Mapt

Summary

Gene Symbol: Mapt
Description: microtubule-associated protein tau
Alias: Mtapt, RNPTAU, Tau, pTau, microtubule-associated protein tau, PHF-tau, Tau microtubule-associated protein, neurofibrillary tangle protein, paired helical filament-tau
Species: rat
Products:     Mapt

Top Publications

  1. Goedert M, Spillantini M, Crowther R. Cloning of a big tau microtubule-associated protein characteristic of the peripheral nervous system. Proc Natl Acad Sci U S A. 1992;89:1983-7 pubmed
    Microtubule-associated protein tau consists in brain of a series of isoforms of 48- to 67-kDa apparent molecular mass that are encoded by mRNAs of approximately 6 kilobases (kb) and that are generated from a single gene by alternative ..
  2. Brandt R, Leger J, Lee G. Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain. J Cell Biol. 1995;131:1327-40 pubmed
    The neuronal microtubule-associated protein tau is required for the development of cell polarity in cultured neurons...
  3. Hutton M, Lendon C, Rizzu P, Baker M, Froelich S, Houlden H, et al. Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17. Nature. 1998;393:702-5 pubmed
    ..and/or glial inclusions that stain positively with antibodies raised against the microtubule-associated protein Tau, although the Tau pathology varies considerably in both its quantity (or severity) and characteristics...
  4. Maas T, Eidenmüller J, Brandt R. Interaction of tau with the neural membrane cortex is regulated by phosphorylation at sites that are modified in paired helical filaments. J Biol Chem. 2000;275:15733-40 pubmed
    The axonal microtubule-associated phosphoprotein tau interacts with neural plasma membrane (PM) components during neuronal development (Brandt, R., Léger, J., and Lee, G. (1995) J. Cell Biol. 131, 1327-1340)...
  5. Gómez Ramos A, Diaz Hernandez M, Rubio A, Miras Portugal M, Avila J. Extracellular tau promotes intracellular calcium increase through M1 and M3 muscarinic receptors in neuronal cells. Mol Cell Neurosci. 2008;37:673-81 pubmed publisher
    Extracellular tau promotes an increase in the level of intracellular calcium in cultured neuronal cells. We have found that such increase is impaired in the presence of antagonists of muscarinic receptors...
  6. Deng Y, Li B, Liu Y, Iqbal K, Grundke Iqbal I, Gong C. Dysregulation of insulin signaling, glucose transporters, O-GlcNAcylation, and phosphorylation of tau and neurofilaments in the brain: Implication for Alzheimer's disease. Am J Pathol. 2009;175:2089-98 pubmed publisher
    ..we investigated insulin signaling, glucose transporters, protein O-GlcNAcylation, and phosphorylation of tau and neurofilaments in the brain...
  7. Garwood C, Pooler A, Atherton J, Hanger D, Noble W. Astrocytes are important mediators of A?-induced neurotoxicity and tau phosphorylation in primary culture. Cell Death Dis. 2011;2:e167 pubmed publisher
    ..characterised by the age-dependent deposition of ?-amyloid (A?) in senile plaques, intraneuronal accumulation of tau as neurofibrillary tangles, synaptic dysfunction and neuronal death...
  8. Lee G, Newman S, Gard D, Band H, Panchamoorthy G. Tau interacts with src-family non-receptor tyrosine kinases. J Cell Sci. 1998;111 ( Pt 21):3167-77 pubmed
    b>Tau and other microtubule-associated proteins promote the assembly and stabilization of neuronal microtubules. While each microtubule-associated protein has distinct properties, their in vivo roles remain largely unknown...
  9. Hanger D, Byers H, Wray S, Leung K, Saxton M, Seereeram A, et al. Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis. J Biol Chem. 2007;282:23645-54 pubmed
    b>Tau in Alzheimer disease brain is highly phosphorylated and aggregated into paired helical filaments comprising characteristic neurofibrillary tangles...

More Information

Publications101 found, 100 shown here

  1. Ittner L, Ke Y, Delerue F, Bi M, Gladbach A, van Eersel J, et al. Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models. Cell. 2010;142:387-97 pubmed publisher
    Alzheimer's disease (AD) is characterized by amyloid-beta (Abeta) and tau deposition in brain. It has emerged that Abeta toxicity is tau dependent, although mechanistically this link remains unclear...
