Gene Symbol: Mef2b
Description: myocyte enhancer factor 2B
Alias: myocyte-specific enhancer factor 2B
Leupin O, Kramer I, Collette N, Loots G, Natt F, Kneissel M, et al
. Control of the SOST bone enhancer by PTH using MEF2 transcription factors. J Bone Miner Res. 2007;22:1957-67 pubmed
..Hence, MEF2s are implicated in the regulation of adult bone mass. ..
RodrÃguez A, CsÃ¡nyi G, Ranayhossaini D, Feck D, Blose K, Assatourian L, et al
. MEF2B-Nox1 signaling is critical for stretch-induced phenotypic modulation of vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2015;35:430-8 pubmed publisher
..was designed to test the hypothesis that pathological CS stimulates NADPH oxidase isoform 1 (Nox1)-derived ROS via MEF2B, leading to VSMC dysfunction via a switch from a contractile to a synthetic phenotype...
Han T, Prywes R. Regulatory role of MEF2D in serum induction of the c-jun promoter. Mol Cell Biol. 1995;15:2907-15 pubmed
..This is the domain homologous to that in the serum response factor which is required for serum induction of the c-fos serum response element, suggesting that serum regulation of c-fos and c-jun may share a common mechanism. ..
Molkentin J, Firulli A, Black B, Martin J, Hustad C, Copeland N, et al
. MEF2B is a potent transactivator expressed in early myogenic lineages. Mol Cell Biol. 1996;16:3814-24 pubmed
..been shown to bind an A/T-rich DNA sequence in the control regions of numerous muscle-specific genes, whereas MEF2B was reported to be unable to bind this sequence unless the carboxyl terminus was deleted...
Morisaki T, Sermsuvitayawong K, Byun S, Matsuda Y, Hidaka K, Morisaki H, et al
. Mouse Mef2b gene: unique member of MEF2 gene family. J Biochem. 1997;122:939-46 pubmed
..To better understand the mouse Mef2 gene family, the mouse Mef2b gene, which was found to be expressed in undifferentiated embryonal cells, was characterized...
Han A, He J, Wu Y, Liu J, Chen L. Mechanism of recruitment of class II histone deacetylases by myocyte enhancer factor-2. J Mol Biol. 2005;345:91-102 pubmed
..have characterized the complex between the MEF2-binding motif of class II HDACs and the MADS-box/MEF2S domain of MEF2B by structural and biochemical methods...
Gregoire S, Xiao L, Nie J, Zhang X, Xu M, Li J, et al
. Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2. Mol Cell Biol. 2007;27:1280-95 pubmed
..These results reveal an unexpected role for HDAC3 and suggest a novel pathway through which MEF2 activity is controlled in vivo. ..