Met

Summary

Gene Symbol: Met
Description: met proto-oncogene
Alias: Hgfr, HGF receptor, HGF/SF receptor, SF receptor, c-Met, hepatocyte growth factor receptor, met proto-oncogene tyrosine kinase, proto-oncogene c-Met, scatter factor receptor, tyrosine-protein kinase Met
Species: rat

Top Publications

  1. ncbi Met proto-oncogene and insulin-like growth factor binding protein 3 overexpression correlates with metastatic ability in well-differentiated pancreatic endocrine neoplasms
    Donna E Hansel
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Clin Cancer Res 10:6152-8. 2004
  2. ncbi Microarray analysis and RNA silencing link fra-1 to cd44 and c-met expression in mesothelioma
    Maria E Ramos-Nino
    Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    Cancer Res 63:3539-45. 2003
  3. ncbi Cell surface proteoglycan syndecan-1 mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma
    Patrick W B Derksen
    Department of Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
    Blood 99:1405-10. 2002
  4. doi Hepatocyte growth factor plays a key role in insulin resistance-associated compensatory mechanisms
    Tiago G Araújo
    Department of Internal Medicine, State University of Campinas, Campinas, 13081 970 São Paulo, Brazil
    Endocrinology 153:5760-9. 2012
  5. pmc A genetic variant that disrupts MET transcription is associated with autism
    Daniel B Campbell
    Department of Pharmacology, Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN 37203, USA
    Proc Natl Acad Sci U S A 103:16834-9. 2006
  6. ncbi Gastrointestinal hormones cause rapid c-Met receptor down-regulation by a novel mechanism involving clathrin-mediated endocytosis and a lysosome-dependent mechanism
    K Martin Hoffmann
    Digestive Diseases Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892 1804, USA
    J Biol Chem 281:37705-19. 2006
  7. ncbi Increased DNA binding activity of NF-kappaB, STAT-3, SMAD3 and AP-1 in acutely damaged liver
    Adriana Salazar-Montes
    Institute for Molecular Biology in Medicine and Gene Therapy, CUCS, University of Guadalajara, Apdo Postal 2 123, Guadalajara 44281, Jal, Mexico
    World J Gastroenterol 12:5995-6001. 2006
  8. ncbi Urokinase-type plasminogen activator gene therapy in liver cirrhosis is mediated by collagens gene expression down-regulation and up-regulation of MMPs, HGF and VEGF
    Miriam Bueno
    Institute for Molecular Biology and Gene Therapy, CUCS, University of Guadalajara, Apdo Postal 2 123, Guadalajara, Jal, Mexico 44281
    J Gene Med 8:1291-9. 2006
  9. pmc Tyrosine residues 654 and 670 in beta-catenin are crucial in regulation of Met-beta-catenin interactions
    Gang Zeng
    Department of Pathology CMP, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Exp Cell Res 312:3620-30. 2006
  10. ncbi Immunolocalization of the hepatocyte growth factor (HGF) system in the rat ovary and the anti-apoptotic effect of HGF in rat ovarian granulosa cells in vitro
    Mehmet Uzumcu
    Department of Animal Sciences, Rutgers University, New Brunswick, New Jersey 08901, USA
    Reproduction 132:291-9. 2006

Scientific Experts

  • Jie Liu
  • William Pao
  • R A Towner
  • Peter K Baier
  • E Homsi
  • Heather R Sanders
  • A Walentinsson
  • Chun Nan Yeh
  • Adriana Salazar-Montes
  • Stephanie J Tyndall
  • Y Liu
  • Randall S Walikonis
  • Juan Armendariz-Borunda
  • A Catizone
  • Tiago G Araújo
  • Xing Guo Tan
  • Jimmy Bernier
  • Lin Feng Zheng
  • Takeshi Yoshida
  • Edgar Mendieta-Condado
  • Thorsten Jung
  • Roya Navab
  • Tsunehisa Ohno
  • Maggie M Lam
  • V V Kurisetty
  • Alessandra Gentile
  • Chol Seung Lim
  • Arantxa Gonzalez
  • Alberto Lopez-Reyes
  • Luis Ruiz-Corro
  • Veronique Orian-Rousseau
  • Shirish Paranjpe
  • Jie Qiu
  • Heping Yang
  • Wakana Ohya
  • Giuseppina Cantarella
  • K Martin Hoffmann
  • Daniel B Campbell
  • Kim A Boost
  • Hui Li
  • Ya li Li
  • Mehmet Uzumcu
  • Gang Zeng
  • Miriam Bueno
  • Xiaoyan Wen
  • Kumiko Nakazawa
  • Hiroshi Funakoshi
  • Toshikazu Nakamura
  • Donna E Hansel
  • Robert T Jensen
  • Carmen Birchmeier
  • Yoshitaka Imaizumi
  • Benjamin Dekel
  • Kenji Shimazaki
  • Maria E Ramos-Nino
  • Woong Sun
  • Patrick W B Derksen
  • Hiroaki Kuroda
  • Paolo L Peghini
  • G Ricci
  • T Nakamura
  • M Galdieri
  • J M Otte
  • P Peschard
