Gene Symbol: Mef2c
Description: myocyte enhancer factor 2C
Alias: RGD1563119, myocyte-specific enhancer factor 2C
Species: rat
Products:     Mef2c

Top Publications

  1. Martin J, Schwarz J, Olson E. Myocyte enhancer factor (MEF) 2C: a tissue-restricted member of the MEF-2 family of transcription factors. Proc Natl Acad Sci U S A. 1993;90:5282-6 pubmed
    ..These results suggest that the MEF-2 site is a target for a diverse family of proteins that regulates transcription in a variety of cell types. ..
  2. McDermott J, Cardoso M, Yu Y, Andres V, Leifer D, Krainc D, et al. hMEF2C gene encodes skeletal muscle- and brain-specific transcription factors. Mol Cell Biol. 1993;13:2564-77 pubmed
  3. Li H, Radford J, Ragusa M, Shea K, McKercher S, Zaremba J, et al. Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo. Proc Natl Acad Sci U S A. 2008;105:9397-402 pubmed publisher
    ..that myocyte enhancer factor 2 (MEF2) transcription factors act as effectors of neurogenesis in the brain, with MEF2C the predominant isoform in developing cerebrocortex...
  4. Lu J, McKinsey T, Zhang C, Olson E. Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases. Mol Cell. 2000;6:233-44 pubmed
    ..These findings reveal central roles for HDACs in chromatin remodeling during myogenesis and as intranuclear targets for signaling pathways controlled by IGF and CaM kinase. ..
  5. Lin Q, Schwarz J, Bucana C, Olson E. Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C. Science. 1997;276:1404-7 pubmed
    ..The murine MEF2C gene is expressed in heart precursor cells before formation of the linear heart tube...
  6. Li Z, McKercher S, Cui J, Nie Z, Soussou W, Roberts A, et al. Myocyte enhancer factor 2C as a neurogenic and antiapoptotic transcription factor in murine embryonic stem cells. J Neurosci. 2008;28:6557-68 pubmed publisher
    ..b>MEF2C has been implicated as a calcium-dependent transcription factor that enhances survival and affects synapse ..
  7. Bi W, Drake C, Schwarz J. The transcription factor MEF2C-null mouse exhibits complex vascular malformations and reduced cardiac expression of angiopoietin 1 and VEGF. Dev Biol. 1999;211:255-67 pubmed
    ..Targeted deletion of the MEF2C gene, in particular, revealed its importance for early cardiogenesis (Q. Lin et al., 1997, Science 276, 1404-1407)...
  8. McKinsey T, Zhang C, Lu J, Olson E. Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. Nature. 2000;408:106-11 pubmed
  9. Barbosa A, Kim M, Ertunc M, Adachi M, Nelson E, McAnally J, et al. MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function. Proc Natl Acad Sci U S A. 2008;105:9391-6 pubmed publisher
    ..We show that deletion of the MEF2C transcription factor in the CNS of mice impairs hippocampal-dependent learning and memory...

More Information


  1. Potthoff M, Arnold M, McAnally J, Richardson J, Bassel Duby R, Olson E. Regulation of skeletal muscle sarcomere integrity and postnatal muscle function by Mef2c. Mol Cell Biol. 2007;27:8143-51 pubmed
    ..Here we show that skeletal muscle-specific deletion of Mef2c in mice results in disorganized myofibers and perinatal lethality...
  2. Xu J, Gong N, Bodi I, Aronow B, Backx P, Molkentin J. Myocyte enhancer factors 2A and 2C induce dilated cardiomyopathy in transgenic mice. J Biol Chem. 2006;281:9152-62 pubmed
    ..Specifically, multiple transgenic mouse lines with cardiac-specific overexpression of MEF2A or MEF2C presented with cardiomyopathy at base line or were predisposed to more fulminant disease following pressure ..
