siddiq M, Hannila S, Carmel J, Bryson J, Hou J, Nikulina E, et al. Metallothionein-I/II Promotes Axonal Regeneration in the Central Nervous System. J Biol Chem. 2015;290:16343-56 pubmed publisher
    ..One gene that was up-regulated under both conditions is metallothionein (MT)-I...
  5. Hao Y, Ren J, Liu J, Luo S, Ma T, Li R, et al. The protective role of zinc against acute toxicity of depleted uranium in rats. Basic Clin Pharmacol Toxicol. 2012;111:402-10 pubmed publisher
    ..N-acethyl-?-d-glucosaminidase concentrations were significantly decreased; the gene expression levels of metallothionein (MT) in kidney tissues were significantly increased; and catalase levels were increased and malondialdehyde ..
  6. Liu C, He X, Hong X, Kang F, Chen S, Wang Q, et al. Suppression of placental metallothionein 1 and zinc transporter 1 mRNA expressions contributes to fetal heart malformations caused by maternal zinc deficiency. Cardiovasc Toxicol. 2014;14:329-38 pubmed publisher
    Zinc has been implicated to have a protective role against heart malformations during fetal development. Metallothionein 1 (MT-1) and zinc transporter 1 (ZnT-1) are two major metabolic factors that are associated with zinc metabolism...
  7. Kwon A, Jeon S, Hwang S, Kim J, Cho H. Expression and functional role of metallothioneins I and II in the spinal cord in inflammatory and neuropathic pain models. Brain Res. 2013;1523:37-48 pubmed publisher
    ..Our results suggest that endogenous MT-I/II might play an important role in the pathogenesis of pain behaviors, participating in the initiation of inflammatory and neuropathic pain rather than in their maintenance. ..
  8. Manso Y, Carrasco J, Comes G, Adlard P, Bush A, Hidalgo J. Characterization of the role of the antioxidant proteins metallothioneins 1 and 2 in an animal model of Alzheimer's disease. Cell Mol Life Sci. 2012;69:3665-81 pubmed publisher
    ..we intend to characterize the roles of the antioxidant, anti-inflammatory, and heavy-metal binding proteins, metallothionein-1 + 2 (MT1 + 2), in a mouse model of Alzheimer's disease, Tg2576 mice...
  9. Ignacio S, Moore D, Smith A, Lee N. Effect of neuroprotective drugs on gene expression in G93A/SOD1 mice. Ann N Y Acad Sci. 2005;1053:121-36 pubmed
    ..to upregulation of microglia/neuroinflammatory genes identified previously, we observed upregulation of metallothionein-I and -II (MT-I, MT-II)...
  10. Izzo G, Francesco A, Ferrara D, Campitiello M, Serino I, Minucci S, et al. Expression of melatonin (MT1, MT2) and melatonin-related receptors in the adult rat testes and during development. Zygote. 2010;18:257-64 pubmed publisher
    ..These data strongly support the hypothesis that melatonin acts directly in male vertebrate gonads suggesting that rat testes may be a suitable model to verify the role of indolamine in vertebrate testicular activity. ..
  11. Romero Isart N, Jensen L, Zerbe O, Winge D, Vasak M. Engineering of metallothionein-3 neuroinhibitory activity into the inactive isoform metallothionein-1. J Biol Chem. 2002;277:37023-8 pubmed
    ..The functional significance of such heterogeneous cluster ensemble is discussed. ..
  12. Lee S. Differential gene expression in nickel(II)-treated normal rat kidney cells. Res Commun Mol Pathol Pharmacol. 2006;119:77-87 pubmed
    ..Two of them (SH3BGRL3 and FHIT) were down-regulated and one (metallothionein) was up-regulated by nickel(II) treatment...
  13. Chang X, Jin T, Zhou Y. Metallothionein 1 isoform gene expression induced by cadmium in human peripheral blood lymphocytes. Biomed Environ Sci. 2006;19:104-9 pubmed
    To study the gene expression of metallothionein 1 (MT-1) isoforms in human peripheral blood lymphocytes (HPBLs)...