  2. Butner K, Kirschner M. Tau protein binds to microtubules through a flexible array of distributed weak sites. J Cell Biol. 1991;115:717-30 pubmed
    b>Tau protein plays a role in the extension and maintenance of neuronal processes through a direct association with microtubules...
  3. Chen Y. Specific tau phosphorylation sites in hippocampus correlate with impairment of step-down inhibitory avoidance task in rats. Behav Brain Res. 2005;158:277-84 pubmed
    b>Microtubule associated protein tau is abnormally phosphorylated in Alzheimer's disease (AD) and aggregates as paired helical filaments (PHFs) in neurofibrillary tangles (NFTs), which are one of the pathological signatures of AD and their ..
  4. Vandrovcova J, Pittman A, Malzer E, Abou Sleiman P, Lees A, Wood N, et al. Association of MAPT haplotype-tagging SNPs with sporadic Parkinson's disease. Neurobiol Aging. 2009;30:1477-82 pubmed
    Mutations in the tau gene (MAPT) have been found in families with frontotemporal dementia with parkinsonism linked to chromosome 17...
  5. Lu Y, Li T, Qureshi H, Han D, Paudel H. Early growth response 1 (Egr-1) regulates phosphorylation of microtubule-associated protein tau in mammalian brain. J Biol Chem. 2011;286:20569-81 pubmed publisher
    In the normal brain, tau protein is phosphorylated at a number of proline- and non-proline directed sites, which reduce tau microtubule binding and thus regulate microtubule dynamics...
  6. Weingarten M, Lockwood A, Hwo S, Kirschner M. A protein factor essential for microtubule assembly. Proc Natl Acad Sci U S A. 1975;72:1858-62 pubmed
    A heat stable protein essentail for microtubule assembly has been isolated. This protein, which we designate tau (tau), is present in association with tubulin purified from porcine brain by repeated cycles of polymerization...
  7. Pickering Brown S, Baker M, Yen S, Liu W, Hasegawa M, Cairns N, et al. Pick's disease is associated with mutations in the tau gene. Ann Neurol. 2000;48:859-67 pubmed
    Recently, mutations within the tau gene have been associated with some familial forms of frontotemporal dementia...
  8. Acosta S, Tajiri N, Sanberg P, Kaneko Y, Borlongan C. Increased Amyloid Precursor Protein and Tau Expression Manifests as Key Secondary Cell Death in Chronic Traumatic Brain Injury. J Cell Physiol. 2017;232:665-677 pubmed publisher
    ..001). Surrogate AD-like phenotypic markers revealed a significant accumulation of phosphorylated tau (AT8) and oligomeric tau (T22) within the neuronal cell bodies in ipsilateral and contralateral cortex, and dentate ..
  9. Canudas A, Gutierrez Cuesta J, Rodríguez M, Acuna Castroviejo D, Sureda F, Camins A, et al. Hyperphosphorylation of microtubule-associated protein tau in senescence-accelerated mouse (SAM). Mech Ageing Dev. 2005;126:1300-4 pubmed
    b>Tau is a neuronal microtubule-associated protein found predominantly on axons. Tau phosphorylation regulates both normal and pathological functions of this protein...
  10. Filipek A, Schneider G, Mietelska A, Figiel I, Niewiadomska G. Age-dependent changes in neuronal distribution of CacyBP/SIP: comparison to tubulin and the tau protein. J Neural Transm (Vienna). 2008;115:1257-64 pubmed publisher
    ..neurons and in brain neurons of young and aged rats, and compared this localization with that of tubulin and the tau protein...
  11. Tan W, Cao X, Wang J, Lv H, Wu B, Ma H. Protective effects of lithium treatment for spatial memory deficits induced by tau hyperphosphorylation in splenectomized rats. Clin Exp Pharmacol Physiol. 2010;37:1010-5 pubmed publisher
    ..used a splenectomized rat model with postoperative spatial learning and memory deficits to investigate the role of tau hyperphosphorylation and glycogen synthase kinase-3? (GSK-3?) within the hippocampus. 2...
  12. Barbato C, Corbi N, Canu N, Fanciulli M, Serafino A, Ciotti M, et al. Rb binding protein Che-1 interacts with Tau in cerebellar granule neurons. Modulation during neuronal apoptosis. Mol Cell Neurosci. 2003;24:1038-50 pubmed
    ..We have investigated the expression of Che-1 in neuronal cells and we showed that Che-1 directly interacts with Tau. Tau is a microtubule-associated protein involved in the assembly and stabilization of neuronal microtubules ..
