Mapk7

Summary

Gene Symbol: Mapk7
Description: mitogen-activated protein kinase 7
Alias: Bmk1, Erk5, Prkm7, mitogen-activated protein kinase 7, BMK-1, BMK1 kinase, ERK-5, MAP kinase 7, MAPK 7, big MAP kinase 1, extracellular signal-regulated kinase 5
Species: rat
Products:     Mapk7

Top Publications

  1. Wang R, Zhang Q, Li C, Zhang G. Activation of extracellular signal-regulated kinase 5 may play a neuroprotective role in hippocampal CA3/DG region after cerebral ischemia. J Neurosci Res. 2005;80:391-9 pubmed
    Extracellular signal-regulated kinase 5 (ERK5), the newest member of the mitogen-activated protein (MAP) kinase family of proteins, is widely expressed in many tissues, including the brain...
  2. Liu L, Cundiff P, Abel G, Wang Y, Faigle R, Sakagami H, et al. Extracellular signal-regulated kinase (ERK) 5 is necessary and sufficient to specify cortical neuronal fate. Proc Natl Acad Sci U S A. 2006;103:9697-702 pubmed
    ..Lentiviral gene delivery of a dominant negative ERK5 or dominant negative MAP kinase kinase 5 reduced the number of neurons generated from rat cortical progenitor cells ..
  3. Xiao C, Zhang L, Cheng Q, Zhang L. The activation of extracellular signal-regulated protein kinase 5 in spinal cord and dorsal root ganglia contributes to inflammatory pain. Brain Res. 2008;1215:76-86 pubmed publisher
    ..In this study, we investigated extracellular signal-regulated protein kinase 5 (ERK5) activation by peripheral inflammation in the spinal cord and DRG of rats and whether this activation contributes ..
  4. Cundiff P, Liu L, Wang Y, Zou J, Pan Y, Abel G, et al. ERK5 MAP kinase regulates neurogenin1 during cortical neurogenesis. PLoS ONE. 2009;4:e5204 pubmed publisher
    ..Activation of ERK5 potentiated, while blocking ERK5 inhibited Neurog1-induced neurogenesis...
  5. Obara Y, Yamauchi A, Takehara S, Nemoto W, Takahashi M, Stork P, et al. ERK5 activity is required for nerve growth factor-induced neurite outgrowth and stabilization of tyrosine hydroxylase in PC12 cells. J Biol Chem. 2009;284:23564-73 pubmed publisher
    ..b>ERK5 is approximately twice the size of ERK1/2, and its amino-terminal half contains the kinase domain that shares ..
  6. Liu L, Cavanaugh J, Wang Y, Sakagami H, Mao Z, Xia Z. ERK5 activation of MEF2-mediated gene expression plays a critical role in BDNF-promoted survival of developing but not mature cortical neurons. Proc Natl Acad Sci U S A. 2003;100:8532-7 pubmed
    Extracellular signal-regulated kinase 5 (ERK5) is a member of the mitogen-activated protein kinase family whose biological function in the CNS has not been defined...
  7. Sohn S, Sarvis B, Cado D, Winoto A. ERK5 MAPK regulates embryonic angiogenesis and acts as a hypoxia-sensitive repressor of vascular endothelial growth factor expression. J Biol Chem. 2002;277:43344-51 pubmed
    ..Here we report that embryos deficient for the ERK5 MAPK die between embryonic days 10.5 and 11.5 with angiogenic failure and cardiovascular defects...
  8. Yang C, Ornatsky O, McDermott J, Cruz T, Prody C. Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1. Nucleic Acids Res. 1998;26:4771-7 pubmed
    ..In this study, a mitogen-activated protein kinase (MAP kinase), ERK5/BMK1 was found to interact with MEF2 in a yeast two hybrid screen...
  9. Wang Y, Su B, Xia Z. Brain-derived neurotrophic factor activates ERK5 in cortical neurons via a Rap1-MEKK2 signaling cascade. J Biol Chem. 2006;281:35965-74 pubmed
    The extracellular signal-regulated kinase 5 (ERK5) is activated in neurons of the central nervous system by neurotrophins including brain-derived neurotrophic factor (BDNF)...