  • Alexandre G Oliveira
  • Jose B C Carvalheira
  • Dioze Guadagnini
  • André O P Protzek
  • Bruno M Carvalho
  • Mario J A Saad
  • Antonio C Boschero
  • Guolin Zhang
  • Xi Nan Yi
  • Rui Wang
  • Walid Chababi
  • Véronique Pomerleau
  • Qi Ben Wang
  • M F Di Renzo
  • Caroline Saucier
  • Gui Xiang Zhang
  • Qing Ping Yu
  • Eric B Haura
  • Han Wang
  • Zhu Lin Yang
  • Yuan zhong Xu
  • Jian Wei Zhang
  • Lourdes Sánchez-Sevilla
  • Shigeru Hirano
  • Dina Ohanessian
  • Isolde Seiden-Long

Detail Information

Publications74

  1. ncbi Met proto-oncogene and insulin-like growth factor binding protein 3 overexpression correlates with metastatic ability in well-differentiated pancreatic endocrine neoplasms
    Donna E Hansel
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Clin Cancer Res 10:6152-8. 2004
    ..Several classes of genes, including growth factors and growth factor-related molecules (IGFBP1, IGFBP3, and MET), developmental factors (TBX3 and MEIS2), cytoskeletal factors (beta 1 tubulin and ACTN2), cholesterol homeostasis ..
  2. ncbi Microarray analysis and RNA silencing link fra-1 to cd44 and c-met expression in mesothelioma
    Maria E Ramos-Nino
    Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    Cancer Res 63:3539-45. 2003
    ..Results reveal that induction of cd44 and c-met is causally linked to fra-1 expression, connecting fra-1 with genes governing cell motility and invasion in ..
  3. ncbi Cell surface proteoglycan syndecan-1 mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma
    Patrick W B Derksen
    Department of Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
    Blood 99:1405-10. 2002
    ..sulfate moieties on syndecan-1 strongly promotes HGF-mediated signaling, resulting in enhanced activation of Met, the receptor tyrosine kinase for HGF...
  4. doi Hepatocyte growth factor plays a key role in insulin resistance-associated compensatory mechanisms
    Tiago G Araújo
    Department of Internal Medicine, State University of Campinas, Campinas, 13081 970 São Paulo, Brazil
    Endocrinology 153:5760-9. 2012
    ..Additionally, blockages of HGF receptor (Met) worsen the impaired insulin-induced insulin signaling in liver of diet-induced obesity rats...
  5. pmc A genetic variant that disrupts MET transcription is associated with autism
    Daniel B Campbell
    Department of Pharmacology, Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN 37203, USA
    Proc Natl Acad Sci U S A 103:16834-9. 2006
    ..and location within a chromosome 7q31 autism candidate gene region, we analyzed the gene encoding the pleiotropic MET receptor tyrosine kinase in a family based study of autism including 1,231 cases...
  6. ncbi Gastrointestinal hormones cause rapid c-Met receptor down-regulation by a novel mechanism involving clathrin-mediated endocytosis and a lysosome-dependent mechanism
    K Martin Hoffmann
    Digestive Diseases Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892 1804, USA
    J Biol Chem 281:37705-19. 2006
    The activated c-Met receptor has potent effects on normal tissues and tumors. c-Met levels are regulated by hepatocyte growth factor (HGF); however, it is unknown if they can be regulated by gastrointestinal (GI) hormones...
  7. ncbi Increased DNA binding activity of NF-kappaB, STAT-3, SMAD3 and AP-1 in acutely damaged liver
    Adriana Salazar-Montes
    Institute for Molecular Biology in Medicine and Gene Therapy, CUCS, University of Guadalajara, Apdo Postal 2 123, Guadalajara 44281, Jal, Mexico
    World J Gastroenterol 12:5995-6001. 2006
    ..To investigate the role of genes and kinetics of specific transcription factors in liver regeneration, and to analyze the gene expression and the activity of some molecules crucially involved in hepatic regeneration...
  8. ncbi Urokinase-type plasminogen activator gene therapy in liver cirrhosis is mediated by collagens gene expression down-regulation and up-regulation of MMPs, HGF and VEGF
    Miriam Bueno
    Institute for Molecular Biology and Gene Therapy, CUCS, University of Guadalajara, Apdo Postal 2 123, Guadalajara, Jal, Mexico 44281
    J Gene Med 8:1291-9. 2006
    ..The harmonized and concerted expression of HGF and c-met resulted in exacerbated hepatocyte proliferation, although these events did not induce an abnormal liver growth...
