Gene Symbol: Mc2r
Description: melanocortin 2 receptor
Alias: adrenocorticotropic hormone receptor, melanocortin 2 receptor (adrenocorticotropic hormone)
Species: rat
Products:     Mc2r

Top Publications

  1. Müller H, Kröger J, Jöhren O, Szymczak S, Bader M, Dominiak P, et al. Stress sensitivity is increased in transgenic rats with low brain angiotensinogen. J Endocrinol. 2010;204:85-92 pubmed publisher
    ..Using quantitative real-time PCR, we found increased mRNA levels of melanocortin 2 (Mc2r) and AT(2) receptors (Agtr2) in the adrenals of TGR(ASrAOGEN), whereas mRNA levels of Crh, Pomc, and AT(1) ..
  2. Shah A, Kriska T, Gauthier K, Falck J, Campbell W. Effect of Angiotensin II and ACTH on Adrenal Blood Flow in the Male Rat Adrenal Gland In Vivo. Endocrinology. 2018;159:217-226 pubmed publisher
    ..The increases in ABF induced by Ang II are mediated by release of NO and EETs, whereas ABF increases with ACTH are mediated by EETs only. ..
  3. Izumi S, Abe K, Hayashi T, Nakane P, Koji T. Immunohistochemical localization of the ACTH (MC-2) receptor in the rat placenta and adrenal gland. Arch Histol Cytol. 2004;67:443-53 pubmed
    ..Our findings suggest that ACTHR may play a physiological role in steroidogenesis in the adrenal cortical parenchymal cells as well as in the trophoblasts of rat placentas during mid-late gestation. ..
  4. Liu Z, He B, Fang F, Tang C, Zou L. Genetic polymorphisms of MC2R gene associated with responsiveness to adrenocorticotropic hormone therapy in infantile spasms. Chin Med J (Engl). 2008;121:1627-32 pubmed
    ..This study was to elucidate the possible associations between the variations of the MC2R gene and ACTH responsiveness in patients with infantile spasms...
  5. Abe S, Matsumi M, Tsukioki M, Mizukawa S, Takahashi T, Iijima Y, et al. Metallothionein and zinc metabolism in endotoxin shock rats. Experientia Suppl. 1987;52:587-94 pubmed
    ..The effect of zinc on superoxide generation of polymorphonuclear leukocytes was also studied. Zinc was found to inhibit superoxide generation dose-dependently. ..
  6. Piedboeuf B, Johnston C, Watkins R, Hudak B, Lazo J, Cherian M, et al. Increased expression of tissue inhibitor of metalloproteinases (TIMP-I) and metallothionein in murine lungs after hyperoxic exposure. Am J Respir Cell Mol Biol. 1994;10:123-32 pubmed
    ..The strong spatial correlation between the presence of localized inflammation and increased TIMP-I and MT expression further supports the importance of TIMP-I and MT in acute lung injury. ..
  7. Chan L, Webb T, Chung T, Meimaridou E, Cooray S, Guasti L, et al. MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family. Proc Natl Acad Sci U S A. 2009;106:6146-51 pubmed publisher
    ..b>MC2R is a critical component of the hypothalamic-pituitary-adrenal axis, whereas MC3R and MC4R have an essential role in ..
  8. Ding Y, Zou L, He B, Yue W, Liu Z, Zhang D. ACTH receptor (MC2R) promoter variants associated with infantile spasms modulate MC2R expression and responsiveness to ACTH. Pharmacogenet Genomics. 2010;20:71-6 pubmed publisher
    ..However, the mechanism of ACTH therapy is still unclear. ACTH exerts the function via melanocortin 2 receptor (MC2R)...
  9. Flück C, Martens J, Conte F, Miller W. Clinical, genetic, and functional characterization of adrenocorticotropin receptor mutations using a novel receptor assay. J Clin Endocrinol Metab. 2002;87:4318-23 pubmed
    The ACTH receptor (MC2R) is expressed predominantly in the adrenal cortex, but is one of five G protein-coupled, seven-transmembrane melanocortin receptors (MCRs), all of which bind ACTH to some degree...

More Information


  1. Catania A, Lonati C, Sordi A, Carlin A, Leonardi P, Gatti S. The melanocortin system in control of inflammation. ScientificWorldJournal. 2010;10:1840-53 pubmed publisher
    ..This review examines the main signaling circuits in anti-inflammatory and immunomodulatory actions of melanocortins, and the potential therapeutic use of these molecules. ..
  2. Cai G, Ziko I, Barwood J, Soch A, Sominsky L, Molero J, et al. Overfeeding during a critical postnatal period exacerbates hypothalamic-pituitary-adrenal axis responses to immune challenge: a role for adrenal melanocortin 2 receptors. Sci Rep. 2016;6:21097 pubmed publisher
    ..On the other hand, expression of the adrenal melanocortin 2 receptor (MC2R) is elevated after LPS in control rats, but significantly less so in the neonatally overfed...
  3. Nankova B, Kvetnansky R, Sabban E. Adrenocorticotropic hormone (MC-2) receptor mRNA is expressed in rat sympathetic ganglia and up-regulated by stress. Neurosci Lett. 2003;344:149-52 pubmed
    ..The results provide the first evidence that rat sympathetic ganglia express MC-2 receptor gene and are a target tissue for the peripheral actions of ACTH in response to stress. ..
  4. Reyes B, Valentino R, Van Bockstaele E. Stress-induced intracellular trafficking of corticotropin-releasing factor receptors in rat locus coeruleus neurons. Endocrinology. 2008;149:122-30 pubmed
  5. Clark A, McLoughlin L, Grossman A. Familial glucocorticoid deficiency associated with point mutation in the adrenocorticotropin receptor. Lancet. 1993;341:461-2 pubmed
    ..This is only the second clinical disorder associated with a GTP-binding-protein-linked hormone-receptor mutation. ..
  6. Malik I, Triebel J, Posselt J, Khan S, Ramadori P, Raddatz D, et al. Melanocortin receptors in rat liver cells: change of gene expression and intracellular localization during acute-phase response. Histochem Cell Biol. 2012;137:279-91 pubmed publisher
    ..Due to the presence of specific ligands in the serum, they may mediate metabolic changes and exert a protective effect on liver cells. ..