  14. Chung R, Adlard P, Dittmann J, Vickers J, Chuah M, West A. Neuron-glia communication: metallothionein expression is specifically up-regulated by astrocytes in response to neuronal injury. J Neurochem. 2004;88:454-61 pubmed
    ..Based upon recent reports indicating that MT-I/-II are major neuroprotective proteins within the brain, our results provide further evidence that MT-I/-II plays an important role in the cellular response to neuronal injury. ..
  15. Kim E, Kim T, Sun W, Kim D, Chung H, Kim D, et al. Differential regulation of metallothionein-I and metallothionein-II mRNA expression in the rat brain following traumatic brain injury. Mol Cells. 2004;18:326-31 pubmed
    In this study, we investigated the expression of metallothionein (MT)-I and MT-II in the rat brain following traumatic brain injury (TBI)...
  16. Melis K, Carter D, Stout C, Winge D. Single crystals of cadmium, zinc metallothionein. J Biol Chem. 1983;258:6255-7 pubmed
    Single crystals have been grown of Cd,Zn metallothionein isoform II from rat liver. The space group is P4(1)2(1)2 (P4(3)2(1)2) with unit cell dimensions a = b = 31.0 A and c = 120...
  17. Andersen R, Taplitz S, Birren B, Bristol G, Herschman H. Rat metallothionein multigene family. Experientia Suppl. 1987;52:373-84 pubmed
    ..We discuss possible applications of recombinant DNA technology to investigating both the expression of MT genes and the functioning of MT proteins, in a tissue specific manner and during development. ..
  18. Kelly E, Palmiter R. A murine model of Menkes disease reveals a physiological function of metallothionein. Nat Genet. 1996;13:219-22 pubmed
    ..Much of the intestinal copper is bound by metallothionein (MT)...
  19. Miyayama T, Ishizuka Y, Iijima T, Hiraoka D, Ogra Y. Roles of copper chaperone for superoxide dismutase 1 and metallothionein in copper homeostasis. Metallomics. 2011;3:693-701 pubmed publisher
    ..In the present study, small interfering RNA (siRNA) targeting CCS was introduced into metallothionein-knockout mouse fibroblasts (MT-KO cells) and their wild type cells (MT-WT cells) to reveal the interactive ..
  20. Ma F, Wang H, Chen B, Wang F, Xu H. Metallothionein 3 attenuated the apoptosis of neurons in the CA1 region of the hippocampus in the senescence-accelerated mouse/PRONE8 (SAMP8). Arq Neuropsiquiatr. 2011;69:105-11 pubmed
    b>Metallothionein 3 (MT-3) has been shown to protect against apoptotic neuronal death in the brains of patients with Alzheimer's disease. Zinc is a potent inhibitor of caspase-3 and its deficiency was found to promote apoptosis...
  21. Schultze P, Wörgötter E, Braun W, Wagner G, Vasak M, Kägi J, et al. Conformation of [Cd7]-metallothionein-2 from rat liver in aqueous solution determined by nuclear magnetic resonance spectroscopy. J Mol Biol. 1988;203:251-68 pubmed
    The three-dimensional structure of [Cd7]-metallothionein-2 from rat liver was determined in aqueous solution, using nuclear magnetic resonance spectrometry and distance geometry calculations...
  22. Caballero B, Vega Naredo I, Sierra V, Huidobro Fernández C, Soria Valles C, De Gonzalo Calvo D, et al. Favorable effects of a prolonged treatment with melatonin on the level of oxidative damage and neurodegeneration in senescence-accelerated mice. J Pineal Res. 2008;45:302-11 pubmed publisher
    ..The effectiveness of melatonin in improving age-related neural impairments is corroborated. ..
  23. Abe M, Usuda K, Hayashi S, Ogawa I, Furukawa S, Igarashi M, et al. Carcinogenic risk of copper gluconate evaluated by a rat medium-term liver carcinogenicity bioassay protocol. Arch Toxicol. 2008;82:563-71 pubmed publisher
  24. Kojima I, Tanaka T, Inagi R, Nishi H, Aburatani H, Kato H, et al. Metallothionein is upregulated by hypoxia and stabilizes hypoxia-inducible factor in the kidney. Kidney Int. 2009;75:268-77 pubmed publisher
    ..Many genes were upregulated in the kidney by chronic hypoxia, but we focused on metallothionein due to its antioxidative properties...