More Information

Publications62

  1. Wang X, Tournier C. Regulation of cellular functions by the ERK5 signalling pathway. Cell Signal. 2006;18:753-60 pubmed
    Extracellular-regulated protein kinase 5 (ERK5) is a mitogen-activated protein kinase (MAPK) regulated by a wide range of mitogens and cellular stresses...
  2. Obara Y, Okano Y, Ono S, Yamauchi A, Hoshino T, Kurose H, et al. Betagamma subunits of G(i/o) suppress EGF-induced ERK5 phosphorylation, whereas ERK1/2 phosphorylation is enhanced. Cell Signal. 2008;20:1275-83 pubmed publisher
    ..b>ERK5 is twice the size of ERK1/2, the amino-terminal half contains the kinase domain that shares the homology with ERK1/..
  3. Watson F, Heerssen H, Bhattacharyya A, Klesse L, Lin M, Segal R. Neurotrophins use the Erk5 pathway to mediate a retrograde survival response. Nat Neurosci. 2001;4:981-8 pubmed
    ..signaling, endocytosed neurotrophin receptors (Trks) activate the extracellular signal-related protein kinase 5 (Erk5) pathway, leading to nuclear translocation of Erk5, phosphorylation of CREB, and enhanced neuronal survival...
  4. Abe J, Kusuhara M, Ulevitch R, Berk B, Lee J. Big mitogen-activated protein kinase 1 (BMK1) is a redox-sensitive kinase. J Biol Chem. 1996;271:16586-90 pubmed
    ..A new MAP kinase family member termed Big MAP kinase 1 (BMK1) or ERK5 was recently cloned...
  5. Yan C, Luo H, Lee J, Abe J, Berk B. Molecular cloning of mouse ERK5/BMK1 splice variants and characterization of ERK5 functional domains. J Biol Chem. 2001;276:10870-8 pubmed
    ..Human MAPK 5 (ERK5) or Big MAP kinase 1 (BMK1) is a recently cloned member of the MAPK family...
  6. Kimura T, Jin J, Zi M, Prehar S, Liu W, Oceandy D, et al. Targeted deletion of the extracellular signal-regulated protein kinase 5 attenuates hypertrophic response and promotes pressure overload-induced apoptosis in the heart. Circ Res. 2010;106:961-70 pubmed publisher
    ..However, the role of ERK5 plays in regulating hypertrophic growth and hypertrophy-induced apoptosis is not completely understood...
  7. Abdelmohsen K, Sauerbier E, Ale Agha N, Beier J, Walter P, Galban S, et al. Epidermal growth factor- and stress-induced loss of gap junctional communication is mediated by ERK-1/ERK-2 but not ERK-5 in rat liver epithelial cells. Biochem Biophys Res Commun. 2007;364:313-7 pubmed
    ..Thus, EGF- or menadione-induced loss of GJC is mediated by ERK-1/2 but not ERK-5 in rat liver epithelial cells. ..
  8. Li Z, Cheng Z, Wang G, Hao X, Zhang L, Xu C. 6 Paths of ERK5 signaling pathway regulate hepatocyte proliferation in rat liver regeneration. Indian J Biochem Biophys. 2012;49:165-72 pubmed
    Generally, extra-cellular-signal-regulated kinase 5 (ERK5) signaling pathway regulates many physiological activities, such as cell proliferation and cell differentiation...
  9. Abbasi S, Lee J, Su B, Chen X, Alcon J, Yang J, et al. Protein kinase-mediated regulation of calcineurin through the phosphorylation of modulatory calcineurin-interacting protein 1. J Biol Chem. 2006;281:7717-26 pubmed
    ..Here, we show that MEK5 and big MAP kinase 1 (BMK1) function downstream of MEKK3 in a signaling cascade that induces calcineurin activity through ..
