Gene Symbol: Mapk14
Description: mitogen activated protein kinase 14
Alias: CRK1, CSBP, CSPB1, Csbp1, Csbp2, Exip, Hog, Mxi2, Prkm14, Prkm15, Sapk2A, p38, p38Hog, p38alpha, mitogen-activated protein kinase 14, Csaids binding protein, MAP kinase 14, MAP kinase 2, MAP kinase Mxi2, MAP kinase p38 alpha, MAPK 14, MAX-interacting protein 2, cytokine suppressive anti-inflammatory drug binding protein, cytokine-supressive anti-inflammatory drug binding protein, mitogen-activated protein kinase 14A, mitogen-activated protein kinase p38 alpha, p38 MAP kinase, p38 mitogen activated protein kinase, p38alpha Exip, reactive kinase, stress-activated protein kinase 2A
Species: rat
Products:     Mapk14

Top Publications

  1. Chu Y, Jiang Y, Zhang J, Ren H, Jiang J, Meng M, et al. [The role of p38 mitogen-activated protein kinase in interleukin-6 induction by lipopolysaccharide in vascular smooth muscle cells]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2010;22:291-4 pubmed
    To investigate the regulation mechanism of p38 mitogen-activated protein kinase (p38MAPK) in interleukin-6 (IL-6) expression of vascular smooth muscle cell (VSMC) induced by lipopolysaccharide (LPS)...
  2. Munoz L, Ralay Ranaivo H, Roy S, Hu W, Craft J, McNamara L, et al. A novel p38 alpha MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model. J Neuroinflammation. 2007;4:21 pubmed
    ..A logical candidate CNS target is p38 alpha MAPK, a well-established drug discovery molecular target for altering proinflammatory cytokine cascades in ..
  3. Fujita H, Omori S, Ishikura K, Hida M, Awazu M. ERK and p38 mediate high-glucose-induced hypertrophy and TGF-beta expression in renal tubular cells. Am J Physiol Renal Physiol. 2004;286:F120-6 pubmed
    We investigated the expression of ERK, p38 mitogen-activated protein kinase (p38), and JNK in renal tubules of diabetic rats following 3 wk after streptozotocin injection (DM)...
  4. Sato H, Tanaka T, Kasai K, Kita T, Tanaka N. Role of p38 mitogen-activated protein kinase on renal dysfunction after hemorrhagic shock in rats. Shock. 2005;24:488-94 pubmed
    ..b>p38 mitogen-activated protein kinase (MAPK) is a key mediator in organ dysfunction relating to the inflammatory states, ..
  5. Cuenda A, Rousseau S. p38 MAP-kinases pathway regulation, function and role in human diseases. Biochim Biophys Acta. 2007;1773:1358-75 pubmed
    ..There are four members of the p38MAPK family (p38alpha, p38beta, p38gamma and p38delta) which are about 60% identical in their amino acid sequence but differ in their ..
  6. MULLEN L, Pak K, Chavez E, Kondo K, Brand Y, Ryan A. Ras/p38 and PI3K/Akt but not Mek/Erk signaling mediate BDNF-induced neurite formation on neonatal cochlear spiral ganglion explants. Brain Res. 2012;1430:25-34 pubmed publisher
    ..In particular, the p38 and cJUN Kinase (JNK), mitogen-activated protein kinase (MAPK) pathways, which participate in JNK signaling in ..
  7. Sato H, Tanaka T, Kasai K, Kita T, Tanaka N. Role of p38 mitogen-activated protein kinase on cardiac dysfunction after hemorrhagic shock in rats. Shock. 2007;28:291-9 pubmed
    ..Several studies have indicated that p38 mitogen-activated protein kinase (MAPK) is a key mediator in organ dysfunction that is associated with the ..
  8. Niswander J, Dokas L. Hyperosmotic stress-induced caspase-3 activation is mediated by p38 MAPK in the hippocampus. Brain Res. 2007;1186:1-11 pubmed
    The cellular response to insult occurs by signaling via the stress-activated protein kinases, p38, and c-Jun NH(2)-terminal kinase (JNK)...
  9. Kita T, Yamaguchi H, Sato H, Kasai K, Tanaka T, Tanaka N. Role of p38 mitogen-activated protein kinase pathway on renal failure in the infant rat after burn injury. Shock. 2004;21:535-42 pubmed
    The p38 mitogen-activated protein kinase (MAPK) pathway is a proinflammatory signal transduction pathway for the production of cytokines and cellular response to stress, such as bacterial LPS or ischemia...

More Information

Publications106 found, 100 shown here

  1. Guner Y, Ochoa C, Wang J, Zhang X, Steinhauser S, Stephenson L, et al. Peroxynitrite-induced p38 MAPK pro-apoptotic signaling in enterocytes. Biochem Biophys Res Commun. 2009;384:221-5 pubmed publisher
    ..Because p38 mitogen-activated protein kinase (MAPK) and serine-threonine kinase (AKT) are well-characterized pro- and anti-..
  2. Dreixler J, Barone F, Shaikh A, Du E, Roth S. Mitogen-activated protein kinase p38alpha and retinal ischemic preconditioning. Exp Eye Res. 2009;89:782-90 pubmed publisher
    ..We examined the role of p38alpha in the mimicking of IPC produced by opening mitochondrial KATP channels using diazoxide, or stimulation of p38 ..
  3. Choi D, Lee J, Lim E, Baik H, Oh T, Yune T. Inhibition of ROS-induced p38MAPK and ERK activation in microglia by acupuncture relieves neuropathic pain after spinal cord injury in rats. Exp Neurol. 2012;236:268-82 pubmed publisher
  4. Lee J, Laydon J, McDonnell P, Gallagher T, Kumar S, Green D, et al. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature. 1994;372:739-46 pubmed
    ..Binding of the pyridinyl-imidazole compounds inhibited CSBP kinase activity and could be directly correlated with their ability to inhibit cytokine production, suggesting that ..