  3. Kobarg C, Kobarg J, Crosara Alberto D, Theizen T, Franchini K. MEF2C DNA-binding activity is inhibited through its interaction with the regulatory protein Ki-1/57. FEBS Lett. 2005;579:2615-22 pubmed
    ..MEF2 proteins are activated by mechanical overload in the heart. In this study, we found the interaction of MEF2C with the regulatory protein Ki-1/57 using yeast two-hybrid system...
  4. Stehling Sun S, Dade J, Nutt S, DeKoter R, Camargo F. Regulation of lymphoid versus myeloid fate 'choice' by the transcription factor Mef2c. Nat Immunol. 2009;10:289-96 pubmed publisher
    ..Here we describe an unexpected function for the myeloid oncogene product Mef2c in lymphoid development...
  5. Vong L, Bi W, O Connor Halligan K, Li C, Cserjesi P, Schwarz J. MEF2C is required for the normal allocation of cells between the ventricular and sinoatrial precursors of the primary heart field. Dev Dyn. 2006;235:1809-21 pubmed
    Targeted deletion of the mef2c gene results in a small left ventricle and complete loss of the right ventricle (Lin et al. [1997] Science 276:1404-1407)...
  6. Phan D, Rasmussen T, Nakagawa O, McAnally J, Gottlieb P, Tucker P, et al. BOP, a regulator of right ventricular heart development, is a direct transcriptional target of MEF2C in the developing heart. Development. 2005;132:2669-78 pubmed
    ..These regions of the heart are severely hypoplastic in mutant mice lacking the myocyte enhancer factor 2C (MEF2C) and BOP transcription factors, suggesting that these cardiogenic regulatory factors may act in a common pathway ..
  7. Potthoff M, Wu H, Arnold M, Shelton J, Backs J, McAnally J, et al. Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers. J Clin Invest. 2007;117:2459-67 pubmed
    ..These findings provide what we believe are new insights into the molecular basis of skeletal muscle function and have important implications for possible therapeutic interventions into muscular diseases. ..
  8. Poizat C, Sartorelli V, Chung G, Kloner R, Kedes L. Proteasome-mediated degradation of the coactivator p300 impairs cardiac transcription. Mol Cell Biol. 2000;20:8643-54 pubmed
    ..we show that exposure of cultured cardiomyocytes to doxorubicin resulted in the rapid depletion of transcripts for MEF2C, dHAND, and NKX2.5, three pivotal regulators of cardiac gene expression...
  9. Wang R, Zhang Q, Li J, Yang L, Yang F, Brann D. The ERK5-MEF2C transcription factor pathway contributes to anti-apoptotic effect of cerebral ischemia preconditioning in the hippocampal CA1 region of rats. Brain Res. 2009;1255:32-41 pubmed publisher
    The purpose of the present study was to investigate the role of myocyte enhancer binding factor 2C (MEF2C), a common substrate of p38 kinase and extracellular signal-regulated kinase 5 (ERK5) in the hippocampal CA1 region following ..
  10. Zang M, Li Y, Xue L, Jia H, Jing H. Cooperative activation of atrial naturetic peptide promoter by dHAND and MEF2C. J Cell Biochem. 2004;93:1255-66 pubmed
    ..5. Here, we determine that dHAND also interacts with the myocyte enhancer binding factor-2c (MEF2C) protein, which belongs to MADS-box transcription factors and is essential for heart development...
  11. Zheng M, Zhu J, Lu T, Liu L, Sun H, Liu Z, et al. p300-mediated histone acetylation is essential for the regulation of GATA4 and MEF2C by BMP2 in H9c2 cells. Cardiovasc Toxicol. 2013;13:316-22 pubmed publisher
    ..substantially inhibited both AdBMP2-induced and basal expression levels of cardiac transcription factors GATA4 and MEF2C, but not Tbx5...