  10. Parmar M, Jaumotte J, Wyrostek S, Zigmond M, Cavanaugh J. Role of ERK1, 2, and 5 in dopamine neuron survival during aging. Neurobiol Aging. 2014;35:669-79 pubmed publisher
    ..An age-related decrease in phosphorylated ERK5 was observed in the SN and STR, whereas an increase in total ERK1 was observed in all 3 regions...
  11. Kim M, Kim S, Lim J, Lee C, Choi H, Woo C. Laminar flow activation of ERK5 protein in vascular endothelium leads to atheroprotective effect via NF-E2-related factor 2 (Nrf2) activation. J Biol Chem. 2012;287:40722-31 pubmed publisher
    Laminar flow protects from atherosclerosis in endothelium. Laminar flow induces Nrf2 activation dependent on ERK5 activation, leading to up-regulation of downstream genes of Nrf2...
  12. Dalmay T, Horsefield R, Braunstein T, Baulcombe D. SDE3 encodes an RNA helicase required for post-transcriptional gene silencing in Arabidopsis. EMBO J. 2001;20:2069-78 pubmed
    ..These proteins are similar to, but clearly distinct from Upf1p and SMG-2, which are required for nonsense-mediated mRNA decay in yeast and Caenorhabditis elegans and, in the case of SMG-2, for PTGS. ..
  13. Ohnesorge N, Viemann D, Schmidt N, Czymai T, Spiering D, Schmolke M, et al. Erk5 activation elicits a vasoprotective endothelial phenotype via induction of Kruppel-like factor 4 (KLF4). J Biol Chem. 2010;285:26199-210 pubmed publisher
    The MEK5/Erk5 MAPK cascade has recently been implicated in the regulation of endothelial integrity and represents a candidate pathway mediating the beneficial effects of laminar flow, a major factor preventing vascular dysfunction and ..
  14. Raviv Z, Kalie E, Seger R. MEK5 and ERK5 are localized in the nuclei of resting as well as stimulated cells, while MEKK2 translocates from the cytosol to the nucleus upon stimulation. J Cell Sci. 2004;117:1773-84 pubmed
    The ERK5 signaling cascade acts through sequential activation of MEKK2/3, MEK5 and ERK5 and transmits signals to a variety of stress and mitogenic related targets...
  15. Izawa Y, Yoshizumi M, Ishizawa K, Fujita Y, Kondo S, Kagami S, et al. Big mitogen-activated protein kinase 1 (BMK1)/extracellular signal regulated kinase 5 (ERK5) is involved in platelet-derived growth factor (PDGF)-induced vascular smooth muscle cell migration. Hypertens Res. 2007;30:1107-17 pubmed publisher
    Big mitogen-activated protein kinase 1 (BMK1), also known as extracellular signal-regulated kinase 5 (ERK5), is a newly identified member of the mitogen-activated protein (MAP) kinase family...
  16. Lai V, Ashraf M, Jiang S, HAIDER K. MicroRNA-143 is a critical regulator of cell cycle activity in stem cells with co-overexpression of Akt and angiopoietin-1 via transcriptional regulation of Erk5/cyclin D1 signaling. Cell Cycle. 2012;11:767-77 pubmed publisher
    ..Ad-Empty transduced MSC; (Emp)MSC). (AA)MSC had higher phosphorylation of FoxO1, which activated Erk5, a distinct mitogen-induced MAPK that drove transcriptional activation of cyclin D1 and Cdk4...
  17. Stankiewicz T, Ramaswami S, Bouchard R, Aktories K, Linseman D. Neuronal apoptosis induced by selective inhibition of Rac GTPase versus global suppression of Rho family GTPases is mediated by alterations in distinct mitogen-activated protein kinase signaling cascades. J Biol Chem. 2015;290:9363-76 pubmed publisher
    ..Instead, targeted inhibition of Rac suppresses distinct MEK5/ERK5, p90Rsk, and Akt-dependent signaling cascades known to regulate the localization and expression of the Bcl-2 ..