  5. Tanoue T, Moriguchi T, Nishida E. Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5. J Biol Chem. 1999;274:19949-56 pubmed
    ..signal-regulated kinase (ERK), stress-activated protein kinase (SAPK)/c-Jun N-terminal kinase (JNK), and p38. Nine members of this group of dual specificity phosphatases have previously been cloned...
  6. Hsu J, Kan W, Hsieh Y, Choudhry M, Schwacha M, Bland K, et al. Mechanism of estrogen-mediated improvement in cardiac function after trauma-hemorrhage: p38-dependent normalization of cardiac Akt phosphorylation and glycogen levels. Shock. 2008;30:372-8 pubmed publisher
    Both p38 mitogen-activated protein kinase (p38) activation and protein kinase B (Akt) activation have been reported to regulate glucose transport during myocardial I/R...
  7. Nakajima K, Tohyama Y, Kohsaka S, Kurihara T. Protein kinase C alpha requirement in the activation of p38 mitogen-activated protein kinase, which is linked to the induction of tumor necrosis factor alpha in lipopolysaccharide-stimulated microglia. Neurochem Int. 2004;44:205-14 pubmed
    ..We found that LPS-induced TNF alpha is suppressed by pretreatment with the p38 mitogen-activated protein kinase (p38MAPK) inhibitor SB203580...
  8. Zhang X, Shan P, Alam J, Fu X, Lee P. Carbon monoxide differentially modulates STAT1 and STAT3 and inhibits apoptosis via a phosphatidylinositol 3-kinase/Akt and p38 kinase-dependent STAT3 pathway during anoxia-reoxygenation injury. J Biol Chem. 2005;280:8714-21 pubmed
    ..shown that CO attenuates endothelial cell apoptosis during anoxia-reoxygenation injury by activating MKK3/p38alpha mitogen-activated protein kinase (MAPK) pathways...
  9. Sigaud S, Evelson P, Gonzalez Flecha B. H2O2-induced proliferation of primary alveolar epithelial cells is mediated by MAP kinases. Antioxid Redox Signal. 2005;7:6-13 pubmed
    ..Inhibition of ERK and p38 activation prevented H2O2-induced proliferation...
  10. Shin H, Oh J, Kang S, Lee J, Shin M, Hwang K, et al. Leptin induces hypertrophy via p38 mitogen-activated protein kinase in rat vascular smooth muscle cells. Biochem Biophys Res Commun. 2005;329:18-24 pubmed
    ..A p38 MAP kinase inhibitor SB203580 significantly inhibited leptin-induced hypertrophy, AG490 (a JAK2 inhibitor) partially ..
  11. Chen S, Qiong Y, Gardner D. A role for p38 mitogen-activated protein kinase and c-myc in endothelin-dependent rat aortic smooth muscle cell proliferation. Hypertension. 2006;47:252-8 pubmed
    ..In the present study, we show that the residual mitogenic activity requires an intact p38 mitogen-activated protein kinase (p38 MAPK) system and increased c-myc gene expression...
  12. Teos L, Zhao A, Alvin Z, Laurence G, Li C, Haddad G. Basal and IGF-I-dependent regulation of potassium channels by MAP kinases and PI3-kinase during eccentric cardiac hypertrophy. Am J Physiol Heart Circ Physiol. 2008;295:H1834-45 pubmed publisher
    ..With the use of specific inhibitors for ERK1/2 (PD98059), p38 MAPK (SB203580) and PI3K/Akt (LY294002), Western blot and whole cell patch-clamp were conducted on sham and aorto-..
  13. Abell A, Granger D, Johnson N, Vincent Jordan N, Dibble C, Johnson G. Trophoblast stem cell maintenance by fibroblast growth factor 4 requires MEKK4 activation of Jun N-terminal kinase. Mol Cell Biol. 2009;29:2748-61 pubmed publisher
    ..FGF4-stimulated Jun N-terminal kinase (JNK) and p38 activity is markedly reduced in MEKK4 kinase-inactive TS cells...
  14. Mícová P, Hahnova K, Hlaváčková M, Elsnicova B, Chytilová A, Holzerova K, et al. Chronic intermittent hypoxia affects the cytosolic phospholipase A2?/cyclooxygenase 2 pathway via ?2-adrenoceptor-mediated ERK/p38 stimulation. Mol Cell Biochem. 2016;423:151-163 pubmed
    ..In parallel, we detected increased phosphorylation of protein kinase C?, ERK1/2 and p38 (by 12, 48 and 19 %, respectively)...
  15. Gao B, Sun W, Meng X, Xue D, Zhang W. Screening of differentially expressed protein kinases in bone marrow endothelial cells and the protective effects of the p38a inhibitor SB203580 on bone marrow in liver fibrosis. Mol Med Rep. 2016;14:4629-4637 pubmed publisher
    ..This suggests that protein kinases and their inhibitors may present novel therapeutic strategies for the treatment of hematological abnormalities in patients with LC. ..
  16. Zhu W, Han J, Nicosia R. Requisite role of p38 MAPK in mural cell recruitment during angiogenesis in the rat aorta model. J Vasc Res. 2003;40:140-8 pubmed
    ..Among the intracellular kinases implicated in angiogenesis, the p38 MAPK has been shown to transduce signals critical for vascular remodeling and maturation...
