Met

Summary

Gene Symbol: Met
Description: MET proto-oncogene, receptor tyrosine kinase
Alias: Hgfr, hepatocyte growth factor receptor, HGF receptor, HGF/SF receptor, SF receptor, c-Met, met proto-oncogene tyrosine kinase, proto-oncogene c-Met, scatter factor receptor, tyrosine-protein kinase Met
Species: rat
Products:     Met

Top Publications

  1. Birchmeier C, Birchmeier W, Gherardi E, Vande Woude G. Met, metastasis, motility and more. Nat Rev Mol Cell Biol. 2003;4:915-25 pubmed
  2. Arechederra M, Carmona R, Gonzalez Nuñez M, Gutierrez Uzquiza A, Bragado P, Cruz Gonzalez I, et al. Met signaling in cardiomyocytes is required for normal cardiac function in adult mice. Biochim Biophys Acta. 2013;1832:2204-15 pubmed publisher
    Hepatocyte growth factor (HGF) and its receptor, Met, are key determinants of distinct developmental processes...
  3. Qiu J, Liu Z, Da L, Li Y, Xuan H, Lin Q, et al. Overexpression of the gene for transmembrane 4 superfamily member 4 accelerates liver damage in rats treated with CCl4. J Hepatol. 2007;46:266-75 pubmed
    ..expression of TM4SF4 affected the expression levels of growth factors and receptors, such as TNF-alpha, TNFR1 and c-met. Furthermore, pro-apoptotic and anti-apoptotic gene expression was altered after TM4SF4 administration...
  4. Walentinsson A, Helou K, Wallenius V, Hedrich H, Szpirer C, Levan G. Independent amplification of two gene clusters on chromosome 4 in rat endometrial cancer: identification and molecular characterization. Cancer Res. 2001;61:8263-73 pubmed
    ..1. The genes Cdk6 (cyclin-dependent kinase 6) and Met (hepatocyte growth factor receptor) were located in the core of each amplified region and were amplified most recurrently and at the ..
  5. Liu Y, Tolbert E, Sun A, Dworkin L. In vivo and in vitro evidence for increased expression of HGF receptor in kidney of diabetic rat. Am J Physiol. 1996;271:F1202-10 pubmed
    ..In this study, we demonstrate that the c-met protooncogene product, a tyrosine kinase receptor for hepatocyte growth factor (HGF), is increased in the kidney of ..
  6. Wen X, Li Y, Hu K, Dai C, Liu Y. Hepatocyte growth factor receptor signaling mediates the anti-fibrotic action of 9-cis-retinoic acid in glomerular mesangial cells. Am J Pathol. 2005;167:947-57 pubmed
    ..growth factor (HGF) mRNA expression and protein secretion, stimulated HGF promoter activity, and activated c-met receptor phosphorylation...
  7. Di Renzo M, Olivero M, Katsaros D, Crepaldi T, Gaglia P, Zola P, et al. Overexpression of the Met/HGF receptor in ovarian cancer. Int J Cancer. 1994;58:658-62 pubmed
    ..DNA level and expression of the Met/HGF receptor gene were examined with Southern- and Western-blot analyses, respectively, in human ovary, benign ovarian ..
  8. Orian Rousseau V, Morrison H, Matzke A, Kastilan T, Pace G, Herrlich P, et al. Hepatocyte growth factor-induced Ras activation requires ERM proteins linked to both CD44v6 and F-actin. Mol Biol Cell. 2007;18:76-83 pubmed
    In several types of cells, the activation of the receptor tyrosine kinase c-Met by its ligand hepatocyte growth factor (HGF) requires the coreceptor CD44v6...
  9. Schmidt L, Duh F, Chen F, Kishida T, Glenn G, Choyke P, et al. Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas. Nat Genet. 1997;16:68-73 pubmed
    ..We identified missense mutations located in the tyrosine kinase domain of the MET gene in the germline of affected members of HPRC families and in a subset of sporadic papillary renal carcinomas...

More Information

Publications62

  1. Li H, Jiang T, Lin Y, Zhao Z, Zhang N. HGF protects rat mesangial cells from high-glucose-mediated oxidative stress. Am J Nephrol. 2006;26:519-30 pubmed
    ..RMC were cultured in 5.6 mM (NG) or 30 mM (HG) glucose in the absence or presence of HGF (20 ng/ml) and c-met inhibitor SU11274 (5 microM) for 24 h. c-met expression in HG was markedly increased...