  18. Zhao J, Kyotani Y, Itoh S, Nakayama H, Isosaki M, Yoshizumi M. Big mitogen-activated protein kinase 1 protects cultured rat aortic smooth muscle cells from oxidative damage. J Pharmacol Sci. 2011;116:173-80 pubmed
    ..Big mitogen-activated protein kinase-1 / extracellular signal-regulated kinase 5 (BMK1/ERK5) is a newly identified member of the mitogen-activated protein kinases family...
  19. Suzaki Y, Yoshizumi M, Kagami S, Koyama A, Taketani Y, Houchi H, et al. Hydrogen peroxide stimulates c-Src-mediated big mitogen-activated protein kinase 1 (BMK1) and the MEF2C signaling pathway in PC12 cells: potential role in cell survival following oxidative insults. J Biol Chem. 2002;277:9614-21 pubmed
    ..b>Big MAP kinase 1 (BMK1), also known as ERK5, is a newly identified member of the MAP kinase family and has been reported to be ..
  20. Obara Y, Nagasawa R, Nemoto W, Pellegrino M, Takahashi M, Habecker B, et al. ERK5 induces ankrd1 for catecholamine biosynthesis and homeostasis in adrenal medullary cells. Cell Signal. 2016;28:177-189 pubmed publisher
    ..In our previous study, we demonstrated that both ERK5 and ERK1/2 were responsible for neurite outgrowth and tyrosine hydroxylase (TH) expression in rat pheochromocytoma ..
  21. McCracken S, Ramsay A, Heer R, Mathers M, Jenkins B, Edwards J, et al. Aberrant expression of extracellular signal-regulated kinase 5 in human prostate cancer. Oncogene. 2008;27:2978-88 pubmed
    ..In this study, we examined the role of extracellular signal-regulated kinase (ERK5, an MAPK and specific substrate for MEK5) in prostate cancer...
  22. Takahashi N, Saito Y, Kuwahara K, Harada M, Tanimoto K, Nakagawa Y, et al. Hypertrophic responses to cardiotrophin-1 are not mediated by STAT3, but via a MEK5-ERK5 pathway in cultured cardiomyocytes. J Mol Cell Cardiol. 2005;38:185-92 pubmed
    ..CT-1 also induced phosphorylations of ERK1/2 and ERK5 in cardiomyocytes, and those, too, were suppressed by overexpression of SOCSs...
  23. Bera A, Das F, Ghosh Choudhury N, Li X, Pal S, Gorin Y, et al. A positive feedback loop involving Erk5 and Akt turns on mesangial cell proliferation in response to PDGF. Am J Physiol Cell Physiol. 2014;306:C1089-100 pubmed publisher
    ..We examined the role of a recently identified MAPK, Erk5, in this process...
  24. Goalstone M. ERK5: a novel IKK?-kinase in rat hippocampal neurons. Can J Neurol Sci. 2011;38:639-48 pubmed
    ..Rat Primmary Hippocampal Neurons (RPHN) were treated with insulin in the absence and presence of Wortmannin and ERK5 small inhibitory RNA and assayed for downstream effectors of activated ERK5...
  25. Yoshizumi M, Kyotani Y, Zhao J, Nagayama K, Ito S, Tsuji Y, et al. Role of big mitogen-activated protein kinase 1 (BMK1) / extracellular signal-regulated kinase 5 (ERK5) in the pathogenesis and progression of atherosclerosis. J Pharmacol Sci. 2012;120:259-63 pubmed
    Big mitogen-activated protein kinase 1 (BMK1), also known as extracellular signal-regulated kinase 5 (ERK5), is a newly identified member of the mitogen-activated protein (MAP) kinase family...
  26. Liu W, Ruiz Velasco A, Wang S, Khan S, Zi M, Jungmann A, et al. Metabolic stress-induced cardiomyopathy is caused by mitochondrial dysfunction due to attenuated Erk5 signaling. Nat Commun. 2017;8:494 pubmed publisher
    ..Here, we show that extracellular signal-regulated protein kinase 5 (Erk5) is lost in the hearts of obese/diabetic animal models and that cardiac-specific deletion of Erk5 in mice (Erk5-CKO)..