  17. Jin E, Lee S, Choi Y, Jung J, Bang O, Kang S. BMP-2-enhanced chondrogenesis involves p38 MAPK-mediated down-regulation of Wnt-7a pathway. Mol Cells. 2006;22:353-9 pubmed
    ..Here, we demonstrate that BMP-2 promotes chondrogenesis by activating p38 mitogen-activated protein kinase (MAPK), which in turn downregulates Wnt-7a/b-catenin signaling responsible for ..
  18. Yuan Y, Kan H, Fang Q, Chen F, Finkel M. CXCR4 receptor antagonist blocks cardiac myocyte p38 MAP kinase phosphorylation by HIV gp120. Cardiovasc Toxicol. 2008;8:173-80 pubmed publisher
    ..We have previously reported that the HIV envelope glycoprotein, gp120, has a p38 MAP kinase-dependent negative inotropic effect on adult rat ventricular myocytes (ARVM)...
  19. Tang J, Chen X, Tu W, Guo Y, Zhao Z, Xue Q, et al. Propofol inhibits the activation of p38 through up-regulating the expression of annexin A1 to exert its anti-inflammation effect. PLoS ONE. 2011;6:e27890 pubmed publisher
    ..that propofol can not only promote the expression of Annexin A1, but also inhibit the phosphorylation level of p38 and release of inflammatory factors (IL-1?, IL-6 and TNF-?) in rats with endotoxemia...
  20. Chen Y, Rajashree R, Liu Q, Hofmann P. Acute p38 MAPK activation decreases force development in ventricular myocytes. Am J Physiol Heart Circ Physiol. 2003;285:H2578-86 pubmed
    Evidence suggests that p38 mitogen-activated protein kinase (MAPK) activation influences cardiac function on an acute basis. The characterization and mechanisms by which this occurs were investigated in the present study...
  21. Maulik N. Effect of p38 MAP kinase on cellular events during ischemia and reperfusion: possible therapy. Am J Physiol Heart Circ Physiol. 2005;289:H2302-3 pubmed
  22. Das M, Cui J, Das D. Generation of survival signal by differential interaction of p38MAPKalpha and p38MAPKbeta with caveolin-1 and caveolin-3 in the adapted heart. J Mol Cell Cardiol. 2007;42:206-13 pubmed
  23. Honmo S, Ozaki A, Yamamoto M, Hashimoto N, Miyakoshi M, Tanaka H, et al. Low p38 MAPK and JNK activation in cultured hepatocytes of DRH rats; a strain highly resistant to hepatocarcinogenesis. Mol Carcinog. 2007;46:758-65 pubmed
    ..signal regulating kinases (ERK1/2)] were activated to the same degree, the stress-activated protein kinases [p38 mitogen-activated protein kinase (p38) and c-jun N-terminal kinase (JNK)] were activated to a lesser degree in the ..
  24. Chen J, Li C, Pei D, Han D, Liu X, Jiang H, et al. GluR6-containing KA receptor mediates the activation of p38 MAP kinase in rat hippocampal CA1 region during brain ischemia injury. Hippocampus. 2009;19:79-89 pubmed publisher
    ..However, whether the KA receptors subunit GluR6 is involved in the activation of p38 MAP kinase during the transient brain ischemia/reperfusion (I/R) in the rat hippocampal CA1 subfield is still unknown...
  25. Morioka N, Tanabe H, Inoue A, Dohi T, Nakata Y. Noradrenaline reduces the ATP-stimulated phosphorylation of p38 MAP kinase via beta-adrenergic receptors-cAMP-protein kinase A-dependent mechanism in cultured rat spinal microglia. Neurochem Int. 2009;55:226-34 pubmed publisher
    ..of noradrenaline (NA) on the phosphorylation of three MAP kinases (extracellular signal-regulated kinase (ERK), p38, or c-Jun N-terminal kinase (JNK)) stimulated by ATP in rat cultured spinal microglia using Western blotting...
  26. Yuan Y, Sun M, Li K. Astragalus mongholicus polysaccharide inhibits lipopolysaccharide-induced production of TNF-alpha and interleukin-8. World J Gastroenterol. 2009;15:3676-80 pubmed
    ..activation of extracellular signal-regulated kinase or c Jun amino-terminal kinase, but inhibited the activation of p38, suggesting that APS inhibits LPS-induced production of TNF-alpha and IL-8 mRNAs, possibly by suppressing the p38 ..
  27. Ji H, Wang H, Zhang F, Li X, Xiang L, Aiguo S. PPAR? agonist pioglitazone inhibits microglia inflammation by blocking p38 mitogen-activated protein kinase signaling pathways. Inflamm Res. 2010;59:921-9 pubmed publisher
    ..iNOS), the p42/44 extracellular signal-regulated kinase (ERK) MAPKs, c-Jun NH2-terminal kinases (JNKs) and p38 MAPK were determined by Western blot analysis...
  28. Zhang X, Shan P, Otterbein L, Alam J, Flavell R, Davis R, et al. Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3. J Biol Chem. 2003;278:1248-58 pubmed
    ..Transfection of p38alpha dominant negative mutant or inhibition of p38 MAPK activity with SB203580 ablates the anti-apoptotic effects of ..
  29. Wang Z, Chang X, Fu X, Sun T, Yang Y, Chen W, et al. [Expression of protooncogene c-jun, p38 and proliferating cell nuclear antigen in intestinal epithelial cells in rats different development stages]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2003;15:77-80 pubmed
    To investigate the expression characteristics of protooncogene c-jun and its related gene p38 in different developmental intestinal epithelial cells in rats, and to explore their biological roles in the intestinal wound healing after ..