  13. Martin L, Magnaudeix A, Esclaire F, Yardin C, Terro F. Inhibition of glycogen synthase kinase-3beta downregulates total tau proteins in cultured neurons and its reversal by the blockade of protein phosphatase-2A. Brain Res. 2009;1252:66-75 pubmed publisher
    In tauopathies such as Alzheimer's disease (AD), the molecular mechanisms of tau protein aggregation into neurofibrillary tangles (NFTs) and their contribution to neurodegeneration remain not understood...
  14. Wang Z, Udeshi N, O Malley M, Shabanowitz J, Hunt D, Hart G. Enrichment and site mapping of O-linked N-acetylglucosamine by a combination of chemical/enzymatic tagging, photochemical cleavage, and electron transfer dissociation mass spectrometry. Mol Cell Proteomics. 2010;9:153-60 pubmed publisher
    ..Using this strategy, eight O-GlcNAc sites were mapped from a tau-enriched sample from rat brain...
  15. Fuster Matanzo A, de Barreda E, Dawson H, Vitek M, Avila J, Hernandez F. Function of tau protein in adult newborn neurons. FEBS Lett. 2009;583:3063-8 pubmed publisher
    Levels of tau phosphorylation are high during the developmental period of intense neurite outgrowth, but decrease later. We here investigated whether tau protein plays a role in adult neurogenesis...
  16. Tian F, Guo T, Dang J, Ma Y, Chen J, Chen Y, et al. [Involvement of Cdk5/p35 and tau protein in the hippocampal mossy fiber sprouting in the PTZ kindling model]. Zhonghua Yi Xue Za Zhi. 2011;91:1197-202 pubmed
    To observe the expression of cyclin-dependent kinase 5 (Cdk5), p35, tau protein and the activity of Cdk5 in rat hippocampus during pentylenetetrazole (PTZ) kindling process and their correlation with mossy fiber sprouting (MFS) so as to ..
  17. Rodríguez Vázquez J, Camacho Arroyo I, Velazquez Moctezuma J. Differential impact of REM sleep deprivation on cytoskeletal proteins of brain regions involved in sleep regulation. Neuropsychobiology. 2012;65:161-7 pubmed publisher
    ..In this study, the effects of REMSD on the content of the cytoskeletal proteins MAP2 and TAU were analyzed. Adult female rats were submitted to selective REMSD by using the multiple platform technique...
  18. Mondragón Rodríguez S, Trillaud Doppia E, Dudilot A, Bourgeois C, Lauzon M, Leclerc N, et al. Interaction of endogenous tau protein with synaptic proteins is regulated by N-methyl-D-aspartate receptor-dependent tau phosphorylation. J Biol Chem. 2012;287:32040-53 pubmed publisher
    Amyloid-? and tau protein are the two most prominent factors in the pathology of Alzheimer disease. Recent studies indicate that phosphorylated tau might affect synaptic function...
  19. Liu J, Liu Z, Zhang Y, Yin F. Leptin signaling plays a critical role in the geniposide-induced decrease of tau phosphorylation. Acta Biochim Biophys Sin (Shanghai). 2015;47:1018-22 pubmed publisher
    ..But the role played by geniposide in the phosphorylation of tau and its underlying molecular mechanisms remain unclear...
  20. Caceres A, Mautino J, Kosik K. Suppression of MAP2 in cultured cerebellar macroneurons inhibits minor neurite formation. Neuron. 1992;9:607-18 pubmed
    ..The small but significant increase in acetylated microtubules was not affected. In contrast, the suppression of tau, which selectively blocks axonal elongation, completely prevented the increase of acetylated microtubules, but did ..
  21. Ferreira A, Busciglio J, Caceres A. Microtubule formation and neurite growth in cerebellar macroneurons which develop in vitro: evidence for the involvement of the microtubule-associated proteins, MAP-1a, HMW-MAP2 and Tau. Brain Res Dev Brain Res. 1989;49:215-28 pubmed
    ..On the other hand, Tau expression and accumulation follows a time course identical to that of the induction of stable microtubules; ..
