Gene Symbol: Mat2a
Description: methionine adenosyltransferase 2A
Alias: Sams2, S-adenosylmethionine synthase isoform type-2, MAT 2, MAT-II, S-adenosylmethionine synthetase isoform type-2, adoMet synthase 2, adoMet synthetase 2, methionine adenosyltransferase 2, methionine adenosyltransferase II, alpha, non-hepatic-type S-adenosylmethionine synthetase
Species: rat
Products:     Mat2a

Top Publications

  1. Lu S, Huang Z, Yang H, Mato J, Avila M, Tsukamoto H. Changes in methionine adenosyltransferase and S-adenosylmethionine homeostasis in alcoholic rat liver. Am J Physiol Gastrointest Liver Physiol. 2000;279:G178-85 pubmed
    Liver-specific and non-liver-specific methionine adenosyltransferase (MAT) are products of two genes, MAT1A and MAT2A, respectively, that catalyze the formation of S-adenosylmethionine (SAM)...
  2. Lu S, Mato J. S-adenosylmethionine in liver health, injury, and cancer. Physiol Rev. 2012;92:1515-42 pubmed publisher
    ..In mammals, two genes, MAT1A that is largely expressed by normal liver and MAT2A that is expressed by all extrahepatic tissues, encode MAT...
  3. Frau M, Tomasi M, Simile M, Demartis M, Salis F, Latte G, et al. Role of transcriptional and posttranscriptional regulation of methionine adenosyltransferases in liver cancer progression. Hepatology. 2012;56:165-75 pubmed publisher
    ..gene, encoding S-adenosylmethionine (SAM) synthesizing isozymes MATI/III, and up-regulation of widely expressed MAT2A, encoding MATII isozyme, known as MAT1A:MAT2A switch, occurs in hepatocellular carcinoma (HCC)...
  4. Perez C, Pérez Zúñiga F, Garrido F, Reytor E, Portillo F, Pajares M. The Oncogene PDRG1 Is an Interaction Target of Methionine Adenosyltransferases. PLoS ONE. 2016;11:e0161672 pubmed publisher
    ..result in a reduced content of the moderate (MAT I) and high Vmax (MAT III) isoenzymes, whereas the low Vmax (MAT II) isoenzyme increases and nuclear accumulation of MAT I is observed...
  5. LeGros H, Halim A, Geller A, Kotb M. Cloning, expression, and functional characterization of the beta regulatory subunit of human methionine adenosyltransferase (MAT II). J Biol Chem. 2000;275:2359-66 pubmed
    b>MAT II, the extrahepatic form of methionine adenosyltransferase (MAT), consists of catalytic alpha(2)/alpha(2') subunits and a noncatalytic beta subunit, believed to have a regulatory function...
  6. De la Rosa J, Ostrowski J, Hryniewicz M, Kredich N, Kotb M, LeGros H, et al. Chromosomal localization and catalytic properties of the recombinant alpha subunit of human lymphocyte methionine adenosyltransferase. J Biol Chem. 1995;270:21860-8 pubmed
    ..The data suggest that the alpha/alpha' subunits mediate the enzyme catalytic activity and that the beta subunit may be a regulatory subunit of extrahepatic MAT. ..
  7. García Trevijano E, Latasa M, Carretero M, Berasain C, Mato J, Avila M. S-adenosylmethionine regulates MAT1A and MAT2A gene expression in cultured rat hepatocytes: a new role for S-adenosylmethionine in the maintenance of the differentiated status of the liver. FASEB J. 2000;14:2511-8 pubmed
    ..MAT is the product of two different genes: MAT1A, which is expressed only in the adult liver, and MAT2A, which is widely distributed, expressed in the fetal liver, and replaces MAT1A in hepatocarcinoma...
  8. Hiroki T, Horikawa S, Tsukada K. Structure of the rat methionine adenosyltransferase 2A gene and its promoter. Eur J Biochem. 1997;250:653-60 pubmed
    ..expression, we isolated the rat MAT2A gene encoding MAT alpha2, the catalytic subunit of non-hepatic-type enzyme MAT II and characterized its structural organization and 5'-flanking region...
  9. Rodriguez J, Boukaba A, Sandoval J, Georgieva E, Latasa M, García Trevijano E, et al. Transcription of the MAT2A gene, coding for methionine adenosyltransferase, is up-regulated by E2F and Sp1 at a chromatin level during proliferation of liver cells. Int J Biochem Cell Biol. 2007;39:842-50 pubmed
    ..Two MAT-encoding genes (MAT1A, MAT2A) are found in mammals...