  12. Kuratomi S, Ohmori Y, Ito M, Shimazaki K, Muramatsu S, Mizukami H, et al. The cardiac pacemaker-specific channel Hcn4 is a direct transcriptional target of MEF2. Cardiovasc Res. 2009;83:682-7 pubmed publisher
    ..These results suggest that the novel enhancer CNS13 and MEF2 may play a critical role in the transcription of Hcn4 in the heart. ..
  13. Khiem D, Cyster J, Schwarz J, Black B. A p38 MAPK-MEF2C pathway regulates B-cell proliferation. Proc Natl Acad Sci U S A. 2008;105:17067-72 pubmed publisher
    ..In the present study, we inactivated Mef2c exclusively in B cells by conditional gene targeting in mice...
  14. Xia S, Li X, Johnson T, Seidel C, Wallace D, Li R. Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts. Development. 2010;137:1075-84 pubmed publisher
    ..Here, we found that myocyte enhancer factor 2C (MEF2C) and histone deacetylase 5 (HDAC5), two key regulators of cardiac hypertrophy, are targets of polycystin-dependent ..
  15. Yelamanchili S, Chaudhuri A, Chen L, Xiong H, Fox H. MicroRNA-21 dysregulates the expression of MEF2C in neurons in monkey and human SIV/HIV neurological disease. Cell Death Dis. 2010;1:e77 pubmed publisher
    ..Furthermore, we show that miR-21 specifically targets the mRNA of myocyte enhancer factor 2C (MEF2C), a transcription factor crucial for neuronal function, and reduces its expression...
  16. Verzi M, Agarwal P, Brown C, McCulley D, Schwarz J, Black B. The transcription factor MEF2C is required for craniofacial development. Dev Cell. 2007;12:645-52 pubmed
    ..We have discovered an unanticipated role for MEF2C in the neural crest, where tissue-specific inactivation results in neonatal lethality due to severe craniofacial ..
  17. Ren X, Li Y, Ma X, Zheng L, Xu Y, Wang J. Activation of p38/MEF2C pathway by all-trans retinoic acid in cardiac myoblasts. Life Sci. 2007;81:89-96 pubmed
    Myocyte enhancer factor 2C (MEF2C) is a transcription factor particularly expressed in cardiac muscle...
  18. Liu N, Williams A, Kim Y, McAnally J, Bezprozvannaya S, Sutherland L, et al. An intragenic MEF2-dependent enhancer directs muscle-specific expression of microRNAs 1 and 133. Proc Natl Acad Sci U S A. 2007;104:20844-9 pubmed
  19. Pagiatakis C, Gordon J, Ehyai S, McDermott J. A novel RhoA/ROCK-CPI-17-MEF2C signaling pathway regulates vascular smooth muscle cell gene expression. J Biol Chem. 2012;287:8361-70 pubmed publisher
    ..b>MEF2C fulfills a critical role in VSMC differentiation and regulates myocardin expression, leading us to investigate ..
  20. Feng B, Chen S, Chiu J, George B, Chakrabarti S. Regulation of cardiomyocyte hypertrophy in diabetes at the transcriptional level. Am J Physiol Endocrinol Metab. 2008;294:E1119-26 pubmed publisher
    ..Cardiomyocytes were analyzed with respect to their size. mRNA expression of p300, MEF2A, MEF2C, atrial natriuretic polypeptide (ANP), brain natriuretic polypeptide (BNP), angiotensinogen (ANG), cAMP-responsive ..
  21. Nagel S, Meyer C, Quentmeier H, Kaufmann M, Drexler H, MacLeod R. MEF2C is activated by multiple mechanisms in a subset of T-acute lymphoblastic leukemia cell lines. Leukemia. 2008;22:600-7 pubmed
    ..analyzed, we identified three genes regulated by NKX2-5 in T-ALL cells, including myocyte enhancer factor 2C (MEF2C). Knockdown and overexpression assays confirmed MEF2C activation by NKX2-5 at both the RNA and protein levels...