  9. pmc Tyrosine residues 654 and 670 in beta-catenin are crucial in regulation of Met-beta-catenin interactions
    Gang Zeng
    Department of Pathology CMP, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Exp Cell Res 312:3620-30. 2006
    ..Previously, we reported its association with the hepatocyte growth factor (HGF) receptor Met at the membrane...
  10. ncbi Immunolocalization of the hepatocyte growth factor (HGF) system in the rat ovary and the anti-apoptotic effect of HGF in rat ovarian granulosa cells in vitro
    Mehmet Uzumcu
    Department of Animal Sciences, Rutgers University, New Brunswick, New Jersey 08901, USA
    Reproduction 132:291-9. 2006
    ..Immunohistochemistry was used to investigate the distribution of HGF, c-met, and HGF activator (HGFA) protein during folliculogenesis in equine chorionic gonadotropin (eCG)-primed rats...
  11. ncbi Further studies on aberrant gene expression associated with arsenic-induced malignant transformation in rat liver TRL1215 cells
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, NCI at NIEHS, Mail Drop F 09, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 216:407-15. 2006
    ..nM of arsenite), the expressions of alpha-fetoprotein (AFP), Wilm's tumor protein-1 (WT-1), c-jun, c-myc, H-ras, c-met and hepatocyte growth factor, heme oxygenase-1, superoxide dismutase-1, glutathione-S-transferase-pi and ..
  12. ncbi [Overexpression of PEMT2 inhibits the phosphorylation and translocation of PLC gamma 1]
    Ya li Li
    Department of Biochemistry and Molecular Biology, Dalian Medical University, Dalian 116027, China
    Zhonghua Gan Zang Bing Za Zhi 14:514-6. 2006
    ..To explore the mechanism of CBRH-7919 cell proliferation inhibition by transfecting phosphatidylethanolamine N-methyltransferase 2 gene (PEMT2)...
  13. ncbi The receptor tyrosine kinase Met and its ligand hepatocyte growth factor are clustered at excitatory synapses and can enhance clustering of synaptic proteins
    Stephanie J Tyndall
    Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut 06269, USA
    Cell Cycle 5:1560-8. 2006
    The receptor protein tyrosine kinase Met and its ligand, hepatocyte growth factor, regulate cellular morphology, intercellular adhesion, and interactions among junctional proteins in numerous cell types...
  14. ncbi Effect of liver regeneration after partial hepatectomy and ischemia-reperfusion on expression of growth factor receptors
    P Baier
    Department of General and Visceral Surgery, Albert Ludwigs University, Freiburg, Germany
    World J Gastroenterol 12:3835-40. 2006
    ..This is relevant due to the potential therapeutic use of growth factors in stimulating liver regeneration...
  15. ncbi c-Met responsiveness of isolated hepatocytes evaluated in an in vitro de-differentiation model
    Kim A Boost
    Klinik fur Anasthesiologie, Intensivmedizin und Schmerztherapie, Zentrum der Chirurgie, Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Int J Mol Med 17:475-82. 2006
    Hepatocyte growth factor (HGF) accelerates tissue regeneration and ameliorates tissue fibrosis through its ligand c-Met receptor tyrosine kinase...
  16. pmc Hepatocyte growth factor receptor signaling mediates the anti-fibrotic action of 9-cis-retinoic acid in glomerular mesangial cells
    Xiaoyan Wen
    Department of Pathology, University of Pittsburgh School of Medicine, S 405 Biomedical Science Tower, 200 Lothrop St, Pittsburgh, PA 15261, USA
    Am J Pathol 167:947-57. 2005
    ..growth factor (HGF) mRNA expression and protein secretion, stimulated HGF promoter activity, and activated c-met receptor phosphorylation...
  17. ncbi Amplification and overexpression of c-erbB-2, epidermal growth factor receptor, and c-met in biliary tract cancers
    Kumiko Nakazawa
    Department of Pathology, School of Medicine, University of Yamanashi, Yamanashi, Japan
    J Pathol 206:356-65. 2005
    ..of tyrosine kinase growth factor receptors such as ErbB-2, epidermal growth factor receptor (EGFR), and Met may play important roles in the development of biliary tract carcinomas...
  18. ncbi HGF protects rat mesangial cells from high-glucose-mediated oxidative stress
    Hui Li
    Department of Pathology, Shanghai Medical College, Fudan University, Shanghai, PR China
    Am J Nephrol 26:519-30. 2006
    ..The aim of the present study was to evaluate whether HGF could prevent rat mesangial cells (RMC) from high-glucose-mediated oxidative stress and explore its relevant mechanism...
  19. ncbi Effect of hepatocyte growth factor on methionine adenosyltransferase genes and growth is cell density-dependent in HepG2 cells
    Heping Yang
    Division of Gastroenterology and Liver Diseases, USC Research Center for Liver Diseases, USC UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Keck School of Medicine USC, Los Angeles, California 90033, USA
    J Cell Physiol 210:766-73. 2007
    ..The current work examined expression of HGF/c-met in HCC and whether HGF regulates MAT genes and growth in HepG2 cells...