  2. Farazi P, Zeisberg M, Glickman J, Zhang Y, Kalluri R, Depinho R. Chronic bile duct injury associated with fibrotic matrix microenvironment provokes cholangiocarcinoma in p53-deficient mice. Cancer Res. 2006;66:6622-7 pubmed
    ..peritumoral fibrosis, increased inducible nitric oxide synthase, nitrotyrosine, and cyclooxygenase-2 expression, c-Met activation, cErbB2 overexpression, down-regulation of membrane-associated E-cadherin, and p53 codon 248 mutation...
  3. Ramos Nino M, Scapoli L, Martinelli M, Land S, Mossman B. Microarray analysis and RNA silencing link fra-1 to cd44 and c-met expression in mesothelioma. Cancer Res. 2003;63:3539-45 pubmed
    ..Results reveal that induction of cd44 and c-met is causally linked to fra-1 expression, connecting fra-1 with genes governing cell motility and invasion in ..
  4. Liu Y, Tolbert E, Sun A, Dworkin L. Primary structure of rat HGF receptor and induced expression in glomerular mesangial cells. Am J Physiol. 1996;271:F679-88 pubmed
    ..The nucleotide sequence of the rat c-met cDNA revealed that the HGF receptor is encoded within single open-reading frame as 190 kDa of a transmembrane glycoprotein consisting of 1,382 ..
  5. Pepper M, Soriano J, Menoud P, Sappino A, Orci L, Montesano R. Modulation of hepatocyte growth factor and c-met in the rat mammary gland during pregnancy, lactation, and involution. Exp Cell Res. 1995;219:204-10 pubmed
    ..The aim of the present studies was to assess the expression and modulation of HGF and its receptor c-Met in the rat mammary gland during pregnancy, lactation, and involution...
  6. Yang H, Magilnick N, Noureddin M, Mato J, Lu S. Effect of hepatocyte growth factor on methionine adenosyltransferase genes and growth is cell density-dependent in HepG2 cells. J Cell Physiol. 2007;210:766-73 pubmed
    ..The current work examined expression of HGF/c-met in HCC and whether HGF regulates MAT genes and growth in HepG2 cells...
  7. Mendieta Condado E, Pichardo Olvera M, Sánchez Sevilla L, Chagoya De Sánchez V, Hernández Muñoz R. Adenosine administration accelerates progression of the cell cycle during rat liver regeneration induced by one-third hepatectomy. J Pharmacol Exp Ther. 2009;331:122-32 pubmed publisher
    ..were also accompanied for a long-lasting increase of serum and liver levels of HGF and liver expression of c-Met and HGF liver activator...
  8. Dai C, Huh C, Thorgeirsson S, Liu Y. Beta-cell-specific ablation of the hepatocyte growth factor receptor results in reduced islet size, impaired insulin secretion, and glucose intolerance. Am J Pathol. 2005;167:429-36 pubmed
    Hepatocyte growth factor (HGF) and its c-met receptor consist of a paired signaling system that has been implicated in the regulation of pancreatic beta-cell survival, proliferation, and function...
  9. Calvo E, Boucher C, Pelletier G, Morisset J. Ontogeny of hepatocyte growth factor and c-met/hgf receptor in rat pancreas. Biochem Biophys Res Commun. 1996;229:257-63 pubmed
    ..HGF is the ligand of a dimeric transmembrane tyrosine kinase receptor encoded by the met proto-oncogene...
  10. Hoffmann K, Tapia J, Berna M, Thill M, Braunschweig T, Mantey S, et al. Gastrointestinal hormones cause rapid c-Met receptor down-regulation by a novel mechanism involving clathrin-mediated endocytosis and a lysosome-dependent mechanism. J Biol Chem. 2006;281:37705-19 pubmed
    The activated c-Met receptor has potent effects on normal tissues and tumors. c-Met levels are regulated by hepatocyte growth factor (HGF); however, it is unknown if they can be regulated by gastrointestinal (GI) hormones...
  11. Ikari T, Hiraki A, Seki K, Sugiura T, Matsumoto K, Shirasuna K. Involvement of hepatocyte growth factor in branching morphogenesis of murine salivary gland. Dev Dyn. 2003;228:173-84 pubmed
    ..5. Real-time reverse transcriptase-polymerase chain reaction showed that the expression of the c-met/HGF receptor gene in SMG increased and peaked between E14 and E16...