  27. Qi S, Guan Q, Wang M, Zhang G. Action of ERK5 in ischemic tolerance suggests its probable participation in the signaling mechanism. J Recept Signal Transduct Res. 2009;29:38-43 pubmed publisher
    ..preconditioning and ketamine, an NMDA receptor antagonist, on the activation and its nucleus translocation of ERK5 in hippocampal CA1 region. Our results showed ERK5 was not activated in rat hippocampus CA1 region...
  28. Wei X, Sun W, Fan R, Hahn J, Joetham A, Li G, et al. MEF2C regulates c-Jun but not TNF-alpha gene expression in stimulated mast cells. Eur J Immunol. 2003;33:2903-9 pubmed
    ..MEKK2 is essential for activation of c-Jun N-terminal kinase (JNK) and extracellular signal-regulated kinase 5 (ERK5)...
  29. Mizushima T, Obata K, Katsura H, Sakurai J, Kobayashi K, Yamanaka H, et al. Intensity-dependent activation of extracellular signal-regulated protein kinase 5 in sensory neurons contributes to pain hypersensitivity. J Pharmacol Exp Ther. 2007;321:28-34 pubmed
    ..In the present study, we investigated the phosphorylation of ERK5, also known as big MAPK1, in the DRG by noxious stimulation using immunohistochemistry...
  30. Urushihara M, Takamatsu M, Shimizu M, Kondo S, Kinoshita Y, Suga K, et al. ERK5 activation enhances mesangial cell viability and collagen matrix accumulation in rat progressive glomerulonephritis. Am J Physiol Renal Physiol. 2010;298:F167-76 pubmed publisher
    ..Here, we investigated whether extracellular signal-regulated kinase 5 (ERK5), a member of the MAPK family, is involved in the pathogenesis of chronic mesangioproliferative GN, using a rat ..
  31. Honda T, Obara Y, Yamauchi A, Couvillon A, Mason J, Ishii K, et al. Phosphorylation of ERK5 on Thr732 is associated with ERK5 nuclear localization and ERK5-dependent transcription. PLoS ONE. 2015;10:e0117914 pubmed publisher
    ..b>ERK5 contains a kinase domain at the N-terminal, and the unique extended C-terminal includes multiple ..
  32. Yan L, Carr J, Ashby P, Murry Tait V, Thompson C, Arthur J. Knockout of ERK5 causes multiple defects in placental and embryonic development. BMC Dev Biol. 2003;3:11 pubmed
    b>ERK5 is a member of the mitogen activated protein kinase family activated by certain mitogenic or stressful stimuli in cells, but whose physiological role is largely unclear...
  33. Yu S, Xia C, Kay J, Qiao L. Activation of extracellular signal-regulated protein kinase 5 is essential for cystitis- and nerve growth factor-induced calcitonin gene-related peptide expression in sensory neurons. Mol Pain. 2012;8:48 pubmed publisher
    ..The molecular mechanism and signal transduction underlying cross talk between the inflamed urinary bladder and sensory sensitization has not been investigated...
  34. Yang T, Yu R, Agadir A, Gao G, Campos Gonzalez R, Tournier C, et al. Integration of protein kinases mTOR and extracellular signal-regulated kinase 5 in regulating nucleocytoplasmic localization of NFATc4. Mol Cell Biol. 2008;28:3489-501 pubmed publisher
    ..of endogenous NFATc4 is mediated by mTOR and, surprisingly, by extracellular signal-regulated kinase 5 (ERK5) mitogen-activated protein kinase as well...
  35. Wu Y, Feng B, Chen S, Zuo Y, Chakrabarti S. Glucose-induced endothelin-1 expression is regulated by ERK5 in the endothelial cells and retina of diabetic rats. Can J Physiol Pharmacol. 2010;88:607-15 pubmed publisher
    ..Extracellular signal-regulated kinase 5 (ERK5) is a member of the MAPK family, which plays a key role in cardiovascular development...
  36. Le N, Takei Y, Shishido T, Woo C, Chang E, Heo K, et al. p90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction. Circ Res. 2012;110:536-50 pubmed publisher
    ..b>ERK5 is known to inhibit cardiac apoptosis after myocardial infarction (MI), especially in hyperglycemic states, via ..