  30. Calloni G, Penno C, Cordova F, Trentin A, Neto V, Leal R. Congenital hypothyroidism alters the phosphorylation of ERK1/2 and p38MAPK in the hippocampus of neonatal rats. Brain Res Dev Brain Res. 2005;154:141-5 pubmed increase in extracellular signal-regulated kinases 1/2 (ERK 1/2) phosphorylation (+50%) and a decrease in p38(MAPK) phosphorylation (-50%) without changing in Jun N-terminal kinases (JNK) phosphorylation...
  31. Liang Q, Elson A, Gerdes A. p38 MAP kinase activity is correlated with angiotensin II type 1 receptor blocker-induced left ventricular reverse remodeling in spontaneously hypertensive heart failure rats. J Card Fail. 2006;12:479-86 pubmed
    ..The present study was to determine if changes in mitogen-activated protein kinase (MAPK, including ERK, JNK, and p38) signaling correlate with ARB-elicited reversal of cardiac hypertrophy in SHHF rats.
  32. Izumi Y, Tokuda K, Zorumski C. Long-term potentiation inhibition by low-level N-methyl-D-aspartate receptor activation involves calcineurin, nitric oxide, and p38 mitogen-activated protein kinase. Hippocampus. 2008;18:258-65 pubmed
    ..Furthermore, both forms of LTP inhibition are overcome by block of p38 mitogen-activated protein kinase (MAPK), but not by inhibition of extracellular signal-regulated kinase 1/2 or c-..
  33. Itoh S, Kanno S, Gai Z, Suemoto H, Kawakatsu M, Tanishima H, et al. Trps1 plays a pivotal role downstream of Gdf5 signaling in promoting chondrogenesis and apoptosis of ATDC5 cells. Genes Cells. 2008;13:355-63 pubmed publisher
    ..Treatment of cells with Gdf5 enhanced Trps1 protein levels and phosphorylation of p38 mitogen-activated protein kinase (MAPK) in a dose-dependent manner...
  34. Khurana A, Dey C. p38 MAPK interacts with actin and modulates filament assembly during skeletal muscle differentiation. Differentiation. 2003;71:42-50 pubmed
    ..The present study reveals an association between actin and p38 MAPK only in differentiated myotubes, not in proliferating myoblasts...
  35. Taniyama Y, Ushio Fukai M, Hitomi H, Rocic P, Kingsley M, Pfahnl C, et al. Role of p38 MAPK and MAPKAPK-2 in angiotensin II-induced Akt activation in vascular smooth muscle cells. Am J Physiol Cell Physiol. 2004;287:C494-9 pubmed
    ..In this study, we tested the hypothesis that the reactive oxygen species (ROS)-sensitive kinase p38 MAPK and its substrate MAPKAPK-2 mediate Akt activation in VSMCs...
  36. Lu G, Kang Y, Han J, Herschman H, Stefani E, Wang Y. TAB-1 modulates intracellular localization of p38 MAP kinase and downstream signaling. J Biol Chem. 2006;281:6087-95 pubmed
    ..In addition, p38 MAP kinase can also be activated by an MKK-independent mechanism involving TAB-1 (TAK-1-binding protein)-mediated ..
  37. Jaswal J, Gandhi M, Finegan B, Dyck J, Clanachan A. Inhibition of p38 MAPK and AMPK restores adenosine-induced cardioprotection in hearts stressed by antecedent ischemia by altering glucose utilization. Am J Physiol Heart Circ Physiol. 2007;293:H1107-14 pubmed
    b>p38 mitogen-activated protein kinase (MAPK) and 5'-AMP-activated protein kinase (AMPK) are activated by metabolic stresses and are implicated in the regulation of glucose utilization and ischemia-reperfusion (IR) injury...
  38. Yang W, Lu C, Yu F, Liu T, Hu Z, Liu Y. Mitogen-activated protein kinase regulates FSH-induced expression of tissue-type plasminogen activator through an activator protein 1 response element. Endocrine. 2008;34:101-7 pubmed publisher
    ..We further examined possible signaling action involved in FSH-activated ERK1/2 and p38 MAPK on tPA production, and observed that FSH receptor occupancy led to both ERK1/2 and p38 MAPK phosphorylation...
  39. Lv B, Huo F, Dang X, Xu Z, Chen T, Zhang T, et al. Puerarin Attenuates N-Methyl-D-aspartic Acid-induced Apoptosis and Retinal Ganglion Cell Damage Through the JNK/p38 MAPK Pathway. J Glaucoma. 2016;25:e792-801 pubmed publisher
    ..Puerarin pretreatment also effectively inhibited NMDA-induced JNK and p38 phosphorylation in the RGCs, whereas pretreatment with either JNK agonist anisomycin or p38 agonist P79350 could ..
  40. Lui W, Lee W, Cheng C. Transforming growth factor beta3 regulates the dynamics of Sertoli cell tight junctions via the p38 mitogen-activated protein kinase pathway. Biol Reprod. 2003;68:1597-612 pubmed
    ..TGFbeta3 action, such as Smad2, Cdc42, Rac2, and N-Ras, suggesting this effect might be mediated via the p38 MAP kinase pathway...
  41. Huang C, Borchers C, Schaller M, Jacobson K. Phosphorylation of paxillin by p38MAPK is involved in the neurite extension of PC-12 cells. J Cell Biol. 2004;164:593-602 pubmed
    ..Thus, phosphorylation of paxillin is involved in NGF-induced neurite extension of PC-12 cells, probably through regulating focal adhesion organization. ..
  42. Cai B, Xia Z. p38 MAP kinase mediates arsenite-induced apoptosis through FOXO3a activation and induction of Bim transcription. Apoptosis. 2008;13:803-10 pubmed publisher
    Sodium arsenite induces apoptosis in PC12 cells by activating the stress-activated p38 MAP kinase and the pro-apoptotic Bcl-2 family protein Bim(EL)...