  22. Lewis J, Dickson D, Lin W, Chisholm L, Corral A, Jones G, et al. Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. Science. 2001;293:1487-91 pubmed
    JNPL3 transgenic mice expressing a mutant tau protein, which develop neurofibrillary tangles and progressive motor disturbance, were crossed with Tg2576 transgenic mice expressing mutant beta-amyloid precursor protein (APP), thus ..
  23. Yang Y, Lin C, Lee E. Serum- and glucocorticoid-inducible kinase 1 (SGK1) increases neurite formation through microtubule depolymerization by SGK1 and by SGK1 phosphorylation of tau. Mol Cell Biol. 2006;26:8357-70 pubmed
    ..Second, SGK1 indirectly depolymerized MTs through the phosphorylation of tau at Ser214. An in vitro kinase assay revealed that active SGK1 phosphorylated tau Ser214 specifically...
  24. Bullmann T, Holzer M, Mori H, Arendt T. Pattern of tau isoforms expression during development in vivo. Int J Dev Neurosci. 2009;27:591-7 pubmed publisher
    ..axonal growth during development are correlated to specific expression of various microtubule-associated protein tau isoforms...
  25. Allyson J, Dontigny E, Auberson Y, Cyr M, Massicotte G. Blockade of NR2A-containing NMDA receptors induces Tau phosphorylation in rat hippocampal slices. Neural Plast. 2010;2010:340168 pubmed publisher
    ..of NR2A and NR2B subunits in the modulatory effect of basal NMDA receptor activity on the phosphorylation of Tau proteins...
  26. Vossel K, Zhang K, Brodbeck J, Daub A, Sharma P, Finkbeiner S, et al. Tau reduction prevents Abeta-induced defects in axonal transport. Science. 2010;330:198 pubmed publisher
    Amyloid-? (A?) peptides, derived from the amyloid precursor protein, and the microtubule-associated protein tau are key pathogenic factors in Alzheimer's disease (AD). How exactly they impair cognitive functions is unknown...
  27. Sultan A, Nesslany F, Violet M, Bégard S, Loyens A, Talahari S, et al. Nuclear tau, a key player in neuronal DNA protection. J Biol Chem. 2011;286:4566-75 pubmed publisher
    b>Tau, a neuronal protein involved in neurodegenerative disorders such as Alzheimer disease, which is primarily described as a microtubule-associated protein, has also been observed in the nuclei of neuronal and non-neuronal cells...
  28. Schaeffer V, Goedert M. Stimulation of autophagy is neuroprotective in a mouse model of human tauopathy. Autophagy. 2012;8:1686-7 pubmed publisher
    ..parkinsonism linked to chromosome 17, are characterized by the accumulation of hyperphosphorylated and filamentous MAPT/tau protein...
  29. Yin X, Jin N, Shi J, Zhang Y, Wu Y, Gong C, et al. Dyrk1A overexpression leads to increase of 3R-tau expression and cognitive deficits in Ts65Dn Down syndrome mice. Sci Rep. 2017;7:619 pubmed publisher
    Alternative splicing of tau exon 10 generates tau isoforms with three or four microtubule-binding repeats, 3R-tau and 4R-tau, which is equally expressed in adult human brain...
  30. Strittmatter W, Saunders A, Goedert M, Weisgraber K, Dong L, Jakes R, et al. Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease. Proc Natl Acad Sci U S A. 1994;91:11183-6 pubmed
    ..tangles contain paired helical filaments formed from hyperphosphorylated microtubule-associated protein tau. In vitro, tau binds avidly to apoE3, but not to apoE4, forming a bimolecular complex...
  31. Zhang C, Tian Q, Wei W, Peng J, Liu G, Zhou X, et al. Homocysteine induces tau phosphorylation by inactivating protein phosphatase 2A in rat hippocampus. Neurobiol Aging. 2008;29:1654-65 pubmed
    ..Here, we found that high plasma homocysteine induced by vena caudalis injection for 2 weeks could induce AD-like tau hyperphosphorylation at multiple sites in rat brain hippocampus...
  32. Klein R, Dayton R, Terry T, Vascoe C, Sunderland J, Tainter K. PET imaging in rats to discern temporal onset differences between 6-hydroxydopamine and tau gene vector neurodegeneration models. Brain Res. 2009;1259:113-22 pubmed publisher
    ..6-hydroxydopamine (6-OHDA) lesioning and the other was direct gene transfer of the microtubule-associated protein tau to the substantia nigra using an adeno-associated virus vector (AAV9)...
