Mapk8

Summary

Gene Symbol: Mapk8
Description: mitogen-activated protein kinase 8
Alias: JNK, mitogen-activated protein kinase 8, MAP kinase 8, MAPK 8, SAPK gamma, c-Jun N-terminal kinase 1, c-jun NH2-terminal kinase, p54 gamma, stress-activated protein kinase JNK1
Species: rat
Products:     Mapk8

Top Publications

  1. Pawate S, Bhat N. C-Jun N-terminal kinase (JNK) regulation of iNOS expression in glial cells: predominant role of JNK1 isoform. Antioxid Redox Signal. 2006;8:903-9 pubmed
    ..c-Jun N-terminal kinase (JNK), a member of the MAPK family, is activated by a variety of stress and proinflammatory signals and in turn ..
  2. Wang Q, Zhang H, Zhao B, Fei H. IL-1beta caused pancreatic beta-cells apoptosis is mediated in part by endoplasmic reticulum stress via the induction of endoplasmic reticulum Ca2+ release through the c-Jun N-terminal kinase pathway. Mol Cell Biochem. 2009;324:183-90 pubmed publisher
    ..primary rat beta-cells and MIN6 cells largely depends on ER stress, ER Ca(2+) release, and c-Jun N-terminal kinase (JNK) activation...
  3. Singh R, Wang Y, Schattenberg J, Xiang Y, Czaja M. Chronic oxidative stress sensitizes hepatocytes to death from 4-hydroxynonenal by JNK/c-Jun overactivation. Am J Physiol Gastrointest Liver Physiol. 2009;297:G907-17 pubmed
    Sustained activation of the c-Jun NH(2)-terminal kinase (JNK) signaling pathway mediates the development and progression of experimental diet-induced nonalcoholic fatty liver disease (NAFLD)...
  4. Björkblom B, Ostman N, Hongisto V, Komarovski V, Filén J, Nyman T, et al. Constitutively active cytoplasmic c-Jun N-terminal kinase 1 is a dominant regulator of dendritic architecture: role of microtubule-associated protein 2 as an effector. J Neurosci. 2005;25:6350-61 pubmed
    ..mediators, we identify the dendrite-specific high-molecular-weight microtubule-associated protein 2 (MAP2) as a JNK substrate in the brain...
  5. Doya H, Ohtori S, Fujitani M, Saito T, Hata K, Ino H, et al. c-Jun N-terminal kinase activation in dorsal root ganglion contributes to pain hypersensitivity. Biochem Biophys Res Commun. 2005;335:132-8 pubmed
    ..We examined the involvement of c-Jun N-terminal kinase (JNK) in the dorsal root ganglion (DRG) in the early phase of inflammation-induced hyperalgesia. An intra-plantar (i.pl...
  6. Tararuk T, Ostman N, Li W, Björkblom B, Padzik A, Zdrojewska J, et al. JNK1 phosphorylation of SCG10 determines microtubule dynamics and axodendritic length. J Cell Biol. 2006;173:265-77 pubmed
    ..In the adult, JNK determines neuronal cytoarchitecture...
  7. Wang Y, Schattenberg J, Rigoli R, Storz P, Czaja M. Hepatocyte resistance to oxidative stress is dependent on protein kinase C-mediated down-regulation of c-Jun/AP-1. J Biol Chem. 2004;279:31089-97 pubmed
    ..menadione in the hepatocyte cell line RALA255-10G is dependent on down-regulation of the c-Jun N-terminal kinase (JNK)/AP-1 signaling pathway by extracellular signal-regulated kinase 1/2 (ERK1/2)...
  8. Fogarty M, Downer E, Campbell V. A role for c-Jun N-terminal kinase 1 (JNK1), but not JNK2, in the beta-amyloid-mediated stabilization of protein p53 and induction of the apoptotic cascade in cultured cortical neurons. Biochem J. 2003;371:789-98 pubmed
    ..The stress-activated protein kinase, c-Jun N-terminal kinase (JNK), is activated in response to cellular stress and has been identified as a proximal mediator of cell death...
  9. Kaneto H, Xu G, Fujii N, Kim S, Bonner Weir S, Weir G. Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression. J Biol Chem. 2002;277:30010-8 pubmed
    ..In this study, subjecting rat islets to oxidative stress activates JNK, p38 MAPK, and protein kinase C, preceding the decrease of insulin gene expression...

More Information

Publications100

  1. Mei X, Zhang H, Wang W, Wei Y, Zhai M, Wang W, et al. Inhibition of spinal astrocytic c-Jun N-terminal kinase (JNK) activation correlates with the analgesic effects of ketamine in neuropathic pain. J Neuroinflammation. 2011;8:6 pubmed publisher
    ..However, the underlying mechanisms are still unclear. c-Jun N-terminal kinase (JNK), a member of mitogen-activated protein kinase (MAPK) family, has been reported to be critical for spinal ..
  2. Gupta S, Barrett T, Whitmarsh A, Cavanagh J, Sluss H, Derijard B, et al. Selective interaction of JNK protein kinase isoforms with transcription factors. EMBO J. 1996;15:2760-70 pubmed
    The JNK protein kinase is a member of the MAP kinase group that is activated in response to dual phosphorylation on threonine and tyrosine. Ten JNK isoforms were identified in human brain by molecular cloning...
  3. Huang C, Rajfur Z, Borchers C, Schaller M, Jacobson K. JNK phosphorylates paxillin and regulates cell migration. Nature. 2003;424:219-23 pubmed
    The c-Jun amino-terminal kinase (JNK) is generally thought to be involved in inflammation, proliferation and apoptosis. Accordingly, its substrates are transcription factors and anti-apoptotic proteins...