  25. Kim D, Kim E, Kim C, Sun W, Kim H, Uhm C, et al. Differential regulation of metallothionein-I, II, and III mRNA expression in the rat brain following kainic acid treatment. Neuroreport. 2003;14:679-82 pubmed
    ..Differential regulation of MT isoforms in neuron and gila suggests that each isoform might have distinct role in the cell-type dependent cellular responses against KA-evoked neural injuries. ..
  26. Tio L, Villarreal L, Atrian S, Capdevila M. Functional differentiation in the mammalian metallothionein gene family: metal binding features of mouse MT4 and comparison with its paralog MT1. J Biol Chem. 2004;279:24403-13 pubmed
    ..As a consequence, there is the suggestion of a possible physiological role played by MT4 related with copper requirements in epithelial differentiating tissues, where MT4 is expressed. ..
  27. Reeves P, Chaney R, Simmons R, Cherian M. Metallothionein induction is not involved in cadmium accumulation in the duodenum of mice and rats fed diets containing high-cadmium rice or sunflower kernels and a marginal supply of zinc, iron, and calcium. J Nutr. 2005;135:99-108 pubmed
    ..In the current study, 2 experiments were performed to determine the role of intestinal metallothionein (MT) in the accumulation of duodenal Cd, and to determine whether endogenous rice grain Cd is as available as ..
  28. Jiang P, Chang L, Pan C, Qi Y, Tang C. Protective role of metallothionein in stress-induced gastric ulcer in rats. World J Gastroenterol. 2005;11:2739-43 pubmed
    To illustrate the pathophysiological role of metallothionein (MT) in gastric ulcer induced by stress...
  29. Lu A, Tang Y, Ran R, Ardizzone T, Wagner K, Sharp F. Brain genomics of intracerebral hemorrhage. J Cereb Blood Flow Metab. 2006;26:230-52 pubmed
    ..chain reaction (RT-PCR) confirmed upregulation of IL-1-beta, Lipcortin 1 (annexin) and metallothionein 1,2, and downregulation of potassium voltage-gated channel, shaker-related subfamily, beta member 2 (Kcnab2)...
  30. Xu D, Shi L, Jia X, Qian X, Tang L, Zhang Y, et al. [Involvement of metallothionein in the protection of lung ischemic preconditioning]. Sheng Li Xue Bao. 2010;62:465-8 pubmed
    The aim of the present study was to investigate whether metallothionein was involved in the protection of lung ischemic preconditioning (IP) against lung ischemia-reperfusion (I/R) injury...
  31. St Croix C, Wasserloos K, Dineley K, Reynolds I, Levitan E, Pitt B. Nitric oxide-induced changes in intracellular zinc homeostasis are mediated by metallothionein/thionein. Am J Physiol Lung Cell Mol Physiol. 2002;282:L185-92 pubmed
    We hypothesized that metallothionein (MT), a cysteine-rich protein with a strong affinity for Zn(2+), plays a role in nitric oxide (NO) signaling events via sequestration or release of Zn(2+) by the unique thiolate clusters of the ..
  32. Devaux S, Maupoil V, Berthelot A. Effects of cadmium on cardiac metallothionein induction and ischemia-reperfusion injury in rats. Can J Physiol Pharmacol. 2009;87:617-23 pubmed publisher
    ..In this context, the protective role of the antioxidant metallothionein, a thiol-rich protein that is induced in different organs in response to heavy metals and oxidative ..
  33. Miyazaki I, Asanuma M, Kikkawa Y, Takeshima M, Murakami S, Miyoshi K, et al. Astrocyte-derived metallothionein protects dopaminergic neurons from dopamine quinone toxicity. Glia. 2011;59:435-51 pubmed publisher
    ..We further reported that the cysteine-rich metal-binding metallothionein (MT) family of proteins protects dopaminergic neurons against dopamine (DA) quinone neurotoxicity by its ..
  34. Chung R, Fung S, Leung Y, Walker A, McCormack G, Chuah M, et al. Metallothionein expression by NG2 glial cells following CNS injury. Cell Mol Life Sci. 2007;64:2716-22 pubmed
    b>Metallothionein (MT) expression is rapidly up-regulated following CNS injury, and there is a strong correlation between the presence or absence of MTand improved or impaired (respectively) recovery from such trauma...
