Gene Symbol: Mcm6
Description: minichromosome maintenance complex component 6
Alias: Mcmd6, DNA replication licensing factor MCM6, intestinal DNA replication protein, mini chromosome maintenance deficient 6, minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe)
Species: rat
Products:     Mcm6

Top Publications

  1. Ishimi Y. A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex. J Biol Chem. 1997;272:24508-13 pubmed
    ..These results suggest that this helicase may be involved in the initiation of DNA replication as a DNA unwinding enzyme. ..
  2. Sykes D, Weiser M. Rat intestinal crypt-cell replication factor with homology to early S-phase proteins required for cell division. Gene. 1995;163:243-7 pubmed
    ..Isolation and functional characterization of small intestinal crypt-cell replication factors should help explain this organ's low incidence of cancer. ..
  3. Tsuji T, Ficarro S, Jiang W. Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells. Mol Biol Cell. 2006;17:4459-72 pubmed
    ..Taken together, these results indicate that Cdc7/Dbf4 phosphorylation of MCM2 is essential for the initiation of DNA replication in mammalian cells. ..
  4. Sakwe A, Nguyen T, Athanasopoulos V, Shire K, Frappier L. Identification and characterization of a novel component of the human minichromosome maintenance complex. Mol Cell Biol. 2007;27:3044-55 pubmed
    ..The results indicate that multicellular eukaryotes contain two types of hexameric MCM complexes with unique properties and functions. ..
  5. Akiyama K, Morita H, Suetsugu S, Kuraba S, Numata Y, Yamamoto Y, et al. Actin -related protein 3 (Arp3) is mutated in proteinuric BUF/Mna rats. Mamm Genome. 2008;19:41-50 pubmed
    ..Taken together, these data suggest that Arp3 is a candidate for the Pur1 gene. This observation is consistent with our growing recognition that abnormal signaling-induced assembly of actin in podocytes leads to the development of FSGS. ..
  6. Fang R, Santiago N, Olds L, Sibley E. The homeodomain protein Cdx2 regulates lactase gene promoter activity during enterocyte differentiation. Gastroenterology. 2000;118:115-27 pubmed
    ..In contrast to a previous report, Cdx2 interaction with the lactase promoter correlates with enterocyte differentiation. These conclusions are consistent with the role of Cdx2 in regulating intestinal cell differentiation. ..
  7. Olds L, Sibley E. Lactase persistence DNA variant enhances lactase promoter activity in vitro: functional role as a cis regulatory element. Hum Mol Genet. 2003;12:2333-40 pubmed
    ..Such differential regulation by the C and T variants is consistent with a causative role in the mechanism specifying the lactase persistence/non-persistence phenotypes in humans. ..
  8. You Z, Masai H. DNA binding and helicase actions of mouse MCM4/6/7 helicase. Nucleic Acids Res. 2005;33:3033-47 pubmed
    ..Taken together, these findings reveal important features on activation and substrate preference of the eukaryotic replicative helicase. ..