  43. Lizárraga Mollinedo E, Fernández Millán E, de Miguel Santos L, Martínez Honduvilla C, Alvarez C, Escriva F. Early undernutrition increases glycogen content and reduces the activated forms of GSK3, AMPK, p38 MAPK, and JNK in the cerebral cortex of suckling rats. J Neurochem. 2010;112:123-33 pubmed publisher
    ..Phospho-p38 and both total JNK and phospho-JNK, which regulate apoptosis, are reduced following undernutrition...
  44. Hamanoue M, Sato K, Takamatsu K. Inhibition of p38 mitogen-activated protein kinase-induced apoptosis in cultured mature oligodendrocytes using SB202190 and SB203580. Neurochem Int. 2007;51:16-24 pubmed
    b>p38 Mitogen-activated protein kinase (p38 MAPK) is expressed in the oligodendrocyte lineage, and its activity has been implicated in the proliferation and transition of early progenitors into late progenitors...
  45. Yin H, Zhang J, Lin H, Wang R, Qiao Y, Wang B, et al. p38 mitogen-activated protein kinase inhibition decreases TNFalpha secretion and protects against left ventricular remodeling in rats with myocardial ischemia. Inflammation. 2008;31:65-73 pubmed
    The purpose of this study was to test our hypothesis that p38 mitogen-activated protein kinase (p38 MAPK) inhibitor SB203580 may favorably affect tumor necrosis factor alpha (TNFalpha) secretion and left ventricular (LV) remodeling after ..
  46. Reinhardt H, Hasskamp P, Schmedding I, Morandell S, van Vugt M, Wang X, et al. DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization. Mol Cell. 2010;40:34-49 pubmed publisher
    ..p53-defective tumor cells rewire their checkpoint response and become dependent on the p38/MK2 pathway for survival after DNA damage, despite a functional ATR-Chk1 pathway...
  47. Diamond Stanic M, Marchionne E, Teachey M, Durazo D, Kim J, Henriksen E. Critical role of the transient activation of p38 MAPK in the etiology of skeletal muscle insulin resistance induced by low-level in vitro oxidant stress. Biochem Biophys Res Commun. 2011;405:439-44 pubmed publisher
    ..Phosphorylation of p38 MAPK Thr180/Tyr182 was transiently increased by H2O2 in the presence and absence of insulin at 2 and 4 h, but not ..
  48. Kondo T, Sakurai J, Miwa H, Noguchi K. Activation of p38 MAPK through transient receptor potential A1 in a rat model of gastric distension-induced visceral pain. Neuroreport. 2013;24:68-72 pubmed publisher
    ..In contrast, it is known that the activation of p38 MAPK (p38) contributes to the development and maintenance of inflammatory and neuropathic pain...
  49. Ghosh S, Gadiparthi L, Zeng Z, Bhanoori M, Tellez C, Bar Eli M, et al. ATF-1 mediates protease-activated receptor-1 but not receptor tyrosine kinase-induced DNA synthesis in vascular smooth muscle cells. J Biol Chem. 2002;277:21325-31 pubmed
    Previously we have demonstrated that activation of p38 mitogen-activated protein kinase (MAPK) and induction of DNA synthesis in response to receptor tyrosine kinase (RTK) and G protein-coupled receptor (GPCR) agonists require NADH/NADPH-..
  50. Yan Z, Ni Y, Wang P, Chen J, He H, Sun J, et al. Peroxisome proliferator-activated receptor delta protects against obesity-related glomerulopathy through the P38 MAPK pathway. Obesity (Silver Spring). 2013;21:538-45 pubmed publisher
    ..this study was to explore the effect of cross-talk between peroxisome proliferator-activated receptor (PPAR)? and p38 mitogen-activated protein kinase (p38 MAPK) on obesity-related glomerulopathy...
  51. Zhu P, Zhan L, Zhu T, Liang D, Hu J, Sun W, et al. The roles of p38 MAPK/MSK1 signaling pathway in the neuroprotection of hypoxic postconditioning against transient global cerebral ischemia in adult rats. Mol Neurobiol. 2014;49:1338-49 pubmed publisher
    ..This study tested the hypothesis that p38-mitogen-activated protein kinase (p38 MAPK)/mitogen- and stress-response kinase 1 (MSK1) signaling pathway plays a ..
  52. Xu Z, Wang B, Wang X, Kuang F, Duan X, Jiao X, et al. ERK1/2 and p38 mitogen-activated protein kinase mediate iNOS-induced spinal neuron degeneration after acute traumatic spinal cord injury. Life Sci. 2006;79:1895-905 pubmed
    ..the synthesis and release of NO, we examined activation of extracellular signal regulated kinase 1/2 (ERK1/2) and p38 mitogen-activated protein kinases (p38 MAPK) in microglia/macrophages in the injured area of adult rats subjected ..
  53. Chang A. Pro-life role for c-Jun N-terminal kinase and p38 mitogen-activated protein kinase at rostral ventrolateral medulla in experimental brain stem death. J Biomed Sci. 2012;19:96 pubmed publisher
    ..The present study assessed the hypothesis that, in addition to ERK1/2, c-Jun NH2-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38MAPK), the other two mammalian members of MAPKs that are originally identified ..
  54. Huang G, Wang Y, Chi H. Control of T cell fates and immune tolerance by p38? signaling in mucosal CD103+ dendritic cells. J Immunol. 2013;191:650-9 pubmed publisher
    ..In this study, we describe that p38? signaling in CD103(+) mesenteric lymph node DCs reciprocally regulates the differentiation of anti-inflammatory ..