  35. Danielyan L, Tolstonog G, Traub P, Salvetter J, Gleiter C, Reisig D, et al. Colocalization of glial fibrillary acidic protein, metallothionein, and MHC II in human, rat, NOD/SCID, and nude mouse skin keratinocytes and fibroblasts. J Invest Dermatol. 2007;127:555-63 pubmed
    ..and dermal fibroblasts showed distinct staining for GFAP as well as colocalization with alpha-actin, metallothionein, and antigens of the class-II major histocompatibility complex (MHC II)...
  36. Mukhopadhyay D, Mitra A, Nandi P, Varghese A, Murmu N, Chowdhury R, et al. Expression of metallothionein-1 (MT-1) mRNA in the rat testes and liver after cadmium injection. Syst Biol Reprod Med. 2009;55:188-92 pubmed publisher
    ..However, upon Cd injection, the level of testes MT-1 mRNA increases 2.16 fold. These results suggest that the testes respond to Cd for at least 6 h post injection through a transcriptional mechanism. ..
  37. Grunblatt E, Koutsilieri E, Hoyer S, Riederer P. Gene expression alterations in brain areas of intracerebroventricular streptozotocin treated rat. J Alzheimers Dis. 2006;9:261-71 pubmed
    ..GDNF, BDNF and integrin-alpha-M were up-regulated, while immediate-early-gene-transcription-factor NGF-IB and metallothionein-1/2 were down-regulated in the cortex of streptozotocin-treated rats...
  38. Klassen R, Crenshaw K, Kozyraki R, Verroust P, Tio L, Atrian S, et al. Megalin mediates renal uptake of heavy metal metallothionein complexes. Am J Physiol Renal Physiol. 2004;287:F393-403 pubmed
    Although several heavy metal toxins are delivered to the kidney on the carrier protein metallothionein (MT), uncertainty as to how MT enters proximal tubular cells limits treatment strategies...
  39. Santon A, Albergoni V, Sturniolo G, Irato P. Evaluation of MT expression and detection of apoptotic cells in LEC rat kidneys. Biochim Biophys Acta. 2004;1688:223-31 pubmed
    ..on Long-Evans Cinnamon (LEC) rats, we extended these studies determining the effects of Zn on trace elements, metallothionein (MT) concentrations and immunolocalization, and on the levels of both MT-1 and MT-2 mRNAs in the LEC rat ..
  40. Winge D, Nielson K, Zeikus R, Gray W. Structural characterization of the isoforms of neonatal and adult rat liver metallothionein. J Biol Chem. 1984;259:11419-25 pubmed
    b>Metallothionein was purified from the livers of adult and neonatal rats...
  41. Grubić Kezele T, Blagojević Zagorac G, Jakovac H, Domitrovic R, Milin C, Radosević Stasić B. Hepatic expression of metallothionein I/II, glycoprotein 96, IL-6, and TGF- ? in rat strains with different susceptibilities to experimental autoimmune encephalomyelitis. Clin Dev Immunol. 2013;2013:750406 pubmed publisher
    ..In contrast, AO rats had a significantly higher expression of MT I/II, IL-6, and TGF- ? in intact liver (P < 0,001), suggesting that the greater constitutive expression of these ..
  42. Juszczak M, Wolak M, Bojanowska E, Piera L, Roszczyk M. The role of melatonin membrane receptors in melatonin-dependent oxytocin secretion from the rat hypothalamo-neurohypophysial system - an in vitro and in vivo approach. Endokrynol Pol. 2016;67:507-514 pubmed publisher
    ..Endokrynol Pol 2016; 67 (5): 507-514). ..
  43. Grubić Kezele T, Blagojević Zagorac G, Jakovac H, Domitrovic R, Radosević Stasić B. Hippocampal expressions of metallothionein I/II and glycoprotein 96 in EAE-prone and EAE-resistant strains of rats. Histol Histopathol. 2017;32:137-151 pubmed publisher
    ..expression of gp96/granular cell, by apoptosis and by microgliosis with appearance of Iba-1+ cells, co-expressing MT I/II and gp96...