  33. Luo H, Xia Y, Shu X, Liu Z, Feng Y, Liu X, et al. SUMOylation at K340 inhibits tau degradation through deregulating its phosphorylation and ubiquitination. Proc Natl Acad Sci U S A. 2014;111:16586-91 pubmed publisher
    Intracellular accumulation of the abnormally modified tau is hallmark pathology of Alzheimer's disease (AD), but the mechanism leading to tau aggregation is not fully characterized...
  34. Matarin M, Salih D, Yasvoina M, Cummings D, Guelfi S, Liu W, et al. A genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology. Cell Rep. 2015;10:633-44 pubmed publisher
    ..lines of "amyloid" transgenic mice (mutant human APP, PSEN1, or APP/PSEN1) and "TAU" transgenic mice (mutant human MAPT gene)...
  35. Tortosa E, Adolfs Y, Fukata M, Pasterkamp R, Kapitein L, Hoogenraad C. Dynamic Palmitoylation Targets MAP6 to the Axon to Promote Microtubule Stabilization during Neuronal Polarization. Neuron. 2017;94:809-825.e7 pubmed publisher
    ..We propose a model in which MAP6's palmitoylation mediates microtubule stabilization, allows efficient organelle trafficking, and controls axon maturation in vitro and in situ. ..
  36. Kempf M, Clement A, Faissner A, Lee G, Brandt R. Tau binds to the distal axon early in development of polarity in a microtubule- and microfilament-dependent manner. J Neurosci. 1996;16:5583-92 pubmed
    Microtubule-associated protein tau is localized to the axon in situ and has been implicated in the development of neuronal polarity...
  37. Utton M, Connell J, Asuni A, van Slegtenhorst M, Hutton M, de Silva R, et al. The slow axonal transport of the microtubule-associated protein tau and the transport rates of different isoforms and mutants in cultured neurons. J Neurosci. 2002;22:6394-400 pubmed
    We demonstrate that the microtubule-associated protein tau, in the form of enhanced green fluorescent protein (EGFP) tau, is transported along axons of neurons in culture in the slow component of axonal transport with a speed comparable ..
  38. Hong D, Pei A, Sun F, Zhu C. [Aberrant neuronal expression of mitotic protein, tau and Bax in the rat brain after injection of Abeta(25-35) into the amygdala]. Sheng Li Xue Bao. 2003;55:142-6 pubmed
    ..Results showed that the levels of neurofibrillary tangle (NFT) related phosphorylated tau protein and apoptosis related protein Bax were increased in Abeta(25-35) injected rat brains, meanwhile the ..
  39. Barghorn S, Davies P, Mandelkow E. Tau paired helical filaments from Alzheimer's disease brain and assembled in vitro are based on beta-structure in the core domain. Biochemistry. 2004;43:1694-703 pubmed
    b>Tau protein, a neuronal microtubule-associated protein, forms insoluble fibers ("paired helical filaments") in Alzheimer's disease and other tauopathies...
  40. Liao X, Zhang Y, Wang Y, Wang J. The effect of cdk-5 overexpression on tau phosphorylation and spatial memory of rat. Sci China C Life Sci. 2004;47:251-7 pubmed
    In Alzheimer's disease (AD), hyperphosphorylation of tau may be the underlying mechanism for the cytoskeletal abnormalities and neuronal death...
  41. Zilka N, Filipcik P, Koson P, Fialova L, Skrabana R, Zilkova M, et al. Truncated tau from sporadic Alzheimer's disease suffices to drive neurofibrillary degeneration in vivo. FEBS Lett. 2006;580:3582-8 pubmed
    Truncated tau protein is the characteristic feature of human sporadic Alzheimer's disease. We have identified truncated tau proteins conformationally different from normal healthy tau...
  42. Zhang Y, Xu Y, Liu Y, Yin J, Li H, Wang Q, et al. Peroxynitrite induces Alzheimer-like tau modifications and accumulation in rat brain and its underlying mechanisms. FASEB J. 2006;20:1431-42 pubmed
    To investigate the upstream effector that led to tau hyperphosphorylation, nitration, and accumulation as seen in Alzheimer's disease brain, and the underlying mechanisms, we bilaterally injected SIN-1, a recognized peroxynitrite donor, ..