  55. Park C, Kim D, Park M, Kim M, Kim N, Kim C, et al. Chinese prescription Kangen-karyu and Salviae Miltiorrhizae Radix improve age-related oxidative stress and inflammatory response through the PI3K/Akt or MAPK pathways. Am J Chin Med. 2014;42:987-1005 pubmed publisher
    ..This study provides scientific evidence that Kangen-karyu and Salviae Miltiorrhizae Radix improve the inflammatory responses via the PI3K/Akt or MAPK pathways in the kidney of old rats...
  56. Palacios S, Pak K, Rivkin A, Kayali A, Austen D, Aletsee C, et al. Role of p38 mitogen-activated protein kinase in middle ear mucosa hyperplasia during bacterial otitis media. Infect Immun. 2004;72:4662-7 pubmed
    ..Endotoxin derived from bacteria involved in middle ear infection can contribute to the hyperplastic response. The p38 mitogen-activated protein kinase (MAPK) is known to be activated by endotoxin as well as cytokines and other ..
  57. Siddiqui S, Siddiqui Z, Uddin S, Minshall R, Malik A. p38 MAPK activation coupled to endocytosis is a determinant of endothelial monolayer integrity. Am J Physiol Lung Cell Mol Physiol. 2007;292:L114-24 pubmed
    ..In RLMVEC grown in serum-free medium, we observed that albumin supplementation induced the phosphorylation of p38 MAPK within 30 min, which persisted for up to 2 h...
  58. Dang H, Elliott J, Lin A, Zhu B, Katz M, Yeh C. Mitogen-activated protein kinase up-regulation and activation during rat parotid gland atrophy and regeneration: role of epidermal growth factor and beta2-adrenergic receptors. Differentiation. 2008;76:546-57 pubmed publisher
    ..of the mitogen-activated protein kinases (MAPKs), extracellular signal-regulated receptor kinase (ERK)1/2, and p38 during the atrophic and regeneration phases of ductal obstruction/release. Similarly, increases in activated, i.e...
  59. Katoh Semba R, Kaneko R, Kitajima S, Tsuzuki M, Ichisaka S, Hata Y, et al. Activation of p38 mitogen-activated protein kinase is required for in vivo brain-derived neurotrophic factor production in the rat hippocampus. Neuroscience. 2009;163:352-61 pubmed publisher
    ..Riluzole increased levels of phospho-p38 mitogen-activated protein kinase (p38 MAPK), as well as BDNF levels...
  60. Xu W, Hou D, Jiang X, Lu Z, Guo T, Liu Y, et al. The protective role of peroxisome proliferator-activated receptor ? coactivator-1? in hyperthyroid cardiac hypertrophy. J Cell Physiol. 2012;227:3243-53 pubmed publisher
    ..Furthermore, we presented evidence to show that T3 decreased PGC-1? expression via p38 mitogen-activated protein kinases (MAPK) pathway...
  61. Martin D, Lonergan P, Boland B, Fogarty M, Brady M, Horrobin D, et al. Apoptotic changes in the aged brain are triggered by interleukin-1beta-induced activation of p38 and reversed by treatment with eicosapentaenoic acid. J Biol Chem. 2002;277:34239-46 pubmed
    ..reversed these changes as well as the accompanying increases in interleukin-1beta concentration and p38 activation...
  62. Kim B, Kim J, Bae Y, Cho S, Kwon S, Jung J, et al. p38 mitogen-activated protein kinase contributes to the diminished aortic contraction by endothelin-1 in DOCA-salt hypertensive rats. Hypertension. 2004;43:1086-91 pubmed
    ..Although ET-1 also increased the phosphorylation of p38 MAPK in both strips, the increment was markedly lower in the strips from DOCA-salt hypertensive rats compared with ..
  63. Fonseca B, Correia da Silva G, Teixeira N. The endocannabinoid anandamide induces apoptosis of rat decidual cells through a mechanism involving ceramide synthesis and p38 MAPK activation. Apoptosis. 2013;18:1526-35 pubmed publisher
    ..The ceramide analogue, C6-ceramide, induced a decrease in decidual cell viability and of p38 MAPK phosphorylation...
  64. Rauhala L, Hämäläinen L, Salonen P, Bart G, Tammi M, Pasonen Seppänen S, et al. Low dose ultraviolet B irradiation increases hyaluronan synthesis in epidermal keratinocytes via sequential induction of hyaluronan synthases Has1-3 mediated by p38 and Ca2+/calmodulin-dependent protein kinase II (CaMKII) signaling. J Biol Chem. 2013;288:17999-8012 pubmed publisher
    ..Silencing of Has2 and especially Has3 decreased the UVB-induced accumulation of hyaluronan. p38 and Ca(2+)/calmodulin-dependent protein kinase II pathways were found to be involved in the UVB-induced up-..
  65. Chen Z, Zhang X, Liu Y, Liu Z. Morphine Postconditioning Protects against Reperfusion Injury via Inhibiting JNK/p38 MAPK and Mitochondrial Permeability Transition Pores Signaling Pathways. Cell Physiol Biochem. 2016;39:61-70 pubmed publisher
    The purpose of this study was to determine whether c-jun NH2 amino-terminal kinases (JNK) and p38 mitogen-activated protein kinases (MAPK) were involved in morphine postconditioning (MpostC)...
  66. Jiang Y, Zeng Y, Huang X, Qin Y, Luo W, Xiang S, et al. Nur77 attenuates endothelin-1 expression via downregulation of NF-?B and p38 MAPK in A549 cells and in an ARDS rat model. Am J Physiol Lung Cell Mol Physiol. 2016;311:L1023-L1035 pubmed publisher
    ..LPS-induced phosphorylation and nuclear translocation of NF-?B and p38 MAPK were blocked by Nur77 overexpression and augmented by Nur77 knockdown in A549 cells...