  4. Tong C, Yin Z, Song Z, Dockendorff A, Huang C, Mariadason J, et al. c-Jun NH2-terminal kinase 1 plays a critical role in intestinal homeostasis and tumor suppression. Am J Pathol. 2007;171:297-303 pubmed
    The c-Jun NH(2)-terminal kinase (JNK) signal transduction pathway plays important roles in cellular processes and stress. However, the role of JNK1 in intestinal homeostasis and tumorigenesis is unknown...
  5. Cao F, Liu M, Hao J, Li Z, Lu Z, Chen J. Different roles of spinal p38 and c-Jun N-terminal kinase pathways in bee venom-induced multiple pain-related behaviors. Neurosci Lett. 2007;427:50-4 pubmed
    ..this hypothesis, the present investigation was designed to detect whether spinal p38 and c-Jun N-terminal kinase (JNK) pathways are equally or differentially involved in the development of persistent spontaneous nociception (PSN), ..
  6. Wang X, Hu S, Mao Ying Q, Li Q, Yang C, Zhang H, et al. Activation of c-jun N-terminal kinase in spinal cord contributes to breast cancer induced bone pain in rats. Mol Brain. 2012;5:21 pubmed publisher
    ..The mechanisms underlying this pain remain unclear. Here we investigated the role of c-jun N-terminal kinase (JNK) pathway in the spinal cord in cancer-induced bone pain (CIBP)...
  7. Okuno S, Saito A, Hayashi T, Chan P. The c-Jun N-terminal protein kinase signaling pathway mediates Bax activation and subsequent neuronal apoptosis through interaction with Bim after transient focal cerebral ischemia. J Neurosci. 2004;24:7879-87 pubmed
    The c-Jun N-terminal protein kinase (JNK) signaling pathway is implicated in neuronal apoptosis...
  8. Yatsushige H, Ostrowski R, Tsubokawa T, Colohan A, Zhang J. Role of c-Jun N-terminal kinase in early brain injury after subarachnoid hemorrhage. J Neurosci Res. 2007;85:1436-48 pubmed
    The c-Jun N-terminal kinase (JNK) is induced by cerebral ischemia and injurious blood components acutely after subarachnoid hemorrhage (SAH)...
  9. Lin H, Tang C, Chen J, Chuang J, Huang S, Tan T, et al. Peptidoglycan induces interleukin-6 expression through the TLR2 receptor, JNK, c-Jun, and AP-1 pathways in microglia. J Cell Physiol. 2011;226:1573-82 pubmed publisher
    ..In contrast, PGN-induced IL-6 mRNA and protein up-regulation were attenuated by the SAPK/JNK (c-Jun N-terminal kinases) inhibitor SP600125...
  10. Mori S, Matsuzaki K, Yoshida K, Furukawa F, Tahashi Y, Yamagata H, et al. TGF-beta and HGF transmit the signals through JNK-dependent Smad2/3 phosphorylation at the linker regions. Oncogene. 2004;23:7416-29 pubmed
    ..regions, we herein showed that either HGF or TGF-beta treatment of normal stomach-origin cells activated the JNK pathway, thereafter inducing endogenous R-Smads phosphorylation at linker regions...
  11. Feng Y, Huang J, Ding Y, Xie F, Shen X. Tamoxifen-induced apoptosis of rat C6 glioma cells via PI3K/Akt, JNK and ERK activation. Oncol Rep. 2010;24:1561-7 pubmed
    ..The activation of AKT significantly decreased in a time-dependent manner in response to TAM treatment, JNK was transiently activated, and subsequently decreased activation and kept stable level, whereas ERK evidenced ..
  12. Shrivastava P, Pantano C, Watkin R, McElhinney B, Guala A, Poynter M, et al. Reactive nitrogen species-induced cell death requires Fas-dependent activation of c-Jun N-terminal kinase. Mol Cell Biol. 2004;24:6763-72 pubmed
    ..We demonstrate here that cell death by RNS was caused by c-Jun N-terminal kinase (JNK). Activation of JNK by RNS was density dependent and caused mitochondrial depolarization and nuclear condensation...
  13. Prada P, Zecchin H, Gasparetti A, Torsoni M, Ueno M, Hirata A, et al. Western diet modulates insulin signaling, c-Jun N-terminal kinase activity, and insulin receptor substrate-1ser307 phosphorylation in a tissue-specific fashion. Endocrinology. 2005;146:1576-87 pubmed
    ..insulin sensitivity by hyperinsulinemic-euglycemic clamp procedures and insulin signaling, c-jun N-terminal kinase (JNK) activation and insulin receptor substrate (IRS)-1(ser307) phosphorylation in liver, muscle, adipose tissue, and ..
  14. Yang X, Guo T, Wang Y, Huang Y, Liu X, Wang X, et al. Ginsenoside Rd attenuates the inflammatory response via modulating p38 and JNK signaling pathways in rats with TNBS-induced relapsing colitis. Int Immunopharmacol. 2012;12:408-14 pubmed publisher
    ..inhibited the activity of MPO, lowered proinflammatory cytokine levels and suppressed phosphorylation of p38 and JNK. The possible mechanism of protection on experimental colitis after GRd administration was that it could reduce the ..
  15. Han Z, Boyle D, Chang L, Bennett B, Karin M, Yang L, et al. c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis. J Clin Invest. 2001;108:73-81 pubmed
    ..In particular, c-Jun N-terminal kinase (JNK) is highly activated in RA fibroblast-like synoviocytes and synovium...
