Gene Symbol: Mapk13
Description: mitogen activated protein kinase 13
Alias: Prkm13, mitogen-activated protein kinase 13, MAP kinase 13, MAP kinase p38 delta, MAPK 13, mitogen-activated protein kinase p38 delta, stress-activated protein kinase 4
Species: rat
Products:     Mapk13

Top Publications

  1. Schoorlemmer J, Goldfarb M. Fibroblast growth factor homologous factors and the islet brain-2 scaffold protein regulate activation of a stress-activated protein kinase. J Biol Chem. 2002;277:49111-9 pubmed
    ..These results support the existence of a signaling module in which IB2 scaffolds a MLK3/MKK/p38delta kinase cascade. FHFs aid in recruitment of p38 to IB2 and may serve as kinase substrates. ..
  2. Yin J, Liu Y, Xu Y, Zhang Y, Chen J, Shu B, et al. Melatonin arrests peroxynitrite-induced tau hyperphosphorylation and the overactivation of protein kinases in rat brain. J Pineal Res. 2006;41:124-9 pubmed
    ..We conclude that MEL can efficiently arrest peroxynitrite-induced tau hyperphosphorylation, and the underlying mechanism may involve scavenging the reactive species and suppressing the activated GSK-3beta and p38 MAPK family. ..
  3. Zhong J, Lardinois D, Szilard J, Tamm M, Roth M. Rat mesothelioma cell proliferation requires p38? mitogen activated protein kinase and C/EBP-?. Lung Cancer. 2011;73:166-70 pubmed publisher
    ..From this rat model, we conclude that in pleural mesothelioma, p38? in C/EBP-? mediate proliferation and thus may represent new targets in mesothelioma therapy. ..
  4. Hu M, Wang Y, Mikhail A, Qiu W, Tan T. Murine p38-delta mitogen-activated protein kinase, a developmentally regulated protein kinase that is activated by stress and proinflammatory cytokines. J Biol Chem. 1999;274:7095-102 pubmed
    ..Moreover, p38-delta is activated by environmental stress, extracellular stimulants, and MAPK kinase-3, -4, -6, and -7, suggesting that p38-delta is a unique stress-responsive protein kinase. ..
  5. Cuenda A, Rousseau S. p38 MAP-kinases pathway regulation, function and role in human diseases. Biochim Biophys Acta. 2007;1773:1358-75 pubmed
    ..Here we focus on these emergent roles of p38MAPKs and their implication in different pathologies. ..
  6. Kitatani K, Sheldon K, Anelli V, Jenkins R, Sun Y, Grabowski G, et al. Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid. J Biol Chem. 2009;284:12979-88 pubmed publisher
    ..Furthermore, the p38delta isoform was identified as a novel and predominant target of ceramide signaling as well as a regulator of IL-6 biosynthesis. ..
  7. Leong D, Li Y, Gu X, Sun L, Zhou Z, Nasser P, et al. Physiological loading of joints prevents cartilage degradation through CITED2. FASEB J. 2011;25:182-91 pubmed publisher
    ..Together, these studies identify a novel regulatory pathway involving CITED2 and p38?, which may be critical for the maintenance of articular cartilage integrity under normal physical activity levels. ..
  8. Pillai M, Sapna S, Shivakumar K. p38 MAPK regulates G1-S transition in hypoxic cardiac fibroblasts. Int J Biochem Cell Biol. 2011;43:919-27 pubmed publisher
    ..The study identifies Skp2 as a potential downstream target of p38 MAPK, suggesting a novel mechanism of G1-S regulation in cardiac fibroblasts exposed to stress conditions. ..
  9. Goedert M, Cuenda A, Craxton M, Jakes R, Cohen P. Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases. EMBO J. 1997;16:3563-71 pubmed
    ..Unlike SAPK2a and SAPK2b, SAPK4 and SAPK3 were not inhibited by the drugs SB 203580 and SB 202190. Our results suggest that cellular functions previously attributed to SAPK1 and/or SAPK2 may be mediated by SAPK3 or SAPK4. ..

More Information


  1. Parker C, Hunt J, Diener K, McGinley M, Soriano B, Keesler G, et al. Identification of stathmin as a novel substrate for p38 delta. Biochem Biophys Res Commun. 1998;249:791-6 pubmed
    ..In transient expression studies, we found that in addition to different stimuli osmotic stress activates p38 delta to phosphorylate stathmin. The sites of phosphorylation were mapped to Ser-25 and Ser-38, both in vitro and in cells. ..
  2. Sabio G, Arthur J, Kuma Y, Peggie M, Carr J, Murray Tait V, et al. p38gamma regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP. EMBO J. 2005;24:1134-45 pubmed
    ..This is likely to regulate the integrity of intercellular-junctional complexes, and cell shape and volume in response to osmotic stress. ..
  3. Eyers C, McNeill H, Knebel A, Morrice N, Arthur S, Cuenda A, et al. The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ. Biochem J. 2005;389:127-35 pubmed
    ..Osmotic shock or anisomycin triggered the dissociation of CapZIP from CapZ in Jurkat cells, suggesting that phosphorylation of CapZIP may regulate the ability of CapZ to remodel actin filament assembly in vivo. ..
  4. Teng M, Jiang X, Zhang Q, Zhang J, Zhang D, Liang G, et al. Microtubular stability affects pVHL-mediated regulation of HIF-1alpha via the p38/MAPK pathway in hypoxic cardiomyocytes. PLoS ONE. 2012;7:e35017 pubmed publisher