  20. doi Expression of HGF/c-Met is dynamically regulated in the dorsal root ganglions and spinal cord of adult rats following sciatic nerve ligation
    Lin Feng Zheng
    Department of Radiology, Shanghai Jiaotong University Affiliated First People s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Neurosignals 18:49-56. 2010
    Hepatocyte growth factor (HGF) and its receptor c-Met play pivotal roles in post-traumatic regeneration of the nervous system. However, following peripheral nerve injury, the role and regulation of the HGF/c-Met system is less clear...
  21. doi Oncogenic engagement of the Met receptor is sufficient to evoke angiogenic, tumorigenic, and metastatic activities in rat intestinal epithelial cells
    Jimmy Bernier
    Département d Anatomie et de Biologie Cellulaire, Universite de Sherbrooke, Quebec, Canada
    Am J Physiol Gastrointest Liver Physiol 299:G677-86. 2010
    The deregulation of Met/hepatocyte growth factor (HGF) receptor tyrosine kinase signaling constitutes a common event in colorectal cancers. However, the physiopathological functions of such a deregulation remain poorly understood...
  22. doi Targeting epidermal growth factor receptor: central signaling kinase in lung cancer
    Takeshi Yoshida
    Department of Thoracic Oncology, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive Tampa, FL 33612, USA
    Biochem Pharmacol 80:613-23. 2010
    ..A secondary mutation of EGFR (T790M) and amplification of MET account for 70% of all cases of acquired resistance to EGFR-TKIs...
  23. pmc Co-overexpression of Met and hepatocyte growth factor promotes systemic metastasis in NCI-H460 non-small cell lung carcinoma cells
    Roya Navab
    Ontario Cancer Institute and Princess Margaret Hospital, University Health Network, Ontario, Canada
    Neoplasia 11:1292-300. 2009
    ..b>Met, the receptor for hepatocyte growth factor (HGF) is a receptor tyrosine kinase with demonstrated roles in ..
  24. ncbi Protective effects of amylin on reserpine-induced gastric damage in the rat
    Giuseppina Cantarella
    Department of Experimental and Clinical Pharmacology, School of Medicine, University of Catania, Italy
    Pharmacol Res 56:27-34. 2007
    ..Hepatocyte growth factor (HGF), its c-Met receptor and cyclooxygenase-2 (COX-2) expression, usually increased in course of reserpine-induced gastric damage, ..
  25. doi Potent antioxidant role of pirfenidone in experimental cirrhosis
    Adriana Salazar-Montes
    Institute for Molecular Biology in Medicine and Gene Therapy, CUCS, University of Guadalajara, Guadalajara, Jalisco, Mexico
    Eur J Pharmacol 595:69-77. 2008
    ..by pirfenidone and increased expression of regenerative genes like hepatocyte growth factor (HGF) and c-met ...
  26. pmc Hepatocyte growth factor and c-Met promote dendritic maturation during hippocampal neuron differentiation via the Akt pathway
    Chol Seung Lim
    Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269, USA
    Cell Signal 20:825-35. 2008
    ..Hepatocyte growth factor (HGF) and its receptor, c-Met, can promote formation of neurites and enhance elaboration of dendrites in mature neurons, but their effects on the ..
  27. doi Ovarian-type stroma in hepatobiliary cystadenomas and pancreatic mucinous cystic neoplasms: an immunohistochemical study
    Maggie M Lam
    Department of Pathology, University of Washington School of Medicine, Seattle 98195, USA
    Am J Clin Pathol 129:211-8. 2008
    We compared immunohistochemical expression of hepatocyte growth factor (HGF), c-met, alpha-inhibin, estrogen receptor (ER), and progesterone receptor (PR) in 10 pancreatic mucinous cystic neoplasms (PMCNs), 8 hepatobiliary cystadenomas (..
  28. doi In vivo detection of c-Met expression in a rat C6 glioma model
    R A Towner
    Small Animal MRI Core Facility, Oklahoma City, OK, USA
    J Cell Mol Med 12:174-86. 2008
    The tyrosine kinase receptor, c-Met, and its substrate, the hepatocyte growth factor (HGF), are implicated in the malignant progression of glioblastomas...
  29. doi The Met tyrosine kinase receptor in development and cancer
    Alessandra Gentile
    Division of Molecular Oncology, University of Turin Medical School, 10060, Candiolo Torino, Italy
    Cancer Metastasis Rev 27:85-94. 2008
    b>Met is a tyrosine kinase receptor, encoded by an oncogene, whose crucial role has been elucidated during the last two decades...