  43. Rahman A, Khan K, Al Khaledi G, Khan I, Al Shemary T. Over activation of hippocampal serine/threonine protein phosphatases PP1 and PP2A is involved in lead-induced deficits in learning and memory in young rats. Neurotoxicology. 2012;33:370-83 pubmed publisher
    ..Total phosphatase activity, and PP1 and PP2A activities were determined. Tau phosphorylation at various epitopes was determined by Western blot...
  44. Kopeikina K, Carlson G, Pitstick R, Ludvigson A, Peters A, Luebke J, et al. Tau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human Alzheimer's disease brain. Am J Pathol. 2011;179:2071-82 pubmed publisher
    Neurofibrillary tangles (NFT), intracellular inclusions of abnormal fibrillar forms of microtubule associated protein tau, accumulate in Alzheimer's disease (AD) and other tauopathies and are believed to cause neuronal dysfunction, but ..
  45. Pittman A, Myers A, Abou Sleiman P, Fung H, Kaleem M, Marlowe L, et al. Linkage disequilibrium fine mapping and haplotype association analysis of the tau gene in progressive supranuclear palsy and corticobasal degeneration. J Med Genet. 2005;42:837-46 pubmed
    The haplotype H1 of the tau gene, MAPT, is highly associated with progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD).
  46. Sul D, Kim H, Lee D, Joo S, Hwang K, Park S. Protective effect of caffeic acid against beta-amyloid-induced neurotoxicity by the inhibition of calcium influx and tau phosphorylation. Life Sci. 2009;84:257-62 pubmed publisher
    ..Furthermore, Abeta-induced tau hyperphosphorylation and neurotoxicity are downstream of Abeta...
  47. Reifert J, Hartung Cranston D, Feinstein S. Amyloid beta-mediated cell death of cultured hippocampal neurons reveals extensive Tau fragmentation without increased full-length tau phosphorylation. J Biol Chem. 2011;286:20797-811 pubmed publisher
    A variety of genetic and biochemical evidence suggests that amyloid ? (A?) oligomers promote downstream errors in Tau action, in turn inducing neuronal dysfunction and cell death in Alzheimer and related dementias...
  48. Gonzalez Billault C, Engelke M, Jimenez Mateos E, Wandosell F, Caceres A, Avila J. Participation of structural microtubule-associated proteins (MAPs) in the development of neuronal polarity. J Neurosci Res. 2002;67:713-9 pubmed
    ..In this report we have characterized the effect of the combined suppression of MAP1B and tau, and MAP1B and MAP2 on neuronal polarization in cultured hippocampal cells grown on a laminin-containing substrate...
  49. Chen X, Huang T, Zhang J, Song J, Chen L, Zhu Y. Involvement of calpain and p25 of CDK5 pathway in ginsenoside Rb1's attenuation of beta-amyloid peptide25-35-induced tau hyperphosphorylation in cortical neurons. Brain Res. 2008;1200:99-106 pubmed publisher
    Increasing evidence have shown that beta-amyloid (Abeta) induced hyperphosphorylation of tau, which eventually resulted in the disruption of microtubule (MT) integrity...
  50. Bullmann T, Hartig W, Holzer M, Arendt T. Expression of the embryonal isoform (0N/3R) of the microtubule-associated protein tau in the adult rat central nervous system. J Comp Neurol. 2010;518:2538-53 pubmed publisher
    b>Tau is a microtubule-associated protein expressed predominantly in neurons. The transcript of the tau gene is alternatively spliced. Resulting isoforms contain three or four microtubule-binding repeats...
  51. Liu Z, Fu Z, Song J, Zhang J, Wei Y, Chu J, et al. Bip enhanced the association of GSK-3? with tau during ER stress both in vivo and in vitro. J Alzheimers Dis. 2012;29:727-40 pubmed publisher
    Hyperphosphorylated tau is the major component of intracellular neurofibrillary tangles, which is positively correlated with the cognitive decline in Alzheimer's disease (AD)...
  52. Tokutake T, Kasuga K, Yajima R, Sekine Y, Tezuka T, Nishizawa M, et al. Hyperphosphorylation of Tau induced by naturally secreted amyloid-? at nanomolar concentrations is modulated by insulin-dependent Akt-GSK3? signaling pathway. J Biol Chem. 2012;287:35222-33 pubmed publisher
    ..by the formation of senile plaques from amyloid-? (A?) and neurofibrillary tangles composed of phosphorylated Tau. Although there is growing evidence for the pathogenic role of soluble A? species in AD, the major question of how ..