  16. Liu Q, Zhang Y, Mao H, Chen W, Luo N, Zhou Q, et al. A crosstalk between the Smad and JNK signaling in the TGF-?-induced epithelial-mesenchymal transition in rat peritoneal mesothelial cells. PLoS ONE. 2012;7:e32009 pubmed publisher
    ..growth factor ? (TGF-?) induces the process of epithelial-mesenchymal transition (EMT) through the Smad and JNK signaling...
  17. Liu J, Sun Z, Ma Y. [Change of JNK and c-Jun in lung injury associated with paraquat poisoning of rats]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2008;26:406-9 pubmed
    To investigate the change of JNK and c-Jun in lung injury associated with paraquat poisoning of rats...
  18. Trotter L, Panton W, Hajimohamadreza I, Petalidis L, Ward R, Fleming Y, et al. Mitogen-activated protein kinase kinase 7 is activated during low potassium-induced apoptosis in rat cerebellar granule neurons. Neurosci Lett. 2002;320:29-32 pubmed
    ..protein kinase pathway comprising mitogen-activated protein kinase kinases (MKKs), c-Jun N-terminal kinase (JNK) and the transcription factor c-Jun is implicated in neuronal apoptosis...
  19. Haisenleder D, Burger L, Walsh H, Stevens J, Aylor K, Shupnik M, et al. Pulsatile gonadotropin-releasing hormone stimulation of gonadotropin subunit transcription in rat pituitaries: evidence for the involvement of Jun N-terminal kinase but not p38. Endocrinology. 2008;149:139-45 pubmed
    We investigated whether Jun N-terminal kinase (JNK) and p38 mediate gonadotropin subunit transcriptional responses to pulsatile GnRH in normal rat pituitaries...
  20. Tseng S, Wang C, Lin S, Chen C, Huang H, Chen Y. Activation of c-Jun N-terminal kinase 1 and caspase 3 in the tamoxifen-induced apoptosis of rat glioma cells. J Cancer Res Clin Oncol. 2004;130:285-93 pubmed
  21. Xu Z, Kukekov N, Greene L. Regulation of apoptotic c-Jun N-terminal kinase signaling by a stabilization-based feed-forward loop. Mol Cell Biol. 2005;25:9949-59 pubmed
    ..increase endogenous cellular levels of pathway components, including POSH, mixed lineage kinases (MLKs), and JNK interacting protein 1, and that this effect occurs through protein stabilization and requires the presence of POSH ..
  22. Zhang J, Wang Q, Zhu N, Yu M, Shen B, Xiang J, et al. Cyclic AMP inhibits JNK activation by CREB-mediated induction of c-FLIP(L) and MKP-1, thereby antagonizing UV-induced apoptosis. Cell Death Differ. 2008;15:1654-62 pubmed publisher
    ..studies revealed that cAMP antagonized UV-induced apoptosis by inhibition of c-Jun N-terminal protein kinase (JNK) activation...
  23. Vinit S, Darlot F, Aoulaïche H, Boulenguez P, Kastner A. Distinct expression of c-Jun and HSP27 in axotomized and spared bulbospinal neurons after cervical spinal cord injury. J Mol Neurosci. 2011;45:119-33 pubmed publisher
    ..However, the molecular cell body response of spared neurons is distinct from that of axotomized neurons since they can up-regulate c-Jun but not HSP27. ..
  24. Rutkute K, Karakashian A, Giltiay N, Dobierzewska A, Nikolova Karakashian M. Aging in rat causes hepatic hyperresposiveness to interleukin-1beta which is mediated by neutral sphingomyelinase-2. Hepatology. 2007;46:1166-76 pubmed
    ..IL-1beta-induced phosphorylation of c-jun N-terminal kinase (JNK) in hepatocytes isolated from aged rats was 3 times more potent than that in hepatocytes from young rats...
  25. Lal H, Verma S, Smith M, Guleria R, Lu G, Foster D, et al. Stretch-induced MAP kinase activation in cardiac myocytes: differential regulation through beta1-integrin and focal adhesion kinase. J Mol Cell Cardiol. 2007;43:137-47 pubmed
    ..In the presence and absence of ATB, mechanical stretch caused maximal phosphorylation of ERK, p38 and JNK at 5 min, which was significantly attenuated in NRVM expressing tac-beta1D...
  26. Basu K, Mukhopadhyay A, Ghosh I, Datta K. Nuclear morphology and c-Jun N-terminal kinase 1 expression differentiate serum-starved oxidative stress signalling from hydrogen peroxide-induced apoptosis in retinal neuronal cell line. Cell Biol Int. 2012;36:1021-7 pubmed publisher
    ..alter JNK1 (c-Jun N-terminal kinase 1) expression, although nuclear translocation and higher level of pJNK (phospho-JNK) was evident...
  27. Hreniuk D, Garay M, Gaarde W, Monia B, McKay R, Cioffi C. Inhibition of c-Jun N-terminal kinase 1, but not c-Jun N-terminal kinase 2, suppresses apoptosis induced by ischemia/reoxygenation in rat cardiac myocytes. Mol Pharmacol. 2001;59:867-74 pubmed
    ..were used as an in vitro ischemia/reperfusion injury model to delineate the role of c-Jun N-terminal kinase (JNK) 1 and JNK2 isoforms in ischemia/reoxygenation-induced apoptosis using an antisense approach...
  28. Yamagishi S, Yamada M, Koshimizu H, Takai S, Hatanaka H, Takeda K, et al. Apoptosis-signal regulating kinase-1 is involved in the low potassium-induced activation of p38 mitogen-activated protein kinase and c-Jun in cultured cerebellar granule neurons. J Biochem. 2003;133:719-24 pubmed
    ..kinase-1 (ASK1), a MAPK kinase kinase (MAPKKK) protein, is known to activate both c-Jun N-terminal kinase (JNK) and p38 via MAPK kinase (MKK) 4/7 and MKK3/6, respectively...