  30. ncbi Attenuation of glycerol-induced acute kidney injury by previous partial hepatectomy: role of hepatocyte growth factor/c-met axis in tubular protection
    Eduardo Homsi
    Division of Nephrology, Department of Medicine, School of Medical Sciences, State University of Campinas, Sao Paulo, Brazil
    Nephron Exp Nephrol 107:e95-106. 2007
    ..Previous partial hepatectomy (HPTX) can attenuate glycerol-induced acute kidney injury (Gly-AKI). The aim of this study was to explore the pathophysiological mechanisms and the role of hepatocyte growth factor (HGF) in kidney protection...
  31. pmc Cell cycle effects resulting from inhibition of hepatocyte growth factor and its receptor c-Met in regenerating rat livers by RNA interference
    Shirish Paranjpe
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Hepatology 45:1471-7. 2007
    Hepatocyte growth factor (HGF) and its receptor c-Met are involved in liver regeneration...
  32. ncbi Hepatocyte growth factor and c-Met expression in pericytes: implications for atherosclerotic plaque development
    Y Liu
    Division of Cardiovascular and Endocrine Sciences, University of Manchester, UK
    J Pathol 212:12-9. 2007
    ..We investigated the localization of hepatocyte growth factor (HGF) and its receptor, c-Met, in human atherosclerotic plaques, together with the effects of HGF on pericyte migration in vitro...
  33. ncbi Hepatocyte growth factor (HGF) promotes oligodendrocyte progenitor cell proliferation and inhibits its differentiation during postnatal development in the rat
    Wakana Ohya
    Division of Molecular Regenerative Medicine, Department of Biochemistry and Molecular Biology, Osaka University Graduate School of Medicine, B 7, Osaka 565 0871, Japan
    Brain Res 1147:51-65. 2007
    ..Double immunostaining for either c-Met/HGF receptor or phospho-c-Met with either NG2 or RIP in rat striatum at postnatal day 3 (P3), P7, and P14 revealed that c-..
  34. ncbi Signaling by hepatocyte growth factor in neurons is induced by pharmacological stimulation of synaptic activity
    Stephanie J Tyndall
    Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut 06269, USA
    Synapse 61:199-204. 2007
    ..The receptor tyrosine kinase Met and its ligand, hepatocyte growth factor (HGF), are clustered at excitatory synapses and may regulate aspects of ..
  35. ncbi Expression of Ezrin, HGF, C-met in pancreatic cancer and non-cancerous pancreatic tissues of rats
    Xing Guo Tan
    Research Laboratory of Hepatobiliary Diseases, Second Xiangya Hospital, Central South University, Changsha 410011, China
    Hepatobiliary Pancreat Dis Int 9:639-44. 2010
    Recent studies have confirmed that the expression of Ezrin, hepatocyte growth factor (HGF) and its receptor (C-met) is related to the genesis, progress, invasion and metastasis of some malignant tumors...
  36. ncbi Met, metastasis, motility and more
    Carmen Birchmeier
    Department of Neuroscience, Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13122 Berlin, Germany
    Nat Rev Mol Cell Biol 4:915-25. 2003
  37. ncbi c-met expression in pancreatic cancer and effects of hepatocyte growth factor on pancreatic cancer cell growth
    K Kiehne
    Department of Medicine, Christian Albrechts Universitat Kiel, Germany
    Pancreas 15:35-40. 1997
    ..The HGF receptor, the product of the c-met protooncogene, is expressed mainly by epithelial cells...
  38. ncbi Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas
    L Schmidt
    Intramural Research Support Program, SAIC Frederick, MD, USA
    Nat Genet 16:68-73. 1997
    ..We identified missense mutations located in the tyrosine kinase domain of the MET gene in the germline of affected members of HPRC families and in a subset of sporadic papillary renal carcinomas...
  39. ncbi In vivo and in vitro evidence for increased expression of HGF receptor in kidney of diabetic rat
    Y Liu
    Department of Medicine, Rhode Island Hospital, Brown University School of Medicine, Providence 02903, USA
    Am J Physiol 271:F1202-10. 1996
    ..In this study, we demonstrate that the c-met protooncogene product, a tyrosine kinase receptor for hepatocyte growth factor (HGF), is increased in the kidney of ..
  40. ncbi Primary structure of rat HGF receptor and induced expression in glomerular mesangial cells
    Y Liu
    Department of Medicine, Rhode Island Hospital, Brown University School of Medicine, Providence 02903, USA
    Am J Physiol 271:F679-88. 1996
    ..The nucleotide sequence of the rat c-met cDNA revealed that the HGF receptor is encoded within single open-reading frame as 190 kDa of a transmembrane glycoprotein consisting of 1,382 ..
  41. ncbi Neurotrophic effect of hepatocyte growth factor on central nervous system neurons in vitro
    M Hamanoue
    Department of Neurochemistry, National Institute of Neuroscience, Tokyo, Japan
    J Neurosci Res 43:554-64. 1996
    Although the expression of hepatocyte growth factor (HGF) and its receptor, proto-oncogene c-met, has been demonstrated in the central nervous system (CNS), the function of HGF in the CNS was not fully understood...
