Mbd2

Summary

Gene Symbol: Mbd2
Description: methyl-CpG binding domain protein 2
Alias: methyl-CpG-binding domain protein 2
Species: rat
Products:     Mbd2

Top Publications

  1. Hendrich B, Bird A. Identification and characterization of a family of mammalian methyl-CpG binding proteins. Mol Cell Biol. 1998;18:6538-47 pubmed
    ..We describe here three novel human and mouse proteins (MBD2, MBD3, and MBD4) that contain the methyl-CpG binding domain...
  2. Pan J, Wang C, Yu Q, Zhang S, Li B, Hu J. Effect of Methyl-CpG binding domain protein 2 (MBD2) on AMD-like lesions in ApoE-deficient mice. J Huazhong Univ Sci Technolog Med Sci. 2014;34:408-414 pubmed publisher
    The role of methyl-CpG binding domain protein 2 (MBD2) in an ApoE-deficient mouse model of age-related macular degeneration (AMD) was investigated...
  3. Buck Koehntop B, Defossez P. On how mammalian transcription factors recognize methylated DNA. Epigenetics. 2013;8:131-7 pubmed publisher
    ..These fresh insights have consequences for the analysis of the many other zinc finger proteins present in the genome, and for the biology of methyl-CpG binding zinc finger proteins. ..
  4. Rupon J, Wang S, Gaensler K, Lloyd J, Ginder G. Methyl binding domain protein 2 mediates gamma-globin gene silencing in adult human betaYAC transgenic mice. Proc Natl Acad Sci U S A. 2006;103:6617-22 pubmed
    ..We describe here a role for DNA methylation and MBD2 in the silencing of the human fetal gamma-globin gene...
  5. Sekimata M, Takahashi A, Murakami Sekimata A, Homma Y. Involvement of a novel zinc finger protein, MIZF, in transcriptional repression by interacting with a methyl-CpG-binding protein, MBD2. J Biol Chem. 2001;276:42632-8 pubmed
    b>MBD2, a methyl-CpG-binding protein, is a component of the MeCP1 histone deacetylase (HDAC) complex and plays a critical role in DNA methylation-mediated transcriptional repression...
  6. Yuan K, Xie K, Fox J, Zeng H, Gao H, Huang C, et al. Decreased levels of miR-224 and the passenger strand of miR-221 increase MBD2, suppressing maspin and promoting colorectal tumor growth and metastasis in mice. Gastroenterology. 2013;145:853-64.e9 pubmed publisher
    ..We identified the 3' untranslated region of MBD2 messenger RNA as a target of miR-221* and miR-224...
  7. Phesse T, Parry L, Reed K, Ewan K, Dale T, Sansom O, et al. Deficiency of Mbd2 attenuates Wnt signaling. Mol Cell Biol. 2008;28:6094-103 pubmed publisher
    We have previously shown that deficiency of the methyl binding domain protein Mbd2 dramatically reduces adenoma burden on an Apc(Min/+) background...
  8. Xie B, Yu Y, Meng X, Yu Q, Shi J, Sang H, et al. Genetic association study between methyl-CpG-binding domain genes and schizophrenia among Chinese family trios. Psychiatr Genet. 2014;24:221-4 pubmed publisher
    ..Four tag SNPs on MBD1 (rs125555, rs140689, rs140687, and rs140686), three tag SNPs on MBD2 (rs3876254, rs7614, and rs1145317), and three tag SNPs on MBD3 (rs7252741, rs4807934, and rs4807122) genes were ..
  9. Tang W, Morey L, Cheung Y, Birch L, Prins G, Ho S. Neonatal exposure to estradiol/bisphenol A alters promoter methylation and expression of Nsbp1 and Hpcal1 genes and transcriptional programs of Dnmt3a/b and Mbd2/4 in the rat prostate gland throughout life. Endocrinology. 2012;153:42-55 pubmed publisher
    ..including genes encoding de novo DNA methyltransferases (Dnmt3a/b) and methyl-CpG binding domain proteins (Mbd2/4) that have demethylating activities...