  29. Oh Y, Yue P, Zhou W, Balko J, Black E, Owonikoko T, et al. Oncogenic Ras and B-Raf proteins positively regulate death receptor 5 expression through co-activation of ERK and JNK signaling. J Biol Chem. 2012;287:257-67 pubmed publisher
    ..Importantly, we have elucidated that Ras induces DR5 expression through co-activation of ERK/RSK and JNK signaling pathways and subsequent cooperative effects among the transcriptional factors CHOP, Elk1, and c-Jun to ..
  30. Zhang G, Wang Y, Li T, Zhang D, Liu X, Yang F. [Change of JNK MAPK and its influence on cardiocyte apoptosis in ischemic postconditioning]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2009;38:611-9 pubmed
    To test whether postconditioning could inhibit the expression of phospho-JNK (P-JNK) mitogen activated protein kinase (MAPK) and study its relation to apoptosis of cardiocyte...
  31. Chen S, Lin J, Liu S, Liang Y, Lin Shiau S. Apoptosis of cultured astrocytes induced by the copper and neocuproine complex through oxidative stress and JNK activation. Toxicol Sci. 2008;102:138-49 pubmed
    ..Their clinical implications in the etiology of neurodegenerative diseases deserve further investigation. ..
  32. Miao B, Yin X, Pei D, Zhang Q, Zhang G. Neuroprotective effects of preconditioning ischemia on ischemic brain injury through down-regulating activation of JNK1/2 via N-methyl-D-aspartate receptor-mediated Akt1 activation. J Biol Chem. 2005;280:21693-9 pubmed
    Our previous studies have demonstrated that the JNK signaling pathway plays an important role in ischemic brain injury and is mediated via glutamate receptor 6...
  33. Motta K, Barbosa A, Bobinski F, Boschero A, Rafacho A. JNK and IKKβ phosphorylation is reduced by glucocorticoids in adipose tissue from insulin-resistant rats. J Steroid Biochem Mol Biol. 2015;145:1-12 pubmed publisher
    ..05). The basal phosphorylation of c-jun-N-terminal kinase (JNK) and inhibitor of nuclear factor kappa-B (IKKβ) proteins was reduced by 46% and 58%, respectively, in the ..
  34. Ge Y, Pan S, Guan D, Yin H, Fan Y, Liu J, et al. MicroRNA-350 induces pathological heart hypertrophy by repressing both p38 and JNK pathways. Biochim Biophys Acta. 2013;1832:1-10 pubmed publisher
    ..luciferase assays confirmed that the target mRNAs of miR-350 are mitogen activated protein kinase (MAPK) 11/14 and MAPK8/9 gene transcripts...
  35. Lal H, Verma S, Golden H, Foster D, Smith M, Dostal D. Stretch-induced regulation of angiotensinogen gene expression in cardiac myocytes and fibroblasts: opposing roles of JNK1/2 and p38alpha MAP kinases. J Mol Cell Cardiol. 2008;45:770-8 pubmed publisher
    ..This suggests that a balance in JNK1/2 and p38alpha activation determines the level of Ao gene expression in myocardial cells. ..
  36. Wang X, Pei D, Xu J, Guan Q, Sun Y, Liu X, et al. Opposing effects of Bad phosphorylation at two distinct sites by Akt1 and JNK1/2 on ischemic brain injury. Cell Signal. 2007;19:1844-56 pubmed
    ..activated Akt1 inhibited the activation of Bad(S128) through downregulating JNK1/2 activation, thus inhibiting JNK-mediated Bad apoptosis pathway...
  37. Tkacova R, Ukropec J, Skyba P, Ukropcova B, Pobeha P, Kurdiova T, et al. Increased adipose tissue expression of proinflammatory CD40, MKK4 and JNK in patients with very severe chronic obstructive pulmonary disease. Respiration. 2011;81:386-93 pubmed publisher
    ..via secondary messengers such as mitogen-activated protein kinase kinase 4 (MKK4) and c-Jun NH(2)-terminal kinases (JNK)...
  38. Prause M, Mayer C, Brorsson C, Frederiksen K, Billestrup N, Størling J, et al. JNK1 Deficient Insulin-Producing Cells Are Protected against Interleukin-1β-Induced Apoptosis Associated with Abrogated Myc Expression. J Diabetes Res. 2016;2016:1312705 pubmed publisher
    The relative contributions of the JNK subtypes in inflammatory β-cell failure and apoptosis are unclear. The JNK protein family consists of JNK1, JNK2, and JNK3 subtypes, encompassing many different isoforms...
  39. Waetzig V, Czeloth K, Hidding U, Mielke K, Kanzow M, Brecht S, et al. c-Jun N-terminal kinases (JNKs) mediate pro-inflammatory actions of microglia. Glia. 2005;50:235-46 pubmed
    ..kinases (JNKs) were investigated in primary microglia cultures from neonatal rat brain, which express all three JNK isoforms...
  40. Fan X, Zhang J, Zhang X, Ma L. Chronic morphine treatment and withdrawal induce up-regulation of c-Jun N-terminal kinase 3 gene expression in rat brain. Neuroscience. 2003;122:997-1002 pubmed
    ..The changes in JNK3 gene expression in brain induced by chronic opioid treatment may play a role in opioid-induced apoptosis and neurotoxicity. ..
  41. Li C, Lin L, Wang X, Guan X, Su M, Xiang Q, et al. [Role of c-Jun N-terminal kinase signal transduction pathway in the course of airway remodeling of asthma rat]. Zhonghua Er Ke Za Zhi. 2008;46:535-9 pubmed
    To study the role of c-Jun N-terminal kinase (JNK) signal transduction pathway in the course of asthma airway remodeling, to explore whether IL-1beta participates in asthma airway remodeling mediated by JNK signal transduction pathway...