  22. Schulte I, Bektas H, Klempnauer J, Borlak J. Vitamin E in heart transplantation: effects on cardiac gene expression. Transplantation. 2006;81:736-45 pubmed
    ..05), as was expression of the myocyte enhancer factor MEF2c. Noteworthy, vitamin E repressed expression of SP1 and c-fos transcript level...
  23. Angelelli C, Magli A, Ferrari D, Ganassi M, Matafora V, Parise F, et al. Differentiation-dependent lysine 4 acetylation enhances MEF2C binding to DNA in skeletal muscle cells. Nucleic Acids Res. 2008;36:915-28 pubmed
    ..In the present report, we provide evidence for a novel regulatory mechanism of MEF2C activity, which occurs at the onset of skeletal muscle differentiation and is based on Lys4 acetylation...
  24. Shen H, McElhinny A, Cao Y, Gao P, Liu J, Bronson R, et al. The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis. Genes Dev. 2006;20:675-88 pubmed
    ..Moreover, we determined that MAML1 interacts with MEF2C (myocyte enhancer factor 2C), functioning as its potent co-transcriptional regulator...
  25. De Angelis L, Borghi S, Melchionna R, Berghella L, Baccarani Contri M, Parise F, et al. Inhibition of myogenesis by transforming growth factor beta is density-dependent and related to the translocation of transcription factor MEF2 to the cytoplasm. Proc Natl Acad Sci U S A. 1998;95:12358-63 pubmed
    ..from the nucleus was causally related to the inhibitory action of TGF-beta, we transfected C2C12 myoblasts with MEF2C containing the nuclear localization signal of simian virus 40 large T antigen (nlsSV40)...
  26. Quinn Z, Yang C, Wrana J, McDermott J. Smad proteins function as co-modulators for MEF2 transcriptional regulatory proteins. Nucleic Acids Res. 2001;29:732-42 pubmed
    ..Thus, the association between Smad2 and MEF2A may subserve a physical link between TGF-ss signalling and a diverse array of genes controlled by the MEF2 cis element. ..
  27. Lin Q, Lu J, Yanagisawa H, Webb R, Lyons G, Richardson J, et al. Requirement of the MADS-box transcription factor MEF2C for vascular development. Development. 1998;125:4565-74 pubmed
    ..The MADS-box transcription factor MEF2C is expressed in developing endothelial cells and smooth muscle cells (SMCs), as well as in surrounding mesenchyme, ..
  28. Wang X, Tang X, Li M, Marshall J, Mao Z. Regulation of neuroprotective activity of myocyte-enhancer factor 2 by cAMP-protein kinase A signaling pathway in neuronal survival. J Biol Chem. 2005;280:16705-13 pubmed
    ..This study identifies the transcription factor MEF2 as a target of cAMP-PKA pathway and demonstrates that PKA phosphorylation of MEF2 is a key step in modulating its DNA binding activity and ability to promote neuronal survival. ..
  29. Ieda M, Fu J, Delgado Olguin P, Vedantham V, Hayashi Y, Bruneau B, et al. Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell. 2010;142:375-86 pubmed publisher
    ..Here, we report that a combination of three developmental transcription factors (i.e., Gata4, Mef2c, and Tbx5) rapidly and efficiently reprogrammed postnatal cardiac or dermal fibroblasts directly into ..
  30. Desjardins C, Naya F. Antagonistic regulation of cell-cycle and differentiation gene programs in neonatal cardiomyocytes by homologous MEF2 transcription factors. J Biol Chem. 2017;292:10613-10629 pubmed publisher
    ..MEF2A and MEF2D were absolutely required for cardiomyocyte survival, whereas MEF2C, despite its major role in cardiac morphogenesis and direct reprogramming, was dispensable for this process...