More Information

Publications25

  1. Jeffery L, Nakielny S. Components of the DNA methylation system of chromatin control are RNA-binding proteins. J Biol Chem. 2004;279:49479-87 pubmed
    ..The RNA and methyl-CG binding properties of the MBD proteins are mutually exclusive. We speculate that DNMTs and MBD proteins allow RNA molecules to participate in DNA methylation-mediated chromatin control. ..
  2. Ghoshal K, Li X, Datta J, Bai S, Pogribny I, Pogribny M, et al. A folate- and methyl-deficient diet alters the expression of DNA methyltransferases and methyl CpG binding proteins involved in epigenetic gene silencing in livers of F344 rats. J Nutr. 2006;136:1522-7 pubmed
    ..001) in the deficient rats. In both diet groups, hepatic MBD2 protein decreased (P < 0.001), whereas MeCP2 protein increased (P < 0.001) with age...
  3. Liu C, Fang T, Ou T, Wu C, Li R, Lin Y, et al. Global DNA methylation, DNMT1, and MBD2 in patients with rheumatoid arthritis. Immunol Lett. 2011;135:96-9 pubmed publisher
    ..levels and mRNA expressions of DNA cytosine-5-methyltransferase 1 (DNMT1) and methyl CpG-binding domain 2 (MBD2) with rheumatoid arthritis (RA)...
  4. Guy J, Hendrich B, Holmes M, Martin J, Bird A. A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome. Nat Genet. 2001;27:322-6 pubmed
  5. Kou C, Lau S, Au K, Leung P, Chim S, Fung K, et al. Epigenetic regulation of neonatal cardiomyocytes differentiation. Biochem Biophys Res Commun. 2010;400:278-83 pubmed publisher
    ..Therefore, we suggest that a hypermethylated genome and a more compact chromatin structure are formed during terminal differentiation of cardiomyocytes. ..
  6. Kovacheva V, Mellott T, Davison J, Wagner N, Lopez Coviella I, Schnitzler A, et al. Gestational choline deficiency causes global and Igf2 gene DNA hypermethylation by up-regulation of Dnmt1 expression. J Biol Chem. 2007;282:31777-88 pubmed
    ..Moreover, mRNA expression of brain and liver Dnmt3a and methyl CpG-binding domain 2 (Mbd2) protein as well as cerebral Dnmt3l was inversely correlated to the intake of choline...
  7. Ruddock D Cruz N, Xue J, Wilson K, Heffernan C, Prashadkumar S, Cooney M, et al. Dynamic changes in the localization of five members of the methyl binding domain (MBD) gene family during murine and bovine preimplantation embryo development. Mol Reprod Dev. 2008;75:48-59 pubmed
    ..b>MBD2 was not expressed in murine or bovine oocytes and MeCP2 was not detected in murine blastocysts, subcellular protein ..
  8. Jung B, Zhang G, Ho W, Francis J, Eubanks J. Transient forebrain ischemia alters the mRNA expression of methyl DNA-binding factors in the adult rat hippocampus. Neuroscience. 2002;115:515-24 pubmed
    ..This delayed pattern of induction is in contrast to the responses of MBD2 and MBD3...
  9. Francis J, Jung B, Zhang G, Cheng J, Ho W, Burnham W, et al. Kindling induces the mRNA expression of methyl DNA-binding factors in the adult rat hippocampus. Neuroscience. 2002;113:79-87 pubmed
    ..the gene expression responses of a family of methyl CpG-binding domain-containing factors (MeCP2, MBD1, MBD2, and MBD3) in the hippocampus of electrically kindled rats...
  10. Jung B, Zhang G, Nitsch R, Trogadis J, Nag S, Eubanks J. Differential expression of methyl CpG-binding domain containing factor MBD3 in the developing and adult rat brain. J Neurobiol. 2003;55:220-32 pubmed
    ..This is in contrast to its related family member MBD2, which displayed only minimal expression in the embryonic brain...
  11. Basta J, Rauchman M. The nucleosome remodeling and deacetylase complex in development and disease. Transl Res. 2015;165:36-47 pubmed publisher
    ..Recent genetic and biochemical studies have elucidated the mechanisms of NuRD action in modifying the chromatin landscape. These advances have the potential to lead to new therapeutic approaches to birth defects and cancer. ..
  12. Hendrich B, Guy J, Ramsahoye B, Wilson V, Bird A. Closely related proteins MBD2 and MBD3 play distinctive but interacting roles in mouse development. Genes Dev. 2001;15:710-23 pubmed
    b>MBD2 and MBD3 are closely related proteins with consensus methyl-CpG binding domains. MBD2 is a transcriptional repressor that specifically binds to methylated DNA and is a component of the MeCP1 protein complex...
  13. Kantor B, Makedonski K, Shemer R, Razin A. Expression and localization of components of the histone deacetylases multiprotein repressory complexes in the mouse preimplantation embryo. Gene Expr Patterns. 2003;3:697-702 pubmed
    ..MBD3 is a component of the HDAC associated chromatin remodeling complex Mi2/NuRD. The addition of MBD2 to the Mi2/NuRD complex creates MeCP1, a complex that is known to inactivate methylated promoters...
  14. Wu X, Sun J, Li L. Chronic cerebrovascular hypoperfusion affects global DNA methylation and histone acetylation in rat brain. Neurosci Bull. 2013;29:685-92 pubmed publisher
    ..The expressions of DNA methyltransferase 1/3a (DNMT1/3a), methyl-CpG binding domain protein 2 (MBD2), histone deacetylase 3 (HDAC3) and acetyltransferase (HAT) were assessed by Western blot...
  15. Cramer J, Scarsdale J, Walavalkar N, Buchwald W, Ginder G, Williams D. Probing the dynamic distribution of bound states for methylcytosine-binding domains on DNA. J Biol Chem. 2014;289:1294-302 pubmed publisher
    ..The highly homologous MBD2 protein shows similar but much stronger localization to methylated as well as unmethylated CpGs...
  16. Weaver I, Hellstrom I, Brown S, Andrews S, Dymov S, Diorio J, et al. The methylated-DNA binding protein MBD2 enhances NGFI-A (egr-1)-mediated transcriptional activation of the glucocorticoid receptor. Philos Trans R Soc Lond B Biol Sci. 2014;369: pubmed publisher
    ..GR expression, paradoxically increases hippocampal expression of the methyl-CpG binding domain protein-2 (MBD2) and MBD2 binding to the exon 17 GR promoter...