  44. Gilmour P, Schladweiler M, Nyska A, McGee J, Thomas R, Jaskot R, et al. Systemic imbalance of essential metals and cardiac gene expression in rats following acute pulmonary zinc exposure. J Toxicol Environ Health A. 2006;69:2011-32 pubmed
    ..levels of essential metals (zinc, copper, and selenium), and induction of zinc transporter-2 (ZT-2) and metallothionein-1 (MT-1) mRNA in the lung, heart, and liver...
  45. van Lookeren Campagne M, Thibodeaux H, van Bruggen N, Cairns B, Lowe D. Increased binding activity at an antioxidant-responsive element in the metallothionein-1 promoter and rapid induction of metallothionein-1 and -2 in response to cerebral ischemia and reperfusion. J Neurosci. 2000;20:5200-7 pubmed
    ..This study suggests a role of ARE-binding proteins in inducing cerebral MT-1 expression and implicates MT-1 as one of the early detoxifying genes in an endogenous defense response to cerebral ischemia and reperfusion. ..
  46. Mercer J, Hudson P. Cloning of metallothionein cDNA from neonatal rat liver. Biosci Rep. 1982;2:761-8 pubmed
    A metallothionein cDNA clone was isolated from a cDNA bank prepared from neonatal rat liver poly(A)-containing RNA by a colony screening procedure using [32P]cDNA probes prepared from mRNA of either metal-induced or uninduced rat livers...
  47. Tian T, Li L, Zhang S, Ni H. Long-Term Effects of Ketogenic Diet on Subsequent Seizure-Induced Brain Injury During Early Adulthood: Relationship of Seizure Thresholds to Zinc Transporter-Related Gene Expressions. Biol Trace Elem Res. 2016;174:369-376 pubmed
  48. Abrahám S, Hermesz E, Szabo A, Ferencz A, Jancsó Z, Duda E, et al. Effects of Kupffer cell blockade on the hepatic expression of metallothionein and heme oxygenase genes in endotoxemic rats with obstructive jaundice. Life Sci. 2012;90:140-6 pubmed publisher
    Heme oxygenase (HO) and metallothionein (MT) genes are rapidly upregulated in the liver by pro-inflammatory cytokines and/or endotoxin as protection against cellular stress and inflammation...
  49. Kimura T, Li Y, Okumura F, Itoh N, Nakanishi T, Sone T, et al. Chromium(VI) inhibits mouse metallothionein-I gene transcription by preventing the zinc-dependent formation of an MTF-1-p300 complex. Biochem J. 2008;415:477-82 pubmed publisher
    Mouse MT-I (metallothionein-I) transcription is regulated by MTF-1 (metal-response-element-binding transcription factor-1) which is recruited to the promoter in response to zinc...
  50. Liu J, Zhou Z, Zhang W, Bell M, Waalkes M. Changes in hepatic gene expression in response to hepatoprotective levels of zinc. Liver Int. 2009;29:1222-9 pubmed publisher
    ..Zn treatment dramatically increased the expression of the metallothionein (Mt), and modestly increased the expression of acute-phase protein genes (ceruloplasmin, Stat3, egr1, Cxc ..
  51. Mocchegiani E, Giacconi R, Fattoretti P, Casoli T, Cipriano C, Muti E, et al. Metallothionein isoforms (I+II and III) and interleukin-6 in the hippocampus of old rats: may their concomitant increments lead to neurodegeneration?. Brain Res Bull. 2004;63:133-42 pubmed
    b>Metallothionein (MT)-III isoform is a brain metal-binding protein that, like the MT-I + II isoform, binds zinc with high affinity...
  52. Furey W, Robbins A, Clancy L, Winge D, Wang B, Stout C. Crystal structure of Cd,Zn metallothionein. Science. 1986;231:704-10 pubmed
    ..data from five Cd in the native protein were used to determine the crystal structure of cadmium, zinc (Cd,Zn) metallothionein isoform II from rat liver. The structure of a 4-Cd cluster was solved by direct methods. A 2...
  53. Garla R, Ganger R, Mohanty B, Verma S, Bansal M, Garg M. Metallothionein does not sequester arsenic(III) ions in condition of acute arsenic toxicity. Toxicology. 2016;366-367:68-73 pubmed publisher
    ..Because of its high content, Metallothionein (MT) provides one of the most favorable conditions for the binding of As(III) ions to it...