  53. Yu J, Rasenick M. Tau associates with actin in differentiating PC12 cells. FASEB J. 2006;20:1452-61 pubmed
    The microtubule-associated protein tau may be involved in cell morphogenesis and axonal maintenance. In addition to microtubules, tau has been shown to interact with actin in vitro...
  54. Liu Y, Lv K, Li Z, Yu A, Chen J, Teng J. PACSIN1, a Tau-interacting protein, regulates axonal elongation and branching by facilitating microtubule instability. J Biol Chem. 2012;287:39911-24 pubmed publisher
    b>Tau is a major member of the neuronal microtubule-associated proteins. It promotes tubulin assembly and stabilizes axonal microtubules...
  55. Wang X, Zeng J, Yang Y, Xiong Y, Zhang Z, Qiu M, et al. Helicobacter pylori filtrate induces Alzheimer-like tau hyperphosphorylation by activating glycogen synthase kinase-3?. J Alzheimers Dis. 2015;43:153-65 pubmed publisher
    Abnormal hyperphosphorylation of microtubule-associated protein tau is involved in the pathogenesis of several neurodegenerative disorders including Alzheimer's disease (AD). Helicobacter pylori (H...
  56. Kanai Y, Takemura R, Oshima T, Mori H, Ihara Y, Yanagisawa M, et al. Expression of multiple tau isoforms and microtubule bundle formation in fibroblasts transfected with a single tau cDNA. J Cell Biol. 1989;109:1173-84 pubmed
    b>Tau proteins are a class of low molecular mass microtubule-associated proteins that are specifically expressed in the nervous system. A cDNA clone of adult rat tau was isolated and sequenced...
  57. Gamblin T, Chen F, Zambrano A, Abraha A, Lagalwar S, Guillozet A, et al. Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease. Proc Natl Acad Sci U S A. 2003;100:10032-7 pubmed
    ..amyloid plaques and intracellular neurofibrillary tangles, the latter composed of the microtubule-binding protein tau assembled into paired helical and straight filaments...
  58. Farah C, Liazoghli D, Perreault S, Desjardins M, Guimont A, Anton A, et al. Interaction of microtubule-associated protein-2 and p63: a new link between microtubules and rough endoplasmic reticulum membranes in neurons. J Biol Chem. 2005;280:9439-49 pubmed
    ..assay, MAP2-containing microtubules were observed to bind to RER membranes in contrast to microtubules containing tau, the axonal MAP. This binding of MAP2c microtubules was reduced when an anti-p63 antibody was added to the assay...
  59. Hou Z, Li Q, He L, Lim H, Fu X, Cheung N, et al. Microtubule association of the neuronal p35 activator of Cdk5. J Biol Chem. 2007;282:18666-70 pubmed
    ..Together, these findings suggest that p35 is a microtubule-associated protein that modulates microtubule dynamics. Also, microtubules play an important role in the control of Cdk5 activation. ..
  60. Atlante A, Amadoro G, Bobba A, de Bari L, Corsetti V, Pappalardo G, et al. A peptide containing residues 26-44 of tau protein impairs mitochondrial oxidative phosphorylation acting at the level of the adenine nucleotide translocator. Biochim Biophys Acta. 2008;1777:1289-300 pubmed publisher
    Having confirmed that adenovirus-mediated overexpression of NH(2)-tau fragment lacking the first 25 aminoacids evokes a potent neurotoxic effect, sustained by protracted stimulation of NMDA receptors, in primary neuronal cultures we ..
  61. Samaranch L, Cervantes S, Barabash A, Alonso A, Cabranes J, Lamet I, et al. The effect of MAPT H1 and APOE ?4 on transition from mild cognitive impairment to dementia. J Alzheimers Dis. 2010;22:1065-71 pubmed publisher
    Microtubule-associated protein tau (MAPT) and apolipoprotein E (APOE) are involved in the pathogenic mechanisms of Alzheimer's disease (AD)...
  62. Kanai Y, Chen J, Hirokawa N. Microtubule bundling by tau proteins in vivo: analysis of functional domains. EMBO J. 1992;11:3953-61 pubmed
    b>Tau varies both in the N-terminal region (three types) and in the C-terminal repeated microtubule binding domain (two types), generating six isoforms through alternative splicing...