  37. Kawakami T, Park S, Kaku R, Yang J. Extracellular-regulated-kinase 5-mediated renal protection against ischemia-reperfusion injury. Biochem Biophys Res Commun. 2012;418:603-8 pubmed publisher
    b>ERK5, a member of the mitogen activated protein kinase, expressed in the kidneys was smaller (?80kDa) in apparent molecular mass compared to other organs (?120kDa)...
  38. Woo C, Le N, Shishido T, Chang E, Lee H, Heo K, et al. Novel role of C terminus of Hsc70-interacting protein (CHIP) ubiquitin ligase on inhibiting cardiac apoptosis and dysfunction via regulating ERK5-mediated degradation of inducible cAMP early repressor. FASEB J. 2010;24:4917-28 pubmed publisher
    ..In the current study, we found that the cardioprotective effect of insulin growth factor-1 (IGF-1) was mediated by ERK5-CHIP signal module via inducible cAMP early repressor (ICER) destabilization...
  39. Su C, Cunningham R, Rybalchenko N, Singh M. Progesterone increases the release of brain-derived neurotrophic factor from glia via progesterone receptor membrane component 1 (Pgrmc1)-dependent ERK5 signaling. Endocrinology. 2012;153:4389-400 pubmed publisher
    ..Given recent data from our laboratory that supported the role of ERK5 in BDNF release, we also tested whether P4-induced BDNF release was mediated by ERK5...
  40. Wang R, Zhang Q, Li J, Yang L, Yang F, Brann D. The ERK5-MEF2C transcription factor pathway contributes to anti-apoptotic effect of cerebral ischemia preconditioning in the hippocampal CA1 region of rats. Brain Res. 2009;1255:32-41 pubmed publisher
    ..enhancer binding factor 2C (MEF2C), a common substrate of p38 kinase and extracellular signal-regulated kinase 5 (ERK5) in the hippocampal CA1 region following cerebral ischemia preconditioning (CIP) and without CIP...
  41. Zhao Z, Wang W, Geng J, Wang L, Su G, Zhang Y, et al. Protein kinase C epsilon-dependent extracellular signal-regulated kinase 5 phosphorylation and nuclear translocation involved in cardiomyocyte hypertrophy with angiotensin II stimulation. J Cell Biochem. 2010;109:653-62 pubmed publisher
    ..Furthermore, Ang II-induced extracellular signal-regulated kinase 5 (ERK5) phosphorylation and translocation was mediated through a signal pathway that involves AT(1) and PKCepsilon, which ..
  42. Mackesy D, Goalstone M. Extracellular signal-regulated kinase-5: Novel mediator of insulin and tumor necrosis factor ?-stimulated vascular cell adhesion molecule-1 expression in vascular cells. J Diabetes. 2014;6:595-602 pubmed publisher
    ..We hypothesized that extracellular signal-regulated kinase-5 (ERK5) plays an important role in insulin and TNF?-stimulated total and cell surface VCAM-1 expression...
  43. Sun J, Xiao C, Lu B, Zhang J, Yuan X, Chen W, et al. CX3CL1/CX3CR1 regulates nerve injury-induced pain hypersensitivity through the ERK5 signaling pathway. J Neurosci Res. 2013;91:545-53 pubmed publisher
    ..regulates microglia activation through the phosphorylation of extracellular signal-regulated protein kinase 5 (ERK5) in the spinal cord of rats with spinal nerve ligation (SNL)...
  44. Nishiyama A, Yao L, Nagai Y, Miyata K, Yoshizumi M, Kagami S, et al. Possible contributions of reactive oxygen species and mitogen-activated protein kinase to renal injury in aldosterone/salt-induced hypertensive rats. Hypertension. 2004;43:841-8 pubmed
    ..extracellular signal-regulated kinases (ERK)1/2, c-Jun-NH2-terminal kinases (JNK), p38MAPK, and big-MAPK-1 (BMK1) in renal cortical tissues were measured by Western blot analysis...