  12. Kurisetty V, Johnston P, Johnston N, Erwin P, Crowe P, Fernig D, et al. RAN GTPase is an effector of the invasive/metastatic phenotype induced by osteopontin. Oncogene. 2008;27:7139-49 pubmed publisher
    ..a combination of mutant protein and inhibitors, it was found that RAN signal transduction occurred through the c-Met receptor and PI3 kinase...
  13. Rong S, Jeffers M, Resau J, Tsarfaty I, Oskarsson M, Vande Woude G. Met expression and sarcoma tumorigenicity. Cancer Res. 1993;53:5355-60 pubmed
    The met protooncogene tyrosine kinase receptor (Met) and its ligand, hepatocyte growth factor/scatter factor (HGF/SF), ordinarily constitute a paracrine signaling system in which cells of mesenchymal origin produce the ligand, which ..
  14. Brusevold I, Søland T, Khuu C, Christoffersen T, Bryne M. Nuclear and cytoplasmic expression of Met in oral squamous cell carcinoma and in an organotypic oral cancer model. Eur J Oral Sci. 2010;118:342-9 pubmed publisher
    Met, the hepatocyte growth factor receptor, is important in transducing signals for tumour growth and metastasis...
  15. Peghini P, Iwamoto M, Raffeld M, Chen Y, Goebel S, Serrano J, et al. Overexpression of epidermal growth factor and hepatocyte growth factor receptors in a proportion of gastrinomas correlates with aggressive growth and lower curability. Clin Cancer Res. 2002;8:2273-85 pubmed
    ..Whether this is true of neuroendocrine tumors such as gastrinomas is unclear...
  16. Salazar Montes A, Ruiz Corro L, Sandoval Rodriguez A, Lopez Reyes A, Armendariz Borunda J. Increased DNA binding activity of NF-kappaB, STAT-3, SMAD3 and AP-1 in acutely damaged liver. World J Gastroenterol. 2006;12:5995-6001 pubmed
    ..SMAD3 and AP-1, and gene expression of inducible nitric oxide synthase (iNOS), hepatocyte growth factor (HGF) and c-met were analyzed in an animal model of chemically induced hepatectomy...
  17. Sadanandam A, Rosenbaugh E, Singh S, Varney M, Singh R. Semaphorin 5A promotes angiogenesis by increasing endothelial cell proliferation, migration, and decreasing apoptosis. Microvasc Res. 2010;79:1-9 pubmed publisher
    ..our data suggest that Sema5A decreases apoptosis through activation of Akt, increases migration through activating Met tyrosine kinases and extracellular matrix degradation through matrix metalloproteinase 9...
  18. Campbell D, Sutcliffe J, Ebert P, Militerni R, Bravaccio C, Trillo S, et al. A genetic variant that disrupts MET transcription is associated with autism. Proc Natl Acad Sci U S A. 2006;103:16834-9 pubmed
    ..and location within a chromosome 7q31 autism candidate gene region, we analyzed the gene encoding the pleiotropic MET receptor tyrosine kinase in a family based study of autism including 1,231 cases...
  19. Bernier J, Chababi W, Pomerleau V, Saucier C. Oncogenic engagement of the Met receptor is sufficient to evoke angiogenic, tumorigenic, and metastatic activities in rat intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2010;299:G677-86 pubmed publisher
    The deregulation of Met/hepatocyte growth factor (HGF) receptor tyrosine kinase signaling constitutes a common event in colorectal cancers. However, the physiopathological functions of such a deregulation remain poorly understood...
  20. Ekuni D, Firth J, Putnins E. Regulation of epithelial cell growth factor receptor protein and gene expression using a rat periodontitis model. J Periodontal Res. 2006;41:340-9 pubmed
    ..chain reaction (qRT-PCR) was used to quantify keratinocyte growth factor receptor (KGFR), hepatocyte growth factor receptor (HGFR), epidermal growth factor receptor (EGFR) and fibroblast growth factor receptor 1 (FGFR1) gene ..
  21. Nakayama N, Kashiwazaki H, Kobayashi N, Hamada J, Ogiso Y, Itakura Y, et al. Hepatocyte growth factor and c-met expression in Long-Evans Cinnamon rats with spontaneous hepatitis and hepatoma. Hepatology. 1996;24:596-602 pubmed
    ..The expression of c-met mRNA was strong in the tissues of LEC rats with fulminant hepatitis and, especially, in the cholangiofibrosis ..