  42. ncbi Hepatocyte growth factor and c-met expression in Long-Evans Cinnamon rats with spontaneous hepatitis and hepatoma
    N Nakayama
    Laboratory of Cell Biology, Hokkaido University School of Medicine, Sapporo, Japan
    Hepatology 24:596-602. 1996
    ..The expression of c-met mRNA was strong in the tissues of LEC rats with fulminant hepatitis and, especially, in the cholangiofibrosis ..
  43. pmc Expression of hepatocyte growth factor and c-met genes during hepatic differentiation and liver development in the rat
    Z Hu
    Laboratory of Experimental Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 0037
    Am J Pathol 142:1823-30. 1993
    ..The receptor for HGF has recently been characterized as the product of the proto-oncogene c-met. We have examined the possible involvement of HGF in hepatic growth and differentiation in the rat...
  44. ncbi Increased expression of c-met messenger RNA following acute gastric injury in rats
    M Tsujii
    First Department of Medicine, Osaka University School of Medicine, Suita, Japan
    Biochem Biophys Res Commun 200:536-41. 1994
    The aim of the present study was to evaluate messenger RNA expression of c-met, a hepatocyte growth factor receptor gene, after gastric mucosal injury in rats. Male Sprague-Dawley rats were fasted for 24 hours, received 0...
  45. ncbi Expression of the Met/hepatocyte growth factor receptor in human pancreatic cancer
    M F Di Renzo
    Imperial Cancer Research Fund Oncology Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom
    Cancer Res 55:1129-38. 1995
    ..The c-MET-encoded HGF receptor is also overexpressed in a proportion of the panel of 31 human pancreatic cancer cell lines examined, which ..
  46. ncbi Roles of hepatocyte growth factor and its receptor in gastric mucosa. A cell biological and molecular biological study
    S Tsuji
    First Department of Medicine, Osaka University School of Medicine, Suita, Japan
    Dig Dis Sci 40:1132-9. 1995
    Hepatocyte growth factor (HGF) stimulates the growth of hepatocytes and other epithelial cells. A gene for the HGF receptor, c-met, is detected in the intestinal tract and the liver, as well as in gastric carcinoma cells...
  47. ncbi Met expression and sarcoma tumorigenicity
    S Rong
    ABL Basic Research Program, National Cancer Institute, Frederick Cancer Research and Development Center, Maryland 21702
    Cancer Res 53:5355-60. 1993
    The met protooncogene tyrosine kinase receptor (Met) and its ligand, hepatocyte growth factor/scatter factor (HGF/SF), ordinarily constitute a paracrine signaling system in which cells of mesenchymal origin produce the ligand, which ..
  48. pmc Hepatocyte growth factor and its receptor (c-MET) in prostatic carcinoma
    P A Humphrey
    Department of Pathology, Washington University Medical Center, St Louis, Missouri 63110, USA
    Am J Pathol 147:386-96. 1995
    ..Expression of the HGF receptor, c-MET, is up-regulated by androgen deprivation and c-MET appears to be preferentially expressed on androgen-..
  49. ncbi Modulation of hepatocyte growth factor and c-met in the rat mammary gland during pregnancy, lactation, and involution
    M S Pepper
    Department of Morphology, University of Geneva Medical Center, Switzerland
    Exp Cell Res 219:204-10. 1995
    ..The aim of the present studies was to assess the expression and modulation of HGF and its receptor c-Met in the rat mammary gland during pregnancy, lactation, and involution...
  50. ncbi Hepatocyte growth factor up-regulates met expression in rat fetal hepatocytes in primary culture
    C De Juan
    Departamento de Bioquimica y Biologia Molecular, Centro Mixto C S I C U C M, Facultad de Farmacia, Ciudad Universitaria, Madrid, Spain
    Biochem Biophys Res Commun 204:1364-70. 1994
    ..In the present study, we have analyzed the c-met/HGF receptor expression in fetal hepatocytes and its modulation by growth factors and hormones...
  51. ncbi Expression and phosphorylation of rat c-met/hepatocyte growth factor receptor during rat liver regeneration
    M Horimoto
    First Department of Medicine, Osaka University School of Medicine, Japan
    J Hepatol 23:174-83. 1995
    b>Hepatocyte growth factor receptor is identified as a heterodimeric tyrosine kinase encoded by the c-met gene...
  52. ncbi Chromosomal localization of rat hepatocyte growth factor (Hgf) and HGF receptor (Met) and characterization of HGF receptor cDNA
    V R Wallenius
    Research Centre for Endocrinology and Metabolism RCEM, Department of Internal Medicine, Grona Straket 8, Sahlgrenska University Hospital, S 413 45 Goteborg, Sweden
    Mamm Genome 8:661-7. 1997
    ..To obtain a probe for the mapping of the HGF receptor/Met gene, we cloned the complete coding region of the rat HGF receptor mRNA...