  63. Mavilia C, Couchie D, Nunez J. Diversity of high-molecular-weight tau proteins in different regions of the nervous system. J Neurochem. 1994;63:2300-6 pubmed
    We show in this work that high-molecular-weight (HMW) tau transcripts are present in all the regions of the CNS and PNS studied, i.e., the dorsal root ganglia (DRG), spinal cord, cerebellum, and forebrain...
  64. Goldbaum O, Richter Landsberg C. Activation of PP2A-like phosphatase and modulation of tau phosphorylation accompany stress-induced apoptosis in cultured oligodendrocytes. Glia. 2002;40:271-82 pubmed
    In a number of neurodegenerative diseases, tau-positive glial cytoplasmic inclusions (GCIs), immunochemically labeled with antibodies to the small heat shock protein (HSP) alphaB-crystallin, occur in oligodendrocytes...
  65. Zhu D, Kosik K, Meigs T, Yanamadala V, Denker B. Galpha12 directly interacts with PP2A: evidence FOR Galpha12-stimulated PP2A phosphatase activity and dephosphorylation of microtubule-associated protein, tau. J Biol Chem. 2004;279:54983-6 pubmed
    ..PP2A dephosphorylates multiple substrates including tau, a microtubule-associated protein that is hyperphosphorylated in neurofibrillary tangles...
  66. van Beuningen S, Will L, Harterink M, Chazeau A, van Battum E, Frias C, et al. TRIM46 Controls Neuronal Polarity and Axon Specification by Driving the Formation of Parallel Microtubule Arrays. Neuron. 2015;88:1208-1226 pubmed publisher
    ..Without TRIM46, all neurites have a dendrite-like mixed microtubule organization resulting in Tau missorting and altered cargo trafficking...
  67. Bian H, Bian W, Lin X, Ma Z, Chen W, Pu Y. RNA Interference Silencing of Glycogen Synthase Kinase 3? Inhibites Tau Phosphorylation in Mice with Alzheimer Disease. Neurochem Res. 2016;41:2470-80 pubmed publisher
    To explore the effect of glycogen synthase kinase 3? (GSK-3?) silencing on Tau-5 phosphorylation in mice suffering Alzheimer disease (AD)...
  68. Huang D, Weisgraber K, Goedert M, Saunders A, Roses A, Strittmatter W. ApoE3 binding to tau tandem repeat I is abolished by tau serine262 phosphorylation. Neurosci Lett. 1995;192:209-12 pubmed
    ..Isoform specific interactions of ApoE have been shown with the microtubule-associated protein tau, which forms the neurofibrillary tangle in this disease...
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    ..Effects of noise on the glutamate (Glu)-N-methyl-D-aspartic acid receptor (NMDAR) signaling system and hippocampal tau phosphorylation were investigated by high performance liquid chromatography, Western blotting, and ..
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    The H1 haplotype of the tau gene, MAPT, has been linked to the sporadic tauopathies corticobasal degeneration and progressive supranuclear palsy; however, there have been inconsistent findings regarding association with frontotemporal ..
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    ..Accumulation of amyloid beta (Abeta)-protein oligomers and the microtubule associated protein-TAU might be responsible for the neurological damage...
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    The imbalance between three-repeat (3R) and four-repeat (4R) tau isoforms produced by the alternative splicing of tau exon 10 leads to neuronal instability and eventual neurodegeneration in tauopathy...
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    ..In contrast, takusan knockdown results in enhanced synaptic damage. ?1-Takusan interacts with tau either directly or indirectly, and prevents A?-induced tau hyperphosphorylation and mitochondrial fragmentation...
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    ..This study aims to assess changes in cognitive functions and the level of hyperphosphorylated tau proteins in central insulin-resistant rats...
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    Filamentous tau inclusions are hallmarks of Alzheimer's disease (AD) and related tauopathies, but earlier pathologies may herald disease onset. To investigate this, we studied wild-type and P301S mutant human tau transgenic (Tg) mice...
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    ..neurofibrillary tangles (NFTs) that are composed of abnormally hyperphosphorylated microtubule-associated protein tau. Abnormal tau hyperphosphorylation is mainly induced due to the imbalance between protein kinases and phosphatases...
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    b>Tau is a microtubule associated protein that is found primarily in neurons, and in pathologic conditions, such as Alzheimer's disease (AD) it accumulates and contributes to the disease process...