  22. Moon W, Park H, Lee H, Pai R, Tarnawski A, Kim K, et al. Co-expression of cox-2, C-met and beta-catenin in cells forming invasive front of gallbladder cancer. Cancer Res Treat. 2005;37:171-6 pubmed publisher
    ..E(2) (PGE(2)), generated by cyclooxygenase 2 (Cox-2), transactivates epidermal growth factor receptor (EGFR), c-Met and beta-catenin; thus, enhancing colon cancer cell growth and invasiveness in vitro...
  23. Bladt F, Riethmacher D, Isenmann S, Aguzzi A, Birchmeier C. Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud. Nature. 1995;376:768-71 pubmed
    ..Here we report that the c-met-encoded receptor tyrosine kinase is essential for migration of myogenic precursor cells into the limb anlage and ..
  24. Sangwan V, Paliouras G, Abella J, Dubé N, Monast A, Tremblay M, et al. Regulation of the Met receptor-tyrosine kinase by the protein-tyrosine phosphatase 1B and T-cell phosphatase. J Biol Chem. 2008;283:34374-83 pubmed publisher
    ..We have identified PTP1B and TCPTP as negative regulators of the hepatocyte growth factor receptor, the Met receptor-tyrosine kinase...
  25. Artigiani S, Conrotto P, Fazzari P, Gilestro G, Barberis D, Giordano S, et al. Plexin-B3 is a functional receptor for semaphorin 5A. EMBO Rep. 2004;5:710-4 pubmed
    ..In addition, Sema5A can trigger the intracellular signalling of the hepatocyte growth factor/scatter factor receptor, Met, associated in a complex with plexin-B3...
  26. Tyndall S, Walikonis R. Signaling by hepatocyte growth factor in neurons is induced by pharmacological stimulation of synaptic activity. Synapse. 2007;61:199-204 pubmed
    ..The receptor tyrosine kinase Met and its ligand, hepatocyte growth factor (HGF), are clustered at excitatory synapses and may regulate aspects of ..
  27. Otte J, Schwenger M, Brunke G, Sparmann G, Emmrich J, Schmitz F, et al. Expression of hepatocyte growth factor, keratinocyte growth factor and their receptors in experimental chronic pancreatitis. Eur J Clin Invest. 2001;31:865-75 pubmed
    ..These peptide growth factors and their receptors c-met and keratinocyte growth factor receptor (KGFR) are overexpressed in pancreatic cancer...
  28. Gherardi E, Sandin S, Petoukhov M, Finch J, Youles M, Ofverstedt L, et al. Structural basis of hepatocyte growth factor/scatter factor and MET signalling. Proc Natl Acad Sci U S A. 2006;103:4046-51 pubmed
    ..or migration of epithelial, endothelial, and muscle progenitor cells through the receptor tyrosine kinase MET. Using small-angle x-ray scattering and cryo-electron microscopy, we show that conversion of pro(single-chain)HGF/..
  29. Humphrey P, Zhu X, Zarnegar R, Swanson P, Ratliff T, Vollmer R, et al. Hepatocyte growth factor and its receptor (c-MET) in prostatic carcinoma. Am J Pathol. 1995;147:386-96 pubmed
    ..Expression of the HGF receptor, c-MET, is up-regulated by androgen deprivation and c-MET appears to be preferentially expressed on androgen-..
  30. Homsi E, Janino P, Biswas S, Mizuno S, Nakamura T, Lopes de Faria J. Attenuation of glycerol-induced acute kidney injury by previous partial hepatectomy: role of hepatocyte growth factor/c-met axis in tubular protection. Nephron Exp Nephrol. 2007;107:e95-106 pubmed
    ..Renal function, acute tubular necrosis, apoptosis, leukocyte infiltration, and the expression of HGF, c-met, monocyte chemoattractant protein-1, interleukin-1beta, and heme oxygenase-1 were evaluated 24 h after glycerol ..
  31. Dekel B, Biton S, Yerushalmi G, Altstock R, Mittelman L, Faletto D, et al. In situ activation pattern of Met docking site following renal injury and hypertrophy. Nephrol Dial Transplant. 2003;18:1493-504 pubmed
    Hepatocyte growth factor/scatter factor (HGF/SF) binds to its tyrosine kinase receptor, Met, thereby stimulating diverse cellular responses...
