Gene Symbol: Mcm2
Description: minichromosome maintenance complex component 2
Alias: DNA replication licensing factor MCM2, minichromosome maintenance deficient 2 mitotin
Chen J, Huang Z, Ma J, Zhu J, Moratalla R, Standaert D, et al
. A(2A) adenosine receptor deficiency attenuates brain injury induced by transient focal ischemia in mice. J Neurosci. 1999;19:9192-200 pubmed
Gao J, Wang Q, Dong C, Chen S, Qi Y, Liu Y. Whole Exome Sequencing Identified MCM2 as a Novel Causative Gene for Autosomal Dominant Nonsyndromic Deafness in a Chinese Family. PLoS ONE. 2015;10:e0133522 pubmed publisher
..Using whole exome sequencing, we identified a missense variant (c.130C>T, p.R44C) in the MCM2 gene, which has a pro-apoptosis effect and is involved in the initiation of eukaryotic genome replication...
Geng Y, Yu Q, Sicinska E, Das M, Schneider J, Bhattacharya S, et al
. Cyclin E ablation in the mouse. Cell. 2003;114:431-43 pubmed
..These findings define a molecular function for E type cyclins in cell cycle reentry and reveal a differential requirement for cyclin E in normal versus oncogenic proliferation. ..
Zhang C, McNeil E, Dressler L, Siman R. Long-lasting impairment in hippocampal neurogenesis associated with amyloid deposition in a knock-in mouse model of familial Alzheimer's disease. Exp Neurol. 2007;204:77-87 pubmed
..In the 9-month-old dentate gyrus, the double knock-in mutations reduced the numbers of MCM2-positive neural stem and progenitor cells by 3-fold and doublecortin-positive neuroblasts by 2-fold...
Sakwe A, Nguyen T, Athanasopoulos V, Shire K, Frappier L. Identification and characterization of a novel component of the human minichromosome maintenance complex. Mol Cell Biol. 2007;27:3044-55 pubmed
..MCM-BP formed a complex with MCM3 to MCM7, which excluded MCM2; and, conversely, hexameric complexes of MCM2 to MCM7 lacked MCM-BP, indicating that MCM-BP can replace MCM2 in the ..
Sivilia S, Giuliani A, Del Vecchio G, Giardino L, Calza L. Age-dependent impairment of hippocampal neurogenesis in chronic cerebral hypoperfusion. Neuropathol Appl Neurobiol. 2008;34:52-61 pubmed
..2VO was performed in 3- and 12-month-old rats. Proliferation was investigated by bromodeoxyuridine uptake and MCM2 nuclear immunoreactivity, neurogenesis by counting doublecortin-IR cells in the subgranular area of the dentate ..
Tsuji T, Ficarro S, Jiang W. Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells. Mol Biol Cell. 2006;17:4459-72 pubmed
We report the identification of Cdc7/Dbf4 phosphorylation sites in human MCM2 and the determination of the role of Cdc7/Dbf4 phosphorylation of MCM2 in the initiation of DNA replication...
Bonda D, Evans T, Santocanale C, Llosá J, Vina J, Bajic V, et al
. Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in Alzheimer disease. Aging (Albany NY). 2009;1:382-8 pubmed
..We found phosphorylated Mcm2 (pMcm2) markedly associated with neurofibrillary tangles, neuropil threads, and dystrophic neurites in AD but not ..
Vannier J, Sandhu S, Petalcorin M, Wu X, Nabi Z, Ding H, et al
. RTEL1 is a replisome-associated helicase that promotes telomere and genome-wide replication. Science. 2013;342:239-42 pubmed publisher
..We propose that RTEL1 plays a critical role in both telomere and genome-wide replication, which is crucial for genetic stability and tumor avoidance. ..