  31. Skerjanc I, Petropoulos H, Ridgeway A, Wilton S. Myocyte enhancer factor 2C and Nkx2-5 up-regulate each other's expression and initiate cardiomyogenesis in P19 cells. J Biol Chem. 1998;273:34904-10 pubmed
    ..differentiation into cardiac muscle, Nkx2-5 expression resulted in the activation of myocyte enhancer factor 2C (MEF2C), but not MEF2A, -B, or -D...
  32. Ballal K, Wilson C, Harmancey R, Taegtmeyer H. Obesogenic high fat western diet induces oxidative stress and apoptosis in rat heart. Mol Cell Biochem. 2010;344:221-30 pubmed publisher
    ..In addition, there was a marked decrease in the expression of the transcription factor MEF2C (myocyte enhancer factor 2C) and its target gene SERCA2a (sarco-endo-plasmic reticulum Ca(2+)-ATPase)...
  33. Dietrich J, Takemori H, Grosch Dirrig S, Bertorello A, Zwiller J. Cocaine induces the expression of MEF2C transcription factor in rat striatum through activation of SIK1 and phosphorylation of the histone deacetylase HDAC5. Synapse. 2012;66:61-70 pubmed publisher
    ..forms of MEF2 transcription factor act as positive or negative regulators of dendritic spine formation, with MEF2C playing a key regulator role in synapse plasticity...
  34. Kolodziejczyk S, Wang L, Balazsi K, DeRepentigny Y, Kothary R, Megeney L. MEF2 is upregulated during cardiac hypertrophy and is required for normal post-natal growth of the myocardium. Curr Biol. 1999;9:1203-6 pubmed
    ..Transgenic mice expressing a dominant-negative form of MEF2C displayed attenuated post-natal growth of the myocardium...
  35. Black B, Ligon K, Zhang Y, Olson E. Cooperative transcriptional activation by the neurogenic basic helix-loop-helix protein MASH1 and members of the myocyte enhancer factor-2 (MEF2) family. J Biol Chem. 1996;271:26659-63 pubmed
    ..These results suggest that members of the MEF2 family perform similar roles in synergistic activation of transcription in myogenic and neurogenic lineages by serving as cofactors for cell type-specific bHLH proteins. ..
  36. Munoz J, Collao A, Chiong M, Maldonado C, Adasme T, Carrasco L, et al. The transcription factor MEF2C mediates cardiomyocyte hypertrophy induced by IGF-1 signaling. Biochem Biophys Res Commun. 2009;388:155-60 pubmed publisher
    Myocyte enhancer factor 2C (MEF2C) plays an important role in cardiovascular development and is a key transcription factor for cardiac hypertrophy...
  37. Zhao M, New L, Kravchenko V, Kato Y, Gram H, Di Padova F, et al. Regulation of the MEF2 family of transcription factors by p38. Mol Cell Biol. 1999;19:21-30 pubmed
    ..We showed previously that the transactivation activity of MEF2C is stimulated by p38 mitogen-activated protein (MAP) kinase...
  38. Dechesne C, Wei Q, Eldridge J, Gannoun Zaki L, Millasseau P, Bougueleret L, et al. E-box- and MEF-2-independent muscle-specific expression, positive autoregulation, and cross-activation of the chicken MyoD (CMD1) promoter reveal an indirect regulatory pathway. Mol Cell Biol. 1994;14:5474-86 pubmed
  39. Paulin R, Sutendra G, Gurtu V, Dromparis P, Haromy A, Provencher S, et al. A miR-208-Mef2 axis drives the decompensation of right ventricular function in pulmonary hypertension. Circ Res. 2015;116:56-69 pubmed publisher
    ..b>Mef2c expression was sharply increased in compensating phase of RVH tissues but was lost in decompensation phase of RVH...
  40. Morin S, Pozzulo G, Robitaille L, Cross J, Nemer M. MEF2-dependent recruitment of the HAND1 transcription factor results in synergistic activation of target promoters. J Biol Chem. 2005;280:32272-8 pubmed
    ..These findings identify a novel mechanism for HAND action in the heart and provide a general paradigm to understand the mechanism of HAND action in organogenesis. ..