  45. Browne J, Pearson A, Zahr R, Niculescu Duvaz I, Baines D, Dockrell M. TGF-beta activates ERK5 in human renal epithelial cells. Biochem Biophys Res Commun. 2008;373:440-4 pubmed publisher
    The role of the MAP kinase, extracellular signal-regulated kinase 5 (ERK5) remains unknown, however it is involved in cell differentiation and survival as highlighted by the embryonic lethality of the ERK5 knockout...
  46. Wang Y, Zhou J, Liang C, Hong K, Cheng X, Wu Z. ERK5 knock down aggravates detrimental effects of hypothermal stimulation on cardiomyocytes via Bim upregulation. Environ Toxicol Pharmacol. 2013;36:724-31 pubmed publisher
    Mechanism of cold induced myocardial injury remained unclear. Our study investigated the role of ERK5/Bim pathway in hypothermal stimulation-induced apoptosis or damage of cardiomyocytes (CMs)...
  47. Sato Y, Harada K, Kizawa K, Sanzen T, Furubo S, Yasoshima M, et al. Activation of the MEK5/ERK5 cascade is responsible for biliary dysgenesis in a rat model of Caroli's disease. Am J Pathol. 2005;166:49-60 pubmed
    ..of MAPK/extracellular signal-regulated protein kinase (ERK) kinase 5 (MEK5), and subsequent phosphorylation of ERK5 in vitro...
  48. Yang Q, Liao L, Deng X, Chen R, Gray N, Yates J, et al. BMK1 is involved in the regulation of p53 through disrupting the PML-MDM2 interaction. Oncogene. 2013;32:3156-64 pubmed publisher
    ..We found that activated big MAP kinase 1 (BMK1) preferentially associates with PML isoform IV and disrupts PML-MDM2 interaction...
  49. Guo Y, Cheng J, Jin G, Gutkind J, Hellmich M, Townsend C. Gastrin stimulates cyclooxygenase-2 expression in intestinal epithelial cells through multiple signaling pathways. Evidence for involvement of ERK5 kinase and transactivation of the epidermal growth factor receptor. J Biol Chem. 2002;277:48755-63 pubmed
    ..These actions were dependent upon the activation of multiple MAPK signal pathways, including ERK5 kinase; transactivation of the epidermal growth factor receptor; and the increased expression and activities of ..
  50. Villa Moruzzi E. Targeting of FAK Ser910 by ERK5 and PP1delta in non-stimulated and phorbol ester-stimulated cells. Biochem J. 2007;408:7-18 pubmed
    ..protein kinase/ERK kinase) inhibitors UO126 and CI-1040 to inhibit ERK1/2 pointed to the involvement of ERK5. This hypothesis was confirmed by: (i) shRNA ERK5 gene silencing, which resulted in complete pSer910 loss in non-..
  51. Wang C, Song S, Ding Y, Guo S, Liu X, Hao S, et al. Extracellular Signal-Regulated Kinase 5 in the Cerebrospinal Fluid-Contacting Nucleus Contributes to Neuropathic Pain in Rats. Pain Physician. 2015;18:E1073-81 pubmed
    ..However, whether extracellular signal-regulated protein kinase 5 (ERK5), a member of MAPKs, in CSF-CN participates in neuropathic pain has not been studied yet...
  52. Buschbeck M, Eickhoff J, Sommer M, Ullrich A. Phosphotyrosine-specific phosphatase PTP-SL regulates the ERK5 signaling pathway. J Biol Chem. 2002;277:29503-9 pubmed
    ..We investigated the role of tyrosine-specific phosphatases (PTPs) in the regulation of ERK5. Although unique in its structure, ERK5 is activated in analogy to other MAPKs by dual phosphorylation of threonine ..
  53. Grewal P, Holzfeind P, Bittner R, Hewitt J. Mutant glycosyltransferase and altered glycosylation of alpha-dystroglycan in the myodystrophy mouse. Nat Genet. 2001;28:151-4 pubmed
    ..We speculate that abnormal post-translational modification of alpha-dystroglycan may contribute to the myd phenotype. ..