  53. ncbi Overexpression and amplification of the met/HGF receptor gene during the progression of colorectal cancer
    M F Di Renzo
    Department of Biomedical Science and Oncology, University of Torino Medical School, Torino, Institute of Histology, University of Sassari Medical School, Sassari, Italy
    Clin Cancer Res 1:147-54. 1995
    The c-met oncogene encodes the receptor for hepatocyte growth factor/scatter factor, a potent mitogen for epithelial cells that also promotes cell motility and invasiveness...
  54. ncbi Overexpression of epidermal growth factor and hepatocyte growth factor receptors in a proportion of gastrinomas correlates with aggressive growth and lower curability
    Paolo L Peghini
    Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland 20892, USA
    Clin Cancer Res 8:2273-85. 2002
    ..Whether this is true of neuroendocrine tumors such as gastrinomas is unclear...
  55. ncbi Distinctive gene expression of receptor-type tyrosine kinase families during rat hepatocarcinogenesis
    Hiroaki Kuroda
    Department of Surgery II, Nagasaki University School of Medicine, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Int J Mol Med 9:473-80. 2002
    ..Sequence analysis of 459 clones identified 23 different RTK genes. The Tie-2, c-Met, and Flk-1 genes were the most abundant RTK genes cloned in rat hepatoma compared to normal liver...
  56. ncbi Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein
    P Peschard
    Department of Biochemistry, McGill University, Molecular Oncology Group, McGill University Health Centre, Montreal, Quebec H3A 1A1, Canada
    Mol Cell 8:995-1004. 2001
    ..In testing this, we show that c-Cbl promotes ubiquitination of the Met RTK. This requires the c-Cbl tyrosine kinase binding (TKB) domain and a juxtamembrane tyrosine residue on Met...
  57. ncbi Expression of the c-Met proto-oncogene and its possible involvement in liver invasion in adult T-cell leukemia
    Yoshitaka Imaizumi
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Medical Sciences, Nagasaki 852 8523, Japan
    Clin Cancer Res 9:181-7. 2003
    c-Met is a tyrosine kinase receptor for hepatocyte growth factor and suggested to be involved in oncogenesis ormetastatic phenotypes in many malignancies...
  58. ncbi Expression of hepatocyte growth factor, keratinocyte growth factor and their receptors in experimental chronic pancreatitis
    J M Otte
    Department of Internal Medicine, Christian Albrechts University, Schittenhelmstrasse 12, 24105 Kiel, Germany
    Eur J Clin Invest 31:865-75. 2001
    ..These peptide growth factors and their receptors c-met and keratinocyte growth factor receptor (KGFR) are overexpressed in pancreatic cancer.
  59. ncbi Independent amplification of two gene clusters on chromosome 4 in rat endometrial cancer: identification and molecular characterization
    A Walentinsson
    Department of Cell and Molecular Biology Genetics, Goteborg University, SE 40530 Gothenburg, Sweden
    Cancer Res 61:8263-73. 2001
    ..1. The genes Cdk6 (cyclin-dependent kinase 6) and Met (hepatocyte growth factor receptor) were located in the core of each amplified region and were amplified most recurrently and at the ..
  60. ncbi Expression and functional role of hepatocyte growth factor receptor (C-MET) during postnatal rat testis development
    A Catizone
    Department of Histology and Medical Embryology, University of Rome La Sapienza, Rome, Italy
    Endocrinology 142:1828-34. 2001
    The met protooncogene encodes the hepatocyte growth factor receptor (HGFR, c-met). C-met, a tyrosine kinase receptor protein, is widely expressed in different cell types including the male reproductive tract...
  61. ncbi Cytokines regulate c-Met expression in cultured astrocytes
    Kenji Shimazaki
    Department of Neurosurgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Brain Res 962:105-10. 2003
    We investigated c-Met expression in cultured astrocytes and their regulation by cytokines. Immunocytochemistry revealed that c-Met was expressed in cultured astrocytes...
  62. ncbi In situ activation pattern of Met docking site following renal injury and hypertrophy
    Benjamin Dekel
    Department of Pediatrics, Chaim Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Nephrol Dial Transplant 18:1493-504. 2003
    Hepatocyte growth factor/scatter factor (HGF/SF) binds to its tyrosine kinase receptor, Met, thereby stimulating diverse cellular responses...
  63. ncbi Thioacetamide-induced intestinal-type cholangiocarcinoma in rat: an animal model recapitulating the multi-stage progression of human cholangiocarcinoma
    Chun Nan Yeh
    Department of Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taiwan
    Carcinogenesis 25:631-6. 2004
    ..normal cholangioles to biliary dysplasia to invasive CCA was accompanied by up-regulation of the proto-oncogenes c-met and c-erbB-2, tyrosine kinase receptors over-expressed in human CCAs...
  64. ncbi Met expression is associated with poor outcome in patients with axillary lymph node negative breast carcinoma
    R L Camp
    Department of Pathology Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Cancer 86:2259-65. 1999
    Activation of Met, the receptor for scatter factor/hepatocyte growth factor, is associated with mitogenesis, motogenesis, and decreased cell adhesion...