  41. Hosking B, Wang S, Chen S, Penning S, Koopman P, Muscat G. SOX18 directly interacts with MEF2C in endothelial cells. Biochem Biophys Res Commun. 2001;287:493-500 pubmed
    ..Sox18 and the MADS box transcription factor, Mef2C, are expressed in developing endothelial cells...
  42. Suzaki Y, Yoshizumi M, Kagami S, Koyama A, Taketani Y, Houchi H, et al. Hydrogen peroxide stimulates c-Src-mediated big mitogen-activated protein kinase 1 (BMK1) and the MEF2C signaling pathway in PC12 cells: potential role in cell survival following oxidative insults. J Biol Chem. 2002;277:9614-21 pubmed
    ..In addition, H(2)O(2) treatment of cells induced an enhancement of DNA binding activity of MEF2C, a downstream transcription factor of BMK1 in PC12 cells...
  43. Janson C, Chen Y, Li Y, Leifer D. Functional regulatory regions of human transcription factor MEF2C. Brain Res Mol Brain Res. 2001;97:70-82 pubmed
    Myocyte enhancer-binding factor 2C (MEF2C), a transcription factor expressed at high levels in muscle and brain, is implicated in the terminal differentiation and post-mitotic survival of neurons...
  44. Akhtar M, Kim M, Adachi M, Morris M, Qi X, Richardson J, et al. In vivo analysis of MEF2 transcription factors in synapse regulation and neuronal survival. PLoS ONE. 2012;7:e34863 pubmed publisher
    ..The role of MEF2 isoforms in the brain has been studied using in vitro manipulations with only MEF2C examined in vivo...
  45. Kobayashi N, Goto K, Horiguchi K, Nagata M, Kawata M, Miyazawa K, et al. c-Ski activates MyoD in the nucleus of myoblastic cells through suppression of histone deacetylases. Genes Cells. 2007;12:375-85 pubmed
    ..We conclude that c-Ski induces myogenic differentiation through acting on MyoD and inhibiting HDAC activity in the nucleus of myogenic cells. ..
  46. Zang M, Li Y, Wang H, Wang J, Jia H. Cooperative interaction between the basic helix-loop-helix transcription factor dHAND and myocyte enhancer factor 2C regulates myocardial gene expression. J Biol Chem. 2004;279:54258-63 pubmed
  47. Zhang Y, Huang L, Zuo Z, Chen Y, Wang C. Phenanthrene exposure causes cardiac arrhythmia in embryonic zebrafish via perturbing calcium handling. Aquat Toxicol. 2013;142-143:26-32 pubmed publisher
    ..These results suggested that exposure to Phe could lead to arrhythmia in zebrafish embryos via perturbing the calcium handling pathway. ..
  48. Scorza C, Cavalheiro E, Scorza F. Myocyte-specific enhancer binding factor 2C (MEF2C) expression in the dentate gyrus during development and after pilocarpine-induced status epilepticus: a preliminary report. Arq Neuropsiquiatr. 2008;66:731-5 pubmed
    ..Using in situ hybridization, we have characterized mRNA expression of myocyte-specific enhancer binding factor 2C (MEF2C) in the dentate gyrus during development (P0, P3, P7, P14 and P28) and at multiple time points following ..
  49. Iida K, Hidaka K, Takeuchi M, Nakayama M, Yutani C, Mukai T, et al. Expression of MEF2 genes during human cardiac development. Tohoku J Exp Med. 1999;187:15-23 pubmed
    ..Expression of all four MEF2 transcripts (MEF2A, MEF2B, MEF2C, and MEF2D) were detected in all developmental stage of the human heart, while Mef2b transcripts were down-..