More Information


  1. Hinojos C, Boerwinkle E, Fornage M, Doris P. Combined genealogical, mapping, and expression approaches to identify spontaneously hypertensive rat hypertension candidate genes. Hypertension. 2005;45:698-704 pubmed
    ..The present approach identifies a number of genes that may influence blood pressure in SHR by virtue of allelic effects on gene expression. ..
  2. Vazquez Chantada M, Fernandez Ramos D, Embade N, Martínez López N, Varela Rey M, Woodhoo A, et al. HuR/methyl-HuR and AUF1 regulate the MAT expressed during liver proliferation, differentiation, and carcinogenesis. Gastroenterology. 2010;138:1943-53 pubmed publisher
    ..are tightly regulated by 2 genes: methionine adenosyltransferase 1A (MAT1A) and methionine adenosyltransferase 2A (MAT2A)...
  3. Murray B, Antonyuk S, Marina A, van Liempd S, Lu S, Mato J, et al. Structure and function study of the complex that synthesizes S-adenosylmethionine. IUCrJ. 2014;1:240-9 pubmed publisher
    ..It is tightly linked with cell proliferation in liver and colon cancer. In humans, there are three genes, mat1A, mat2A and mat2B, which encode MAT enzymes...
  4. Horikawa S, Sasuga J, Shimizu K, Ozasa H, Tsukada K. Molecular cloning and nucleotide sequence of cDNA encoding the rat kidney S-adenosylmethionine synthetase. J Biol Chem. 1990;265:13683-6 pubmed
    ..Thus, kidney- and liver-type S-adenosylmethionine synthetase isozyme mRNAs were expressed in various tissues with different tissue specificities. ..
  5. Farrar C, Clarke S. Altered levels of S-adenosylmethionine and S-adenosylhomocysteine in the brains of L-isoaspartyl (D-Aspartyl) O-methyltransferase-deficient mice. J Biol Chem. 2002;277:27856-63 pubmed
    ..Because changes in the AdoMet/AdoHcy ratio could potentially alter the overall excitatory state of the brain, this effect may play a role in the progressive epilepsy seen in the Pcmt1-/- mice. ..
  6. Paneda C, Gorospe I, Herrera B, Nakamura T, Fabregat I, Varela Nieto I. Liver cell proliferation requires methionine adenosyltransferase 2A mRNA up-regulation. Hepatology. 2002;35:1381-91 pubmed that, in H35 hepatoma cells, growth factors such as hepatocyte growth factor (HGF) and insulin up-regulated MAT2A expression. HGF actions were time- and dose-response dependent and required transcriptional activity...
  7. Kim J, Coon S, Blackshaw S, Cepko C, Møller M, Mukda S, et al. Methionine adenosyltransferase:adrenergic-cAMP mechanism regulates a daily rhythm in pineal expression. J Biol Chem. 2005;280:677-84 pubmed
    ..5-fold at night in the pineal gland. In this study, we found that pineal MAT2A mRNA and the protein it encodes, MAT II, also increase at night, suggesting that the increase in MAT activity is caused by an increase in MAT II gene ..
  8. Fang H, Lai J, Lin W, Lin W. A fermented substance from Aspergillus phoenicis reduces liver fibrosis induced by carbon tetrachloride in rats. Biosci Biotechnol Biochem. 2007;71:1154-61 pubmed
    ..These results clearly indicate that FSAP partially reduced the liver fibrosis in rats induced by CCl(4). ..
  9. Ramani K, Tomasi M. Transcriptional regulation of methionine adenosyltransferase 2A by peroxisome proliferator-activated receptors in rat hepatic stellate cells. Hepatology. 2012;55:1942-53 pubmed publisher
    ..The MAT2A gene, which encodes the catalytic subunit ?2, is induced in dedifferentiated liver...