  65. ncbi Functional role of hepatocyte growth factor receptor during sperm maturation
    A Catizone
    Department of Histology and Medical Embryology, University of Rome La Sapienza, Italy
    J Androl 23:911-8. 2002
    ..In the present paper we report that in rats, HGF receptor, c-met, is expressed in testicular and epididymal spermatozoa...
  66. pmc CD44v6 dependence of premetastatic niche preparation by exosomes
    Thorsten Jung
    Department of Tumor Cell Biology, University Hospital of Surgery and German Cancer Research Center, D 69120 Heidelberg, Germany
    Neoplasia 11:1093-105. 2009
    ..Analyzing the composition revealed that only the ASML(wt)-matrix contains c-Met and urokinase-type plasminogen activator receptor...
  67. doi Adenosine administration accelerates progression of the cell cycle during rat liver regeneration induced by one-third hepatectomy
    Edgar Mendieta-Condado
    Departamento de Biologia Celular, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Ciudad de Mexico, Mexico
    J Pharmacol Exp Ther 331:122-32. 2009
    ..were also accompanied for a long-lasting increase of serum and liver levels of HGF and liver expression of c-Met and HGF liver activator...
  68. doi Gene expression of transforming growth factor-beta1 and hepatocyte growth factor during wound healing of injured rat vocal fold
    Tsunehisa Ohno
    Department of Otolaryngology, Vanderbilt University Bill Wilkerson Center for Otolaryngology and Communication Sciences, Nashville, Tennessee 37232 4480, USA
    Laryngoscope 119:806-10. 2009
    ..the expression of genes coding transforming growth factor (TGF)-beta1, hepatocyte growth factor (HGF), and c-Met, its membrane-spanning tyrosine kinase receptor, during the inflammatory, proliferative, and remodeling phases of ..
  69. ncbi Localization and functional role of hepatocyte growth factor (HGF) and its receptor c-met in the rat developing cerebral cortex
    Woong Sun
    Division of Molecular Regenerative Medicine, Course of Advanced Medicine, Osaka University Graduate School of Medicine, B 7, Osaka 565 0871, Japan
    Brain Res Mol Brain Res 103:36-48. 2002
    ..In the present study, we examined expression and functional roles of HGF and c-Met during development of the rat cerebral cortex...
  70. doi Activation of cardiac progenitor cells reverses the failing heart senescent phenotype and prolongs lifespan
    Arantxa Gonzalez
    Department of Anesthesia, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Circ Res 102:597-606. 2008
    ..of the insulin-like growth factor-1/insulin-like growth factor-1 receptor and hepatocyte growth factor/c-Met systems, which do not counteract any longer the CPC renin-angiotensin system, resulting in cellular senescence, ..
  71. ncbi Ontogeny of hepatocyte growth factor and c-met/hgf receptor in rat pancreas
    E L Calvo
    Dept Médecine, Fac Médecine, Univ Sherbrooke, Quebec, Canada
    Biochem Biophys Res Commun 229:257-63. 1996
    ..HGF is the ligand of a dimeric transmembrane tyrosine kinase receptor encoded by the met proto-oncogene...
  72. pmc Hepatocyte growth factor-induced Ras activation requires ERM proteins linked to both CD44v6 and F-actin
    Veronique Orian-Rousseau
    Forschungszentrum Karlsruhe, Institute of Toxicology and Genetics, 76021 Karlsruhe, Germany
    Mol Biol Cell 18:76-83. 2007
    In several types of cells, the activation of the receptor tyrosine kinase c-Met by its ligand hepatocyte growth factor (HGF) requires the coreceptor CD44v6...
  73. ncbi Overexpression of the gene for transmembrane 4 superfamily member 4 accelerates liver damage in rats treated with CCl4
    Jie Qiu
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, People s Republic of China
    J Hepatol 46:266-75. 2007
    ..Therefore, we investigated the role of TM4SF4 during liver injury...
  74. doi RAN GTPase is an effector of the invasive/metastatic phenotype induced by osteopontin
    V V Kurisetty
    Centre for Cancer Research and Cell Biology, Queen s University Belfast, Belfast, UK
    Oncogene 27:7139-49. 2008
    ..a combination of mutant protein and inhibitors, it was found that RAN signal transduction occurred through the c-Met receptor and PI3 kinase...

Research Grants4

  1. Molecular-Specific Detection of Tumors: MRI Investigations
    Rheal Towner; Fiscal Year: 2007
    ..Once we have established the optimal molecular-targeting agent in a mouse hepatocarcinogenesis model, then the groundwork is established for initiation of human cell and planning of clinical evaluations for patients with liver cancer. ..
  2. Overcoming acquired resistance to EGFR inhibitors in lung cancer
    William Pao; Fiscal Year: 2010
    ....