  50. Yuan Y, Singh D, Arikkath J. Mef2 promotes spine elimination in absence of ?-catenin. Neurosci Lett. 2013;536:10-3 pubmed publisher
    ..These results establish a molecular mechanism by which excessive spines in the absence of ?-catenin may be eliminated and may point toward pharmacological therapy for the Cri du chat syndrome. ..
  51. Schuler A, Schwieger M, Engelmann A, Weber K, Horn S, Muller U, et al. The MADS transcription factor Mef2c is a pivotal modulator of myeloid cell fate. Blood. 2008;111:4532-41 pubmed publisher
    b>Mef2c is a MADS (MCM1-agamous-deficient serum response factor) transcription factor best known for its role in muscle and cardiovascular development...
  52. Fu W, Wei J, Gu J. MEF2C mediates the activation induced cell death (AICD) of macrophages. Cell Res. 2006;16:559-65 pubmed
    ..We found that the stability of the transcription factor MEF2C is increased in primed RAW264.7 cell...
  53. Molkentin J, Firulli A, Black B, Martin J, Hustad C, Copeland N, et al. MEF2B is a potent transactivator expressed in early myogenic lineages. Mol Cell Biol. 1996;16:3814-24 pubmed
  54. Arnold M, Kim Y, Czubryt M, Phan D, McAnally J, Qi X, et al. MEF2C transcription factor controls chondrocyte hypertrophy and bone development. Dev Cell. 2007;12:377-89 pubmed
    Chondrocyte hypertrophy is essential for endochondral bone development. Unexpectedly, we discovered that MEF2C, a transcription factor that regulates muscle and cardiovascular development, controls bone development by activating the gene ..
  55. Han T, Prywes R. Regulatory role of MEF2D in serum induction of the c-jun promoter. Mol Cell Biol. 1995;15:2907-15 pubmed
    ..This is the domain homologous to that in the serum response factor which is required for serum induction of the c-fos serum response element, suggesting that serum regulation of c-fos and c-jun may share a common mechanism. ..
  56. Creemers E, Sutherland L, Oh J, Barbosa A, Olson E. Coactivation of MEF2 by the SAP domain proteins myocardin and MASTR. Mol Cell. 2006;23:83-96 pubmed
    ..This unique protein-protein interaction motif expands the regulatory potential of myocardin, and its presence in MASTR reveals a new mechanism for the control of MEF2 activity. ..
  57. Leupin O, Kramer I, Collette N, Loots G, Natt F, Kneissel M, et al. Control of the SOST bone enhancer by PTH using MEF2 transcription factors. J Bone Miner Res. 2007;22:1957-67 pubmed
    ..MEF2s and sclerostin co-localized in osteocytes. Enhancer activity was stimulated by MEF2C overexpression and inhibited by co-expression of a dominant negative MEF2C mutant...
  58. Jung S, Ko Y. TRIM72, a novel negative feedback regulator of myogenesis, is transcriptionally activated by the synergism of MyoD (or myogenin) and MEF2. Biochem Biophys Res Commun. 2010;396:238-45 pubmed publisher
    ..Taken together all these data, we concluded that the synergism of MyoD (or myogenin) and MEF2 is necessary for TRIM72 expression during C2C12 differentiation. ..
  59. Ghosh T, Song F, Packham E, Buxton S, Robinson T, Ronksley J, et al. Physical interaction between TBX5 and MEF2C is required for early heart development. Mol Cell Biol. 2009;29:2205-18 pubmed publisher
    ..Here, we report a physical interaction between TBX5 and MEF2C leading to a synergistic activation of the alpha-cardiac myosin heavy chain (MYH6)...
  60. Cardoso A, Pereira A, Ambrosio A, Consonni S, Rocha de Oliveira R, Bajgelman M, et al. FAK Forms a Complex with MEF2 to Couple Biomechanical Signaling to Transcription in Cardiomyocytes. Structure. 2016;24:1301-1310 pubmed publisher
    ..These findings underscore a connection between the mechanotransduction involving FAK and transcriptional regulation by MEF2, with potential relevance to the pathogenesis of cardiac disease. ..