  42. Tanabe K, Nishimura K, Dohi S, Kozawa O. Mechanisms of interleukin-1beta-induced GDNF release from rat glioma cells. Brain Res. 2009;1274:11-20 pubmed publisher
    ..protein (MAP) kinase, p44/p42 MAP kinase, stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) and signal transducer and activator of transcription (STAT) 3...
  43. Vairaktaris E, Goutzanis L, Kalokerinos G, Vassiliou S, Spyridonidou S, Avgoustidis D, et al. Increased risk of oral cancer in diabetic animals is not associated with c-jun activation pathway. J Craniomaxillofac Surg. 2007;35:382-7 pubmed
    ..It seems that diabetes does not affect the c-jun N-terminal kinase (JNK)/c-jun pathway.
  44. Ronaldson P, Ashraf T, Bendayan R. Regulation of multidrug resistance protein 1 by tumor necrosis factor alpha in cultured glial cells: involvement of nuclear factor-kappaB and c-Jun N-terminal kinase signaling pathways. Mol Pharmacol. 2010;77:644-59 pubmed publisher
    ..astrocyte cultures were pretreated with 1,9-pyrazoloanthrone (SP600125), an established c-Jun N-terminal kinase (JNK) inhibitor. SP600125 did not affect TNF-alpha release from cultured astrocytes triggered with gp120...
  45. Oliva A, Atkins C, Copenagle L, Banker G. Activated c-Jun N-terminal kinase is required for axon formation. J Neurosci. 2006;26:9462-70 pubmed
    ..We demonstrate here that axonogenesis requires activated c-Jun N-terminal kinase (JNK). JNK is expressed throughout the neuron, but its phosphorylated, activated form is highly enriched in the axon...
  46. García Hernández V, Sarmiento N, Sánchez Bernal C, Matellán L, Calvo J, Sánchez Yagüe J. Modulation in the expression of SHP-1, SHP-2 and PTP1B due to the inhibition of MAPKs, cAMP and neutrophils early on in the development of cerulein-induced acute pancreatitis in rats. Biochim Biophys Acta. 2014;1842:192-201 pubmed publisher
    ..show that cerulein treatment activates extracellular signal-regulated kinase (ERK) and c-Jun NH2-terminal kinase (JNK) but not p38 MAPK during the early phase of cerulein-induced AP (2h after the first injection of cerulein)...
  47. Deng H, Zhang J, Yoon T, Song D, Li D, Lin A. Phosphorylation of Bcl-associated death protein (Bad) by erythropoietin-activated c-Jun N-terminal protein kinase 1 contributes to survival of erythropoietin-dependent cells. Int J Biochem Cell Biol. 2011;43:409-15 pubmed publisher
    ..Replacement of threonine 201 by alanine in Bad promoted Epo withdrawal-induced apoptosis. Thus, our results provide a molecular mechanism by which JNK1 contributes to the survival of erythroid cells. ..
  48. Wang R, Zhang Q, Han D, Xu J, Lu Q, Zhang G. Inhibition of MLK3-MKK4/7-JNK1/2 pathway by Akt1 in exogenous estrogen-induced neuroprotection against transient global cerebral ischemia by a non-genomic mechanism in male rats. J Neurochem. 2006;99:1543-54 pubmed
    ..In addition, E2 reduced downstream JNK nuclear and non-nuclear components, c-Jun and Bcl-2 phosphorylation and Fas ligand protein expression induced by ..
  49. Zhang J, Li X, Bian H, Liu X, Ji X, Zhang Y. Inhibition of the activity of Rho-kinase reduces cardiomyocyte apoptosis in heart ischemia/reperfusion via suppressing JNK-mediated AIF translocation. Clin Chim Acta. 2009;401:76-80 pubmed publisher
    ..Ischemia followed by reperfusion caused a significant increase in Rho-kinase, c-Jun NH2-terminal kinase (JNK) and apoptosis-inducing factor (AIF) activity...
  50. Thomas G, Lin D, Nuriya M, Huganir R. Rapid and bi-directional regulation of AMPA receptor phosphorylation and trafficking by JNK. EMBO J. 2008;27:361-72 pubmed publisher
    ..and biochemical approaches, we identify the AMPA receptor GluR2L and GluR4 subunits as novel physiological JNK substrates in vitro, in heterologous cells and in neurons...
  51. Antoniou X, Sclip A, Ploia C, Colombo A, Moroy G, Borsello T. JNK contributes to Hif-1alpha regulation in hypoxic neurons. Molecules. 2009;15:114-27 pubmed publisher
    ..The purpose of this study was to investigate how Hif-1alpha, a major neuroprotective factor, and JNK signaling, a key pathway in neurodegeneration, relate to hypoxic injury in young (6DIV) and adult (12DIV) neurons...
  52. Li C, Zhang C, Wang T, Xuan J, Su C, Wang Y. Heme oxygenase 1 induction protects myocardiac cells against hypoxia/reoxygenation-induced apoptosis : The role of JNK/c-Jun/Caspase-3 inhibition and Akt signaling enhancement. Herz. 2016;41:715-724 pubmed
    ..Furthermore, the effect of HO-1 on Akt, JNK, and the expression of apoptosis-related proteins (c-JUN and Caspase-3) was determined by Western blotting...