  67. Kelly A, Vereker E, Nolan Y, Brady M, Barry C, Loscher C, et al. Activation of p38 plays a pivotal role in the inhibitory effect of lipopolysaccharide and interleukin-1 beta on long term potentiation in rat dentate gyrus. J Biol Chem. 2003;278:19453-62 pubmed
    ..inhibition of LTP induced by LPS and IL-1 beta was coupled with stimulation of the stress-activated protein kinase p38 in hippocampus and entorhinal cortex and that this effect was abrogated by the p38 inhibitor SB203580, while the ..
  68. Stambe C, Atkins R, Hill P, Nikolic Paterson D. Activation and cellular localization of the p38 and JNK MAPK pathways in rat crescentic glomerulonephritis. Kidney Int. 2003;64:2121-32 pubmed
    The p38 and c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase (MAPK) are intracellular signal transduction pathways involved in the production of inflammatory mediators...
  69. Sharma V, Mustafa S, Patel N, Wambolt R, Allard M, McNeill J. Stimulation of cardiac fatty acid oxidation by leptin is mediated by a nitric oxide-p38 MAPK-dependent mechanism. Eur J Pharmacol. 2009;617:113-7 pubmed publisher
    ..Nitric oxide and p38 mitogen activated protein kinase (MAPK) are known effectors of leptin signaling...
  70. Feng A, Zhou G, Yuan X, Huang X, Zhang Z, Zhang T. Inhibitory effect of baicalin on iNOS and NO expression in intestinal mucosa of rats with acute endotoxemia. PLoS ONE. 2013;8:e80997 pubmed publisher
    ..receptor 4 (TLR4) and peroxisome proliferator-activated receptor gamma (PPAR?) content, but also activated p38 and activating transcription factor 2 (ATF2) and inactivated PPAR? via phosphorylation...
  71. Thoresen G, Guren T, Christoffersen T. Role of ERK, p38 and PI3-kinase in EGF receptor-mediated mitogenic signalling in cultured rat hepatocytes: requirement for sustained ERK activation. Cell Physiol Biochem. 2003;13:229-38 pubmed
    ..EGF receptor stimulation also transiently activated p38, and inhibition of p38 by SB203580 markedly decreased the DNA synthesis...
  72. Park S, Kim H, Min Y, Choi E, Shin Y, Park B, et al. Human lysyl-tRNA synthetase is secreted to trigger proinflammatory response. Proc Natl Acad Sci U S A. 2005;102:6356-61 pubmed
    ..The mitogen-activated protein kinases, extracellular signal-regulated kinase and p38 mitogen-activated protein kinase, and Galphai were determined to be involved in the signal transduction triggered ..
  73. Briata P, Forcales S, Ponassi M, Corte G, Chen C, Karin M, et al. p38-dependent phosphorylation of the mRNA decay-promoting factor KSRP controls the stability of select myogenic transcripts. Mol Cell. 2005;20:891-903 pubmed
    ..The extracellular signal-activated p38 MAP kinase (p38) pathway plays a fundamental role in conversion of myoblasts to differentiated myocytes...
  74. Tristano A, Castejon A, Castro A, Cubeddu L. Effects of statin treatment and withdrawal on angiotensin II-induced phosphorylation of p38 MAPK and ERK1/2 in cultured vascular smooth muscle cells. Biochem Biophys Res Commun. 2007;353:11-7 pubmed
    ..In VSMC, AII stimulated the phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2), and of p38 mitogen-activated protein kinase (p38 MAPK), with an EC50% of 0.86 and 3 nM, respectively...
  75. Zhang G, Du Y, Yao L, Zhang R, Liu J, Bu N, et al. [Expression of p38MAPK in the olfactory bulb of rats with Alzheimer's disease]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2009;40:40-3 pubmed
    ..01). CONCLUSIONS; Abeta25-35 can activate p38MAPK signal transduction pathway. p38MAPK may play a role in the formation of dysosmia in AD. SB203580, a p38MAPK inhibitor, can reduce the neurotoxicity evoked by p38MAPK. ..
  76. Chen Y, Li G, Huang L. p38 MAPK mediates glial P2X7R-neuronal P2Y1R inhibitory control of P2X3R expression in dorsal root ganglion neurons. Mol Pain. 2015;11:68 pubmed publisher
    ..Examining the effect of the activation of p38 mitogen-activated protein kinase on the expression of P2X3Rs in DRGs, we found that the p38 activator, anisomycin (..
  77. Carter Y, Liu G, Stephens W, Carter G, Yang J, Mendez C. Heat shock protein (HSP72) and p38 MAPK involvement in sublethal hemorrhage (SLH)-induced tolerance. J Surg Res. 2003;111:70-7 pubmed
    ..immunosorbent assay were performed for gene, MAPK, and protein expression (tumor necrosis factor [TNF], HSP, p38). SLH induced significantly more lung HSP72 mRNA and protein...
  78. Vary T, Deiter G, Lang C. Diminished ERK 1/2 and p38 MAPK phosphorylation in skeletal muscle during sepsis. Shock. 2004;22:548-54 pubmed
    ..The present study examines the phosphorylation of Erk 1/2 MAPK and p38 MAPK in skeletal muscle of rats with a chronic (5-day) intra-abdominal septic abscess...
  79. Zhang G, Nagai Y, Nakagawa T, Miyanaka H, Fujisawa Y, Nishiyama A, et al. Involvement of endogenous nitric oxide in angiotensin II-induced activation of vascular mitogen-activated protein kinases. Am J Physiol Heart Circ Physiol. 2007;293:H2403-8 pubmed
    ..5 mg/kg) enhanced phosphorylation of aortic MAP kinases extracellular signal regulated kinase (ERK) 1/2 and p38, which were suppressed only partially by a superoxide dismutase mimetic (Tempol), whereas ANG II-induced MAP kinase ..