  61. Al Madhoun A, Mehta V, Li G, Figeys D, Wiper Bergeron N, Skerjanc I. Skeletal myosin light chain kinase regulates skeletal myogenesis by phosphorylation of MEF2C. EMBO J. 2011;30:2477-89 pubmed publisher
    ..Here, we show that phosphorylation of MEF2C on T(80) by skeletal myosin light chain kinase (skMLCK) enhances skeletal and not cardiac myogenesis...
  62. Wei X, Sun W, Fan R, Hahn J, Joetham A, Li G, et al. MEF2C regulates c-Jun but not TNF-alpha gene expression in stimulated mast cells. Eur J Immunol. 2003;33:2903-9 pubmed
    ..A consequence of ERK5 activation is activation of the transcriptional factor myocyte enhancing factor-2C (MEF2C), leading to increased c-Jun expression...
  63. Lynch J, Guo L, Gelebart P, Chilibeck K, Xu J, Molkentin J, et al. Calreticulin signals upstream of calcineurin and MEF2C in a critical Ca(2+)-dependent signaling cascade. J Cell Biol. 2005;170:37-47 pubmed
    ..We establish that calreticulin works upstream of calcineurin and MEF2C in a Ca(2+)-dependent signal transduction cascade that links the endoplasmic reticulum and the nucleus during ..
  64. Sato H, Tsukada T, Nagayoshi M, Ikawa Y, Aizawa S, Kato M. Repression of p53-dependent sequence-specific transactivation by MEF2c. Biochem Biophys Res Commun. 1995;214:468-74 pubmed
    ..One (clone 2) of six clones isolated was identical to MEF2c, a MADS-family transcription factor...
  65. Agarwal P, Verzi M, Nguyen T, Hu J, Ehlers M, McCulley D, et al. The MADS box transcription factor MEF2C regulates melanocyte development and is a direct transcriptional target and partner of SOX10. Development. 2011;138:2555-65 pubmed publisher
    ..The MADS box transcription factor MEF2C is an important regulator of brain, skeleton, lymphocyte and cardiovascular development and is required in the ..
  66. Stephens A, Stephens S, Hobbs C, Hutmacher D, Bacic Welsh D, Woodruff M, et al. Myocyte enhancer factor 2c, an osteoblast transcription factor identified by dimethyl sulfoxide (DMSO)-enhanced mineralization. J Biol Chem. 2011;286:30071-86 pubmed publisher
    ..Myocyte enhancer factor 2c (Mef2c) was identified as the transcription factor most induced by DMSO, among the numerous DMSO-induced genes, ..
  67. Wilker P, Kohyama M, Sandau M, Albring J, Nakagawa O, Schwarz J, et al. Transcription factor Mef2c is required for B cell proliferation and survival after antigen receptor stimulation. Nat Immunol. 2008;9:603-12 pubmed publisher
    ..Here we demonstrate a function for the calcineurin-regulated transcription factor Mef2c in B cells...
  68. Micheli L, Leonardi L, Conti F, Buanne P, Canu N, Caruso M, et al. PC4 coactivates MyoD by relieving the histone deacetylase 4-mediated inhibition of myocyte enhancer factor 2C. Mol Cell Biol. 2005;25:2242-59 pubmed
    ..Furthermore, PC4 localizes in the nucleus of differentiating myoblasts, associates with MEF2C, and is able to counteract the HDAC4-mediated inhibition of MEF2C...
  69. Infantino V, Convertini P, Menga A, Iacobazzi V. MEF2C exon ?: role in gene activation and differentiation. Gene. 2013;531:355-62 pubmed publisher
    Myocyte enhancer factor 2C (MEF2C) belongs to the MEF2 transcription factors. All products of MEF2 genes have a common amino-terminal DNA binding and dimerization domain...