  53. Pechtelidou A, Beis I, Gaitanaki C. Transient and sustained oxidative stress differentially activate the JNK1/2 pathway and apoptotic phenotype in H9c2 cells. Mol Cell Biochem. 2008;309:177-89 pubmed
  54. Huang W, Lv B, Zeng H, Shi D, Liu Y, Chen F, et al. Paracrine Factors Secreted by MSCs Promote Astrocyte Survival Associated With GFAP Downregulation After Ischemic Stroke via p38 MAPK and JNK. J Cell Physiol. 2015;230:2461-75 pubmed publisher
    ..Paracrine factors suppressed the activation of p38 MAPK, JNK, and their downstream targets p53 and STAT1...
  55. Produit Zengaffinen N, Favez T, Pournaras C, Schorderet D. JNK Inhibition Reduced Retinal Ganglion Cell Death after Ischemia/Reperfusion In Vivo and after Hypoxia In Vitro. Adv Exp Med Biol. 2016;854:677-83 pubmed publisher
    ..Among the main classes of MAPKs, c-jun N-terminal kinase (JNK) has been shown to mediate cell stress responses associated with apoptosis...
  56. Auer K, Contessa J, Brenz Verca S, Pirola L, Rusconi S, Cooper G, et al. The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytes. Mol Biol Cell. 1998;9:561-73 pubmed
    The ability of signaling via the JNK (c-Jun NH2-terminal kinase)/stress-activated protein kinase cascade to stimulate or inhibit DNA synthesis in primary cultures of adult rat hepatocytes was examined...
  57. Shi L, Li G, Wang J, Sun B, Yang L, Wang G, et al. Bone marrow stromal cells control the growth of hepatic stellate cells in vitro. Dig Dis Sci. 2008;53:2969-74 pubmed publisher
    ..The effect of BMSCs on the apoptosis of HSCs is possibly via the JNK pathway activated by nerve growth factor (NGF) and hepatocyte growth factor (HGF) secreted by BMSCs...
  58. Johnson G, Nakamura K. The c-jun kinase/stress-activated pathway: regulation, function and role in human disease. Biochim Biophys Acta. 2007;1773:1341-8 pubmed
    ..b>JNK/SAPKs have since been characterized to be involved in proliferation, apoptosis, motility, metabolism and DNA repair...
  59. Heidbreder M, Naumann A, Tempel K, Dominiak P, Dendorfer A. Remote vs. ischaemic preconditioning: the differential role of mitogen-activated protein kinase pathways. Cardiovasc Res. 2008;78:108-15 pubmed
    ..All investigated MAPK pathways appear to be involved in RPC-induced cardioprotection; however, they do not contribute to the alterations that define the preconditioned state of the myocardium prior to the infarction. ..
  60. Baines C, Zhang J, Wang G, Zheng Y, Xiu J, Cardwell E, et al. Mitochondrial PKCepsilon and MAPK form signaling modules in the murine heart: enhanced mitochondrial PKCepsilon-MAPK interactions and differential MAPK activation in PKCepsilon-induced cardioprotection. Circ Res. 2002;90:390-7 pubmed
    ..Furthermore, formation of mitochondrial PKCepsilon-ERK modules appears to play a role in PKCepsilon-mediated cardioprotection, in part by the phosphorylation and inactivation of Bad. ..
  61. Eyers C, McNeill H, Knebel A, Morrice N, Arthur S, Cuenda A, et al. The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ. Biochem J. 2005;389:127-35 pubmed
    ..Our results suggest that CapZIP may be phosphorylated by JNK (c-Jun N-terminal kinase), which phosphorylates CapZIP to >5 mol/mol within minutes in vitro...
  62. Wang Z, Wang M, Carr B. Integrin alpha5-induced EGFR activation by prothrombin triggers hepatocyte apoptosis via the JNK signaling pathway. J Cell Physiol. 2008;216:551-7 pubmed publisher
    ..triggered phosphorylation of its down-stream target Shc and the activation of the c-Jun N-terminal kinase (JNK) pathway. Prothrombin also induced hepatocyte apoptosis, a change in cell shape and activation of caspase 3 pathway...
  63. He Q, Ding C, Li P. Effects of hyperglycemic and normoglycemic cerebral ischemia on phosphorylation of c-jun NH2-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK). Cell Mol Biol (Noisy-le-grand). 2003;49:1241-7 pubmed
    ..Using phopho-specific antibodies against c-jun NH2-terminal kinase (JNK) and p38 MAPK, we studied activation of these two MAPKs in ischemia-vulnerable neocortex and ischemia-resistant ..
  64. Ryan J, Ma F, Kanellis J, Delgado M, Blease K, Nikolic Paterson D. Spleen tyrosine kinase promotes acute neutrophil-mediated glomerular injury via activation of JNK and p38 MAPK in rat nephrotoxic serum nephritis. Lab Invest. 2011;91:1727-38 pubmed publisher
    ..deposition induces acute neutrophil-mediated glomerular injury via activation of c-Jun amino terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK)...
  65. Slattery M, Lundgreen A, Wolff R. MAP kinase genes and colon and rectal cancer. Carcinogenesis. 2012;33:2398-408 pubmed publisher
    ..DUSP2, DUSP4, DUSP6, DUSP7, MAP2K1, MAP3K1, MAP3K2, MAP3K3, MAP3K7, MAP3K9, MAP3K10, MAP3K11, MAPK1, MAPK3, MAPK8, MAPK12, MAPK14 and RAF1). MAP2K1 rs8039880 [odds ratio (OR) = 0.57, 95% confidence interval (CI) = 0.38, 0...
  66. Gautam S, Rahuja N, Ishrat N, Asthana R, Mishra D, Maurya R, et al. Nymphaea rubra ameliorates TNF-α-induced insulin resistance via suppression of c-Jun NH2-terminal kinase and nuclear factor-κB in the rat skeletal muscle cells. Appl Biochem Biotechnol. 2014;174:2446-57 pubmed publisher
    ..Moreover, N. rubra decreases Ser(307) phosphorylation of IRS-1 by the suppression of JNK and NF-κB activation. In conclusion, N...