  32. Nakayama M, Sakai K, Yamashita A, Nakamura T, Suzuki Y, Matsumoto K. Met/HGF receptor activation is regulated by juxtamembrane Ser985 phosphorylation in hepatocytes. Cytokine. 2013;62:446-52 pubmed publisher
    b>Met/hepatocyte growth factor (HGF) receptor plays a definitive role in hepatocyte proliferation and liver regeneration. Phosphorylation of Ser985 in Met (Met-Ser985) down regulate tyrosine phosphorylation and activation of Met...
  33. Ponzetto C, Pante G, Prunotto C, Ieraci A, Maina F. Met signaling mutants as tools for developmental studies. Int J Dev Biol. 2000;44:645-53 pubmed
    The Met receptor is widely expressed in embryonic and adult epithelial tissues; its ligand (hepatocyte growth factor/scatter factor, HGF/SF) is expressed in the mesenchymal component of various organs...
  34. Wu Y, Cheng M, Shi Z, Feng Z, Guan X. Dynamic expression and localization of c-MET isoforms in the developing rat pancreas. Int J Clin Exp Pathol. 2014;7:8563-72 pubmed
    ..of different developmental stages were studied to determine the expression and cellular localization of different c-MET isoforms in the developing rat pancreas...
  35. Uzumcu M, Pan Z, Chu Y, Kuhn P, Zachow R. Immunolocalization of the hepatocyte growth factor (HGF) system in the rat ovary and the anti-apoptotic effect of HGF in rat ovarian granulosa cells in vitro. Reproduction. 2006;132:291-9 pubmed
    ..Immunohistochemistry was used to investigate the distribution of HGF, c-met, and HGF activator (HGFA) protein during folliculogenesis in equine chorionic gonadotropin (eCG)-primed rats...
  36. Kim C, Koh Y, Han J, Kim J, Lee J, Baek S, et al. c-Met expression as an indicator of survival outcome in patients with oral tongue carcinoma. Head Neck. 2010;32:1655-64 pubmed publisher
    ..However, the prognosis according to expression of HGF/c-Met has not been reported in patients with squamous cell carcinoma of the oral tongue (SCCOT)...
  37. Xu J, Huang Z, Lin L, Fu M, Gao Y, Shen Y, et al. miR-210 over-expression enhances mesenchymal stem cell survival in an oxidative stress environment through antioxidation and c-Met pathway activation. Sci China Life Sci. 2014;57:989-97 pubmed publisher
    ..Moreover, the above beneficial effects of miR-210 could be significantly reduced by c-Met pathway repression...
  38. Pao W, Girard N. New driver mutations in non-small-cell lung cancer. Lancet Oncol. 2011;12:175-80 pubmed publisher
    ..subsets defined by so-called driver mutations in ALK, HER2 (also known as ERBB2), BRAF, PIK3CA, AKT1, MAP2K1, and MET. The adoption of treatment tailored according to the genetic make-up of individual tumours would involve a paradigm ..
  39. Baier P, Wolf Vorbeck G, Hempel S, Hopt U, von Dobschuetz E. Effect of liver regeneration after partial hepatectomy and ischemia-reperfusion on expression of growth factor receptors. World J Gastroenterol. 2006;12:3835-40 pubmed
    ..In immunohistochemistry, EGFR, HGFR, FGFR and TNFR1 showed biphasic kinetics after partial hepatectomy with a peak up to 12 h, a nadir after 24 h and ..
  40. Yoshida T, Zhang G, Haura E. Targeting epidermal growth factor receptor: central signaling kinase in lung cancer. Biochem Pharmacol. 2010;80:613-23 pubmed publisher
    ..A secondary mutation of EGFR (T790M) and amplification of MET account for 70% of all cases of acquired resistance to EGFR-TKIs...
  41. Tolbert W, Daugherty Holtrop J, Gherardi E, Vande Woude G, Xu H. Structural basis for agonism and antagonism of hepatocyte growth factor. Proc Natl Acad Sci U S A. 2010;107:13264-9 pubmed publisher
    Hepatocyte growth factor (HGF) is an activating ligand of the Met receptor tyrosine kinase, whose activity is essential for normal tissue development and organ regeneration but abnormal activation of Met has been implicated in growth, ..
  42. Kato T, Oka K, Nakamura T, Ito A. Decreased expression of Met during differentiation in rat lung. Eur J Histochem. 2016;60:2575 pubmed publisher
    ..mitogenic, morphogenic, and anti-apoptotic effects on lung epithelial cells through tyrosine phosphorylation of Met receptor, and thus is recognized as a pulmotrophic factor...