  80. An H, Lu X, Liu D, Yarbrough W. LZAP inhibits p38 MAPK (p38) phosphorylation and activity by facilitating p38 association with the wild-type p53 induced phosphatase 1 (WIP1). PLoS ONE. 2011;6:e16427 pubmed publisher
    ..b>p38 MAPK can increase or decrease proliferation and cell death depending on cellular context...
  81. Kuang D, Zhao X, Xiao G, Ni J, Feng Y, Wu R, et al. Stem cell factor/c-kit signaling mediated cardiac stem cell migration via activation of p38 MAPK. Basic Res Cardiol. 2008;103:265-73 pubmed
    ..was matched with more accumulation of CSCs in the region and improvement of cardiac function, which was blocked by p38 MAPK selective inhibitor SB203580...
  82. Fitzsimmons B, Zattoni M, Svensson C, Steinauer J, Hua X, Yaksh T. Role of spinal p38alpha and beta MAPK in inflammatory hyperalgesia and spinal COX-2 expression. Neuroreport. 2010;21:313-7 pubmed publisher
    ..We investigated whether either the spinal isoform p38alpha or p38beta is involved in peripheral inflammation evoked pain state and increased expression of spinal COX-2...
  83. Chen L, Wang Y, Tseng G. Compression alters kinase and phosphatase activity and tau and MAP2 phosphorylation transiently while inducing the fast adaptive dendritic remodeling of underlying cortical neurons. J Neurotrauma. 2010;27:1657-69 pubmed publisher
    ..10?min to 1 day, and transient excitatory phosphorylation of extracellular signal-regulated protein kinase 1/2 and p38/mitogen-activated protein kinase...
  84. Yoshino Y, Yamamoto S, Kohsaka S, Oshiro S, Nakajima K. Superoxide anion contributes to the induction of tumor necrosis factor alpha (TNF?) through activation of the MKK3/6-p38 MAPK cascade in rat microglia. Brain Res. 2011;1422:1-12 pubmed publisher
    ..NAC strongly depressed phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK), which is necessary for inducing TNF? in microglia...
  85. Chang M, Li Y, Liu D, Zhang L, Zhang H, Tang H, et al. Melatonin prevents secondary intra-abdominal hypertension in rats possibly through inhibition of the p38 MAPK pathway. Free Radic Biol Med. 2016;97:192-203 pubmed publisher
    ..The expression of extracellular signal-regulated kinase, p38, c-Jun NH2-terminal kinase, translocation of nuclear factor kappa B subunit, signal transducers and activators of ..
  86. Slone S, Anthony S, Wu X, Benoit J, AUBE J, Xu L, et al. Activation of HuR downstream of p38 MAPK promotes cardiomyocyte hypertrophy. Cell Signal. 2016;28:1735-41 pubmed publisher
    ..This Gq-mediated HuR activation is dependent on p38 MAP kinase, but not canonical Gq-PKC signaling...
  87. Dong Y, Ding C, Gu W, Suo X. [Inhibitory effects of melatonin on the expression of phosphorylation p38 mitogen-activated protein kinase during acute lung injury in rats]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2010;22:418-21 pubmed
    ..In addition, the expression of phosphorylation p38 mitogen-activated protein kinase (p-p38 MAPK) in lung tissue was assayed with immunohistochemistry staining...
  88. Ge J, Zhao Z, Zhou Z, Wu S, Zhang R, Pan F, et al. p38 MAPK inhibitor, CBS3830 limits vascular remodelling in arterialised vein grafts. Heart Lung Circ. 2013;22:751-8 pubmed publisher
    ..investigated whether CBS3830 (c-a-i-r biosciences GmbH, Tübingen, Germany), a new highly selectively inhibitor of p38 MAPK, has a significant effect on inhibiting intimal, medial and adventitial hyperplasia...
  89. Woo C, Kim J. Rac GTPase activity is essential for lipopolysaccharide signaling to extracellular signal-regulated kinase and p38 MAP kinase activation in rat-2 fibroblasts. Mol Cells. 2002;13:470-5 pubmed
    ..Our results showed that LPS induced the activation of ERK and p38 MAP kinase in a Rac-dependent manner, suggesting a mediatory role of Rac1 in LPS signaling to MAPKs stimulation...
  90. Pantos C, Malliopoulou V, Mourouzis I, Moraitis P, Tzeis S, Thempeyioti A, et al. Involvement of p38 MAPK and JNK in heat stress-induced cardioprotection. Basic Res Cardiol. 2003;98:158-64 pubmed
    ..investigated whether heat stress-induced cardioprotection involves alterations in the pattern of p38 mitogen activated protein kinase (p38MAPK) and c-Jun NH2 - terminal kinase (JNK) activation during ischaemia - reperfusion in a ..
  91. Auger R, Motta I, Benihoud K, Ojcius D, Kanellopoulos J. A role for mitogen-activated protein kinase(Erk1/2) activation and non-selective pore formation in P2X7 receptor-mediated thymocyte death. J Biol Chem. 2005;280:28142-51 pubmed
    ..These results therefore suggest a role for both activation of MAP kinase(Erk1/2) and non-selective pore opening in P2X7R-induced thymocyte death. ..
  92. Zhou F, Foster B, Zhou X, Cowin A, Xian C. TNF-alpha mediates p38 MAP kinase activation and negatively regulates bone formation at the injured growth plate in rats. J Bone Miner Res. 2006;21:1075-88 pubmed
    ..These observations suggest that TNF-alpha activates p38 MAP kinase during the inflammatory response at the injured growth plate, and TNF-alpha-p38 signaling seems to be required ..