  67. Bas D, Abdelmoaty S, Sandor K, Codeluppi S, Fitzsimmons B, Steinauer J, et al. Spinal release of tumour necrosis factor activates c-Jun N-terminal kinase and mediates inflammation-induced hypersensitivity. Eur J Pain. 2015;19:260-70 pubmed publisher
    ..evidence points to individual contributions of tumour necrosis factor-alpha (TNF) and the c-Jun N-terminal kinase (JNK) pathway to the induction and maintenance of various pain states...
  68. Rodriguez Blanco J, Martin V, García Santos G, Herrera F, Casado Zapico S, Antolin I, et al. Cooperative action of JNK and AKT/mTOR in 1-methyl-4-phenylpyridinium-induced autophagy of neuronal PC12 cells. J Neurosci Res. 2012;90:1850-60 pubmed publisher
    ..Results showed an early increase in oxidants, which drives the modulation of c-Jun N-terminal kinase (JNK) and AKT/mammalian target of rapamycin (mTOR) pathways, mimicking peroxide treatment...
  69. Butterfield L, Zentrich E, Beekman A, Heasley L. Stress- and cell type-dependent regulation of transfected c-Jun N-terminal kinase and mitogen-activated protein kinase kinase isoforms. Biochem J. 1999;338 ( Pt 3):681-6 pubmed
    ..The specific role of the JNK family members in these diverse cell programmes is largely undefined...
  70. Wu W, Huang Q, He F, Xiao M, Pang S, Guo X, et al. Roles of mitogen-activated protein kinases in the modulation of endothelial cell function following thermal injury. Shock. 2011;35:618-25 pubmed publisher
    ..The JNK MAPK inhibitor, SP600125, on the contrary, influences neither stress-fiber formation nor EC tight-junction damage...
  71. Inukai T, Osuka K, Takagi T, Usuda N, Yoshida J, Takayasu M. Activation of c-jun in the rat basilar artery after subarachnoid hemorrhage. Neurosci Lett. 2007;424:175-8 pubmed
    ..cellular and molecular events, some of which involve a mitogen activated protein kinase, c-jun N-terminal kinase (JNK)...
  72. Lai B, Pu H, Cao Q, Jing H, Liu X. Activation of caspase-3 and c-Jun NH2-terminal kinase signaling pathways involving heroin-induced neuronal apoptosis. Neurosci Lett. 2011;502:209-13 pubmed publisher
    ..that heroin could induce apoptosis of primary cultured cerebellar granule cells (CGC) and c-Jun N-terminal kinase (JNK) pathway is activated during CGCs apoptosis...
  73. Liu J, Chang F, Li F, Fu H, Wang J, Zhang S, et al. Palmitate promotes autophagy and apoptosis through ROS-dependent JNK and p38 MAPK. Biochem Biophys Res Commun. 2015;463:262-7 pubmed publisher
    ..The antioxidant N-Acety-l-Cysteine (NAC) was found to attenuate the JNK and p38 MAPK activation with a concomitant reduction of PA-induced autophagy and apoptosis...
  74. Wang Y, Luo W, Reiser G. Proteinase-activated receptor-1 and -2 induce the release of chemokine GRO/CINC-1 from rat astrocytes via differential activation of JNK isoforms, evoking multiple protective pathways in brain. Biochem J. 2007;401:65-78 pubmed
    ..Despite such clear differences between PAR-1 and PAR-2 signalling pathways, JNK (c-Jun N-terminal kinase) was identified in both signalling pathways to play a pivotal role...
  75. Seow K, Zhou L, Stephanopoulos G, Too H. c-Jun N-terminal kinase in synergistic neurite outgrowth in PC12 cells mediated through P90RSK. BMC Neurosci. 2013;14:153 pubmed publisher
    ..neurite outgrowth, such as Akt, extracellular signal-regulated kinase (Erk), c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (P38), have been extensively studied, the mechanisms underlying multi-..
  76. Chaudhary L, Avioli L. Activation of c-Jun NH2-terminal kinases by interleukin-1 beta in normal human osteoblastic and rat UMR-106 cells. J Cell Biochem. 1998;69:87-93 pubmed
    ..In this report, we have examined whether c-Jun NH2-Terminal Kinase (JNK) pathway is activated by growth factors and interleukin-1 beta (IL-1 beta) in normal HOB and rat UMR-106 cells ..
  77. Murayama T, Tanabe M, Matsuda S, Shimazu M, Kamei S, Wakabayashi G, et al. JNK (c-Jun NH2 terminal kinase) and p38 during ischemia reperfusion injury in the small intestine. Transplantation. 2006;81:1325-30 pubmed
    ..intestinal ischemia reperfusion injury, we investigated the pathophysiological role of c-Jun NH2 terminal kinase (JNK) and p38 in order to determine whether the dual inhibition of JNK and p38 was beneficial...
  78. Crocker S, Hayley S, Smith P, Mount M, Lamba W, Callaghan S, et al. Regulation of axotomy-induced dopaminergic neuron death and c-Jun phosphorylation by targeted inhibition of cdc42 or mixed lineage kinase. J Neurochem. 2006;96:489-99 pubmed
    ..Taken together, these findings suggest that death of nigral dopaminergic neurons following axotomy can be attenuated by targeting cell signaling events upstream of c-Jun N-terminal mitogen-activated protein kinase/c-Jun. ..