  43. Wong H, Lemoine N. Pancreatic cancer: molecular pathogenesis and new therapeutic targets. Nat Rev Gastroenterol Hepatol. 2009;6:412-22 pubmed publisher
    ..This Review describes some of the important developments and targeted agents for pancreatic cancer that have been tested in clinical trials. ..
  44. Tyndall S, Walikonis R. The receptor tyrosine kinase Met and its ligand hepatocyte growth factor are clustered at excitatory synapses and can enhance clustering of synaptic proteins. Cell Cycle. 2006;5:1560-8 pubmed
    The receptor protein tyrosine kinase Met and its ligand, hepatocyte growth factor, regulate cellular morphology, intercellular adhesion, and interactions among junctional proteins in numerous cell types...
  45. Prunotto C, Crepaldi T, Forni P, Ieraci A, Kelly R, Tajbakhsh S, et al. Analysis of Mlc-lacZ Met mutants highlights the essential function of Met for migratory precursors of hypaxial muscles and reveals a role for Met in the development of hyoid arch-derived facial muscles. Dev Dyn. 2004;231:582-91 pubmed
    The Pax3 and c-met genes are necessary for the development of tongue, diaphragm, and limb muscles...
  46. Boost K, Kim H, Engl T, Oppermann E, Jonas D, Oertl A, et al. c-Met responsiveness of isolated hepatocytes evaluated in an in vitro de-differentiation model. Int J Mol Med. 2006;17:475-82 pubmed
    Hepatocyte growth factor (HGF) accelerates tissue regeneration and ameliorates tissue fibrosis through its ligand c-Met receptor tyrosine kinase...
  47. Zlot C, Ingle G, Hongo J, Yang S, Sheng Z, Schwall R, et al. Stanniocalcin 1 is an autocrine modulator of endothelial angiogenic responses to hepatocyte growth factor. J Biol Chem. 2003;278:47654-9 pubmed
    ..endothelial migration seem to occur secondary to receptor activation because STC1 did not inhibit HGF-induced c-met receptor phosphorylation, but did block HGF-induced focal adhesion kinase activation...
  48. Tian X, Tian Y, Moldobaeva N, Sarich N, Birukova A. Microtubule dynamics control HGF-induced lung endothelial barrier enhancement. PLoS ONE. 2014;9:e105912 pubmed publisher
    ..These effects were abolished by EC pretreatment with HGF receptor inhibitor, downregulation of Rac1 pathway, or by expression of a stathmin-S63A phosphorylation deficient mutant...
  49. Tsujii M, Kawano S, Tsuji S, Ito T, Horimoto M, Mita E, et al. Increased expression of c-met messenger RNA following acute gastric injury in rats. Biochem Biophys Res Commun. 1994;200:536-41 pubmed
    The aim of the present study was to evaluate messenger RNA expression of c-met, a hepatocyte growth factor receptor gene, after gastric mucosal injury in rats. Male Sprague-Dawley rats were fasted for 24 hours, received 0...
  50. Gentile A, Trusolino L, Comoglio P. The Met tyrosine kinase receptor in development and cancer. Cancer Metastasis Rev. 2008;27:85-94 pubmed publisher
    b>Met is a tyrosine kinase receptor, encoded by an oncogene, whose crucial role has been elucidated during the last two decades...
  51. Qiu S, Anderson C, Levitt P, Shepherd G. Circuit-specific intracortical hyperconnectivity in mice with deletion of the autism-associated Met receptor tyrosine kinase. J Neurosci. 2011;31:5855-64 pubmed publisher
    ..b>MET, a receptor tyrosine kinase that regulates dendrite and spine morphogenesis, has been established as a risk gene ..
  52. Imaizumi Y, Murota H, Kanda S, Hishikawa Y, Koji T, Taguchi T, et al. Expression of the c-Met proto-oncogene and its possible involvement in liver invasion in adult T-cell leukemia. Clin Cancer Res. 2003;9:181-7 pubmed
    c-Met is a tyrosine kinase receptor for hepatocyte growth factor and suggested to be involved in oncogenesis ormetastatic phenotypes in many malignancies...
  53. Di Renzo M, Poulsom R, Olivero M, Comoglio P, Lemoine N. Expression of the Met/hepatocyte growth factor receptor in human pancreatic cancer. Cancer Res. 1995;55:1129-38 pubmed
    ..The c-MET-encoded HGF receptor is also overexpressed in a proportion of the panel of 31 human pancreatic cancer cell lines examined, which ..