  79. Honmo S, Ozaki A, Yamamoto M, Hashimoto N, Miyakoshi M, Tanaka H, et al. Low p38 MAPK and JNK activation in cultured hepatocytes of DRH rats; a strain highly resistant to hepatocarcinogenesis. Mol Carcinog. 2007;46:758-65 pubmed
    ..the stress-activated protein kinases [p38 mitogen-activated protein kinase (p38) and c-jun N-terminal kinase (JNK)] were activated to a lesser degree in the DRH hepatocytes...
  80. Song B, Xie B, Wang C, Li M. c-Jun induction is independent of early growth response factor during cerebellar granule neuron apoptosis. Neuroreport. 2012;23:67-72 pubmed publisher
    ..We conclude that c-Jun induction is independent of Egr during apoptosis induced by activity deprivation in cerebellar granule neurons. ..
  81. Zhou Q, Lam P, Han D, Cadenas E. Activation of c-Jun-N-terminal kinase and decline of mitochondrial pyruvate dehydrogenase activity during brain aging. FEBS Lett. 2009;583:1132-40 pubmed publisher
    Mitochondrial dysfunction is often associated with aging and neurodegeneration. c-Jun-N-terminal kinase (JNK) phosphorylation and its translocation to mitochondria increased as a function of age in rat brain...
  82. Ribas V, Arruda Carvalho M, Linden R, Chiarini L. Early c-Jun N-terminal kinase-dependent phosphorylation of activating transcription factor-2 is associated with degeneration of retinal ganglion cells. Neuroscience. 2011;180:64-74 pubmed publisher
    ..of ATF-2 and ganglion cell death were blocked by treatment with an inhibitor of c-Jun N-terminal kinase (JNK), whereas an inhibitor of p38 reduced only slightly the rate of ganglion cell death with no effect upon ..
  83. Shioi T, McMullen J, Tarnavski O, Converso K, Sherwood M, Manning W, et al. Rapamycin attenuates load-induced cardiac hypertrophy in mice. Circulation. 2003;107:1664-70 pubmed
    ..Because systemic administration of rapamycin has been used successfully for the treatment of transplant rejection in clinical practice, it may be a useful therapeutic modality to suppress cardiac hypertrophy in patients. ..
  84. Kaur S, Wang F, Venkatraman M, Arsura M. X-linked inhibitor of apoptosis (XIAP) inhibits c-Jun N-terminal kinase 1 (JNK1) activation by transforming growth factor beta1 (TGF-beta1) through ubiquitin-mediated proteosomal degradation of the TGF-beta1-activated kinase 1 (TAK1). J Biol Chem. 2005;280:38599-608 pubmed
    ..In addition, induction of NF-kappaB by TGF-beta1 inhibits JNK signaling, thereby attenuating TGF-beta1-induced cell death of normal hepatocytes...
  85. Bi X, Pohl N, Dong H, Yang W. Selenium and sulindac are synergistic to inhibit intestinal tumorigenesis in Apc/p21 mice. J Hematol Oncol. 2013;6:8 pubmed publisher
    ..This finding provides an important chemopreventive strategy using combination of anti-cancer agents, which has a great impact on cancer prevention and has a promising translational potential. ..
  86. Sury M, McShane E, Hernandez Miranda L, Birchmeier C, Selbach M. Quantitative proteomics reveals dynamic interaction of c-Jun N-terminal kinase (JNK) with RNA transport granule proteins splicing factor proline- and glutamine-rich (Sfpq) and non-POU domain-containing octamer-binding protein (Nono) during neuronal d. Mol Cell Proteomics. 2015;14:50-65 pubmed publisher
    The c-Jun N-terminal kinase (JNK) is an important mediator of physiological and pathophysiological processes in the central nervous system...
  87. Liu H, Liu Y, Viggeswarapu M, Zheng Z, Titus L, Boden S. Activation of c-Jun NH(2)-terminal kinase 1 increases cellular responsiveness to BMP-2 and decreases binding of inhibitory Smad6 to the type 1 BMP receptor. J Bone Miner Res. 2011;26:1122-32 pubmed publisher
    ..c-Jun NH(2)-terminal kinase (JNK) is a MAPK that has been reported to be required for late-stage differentiation of preosteoblasts and BMP-2-induced ..
  88. Stambe C, Atkins R, Hill P, Nikolic Paterson D. Activation and cellular localization of the p38 and JNK MAPK pathways in rat crescentic glomerulonephritis. Kidney Int. 2003;64:2121-32 pubmed
    The p38 and c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase (MAPK) are intracellular signal transduction pathways involved in the production of inflammatory mediators...
  89. Cao S, Sun L, Zhao G, Liu H, Zhang H. [Effects of exercise on JNK phosphorylation and expression in skeletal muscle of rats]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2009;25:103-6 pubmed
    To investigate the effects of exercise on JNK phosphorylation, protein and gene expression. Male rats were randomly divided into control and trained groups. The trained rats were submitted to 1 h or 1...
  90. Liu M, Zhang F, Guo S, Zhao L, An Y, Cui X, et al. Phosphorylation of c-Jun N-terminal kinase isoforms and their different roles in spinal cord dorsal horn and primary somatosensory cortex. Neurosci Lett. 2007;427:39-43 pubmed
    The present study was undertaken to investigate whether isoforms of c-Jun N-terminal kinase (JNK 46 kDa and 54 kDa), one component of the mitogen-activated protein kinase (MAPK) family, might show region-related differential activation ..
  91. Kyriakis J, Banerjee P, Nikolakaki E, Dai T, Rubie E, Ahmad M, et al. The stress-activated protein kinase subfamily of c-Jun kinases. Nature. 1994;369:156-60 pubmed
    ..9). SAPKs therefore define a new TNF-alpha and stress-activated signalling pathway, possibly initiated by sphingomyelin-based second messengers, which regulates the activity of c-Jun. ..